| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Jenkins, G V Johnso. Microtubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domain. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737602. |
tau is a microtubule-associated protein (map) that is functionally modulated by phosphorylation and that is hyperphosphorylated in several neurodegenerative diseases. |
2000-04-11 |
2023-08-12 |
human |
| M E King, T C Gamblin, J Kuret, L I Binde. Differential assembly of human tau isoforms in the presence of arachidonic acid. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737634. |
insoluble, filamentous deposits of tau protein occur in a number of neurodegenerative diseases, and in some of these diseases, the deposition of polymers enriched in certain tau isoforms has been documented. |
2000-04-11 |
2023-08-12 |
human |
| S Ikegami, A Harada, N Hirokaw. Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice. Neuroscience letters. vol 279. issue 3. 2000-03-17. PMID:10688046. |
recently, mutations in the tau gene were found in a hereditary neurodegenerative disease called frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) which exhibits various neurological and neuropathological characteristics including phf-like intracellular tau deposit formation. |
2000-03-17 |
2023-08-12 |
mouse |
| S M Jenkins, M Zinnerman, C Garner, G V Johnso. Modulation of tau phosphorylation and intracellular localization by cellular stress. The Biochemical journal. vol 345 Pt 2. 2000-03-02. PMID:10620503. |
tau is a microtubule-associated protein that is functionally modulated by phosphorylation and hyperphosphorylated in several neurodegenerative diseases. |
2000-03-02 |
2023-08-12 |
Not clear |
| H R Morris, N W Wood, A J Lee. Progressive supranuclear palsy (Steele-Richardson-Olszewski disease). Postgraduate medical journal. vol 75. issue 888. 2000-01-20. PMID:10621897. |
evidence from familial fronto-temporal dementia with parkinsonism linked to chromosome 17 suggests that tau protein deposition is a primary pathogenic event in some neurodegenerative diseases. |
2000-01-20 |
2023-08-12 |
Not clear |
| M G Spillantini, M Tolnay, S Love, M Goeder. Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. Acta neuropathologica. vol 97. issue 6. 2000-01-14. PMID:10378377. |
microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. |
2000-01-14 |
2023-08-12 |
Not clear |
| M G Spillantini, M Tolnay, S Love, M Goeder. Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. Acta neuropathologica. vol 97. issue 6. 2000-01-14. PMID:10378377. |
these findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments. |
2000-01-14 |
2023-08-12 |
Not clear |
| K Spittaels, C Van den Haute, J Van Dorpe, K Bruynseels, K Vandezande, I Laenen, H Geerts, M Mercken, R Sciot, A Van Lommel, R Loos, F Van Leuve. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595944. |
this transgenic model, overexpressing the longest isoform of human tau protein, recapitulates features of known neurodegenerative diseases, including alzheimer's disease and other tauopathies. |
1999-12-28 |
2023-08-12 |
mouse |
| C B Chambers, J M Lee, J C Troncoso, S Reich, N A Mum. Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease. Annals of neurology. vol 46. issue 3. 1999-10-20. PMID:10482263. |
perturbations in the microtubule-associated protein tau occur in several human neurodegenerative diseases. |
1999-10-20 |
2023-08-12 |
human |
| J Pérez-Tur, L Buée, H R Morris, S C Waring, L Onstead, F Wavrant-De Vrièze, R Crook, V Buée-Scherrer, P R Hof, R C Petersen, P L McGeer, A Delacourte, M Hutton, T Siddique, J E Ahlskog, J Hardy, J C Steel. Neurodegenerative diseases of Guam: analysis of TAU. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430438. |
neurodegenerative diseases of guam: analysis of tau. |
1999-09-21 |
2023-08-12 |
Not clear |
| Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377336. |
the nature of the extracellular signals that regulate the expression and the phosphorylation of the microtubule-associated protein tau, which is aberrantly hyperphosphorylated in alzheimer disease and other adult-onset neurodegenerative diseases, is not known. |
1999-07-15 |
2023-08-12 |
rat |
| C Janke, M Beck, T Stahl, M Holzer, K Brauer, V Bigl, T Arend. Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders. Brain research. Molecular brain research. vol 68. issue 1-2. 1999-07-07. PMID:10320789. |
thus, splicing of tau might critically influence the physiological functions of tau protein as well as the pathogenesis of neurodegenerative diseases with tauopathy. |
1999-07-07 |
2023-08-12 |
human |
| H R Morris, J C Janssen, O Bandmann, S E Daniel, M N Rossor, A J Lees, N W Woo. The tau gene A0 polymorphism in progressive supranuclear palsy and related neurodegenerative diseases. Journal of neurology, neurosurgery, and psychiatry. vol 66. issue 5. 1999-05-25. PMID:10209184. |
the tau gene a0 polymorphism in progressive supranuclear palsy and related neurodegenerative diseases. |
1999-05-25 |
2023-08-12 |
human |
| G A Jicha, J M Rockwood, B Berenfeld, M Hutton, P Davie. Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins. Neuroscience letters. vol 260. issue 3. 1999-05-17. PMID:10076890. |
these data suggest that the previously identified mutations in the tau gene seen in frontotemporal dementia-17 are not merely benign polymorphisms, but may have functional consequences for microtubule binding, microtubule polymerization, and the abnormal aggregation of tau seen in a variety of neurodegenerative diseases. |
1999-05-17 |
2023-08-12 |
Not clear |
| M Moorthamer, B Chaudhur. Identification of ribosomal protein L34 as a novel Cdk5 inhibitor. Biochemical and biophysical research communications. vol 255. issue 3. 1999-04-01. PMID:10049762. |
active cdk5 is thought to be involved in the in vivo phosphorylation of the neurofilament proteins and tau which are hyperphosphorylated in neurodegenerative diseases. |
1999-04-01 |
2023-08-12 |
Not clear |
| E M Mandelkow, E Mandelko. Tau in Alzheimer's disease. Trends in cell biology. vol 8. issue 11. 1999-03-22. PMID:9854307. |
there is renewed interest in tau as a causative factor in neurodegenerative disease based on recently discovered mutations in the gene encoding tau. |
1999-03-22 |
2023-08-12 |
Not clear |
| N Sergeant, A Wattez, A Delacourt. Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037497. |
together, tau isoforms with exon 10 clearly differentiate three groups of neurodegenerative diseases: ad, pid, and psp/cbd. |
1999-03-18 |
2023-08-12 |
Not clear |
| K K Burkhart, D C Beard, R A Lehman, M L Billingsle. Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878182. |
highly phosphorylated tau does not bind microtubules and is the main component of the paired helical filaments seen in alzheimer's and related neurodegenerative diseases. |
1999-02-04 |
2023-08-12 |
human |
| M Hong, V Zhukareva, V Vogelsberg-Ragaglia, Z Wszolek, L Reed, B I Miller, D H Geschwind, T D Bird, D McKeel, A Goate, J C Morris, K C Wilhelmsen, G D Schellenberg, J Q Trojanowski, V M Le. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science (New York, N.Y.). vol 282. issue 5395. 1998-12-28. PMID:9836646. |
tau proteins aggregate as cytoplasmic inclusions in a number of neurodegenerative diseases, including alzheimer's disease and hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
1998-12-28 |
2023-08-12 |
Not clear |
| M G Spillantini, M Goeder. Tau protein pathology in neurodegenerative diseases. Trends in neurosciences. vol 21. issue 10. 1998-12-18. PMID:9786340. |
tau protein pathology in neurodegenerative diseases. |
1998-12-18 |
2023-08-12 |
Not clear |