| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Garcia, D W Clevelan. Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Current opinion in cell biology. vol 13. issue 1. 2001-04-12. PMID:11163132. |
going new places using an old map: tau, microtubules and human neurodegenerative disease. |
2001-04-12 |
2023-08-12 |
human |
| S Hoye. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113614. |
this may indicate that the amyloid cascade hypothesis in not valid for sporadic alzheimer disease but that the formation of both, amyloidogenic derivatives and hyperphosphorylated tau protein is downstream the origin of this neurodegenerative disease. |
2001-03-29 |
2023-08-12 |
Not clear |
| N A Muma, J M Lee, L Gorman, B A Heidenreich, I Mitrovic, T C Napie. 6-hydroxydopamine-induced lesions of dopaminergic neurons alter the function of postsynaptic cholinergic neurons without changing cytoskeletal proteins. Experimental neurology. vol 168. issue 1. 2001-03-29. PMID:11170728. |
the neuropathological hallmarks of many neurodegenerative diseases are intraneuronal inclusions containing cytoskeletal proteins such as neurofilaments in lewy bodies in parkinson's disease and tau in neurofibrillary tangles in alzheimer's disease. |
2001-03-29 |
2023-08-12 |
rat |
| M Goedert, B Ghetti, M G Spillantin. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193179. |
filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy, and corticobasal degeneration. |
2001-02-08 |
2023-08-12 |
human |
| B L Goode, M Chau, P E Denis, S C Feinstei. Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10984497. |
consistent with this hypothesis, regulatory mutations in the human tau gene that disrupt the normal balance between 3-repeat and 4-repeat tau isoform expression lead to a collection of neurodegenerative diseases known as ftdp-17 (fronto-temporal dementias and parkinsonism linked to chromosome 17), which are characterized by the formation of pathological tau filaments and neuronal cell death. |
2001-01-18 |
2023-08-12 |
human |
| B L Goode, M Chau, P E Denis, S C Feinstei. Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10984497. |
the relevance of isoform-specific structure and function to normal tau action and the onset of neurodegenerative disease are discussed. |
2001-01-18 |
2023-08-12 |
human |
| M G Spillantini, J C Van Swieten, M Goeder. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Neurogenetics. vol 2. issue 4. 2001-01-09. PMID:10983715. |
filamentous tau protein deposits are also the defining characteristic of other neurodegenerative diseases, many of which are frontotemporal dementias or movement disorders, such as pick's disease, progressive supranuclear palsy and corticobasal degeneration. |
2001-01-09 |
2023-08-12 |
human |
| M van Slegtenhorst, J Lewis, M Hutto. The molecular genetics of the tauopathies. Experimental gerontology. vol 35. issue 4. 2000-12-22. PMID:10959034. |
the mechanism by which this common variability in the tau gene influences the development of these neurodegenerative diseases is unclear; however, it further suggests a central role for tau in the pathogenesis of several neurodegenerative conditions including alzheimer's disease (ad). |
2000-12-22 |
2023-08-12 |
Not clear |
| A Delacourte, L Bué. Tau pathology: a marker of neurodegenerative disorders. Current opinion in neurology. vol 13. issue 4. 2000-12-22. PMID:10970052. |
polymorphisms on the tau gene and the hierarchical invasion of neocortical areas by tau pathology in numerous sporadic neurodegenerative diseases also suggest that tau pathology is a primary pathogenic event in non-familial dementing diseases and a lead for solid diagnostic and therapeutic approaches. |
2000-12-22 |
2023-08-12 |
Not clear |
| H Ksiezak-Reding, D He, W Gordon-Krajcer, Y Kress, S Lee, D W Dickso. Induction of Alzheimer-specific Tau epitope AT100 in apoptotic human fetal astrocytes. Cell motility and the cytoskeleton. vol 47. issue 3. 2000-12-07. PMID:11056524. |
in alzheimer's and other neurodegenerative diseases, hyperphosphorylated tau accumulates in affected neuronal and glial cells in the form of paired helical filaments (phfs). |
2000-12-07 |
2023-08-12 |
human |
| M O Zemaitaitis, J M Lee, J C Troncoso, N A Mum. Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy. Journal of neuropathology and experimental neurology. vol 59. issue 11. 2000-12-07. PMID:11089576. |
double-label immunofluorescence demonstrated the colocalization of the cross-link and phf-tau in nft in pons of psp previous studies and present data are consistent with the hypothesis that transglutaminase-induced cross-linking may be a factor contributing to the abnormal polymerization and stabilization of tau in straight and phfs leading to neurofibrillary tangle formation in neurodegenerative diseases, including psp and ad. |
2000-12-07 |
2023-08-12 |
Not clear |
| M B Delisle, E Uro-Coste, J R Murrell, O Rascol, B Ghett. [Neurodegenerative disease associated with a mutation of codon 279 (N279K) in exon 10 of Tau protein]. Bulletin de l'Academie nationale de medecine. vol 184. issue 4. 2000-10-26. PMID:10989564. |
[neurodegenerative disease associated with a mutation of codon 279 (n279k) in exon 10 of tau protein]. |
2000-10-26 |
2023-08-12 |
Not clear |
| M B Delisle, E Uro-Coste, J R Murrell, O Rascol, B Ghett. [Neurodegenerative disease associated with a mutation of codon 279 (N279K) in exon 10 of Tau protein]. Bulletin de l'Academie nationale de medecine. vol 184. issue 4. 2000-10-26. PMID:10989564. |
the selectivity of neuronal death in hereditary diseases, when compared to data concerning sporadic neurodegenerative diseases which share similar clinical signs and neuropathological lesions, reinforces the hypothesis of an increased vulnerability of some neuronal populations which express specific sets of tau isoforms. |
2000-10-26 |
2023-08-12 |
Not clear |
| C Schwab, A J DeMaggio, N Ghoshal, L I Binder, J Kuret, P L McGee. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiology of aging. vol 21. issue 4. 2000-09-07. PMID:10924763. |
casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. |
2000-09-07 |
2023-08-12 |
Not clear |
| S Doré, S Kar, W H Zheng, R Quirio. Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke. Pharmaceutica acta Helvetiae. vol 74. issue 2-3. 2000-08-09. PMID:10812969. |
the effects, particularly those of igf-i on key markers of the alzheimer's (ad) brains namely cholinergic dysfunction, neuronal amyloid toxicity, tau phosphorylation and glucose metabolism suggest the potential usefulness of this growth factor in the treatment of neurodegenerative diseases. |
2000-08-09 |
2023-08-12 |
Not clear |
| K Yasojima, J Kuret, A J DeMaggio, E McGeer, P L McGee. Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814741. |
recently we have demonstrated that one family member, ckidelta, colocalizes with tau containing neurofibrillary tangles (nfts) and other tau deposits in a number of neurodegenerative diseases. |
2000-07-21 |
2023-08-12 |
Not clear |
| Z Jiang, J Cote, J M Kwon, A M Goate, J Y W. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and cellular biology. vol 20. issue 11. 2000-07-06. PMID:10805746. |
to establish a model system for studying the role of pre-mrna splicing in neurodegenerative diseases, we have constructed a tau minigene that reproduces tau alternative splicing in both cultured cells and in vitro biochemical assays. |
2000-07-06 |
2023-08-12 |
human |
| T C Gamblin, M E King, H Dawson, M P Vitek, J Kuret, R W Berry, L I Binde. In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. Biochemistry. vol 39. issue 20. 2000-06-21. PMID:10821687. |
tau polymerization into the filaments that compose neurofibrillary tangles is seminal to the development of many neurodegenerative diseases. |
2000-06-21 |
2023-08-12 |
Not clear |
| M K Ahlijanian, N X Barrezueta, R D Williams, A Jakowski, K P Kowsz, S McCarthy, T Coskran, A Carlo, P A Seymour, J E Burkhardt, R B Nelson, J D McNeis. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706614. |
hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in several neurodegenerative diseases including alzheimer's disease. |
2000-04-25 |
2023-08-12 |
mouse |
| M K Ahlijanian, N X Barrezueta, R D Williams, A Jakowski, K P Kowsz, S McCarthy, T Coskran, A Carlo, P A Seymour, J E Burkhardt, R B Nelson, J D McNeis. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706614. |
the overexpression of an activator of cdk5 in transgenic mice results in increased cdk5 activity that is sufficient to produce hyperphosphorylation of tau and neurofilament as well as cytoskeletal disruptions reminiscent of alzheimer's disease and other neurodegenerative diseases. |
2000-04-25 |
2023-08-12 |
mouse |