| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario Stampanoni Bassi, Ennio Iezzi, Luana Gilio, Diego Centonze, Fabio Buttar. Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology. International journal of molecular sciences. vol 20. issue 24. 2020-05-12. PMID:31817968. |
in addition, synaptic plasticity dysfunction may drive brain network disruption in neuropsychiatric conditions such as alzheimer's disease and schizophrenia. |
2020-05-12 |
2023-08-13 |
Not clear |
| S Gulsuner, D J Stein, E S Susser, G Sibeko, A Pretorius, T Walsh, L Majara, M M Mndini, S G Mqulwana, O A Ntola, S Casadei, L L Ngqengelele, V Korchina, C van der Merwe, M Malan, K M Fader, M Feng, E Willoughby, D Muzny, A Baldinger, H F Andrews, R C Gur, R A Gibbs, Z Zingela, M Nagdee, R S Ramesar, M-C King, J M McClella. Genetics of schizophrenia in the South African Xhosa. Science (New York, N.Y.). vol 367. issue 6477. 2020-04-08. PMID:32001654. |
schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. |
2020-04-08 |
2023-08-13 |
human |
| Steven J Girdler, Jamie E Confino, Mary E Woesne. Exercise as a Treatment for Schizophrenia: A Review. Psychopharmacology bulletin. vol 49. issue 1. 2020-03-30. PMID:30858639. |
although no clear etiology of schizophrenia has been discovered, many factors have been identified that contribute to the development of the disease, such as neurotransmitter alterations, decreased synaptic plasticity, and diminished hippocampal volume. |
2020-03-30 |
2023-08-13 |
Not clear |
| Tsung-Ming Hu, Shaw-Ji Chen, Shih-Hsin Hsu, Min-Chih Chen. Functional analyses and effect of DNA methylation on the EGR1 gene in patients with schizophrenia. Psychiatry research. vol 275. 2019-12-30. PMID:30952071. |
egr1, involved in the regulation of synaptic plasticity, learning, and memory, is considered a candidate gene for schizophrenia. |
2019-12-30 |
2023-08-13 |
Not clear |
| Johanna Lilja, Johanna Ivask. Integrin activity in neuronal connectivity. Journal of cell science. vol 131. issue 12. 2019-11-22. PMID:29907643. |
the integrin family of cell adhesion receptors and their ligands play essential roles in the control of several processes regulating neuronal connectivity - including neurite outgrowth, the formation and maintenance of synapses, and synaptic plasticity - that are affected in neurodevelopmental disorders, such as autism spectrum disorders (asds) and schizophrenia. |
2019-11-22 |
2023-08-13 |
Not clear |
| Nicholas E Clifton, Kerrie L Thomas, Jeremy Hal. The effect of ketamine on the consolidation and extinction of contextual fear memory. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29338491. |
genomic studies further implicate n-methyl-ᴅ-aspartate receptor-mediated processes in schizophrenia pathology, together with more broadly-defined synaptic plasticity and associative learning processes. |
2019-10-24 |
2023-08-13 |
rat |
| Julia C Bartsch, Björn H Schott, Joachim Beh. Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review. Pharmacopsychiatry. 2019-08-01. PMID:31370081. |
hippocampal dysfunction in schizophrenia and aberrant hippocampal synaptic plasticity in rodent model psychosis: a selective review. |
2019-08-01 |
2023-08-13 |
Not clear |
| Julia C Bartsch, Björn H Schott, Joachim Beh. Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review. Pharmacopsychiatry. 2019-08-01. PMID:31370081. |
taken together, the results put the case for maladaptive hippocampal synaptic plasticity and its extrinsic connections as mechanistic underpinnings of cognitive impairments in schizophrenia. |
2019-08-01 |
2023-08-13 |
Not clear |
| Clémentine Quintana, Jean-Martin Beaulie. A fresh look at cortical dopamine D2 receptor expressing neurons. Pharmacological research. vol 139. 2019-05-14. PMID:30528973. |
these findings underscore the need for a reexamination of cortical drd2 mediated synaptic plasticity in the context of schizophrenia and other psychotic disorders. |
2019-05-14 |
2023-08-13 |
Not clear |
| Mario de la Fuente Revenga, Daisuke Ibi, Justin M Saunders, Travis Cuddy, Maryum K Ijaz, Rudy Toneatti, Mitsumasa Kurita, Terrell Holloway, Li Shen, Jeremy Seto, Mikhail G Dozmorov, Javier González-Maes. HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice. Neuroscience. vol 388. 2019-03-29. PMID:30025863. |
together, these findings suggest that hdac2 may represent a novel target to improve synaptic plasticity and cognition in treated schizophrenia patients. |
2019-03-29 |
2023-08-13 |
mouse |
| Elise L V Malavasi, Kyriakos D Economides, Ellen Grünewald, Paraskevi Makedonopoulou, Philippe Gautier, Shaun Mackie, Laura C Murphy, Hannah Murdoch, Darragh Crummie, Fumiaki Ogawa, Daniel L McCartney, Shane T O'Sullivan, Karen Burr, Helen S Torrance, Jonathan Phillips, Marion Bonneau, Susan M Anderson, Paul Perry, Matthew Pearson, Costas Constantinides, Hazel Davidson-Smith, Mostafa Kabiri, Barbara Duff, Mandy Johnstone, H Greg Polites, Stephen M Lawrie, Douglas H Blackwood, Colin A Semple, Kathryn L Evans, Michel Didier, Siddharthan Chandran, Andrew M McIntosh, David J Price, Miles D Houslay, David J Porteous, J Kirsty Milla. DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness. Translational psychiatry. vol 8. issue 1. 2019-03-14. PMID:30190480. |
n-methyl-d-aspartate receptors (nmdar) play a central role in synaptic plasticity and cognition, and are implicated in the pathophysiology of schizophrenia through genetic and functional studies. |
2019-03-14 |
2023-08-13 |
mouse |
| Gauri Ang, Laura E McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N Peirson, Russell G Foster, Paul J Harrison, Rolf Sprengel, Kay E Davies, Peter L Oliver, David M Bannerman, Vladyslav V Vyazovski. Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders. Translational psychiatry. vol 8. issue 1. 2019-03-04. PMID:30108203. |
genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the gria1 gene which codes for the glua1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor. |
2019-03-04 |
2023-08-13 |
mouse |
| Jian Xu, Pradeep Kurup, Angus C Nairn, Paul J Lombros. Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28466270. |
synaptic nmda receptor activation induces ubiquitination and degradation of step nmda receptor signaling is critical for the development of synaptic plasticity, learning, and memory, and dysregulation of nmdar signaling is implicated in a number of neurological disorders including schizophrenia (sz). |
2019-02-26 |
2023-08-13 |
Not clear |
| Andrea de Bartolomeis, Felice Iasevoli, Federica Marmo, Elisabetta Filomena Buonaguro, Livia Avvisati, Gianmarco Latte, Carmine Tomasett. Nicotine and caffeine modulate haloperidol-induced changes in postsynaptic density transcripts expression: Translational insights in psychosis therapy and treatment resistance. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 4. 2019-02-11. PMID:29475793. |
here we investigated whether caffeine and nicotine, alone or combined with haloperidol, elicited significant changes in the levels of both transcripts and proteins of the psd members homer1 and arc, which have been implicated in synaptic plasticity, schizophrenia pathophysiology, and antipsychotics molecular action. |
2019-02-11 |
2023-08-13 |
Not clear |
| Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Duncan Sinclair, Mari A Kondo, Tim Karl, Cynthia Shannon Weicker. Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice. Schizophrenia bulletin. vol 44. issue 4. 2019-01-09. PMID:28981869. |
neuregulin 1 (nrg1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of specific isoforms. |
2019-01-09 |
2023-08-13 |
mouse |
| Katsunori Kobayashi, Tsuyoshi Takagi, Shunsuke Ishii, Hidenori Suzuki, Tsuyoshi Miyakaw. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular brain. vol 11. issue 1. 2019-01-07. PMID:30285890. |
attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of schnurri-2 knockout mice, a model of schizophrenia. |
2019-01-07 |
2023-08-13 |
mouse |
| James Ashley, Benjamin Cordy, Diandra Lucia, Lee G Fradkin, Vivian Budnik, Travis Thomso. Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Cell. vol 172. issue 1-2. 2018-12-31. PMID:29328915. |
arc/arg3.1 is required for synaptic plasticity and cognition, and mutations in this gene are linked to autism and schizophrenia. |
2018-12-31 |
2023-08-13 |
drosophila_melanogaster |
| Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesk. Differential effect of disease-associated ST8SIA2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls. Translational psychiatry. vol 8. issue 1. 2018-11-26. PMID:29353880. |
the st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (st8sia2) gene, which encodes the alpha-2,8-sialyltransferase 8b enzyme that aids neuronal migration and synaptic plasticity, was previously implicated as a schizophrenia susceptibility gene. |
2018-11-26 |
2023-08-13 |
Not clear |
| Jasmin Lalonde, Surya A Reis, Sudhir Sivakumaran, Carl S Holland, Hendrik Wesseling, John F Sauld, Begum Alural, Wen-Ning Zhao, Judith A Steen, Stephen J Haggart. Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29162813. |
the role of arc in synaptic plasticity and memory consolidation has been investigated for many years with recent evidence that defects in the expression or activity of this immediate-early gene may also contribute to the pathophysiology of brain disorders including schizophrenia and fragile x syndrome. |
2018-10-01 |
2023-08-13 |
Not clear |
| Nicholas E Clifton, Darren Cameron, Simon Trent, Lucy H Sykes, Kerrie L Thomas, Jeremy Hal. Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. Neural plasticity. vol 2017. 2018-07-30. PMID:29238619. |
genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. |
2018-07-30 |
2023-08-13 |
Not clear |