Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
N Oyaizu, S Pahw. Role of apoptosis in HIV disease pathogenesis. Journal of clinical immunology. vol 15. issue 5. 1996-02-07. PMID:8537466. |
accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of cd4 t-cells in hiv infection. |
1996-02-07 |
2023-08-12 |
Not clear |
Y Zhao, M Iwat. Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. International immunology. vol 7. issue 9. 1996-01-18. PMID:7495746. |
as positive selection depends on the inhibition of thymocyte apoptosis at its dp stage by signaling through the tcr-cd3 complex and some of the accessory molecules, including cd4, cd8 and lfa-1, we studied the possibility that fk506 enhanced apoptosis by itself or canceled the inhibition of apoptosis. |
1996-01-18 |
2023-08-12 |
Not clear |
M Leno, B F Hague, R Teller, T J Kind. HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits. Virology. vol 213. issue 2. 1996-01-02. PMID:7491769. |
hiv-1 mediates rapid apoptosis of lymphocytes from human cd4 transgenic but not normal rabbits. |
1996-01-02 |
2023-08-12 |
human |
L Tuosto, M S Gilardini Montani, S Lorenzetti, E Cundari, S Moretti, G Lombardi, E Piccolell. Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations. European journal of immunology. vol 25. issue 10. 1995-12-12. PMID:7589091. |
we show that monomeric gp120 induces apoptosis only in t lymphocytes repeatedly stimulated with the antigen, that primary t lymphocytes are resistant to programmed cell death mediated by monomeric gp120, but are sensitive to anti-cd4 antibodies, and that gp120-mediated apoptosis is dependent on the period of time between the binding of gp120 to cd4 and the encounter with antigen. |
1995-12-12 |
2023-08-12 |
Not clear |
L Tuosto, M S Gilardini Montani, S Lorenzetti, E Cundari, S Moretti, G Lombardi, E Piccolell. Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations. European journal of immunology. vol 25. issue 10. 1995-12-12. PMID:7589091. |
to investigate the different susceptibility to gp120 induced apoptosis of primary cd4+ and t cell clones further, the number of membrane cd4 molecules and their affinity for gp120, together with bcl-2 and fas expression, were studied. |
1995-12-12 |
2023-08-12 |
Not clear |
L Tuosto, M S Gilardini Montani, S Lorenzetti, E Cundari, S Moretti, G Lombardi, E Piccolell. Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations. European journal of immunology. vol 25. issue 10. 1995-12-12. PMID:7589091. |
our data suggest that a down-modulation of membrane cd4 together with high expression of the bcl-2 gene and protein characterizes the susceptibility to apoptosis of gp120-treated cells. |
1995-12-12 |
2023-08-12 |
Not clear |
L Tuosto, C Piazza, S Moretti, A Modesti, R Greenlaw, R Lechler, G Lombardi, E Piccolell. Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis. European journal of immunology. vol 25. issue 10. 1995-12-12. PMID:7589092. |
temporal or quantitative imbalance in signals delivered to t cells via t cell antigen receptor (tcr), the cd4 co-receptor, and accessory molecules can lead to anergy, apoptosis, or both. |
1995-12-12 |
2023-08-12 |
Not clear |
J Corbeil, D D Richma. The role of surface CD4 in HIV-induced apoptosis. Advances in experimental medicine and biology. vol 374. 1995-11-14. PMID:7572403. |
the role of surface cd4 in hiv-induced apoptosis. |
1995-11-14 |
2023-08-12 |
Not clear |
F Maldarelli, H Sato, E Berthold, J Orenstein, M A Marti. Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1. Journal of virology. vol 69. issue 10. 1995-10-12. PMID:7666547. |
soluble cd4 inhibited apoptosis, demonstrating that env-cd4 interactions were required for apoptosis. |
1995-10-12 |
2023-08-12 |
human |
X Zhang, L Giangreco, H E Broome, C M Dargan, S L Swai. Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. The Journal of experimental medicine. vol 182. issue 3. 1995-09-28. PMID:7650478. |
control of cd4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. |
1995-09-28 |
2023-08-12 |
mouse |
P Benveniste, W Zhu, A Cohe. Interference with thymocyte differentiation by an inhibitor of S-adenosylhomocysteine hydrolase. Journal of immunology (Baltimore, Md. : 1950). vol 155. issue 2. 1995-08-16. PMID:7608534. |
this inhibition is not due to induction of apoptosis, rather it is a result of specific inhibition of regulation of the levels of the mrnas coding for tcr and cd4 and cd8 co-receptor molecules that normally occurs at these stages of thymocyte differentiation. |
1995-08-16 |
2023-08-12 |
Not clear |
M O Westendorp, R Frank, C Ochsenbauer, K Stricker, J Dhein, H Walczak, K M Debatin, P H Kramme. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature. vol 375. issue 6531. 1995-07-10. PMID:7539892. |
we show here that hiv-1 tat strongly sensitizes tcr- and cd4(gp120)-induced apoptosis by upregulation of cd95 ligand expression. |
1995-07-10 |
2023-08-12 |
human |
A G Laurent-Crawford, E Coccia, B Krust, A G Hovanessia. Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells. Research in virology. vol 146. issue 1. 1995-06-22. PMID:7754236. |
apoptosis is triggered by the interaction of the cell membrane-expressed hiv envelope glycoprotein heterodimer gp120-gp41 complex (external and transmembrane glycoprotein complex) with the cd4 receptor. |
1995-06-22 |
2023-08-12 |
Not clear |
A G Laurent-Crawford, E Coccia, B Krust, A G Hovanessia. Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells. Research in virology. vol 146. issue 1. 1995-06-22. PMID:7754236. |
single amino acid point mutations of the envelope products that affect binding to the cd4 receptor or the fusion process abrogate the capacity of the gp120-gp41 complex to induce apoptosis. |
1995-06-22 |
2023-08-12 |
Not clear |
A G Laurent-Crawford, E Coccia, B Krust, A G Hovanessia. Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells. Research in virology. vol 146. issue 1. 1995-06-22. PMID:7754236. |
interestingly, a point mutation in the v3 loop which inhibits fusion without affecting cd4 binding also results in the abrogation of apoptosis. |
1995-06-22 |
2023-08-12 |
Not clear |
Z Q Wang, A Dudhane, T Orlikowsky, M K Hoffman. T cell antigen receptor engagement abrogates CD4-mediated T cell deletion in vivo. International immunology. vol 7. issue 2. 1995-06-07. PMID:7734416. |
we have previously shown that the engagement of cd4 by specific antibody in the mouse initiates a t cell apoptosis response with the following features: spleen and lymph node cd4+ t cells migrate into the bloodstream within minutes of anti-cd4 administration where they exhibit the phenotype of null cells. |
1995-06-07 |
2023-08-12 |
mouse |
M M Di Somma, S Nuti, J L Telford, C T Baldar. p56lck plays a key role in transducing apoptotic signals in T cells. FEBS letters. vol 363. issue 1-2. 1995-05-30. PMID:7729528. |
however cd4 cross-linking in the absence of simultaneous tcr engagement leaves the cells primed to activation dependent apoptosis. |
1995-05-30 |
2023-08-12 |
Not clear |
M M Di Somma, S Nuti, J L Telford, C T Baldar. p56lck plays a key role in transducing apoptotic signals in T cells. FEBS letters. vol 363. issue 1-2. 1995-05-30. PMID:7729528. |
to assess the role of the cd4 associated protein tyrosine kinase p56lck in cd4 priming to apoptosis we have constructed jurkat t-cell lines stably transfected with a constitutively active form of p56lck. |
1995-05-30 |
2023-08-12 |
Not clear |
M M Di Somma, S Nuti, J L Telford, C T Baldar. p56lck plays a key role in transducing apoptotic signals in T cells. FEBS letters. vol 363. issue 1-2. 1995-05-30. PMID:7729528. |
these data indicate that p56lck is required for t-cell apoptosis and that cd4 priming of t-cells for antigen dependent apoptosis is due to inappropriate or partial activation of the p56lck signal transduction pathway. |
1995-05-30 |
2023-08-12 |
Not clear |
M X Wu, J F Daley, R A Rasmussen, S F Schlossma. Monocytes are required to prime peripheral blood T cells to undergo apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 5. 1995-04-04. PMID:7878013. |
it was also found that once pbt cells became primed for apoptosis by incubation with pma-pretreated mo, the primed pbt cells were susceptible to apoptosis triggered not only by pma but also by either ionomycin or by monoclonal antibody crosslinking of t-cell surface molecules such as cd4 and cd3. |
1995-04-04 |
2023-08-12 |
human |