| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Ohoka, T Kuwata, Y Tozawa, Y Zhao, M Mukai, Y Motegi, R Suzuki, M Yokoyama, M Iwat. In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement. International immunology. vol 8. issue 3. 1996-10-23. PMID:8671615. |
thymocyte positive selection is based on protection of immature cd4/cd8 double-positive (dp) thymocytes from apoptosis and their differentiation into cd4 or cd8 single-positive (sp) cells. |
1996-10-23 |
2023-08-12 |
mouse |
| Y Ohoka, T Kuwata, Y Tozawa, Y Zhao, M Mukai, Y Motegi, R Suzuki, M Yokoyama, M Iwat. In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement. International immunology. vol 8. issue 3. 1996-10-23. PMID:8671615. |
we have previously shown that proper cross-linking of tcr-cd3 with lfa-1, cd4 or cd8 inhibited glucocorticoid-induced thymocyte apoptosis in vitro, and that a proper combination of the calcium ionophore, ionomycin and the protein kinase c (pkc) activator, phorbol 12-myristate 13-acetate (pma), mimicked the inhibitory effect. |
1996-10-23 |
2023-08-12 |
mouse |
| G Süss, K Shortma. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. The Journal of experimental medicine. vol 183. issue 4. 1996-08-05. PMID:8666935. |
a subclass of dendritic cells kills cd4 t cells via fas/fas-ligand-induced apoptosis. |
1996-08-05 |
2023-08-12 |
mouse |
| G Süss, K Shortma. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. The Journal of experimental medicine. vol 183. issue 4. 1996-08-05. PMID:8666935. |
whereas cd8- dc induce a vigorous proliferative response in cd4 t cells, cd8+ dc induce a lesser response that is associated with marked t cell apoptosis. |
1996-08-05 |
2023-08-12 |
mouse |
| A Bergamini, L Dini, M Capozzi, L Ghibelli, R Placido, E Faggioli, A Salanitro, E Buonanno, L Cappannoli, L Ventura, M Cepparulo, L Falasca, G Rocch. Human immunodeficiency virus-induced cell death in cytokine-treated macrophages can be prevented by compounds that inhibit late stages of viral replication. The Journal of infectious diseases. vol 173. issue 6. 1996-07-25. PMID:8648208. |
programmed cell death (apoptosis), a potential mechanism of hiv-mediated cell death in cd4 t lymphocytes, does not occur in infected macrophages as shown by electron microscopy, cytofluorometric and gel electrophoretic dna analysis, and nuclear fluorescent staining by hoechst and terminal dutp-nick-end-labeling (tunel) assay. |
1996-07-25 |
2023-08-12 |
human |
| N Oyaizu, T W McCloskey, S Than, S Pahw. Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion. Blood. vol 87. issue 6. 1996-07-02. PMID:8630399. |
inhibition of cd4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits fas expression and apoptosis by blocking cytokine secretion. |
1996-07-02 |
2023-08-12 |
human |
| N Oyaizu, T W McCloskey, S Than, S Pahw. Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion. Blood. vol 87. issue 6. 1996-07-02. PMID:8630399. |
we have recently demonstrated that the cross-linking of cd4 molecules (cd4xl) results in death of normal peripheral t cells through apoptosis and imbalanced cytokine secretion (ie, induction of tumor necrosis factor-alpha [tnf-alpha] and interferon-gamma [ifn-gamma] in the absence of interleukin-2 [il-2] or il-4 secretion). |
1996-07-02 |
2023-08-12 |
human |
| M L Gougeon, H Lecoeur, A Dulioust, M G Enouf, M Crouvoiser, C Goujard, T Debord, L Montagnie. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 9. 1996-06-13. PMID:8617980. |
programmed cell death in peripheral lymphocytes from hiv-infected persons: increased susceptibility to apoptosis of cd4 and cd8 t cells correlates with lymphocyte activation and with disease progression. |
1996-06-13 |
2023-08-12 |
Not clear |
| M L Gougeon, H Lecoeur, A Dulioust, M G Enouf, M Crouvoiser, C Goujard, T Debord, L Montagnie. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 9. 1996-06-13. PMID:8617980. |
however, a significant correlation was found between the intensity of anti-cd3-induced apoptosis in both cd4 and cd8 t cells from hiv-infected persons and their in vivo expression of cd45ro and hla-dr molecules. |
1996-06-13 |
2023-08-12 |
Not clear |
| M L Gougeon, H Lecoeur, A Dulioust, M G Enouf, M Crouvoiser, C Goujard, T Debord, L Montagnie. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 9. 1996-06-13. PMID:8617980. |
finally, a significant correlation was found between the intensity of spontaneous or anti-cd3-induced apoptosis in total lymphocytes and disease progression; this was confirmed when the cd4 and cd8 t cell subsets were analyzed separately. |
1996-06-13 |
2023-08-12 |
Not clear |
| G Zauli, L Catani, D Gibellini, M C Re, N Vianelli, V Colangeli, C Celeghini, S Capitani, M La Plac. Impaired survival of bone marrow GPIIb/IIa+ megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia. British journal of haematology. vol 92. issue 3. 1996-06-10. PMID:8616042. |
moreover, the degree of apoptosis in bone marrow gpiib/iiia+ cells purified from hiv-1 seropositive thrombocytopenic patients was inversely (p < 0.01) related to the count of circulating platelets, whereas it did not show any significant correlation with the absolute number of circulating cd4 t cells, the cd4/cd8 ratio or the presence of proviral gag dna sequences. |
1996-06-10 |
2023-08-12 |
Not clear |
| J Laurence, D Mitra, M Steiner, D H Lynch, F P Siegal, L Staiano-Coic. Apoptotic depletion of CD4+ T cells in idiopathic CD4+ T lymphocytopenia. The Journal of clinical investigation. vol 97. issue 3. 1996-05-29. PMID:8609222. |
in addition, apoptosis was suppressed by aurintricarboxylic acid, an inhibitor of calcium-dependent endonucleases and proteases, in cells from four of seven patients, the in vivo significance of these findings was supported by three factors: the absence of accelerated apoptosis in persons with stable, physiologic cd4 lymphopenia without clinical immune deficiency; detection of serum antihistone h2b autoantibodies, one consequence of dna fragmentation, in some patients; and its selectivity, with apoptosis limited to the cd4 population in some, and occurring among cd8+ t cells predominantly in those individuals with marked depletion of both cd4+ t lymphocytes linked to clinical immune suppression have evidence for accelerated t cell apoptosis in vitro that may be pathophysiologic and amenable to therapy with apoptosis inhibitors. |
1996-05-29 |
2023-08-12 |
Not clear |
| L Lanza, M Scudeletti, F Puppo, O Bosco, L Peirano, G Filaci, E Fecarotta, G Vidali, F Indiver. Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes. Clinical and experimental immunology. vol 103. issue 3. 1996-05-28. PMID:8608650. |
apoptosis is clearly increased by pdn in pha-activated human pbl, and the apoptotic effect of pdn is stronger on cd8(+) than on cd4(+) t lymphocytes. |
1996-05-28 |
2023-08-12 |
human |
| H Schmid-Antomarchi, M Benkirane, V Breittmayer, H Husson, M Ticchioni, C Devaux, B Ross. HIV induces activation of phosphatidylinositol 4-kinase and mitogen-activated protein kinase by interacting with T cell CD4 surface molecules. European journal of immunology. vol 26. issue 3. 1996-05-20. PMID:8605943. |
these results contribute to understand better the control that hiv may exert on its own replication or on t cell apoptosis by modulating the activation status of its target cells through its interaction with t cell surface cd4 molecules. |
1996-05-20 |
2023-08-12 |
Not clear |
| J Corbeil, M Tremblay, D D Richma. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. The Journal of experimental medicine. vol 183. issue 1. 1996-02-22. PMID:8551242. |
hiv-induced apoptosis requires the cd4 receptor cytoplasmic tail and is accelerated by interaction of cd4 with p56lck. |
1996-02-22 |
2023-08-12 |
Not clear |
| J Corbeil, M Tremblay, D D Richma. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. The Journal of experimental medicine. vol 183. issue 1. 1996-02-22. PMID:8551242. |
the roles of the cd4 receptor and the src kinase p56lck were examined in the process of hiv-induced apoptosis of cd4+ t lymphocytes. |
1996-02-22 |
2023-08-12 |
Not clear |
| J Corbeil, M Tremblay, D D Richma. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. The Journal of experimental medicine. vol 183. issue 1. 1996-02-22. PMID:8551242. |
the presence of the cd4 cytoplasmic tail was found to be essential in delivering an apoptotic signal, and interaction of cd4 with p56lck potentiated hiv-induced apoptosis. |
1996-02-22 |
2023-08-12 |
Not clear |
| J Corbeil, M Tremblay, D D Richma. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. The Journal of experimental medicine. vol 183. issue 1. 1996-02-22. PMID:8551242. |
apoptosis, but not hiv replication, was abrogated by deleting the nh2-terminal intracytoplasmic tail of cd4, or by mutating the two critical cysteines in this tail that are responsible for cd4-p56lck interaction. |
1996-02-22 |
2023-08-12 |
Not clear |
| G Zauli, L Catani, D Gibellini, M C Re, D Milani, P Borgatti, A Bassini, M La Placa, S Capitan. The CD4 receptor plays essential but distinct roles in HIV-1 infection and induction of apoptosis in primary bone marrow GPIIb/IIIa+ megakaryocytes and the HEL cell line. British journal of haematology. vol 91. issue 2. 1996-02-16. PMID:8547064. |
the cd4 receptor plays essential but distinct roles in hiv-1 infection and induction of apoptosis in primary bone marrow gpiib/iiia+ megakaryocytes and the hel cell line. |
1996-02-16 |
2023-08-12 |
human |
| N Oyaizu, S Pahw. Role of apoptosis in HIV disease pathogenesis. Journal of clinical immunology. vol 15. issue 5. 1996-02-07. PMID:8537466. |
there has been a dichotomy between virological and immunological viewpoints in understanding hiv-mediated cytopathicity, the former emphasizing a killing of infected cells by hiv-1 and the latter emphasizing indirect mechanisms wherein hiv or its soluble component(s) alter cd4 t-cell function and induce susceptibility to apoptosis. |
1996-02-07 |
2023-08-12 |
Not clear |