| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Arimilli, J B Mumm, B Na. Antigen-specific apoptosis in immortalized T cells by soluble MHC class II-peptide complexes. Immunology and cell biology. vol 74. issue 1. 1997-01-24. PMID:8934660. |
these results suggest that the binding of soluble mhc class ii-peptide complexes to tcr induces antigen-specific apoptosis in transformed cd4 positive t cells in vitro. |
1997-01-24 |
2023-08-12 |
human |
| J P Kovalik, B Ansari, M Boothb. Rapid commitment to negative selection of a thymocyte line independent of CD4 co-engagement. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 12. 1997-01-23. PMID:8955175. |
in contrast to superantigen-induced selection, apoptosis in this model is unaffected by blocking co-engagement of cd4 and the tcr. |
1997-01-23 |
2023-08-12 |
Not clear |
| I A Khan, T Matsuura, L H Kaspe. Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice. International immunology. vol 8. issue 6. 1997-01-21. PMID:8671678. |
here evidence is presented that t. gondii, a major opportunistic pathogen of the newborn and those with aids, is able to induce cd4(+) t cell apoptosis in the infected murine host. |
1997-01-21 |
2023-08-12 |
mouse |
| U Dittmer, H Petry, C Stahl-Hennig, T Nisslein, M Spring, W Luke, W Bodemer, F J Kaup, G Hunsman. T cell apoptosis in human immunodeficiency virus type 2- and simian immunodeficiency virus-infected macaques. The Journal of general virology. vol 77 ( Pt 10). 1996-12-13. PMID:8887474. |
in siv-infected monkeys both cd4 and cd8 cells underwent apoptosis to a large extent. |
1996-12-13 |
2023-08-12 |
human |
| U Dittmer, H Petry, C Stahl-Hennig, T Nisslein, M Spring, W Luke, W Bodemer, F J Kaup, G Hunsman. T cell apoptosis in human immunodeficiency virus type 2- and simian immunodeficiency virus-infected macaques. The Journal of general virology. vol 77 ( Pt 10). 1996-12-13. PMID:8887474. |
the lack of apoptosis in cd4 cells of healthy hiv-2-infected macaques implies an important role for cd4 cell apoptosis in aids pathogenesis. |
1996-12-13 |
2023-08-12 |
human |
| V Kronin, K Winkel, G Süss, A Kelso, W Heath, J Kirberg, H von Boehmer, K Shortma. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 9. 1996-12-13. PMID:8892611. |
previous work indicated that a subclass of mouse spleen dendritic cells (dc), those bearing cd8alpha, expresses the fas ligand and restricts peripheral cd4 t cell responses by initiating fas-mediated apoptosis. |
1996-12-13 |
2023-08-12 |
mouse |
| V Kronin, K Winkel, G Süss, A Kelso, W Heath, J Kirberg, H von Boehmer, K Shortma. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 9. 1996-12-13. PMID:8892611. |
in contrast with cd4 t cells, the reduced proliferation of cd8 t cells occurred even with t cells from fas-deficient ipr mice, or with dc from fas ligand-deficient gld mice, indicating that fas-induced apoptosis was not involved. |
1996-12-13 |
2023-08-12 |
mouse |
| H Tian, R Lempicki, L King, E Donoghue, L E Samelson, D I Cohe. HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation. International immunology. vol 8. issue 1. 1996-12-06. PMID:8671590. |
unlike t cell apoptosis triggered by soluble hivenv glycoproteins, which requires co-stimulation of cd4 and the antigen-specific tcr, t cell killing by membrane-associated hivenv does not require tcr co-stimulation, because aberrant signaling and cell death are triggered by cd4(+) but tcr- cell lines. |
1996-12-06 |
2023-08-12 |
Not clear |
| F Colucci, C M Cilio, K Lejon, C P Gonçalves, M L Bergman, D Holmber. Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. Journal of autoimmunity. vol 9. issue 2. 1996-11-27. PMID:8738973. |
we now report that cyclophosphamide constitutes an apoptosis signal to peripheral lymphocytes and we provide evidence that nod b cells as well as both cd4 and cd8 t cells display resistance to cyclophosphamide-induced apoptosis. |
1996-11-27 |
2023-08-12 |
mouse |
| Y Kog. [Apoptosis induction and its mechanism in HIV infection]. Nihon rinsho. Japanese journal of clinical medicine. vol 54. issue 7. 1996-11-26. PMID:8741676. |
the participation of apoptosis in the cytopathic effect of cd4 t cells infected with hiv, in vitro, has already been shown. |
1996-11-26 |
2023-08-12 |
human |
| Y Kog. [Apoptosis induction and its mechanism in HIV infection]. Nihon rinsho. Japanese journal of clinical medicine. vol 54. issue 7. 1996-11-26. PMID:8741676. |
in our study using human cd4 cell clones expressing gp160 of hiv-1 under the control of inducible promoter, cell killing due to apoptosis was induced in the cells when gp160 was synthesized and a complex formed with gp160 in the cell. |
1996-11-26 |
2023-08-12 |
human |
| Y Kog. [Apoptosis induction and its mechanism in HIV infection]. Nihon rinsho. Japanese journal of clinical medicine. vol 54. issue 7. 1996-11-26. PMID:8741676. |
cross-linking of cd4 by such gp120 or by further binding of anti-gp120 antibody to gp120 may prime cd4 t cells for apoptosis following antigen-driven activation. |
1996-11-26 |
2023-08-12 |
human |
| M Sarih, W E Maâtaoui, A Bensliman. Analysis of apoptosis and a Th1/Th2 phenotype in HIV-infected patients. Immunology letters. vol 50. issue 3. 1996-11-20. PMID:8803608. |
we found that the percentage of lymphocytes undergoing apoptosis was significantly higher (p = 0.005) in patients with low cd4 cell counts (< 200 cd4 cells/microliter) (60%) than in patients at earlier stage (> 500 cd4 cells/microliter) (35%). |
1996-11-20 |
2023-08-12 |
human |
| E Jacotot, C Callebaut, J Blanco, Y Rivière, B Krust, A G Hovanessia. HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells. Virology. vol 223. issue 2. 1996-11-13. PMID:8806567. |
in both of the experimental models used, no significant differences were observed between the transfected cells expressing either the wild-type or the mutated form of cd26, thus suggesting that the dpp iv activity of cd26 is not essential for its function as a cofactor of cd4 in the mechanism of initiation of apoptosis by the hiv envelope gp120/gp41 complex. |
1996-11-13 |
2023-08-12 |
Not clear |
| E Jacotot, C Callebaut, J Blanco, Y Rivière, B Krust, A G Hovanessia. HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells. Virology. vol 223. issue 2. 1996-11-13. PMID:8806567. |
taken together, these results indicate that cd26 in cd4+ t cells may determine the rate of initiation of apoptosis by the mature hiv-1 envelope glycoproteins, i.e., cd26 is being involved as a cofactor of cd4 in the mechanism of triggering apoptosis by the gp120/gp41 complex. |
1996-11-13 |
2023-08-12 |
Not clear |
| E Jacotot, C Callebaut, J Blanco, Y Rivière, B Krust, A G Hovanessia. HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells. Virology. vol 223. issue 2. 1996-11-13. PMID:8806567. |
as signaling through cd26 could lead to t cell activation, we propose that this latter might be modified following the binding of the gp120/gp41 complex to cd4 and thus leading to apoptosis. |
1996-11-13 |
2023-08-12 |
Not clear |
| G Muralidhar, S Koch, H E Broome, S L Swai. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752910. |
tcr triggering of anergic cd4 t cells in murine aids induces apoptosis rather than cytokine synthesis and proliferation. |
1996-11-07 |
2023-08-12 |
mouse |
| G Muralidhar, S Koch, H E Broome, S L Swai. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752910. |
in addition, a significant fraction of the cd4 t cell population in infected mice undergoes spontaneous apoptosis in vivo. |
1996-11-07 |
2023-08-12 |
mouse |
| G Muralidhar, S Koch, H E Broome, S L Swai. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752910. |
upon in vitro stimulation with anti-cd3 plus pma, anergic cd4 t cells from mice with maids fail to progress through the cell cycle (g0/g1 arrest), and a fraction of the cells undergoes apoptosis. |
1996-11-07 |
2023-08-12 |
mouse |
| G Muralidhar, S Koch, H E Broome, S L Swai. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752910. |
the addition of il-2 along with tcr-mediated stimulation not only fails to rescue cd4 t cells from apoptosis, but enhances activation-induced cell death. |
1996-11-07 |
2023-08-12 |
mouse |