| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyu Yu, Jian Ma, Yueru Gu, Wei Zou, Na Zha. Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus. Experimental and therapeutic medicine. vol 27. issue 5. 2024-03-27. PMID:38533430. |
cell division cycle 42 (cdc42) regulates podocyte apoptosis to take part in the development and progression of diabetic nephropathy (dn), but currently the clinical evidence is limited. |
2024-03-27 |
2024-03-29 |
human |
| Shanshan Zheng, Na Zhao, Chuwen Feng, Jian M. Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway. Clinical and experimental nephrology. 2024-02-28. PMID:38416339. |
this study intended to further investigate the influence of cdc42 on viability, apoptosis, inflammation, epithelial-mesenchymal transition, and fibrosis in high glucose (hg)-treated renal tubular epithelial cells. |
2024-02-28 |
2024-03-01 |
Not clear |
| Hui Cao, Changzheng Ho. Cell Division Control Protein 42 Facilitates Diabetic Retinopathy Progression by Activating the MEK/ERK Pathway. The Tohoku journal of experimental medicine. vol 261. issue 3. 2023-11-21. PMID:37635064. |
our study showed that hg increased cdc42 mrna and protein, cell viability, invasive cell count, branch points, and tube length but reduced cell apoptosis in hrmecs. |
2023-11-21 |
2023-11-29 |
human |
| Hui Cao, Changzheng Ho. Cell Division Control Protein 42 Facilitates Diabetic Retinopathy Progression by Activating the MEK/ERK Pathway. The Tohoku journal of experimental medicine. vol 261. issue 3. 2023-11-21. PMID:37635064. |
cdc42 upregulation enhanced cell viability, invasive cell count, branch points, tube length, p-mek, and p-erk, but attenuated cell apoptosis. |
2023-11-21 |
2023-11-29 |
human |
| Hui Cao, Changzheng Ho. Cell Division Control Protein 42 Facilitates Diabetic Retinopathy Progression by Activating the MEK/ERK Pathway. The Tohoku journal of experimental medicine. vol 261. issue 3. 2023-11-21. PMID:37635064. |
conclusively, cdc42 promotes hg-induced hrmec viability and invasion, as well as angiogenesis, but inhibits apoptosis by activating the mek/erk pathway, which may be responsible for the progression of diabetic retinopathy. |
2023-11-21 |
2023-11-29 |
human |
| Noelle C Punessen, Claudia Pena, Alexandra Sandberg, Lilia A Koza, Daniel A Linsema. A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons. Molecular and cellular neurosciences. 2023-06-01. PMID:37263460. |
here, we investigated a role for the rho gtpase family member, cdc42, and its downstream effectors, in neuronal survival and apoptosis. |
2023-06-01 |
2023-08-14 |
rat |
| Dan-Ni Wang, Jin-Jing Ni, Jian-Hui Li, Ya-Qi Gao, Fang-Jing Ni, Zhen-Zhen Zhang, Jing-Yuan Fang, Jie Lu, Yu-Feng Ya. Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation. PLoS pathogens. vol 19. issue 2. 2023-02-22. PMID:36812247. |
non-acetylated cdc42 at lysine 153 shows an impaired binding of its downstream effector pak4 and an attenuated phosphorylation of p38 and jnk, consequently reduces cell apoptosis. |
2023-02-22 |
2023-08-14 |
Not clear |
| Shan Jiang, Chun-Mei Xu, Shuai Yao, Rui Zhang, Xian-Zhi Li, Ru-Zhen Zhang, Tian-Yue Xie, Yi-Qian Xing, Qian Zhang, Xiao-Jun Zhou, Lin Liao, Jian-Jun Don. Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. Frontiers in endocrinology. vol 13. 2022-08-29. PMID:36034435. |
cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. |
2022-08-29 |
2023-08-14 |
Not clear |
| Shan Jiang, Chun-Mei Xu, Shuai Yao, Rui Zhang, Xian-Zhi Li, Ru-Zhen Zhang, Tian-Yue Xie, Yi-Qian Xing, Qian Zhang, Xiao-Jun Zhou, Lin Liao, Jian-Jun Don. Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. Frontiers in endocrinology. vol 13. 2022-08-29. PMID:36034435. |
therefore, we aimed to investigate cell division cycle 42 (cdc42)-mediated podocyte apoptosis and its effect on insulin secretion in islet β-cells. |
2022-08-29 |
2023-08-14 |
Not clear |
| Gang Li, Yu Wang, Xiao-Bo Guo, Bo Zha. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway. Biochemical genetics. 2022-04-12. PMID:35412170. |
cdc42 regulates cell proliferation and apoptosis in bladder cancer via the iqgap3-mediated ras/erk pathway. |
2022-04-12 |
2023-08-13 |
rat |
| Gang Li, Yu Wang, Xiao-Bo Guo, Bo Zha. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway. Biochemical genetics. 2022-04-12. PMID:35412170. |
in addition, cdc42 silencing markedly promoted apoptosis and inhibited proliferation in bc cells. |
2022-04-12 |
2023-08-13 |
rat |
| Gang Li, Yu Wang, Xiao-Bo Guo, Bo Zha. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway. Biochemical genetics. 2022-04-12. PMID:35412170. |
further experiments showed that overexpression of iqgap3 dramatically abolished the bioeffects mediated by cdc42 silencing on the proliferation and apoptosis of bc cells. |
2022-04-12 |
2023-08-13 |
rat |
| Gang Li, Yu Wang, Xiao-Bo Guo, Bo Zha. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway. Biochemical genetics. 2022-04-12. PMID:35412170. |
all our results suggested that cdc42 promoted the ras/erk pathway by regulating iqgap3, thus enhancing cell proliferation and suppressing cell apoptosis in bc cells and ultimately participating in the pathogenesis of bc. |
2022-04-12 |
2023-08-13 |
rat |
| Anna Heinrich, Bidur Bhandary, Sarah J Potter, Nancy Ratner, Tony DeFalc. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell reports. vol 37. issue 4. 2021-11-20. PMID:34706238. |
sertoli cdc42 deletion leads to increased apoptosis and disrupted polarity of juvenile and adult testes but does not affect fetal and postnatal testicular development. |
2021-11-20 |
2023-08-13 |
Not clear |
| Jiaoyun Dong, Chun Qing, Fei Song, Xiqiao Wang, Shuliang Lu, Ming Tia. Potential molecular mechanisms of negative pressure in promoting wound healing. International wound journal. vol 17. issue 5. 2021-08-18. PMID:32515909. |
cell ultrastructure; viability; apoptosis; and protein factors such as tumour necrosis factor-α (tnf-α), interferon-γ (ifn-γ), epidermal growth factor (egf), epidermal growth factor receptor (egfr), interleukin-17 (il-17), and cell division cycle 42 (cdc42) were determined by transmission electron microscopy (tem), cck8, flow cytometry (fcm), elisa, and simple western assays, respectively. |
2021-08-18 |
2023-08-13 |
Not clear |
| Quantao Ma, Chunguo Wang, Min Wang, Yaqi Li, Pengfei Li, Jingkang Wang, Long Cheng, Yongcheng An, Hongyu Dai, Yuhui Duan, Ting Wang, Baosheng Zha. Investigation of brain damage mechanism in middle cerebral artery occlusion/reperfusion rats based on i-TRAQ quantitative proteomics. Experimental brain research. vol 239. issue 4. 2021-07-28. PMID:33599834. |
network analysis of differential proteins showed that alb, ndufb5, ndufs7, apob, cdc42, ndufa3, igf1r, p4hb, mbp, gc, nme1, akt2, and other proteins may play an important role in regulating oxidative stress, apoptosis, and inflammatory response in mcao/r. |
2021-07-28 |
2023-08-13 |
rat |
| Xiaoying Hao, Qingqing Jia, Jieling Yuan, Xiangrong Shi, Huihui Guo, Jiefang Gao, Ye Gu. MicroRNA‑195 suppresses cell proliferation, migration and invasion in epithelial ovarian carcinoma via inhibition of the CDC42/CCND1 pathway. International journal of molecular medicine. vol 46. issue 5. 2021-06-30. PMID:32901852. |
thus, it was suggested that mir‑195 functions as a tumor suppressor, but cdc42 and ccnd1 act as tumor promoters based their abilities to enhance cell proliferation, cell cycle entry, migration and invasion, as well as decrease apoptosis in ovcar‑3 cells. |
2021-06-30 |
2023-08-13 |
human |
| Xiao Zhang, Sheila Bandyopadhyay, Leandro Pires Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo Ferraris, Lanjing Zhang, Wenwei Hu, Edward M Bonder, Pawel R Kiela, Robert Coffey, Michael P Verzi, Ivaylo I Ivanov, Nan Ga. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32686657. |
ex vivo survival and clonogenicity of intestinal stem cells (iscs) strictly required growth response mediated by cell division control 42 (cdc42) and cdc42-deficient enteroids to undergo rapid apoptosis. |
2021-06-11 |
2023-08-13 |
mouse |
| Ping Yin, Shuang Wang, Yafen Wei, Xu Wang, Jingdian Zhang, Xiang Yin, Jiachun Feng, Mingqin Zh. Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β42 in Neuron-Microglia Co-Culture Models. Journal of Alzheimer's disease : JAD. vol 73. issue 2. 2020-11-18. PMID:31796671. |
moreover, by proteomics analysis, we identified cell signaling pathways affected by mar1 were not only limited to inflammation-related pathways such as p38, but also in pathways involved in cell survival, autophagy, axon formation, and apoptosis, including pi3k/akt, mtor, erk, caspase3, cdc42, and p75ntr. |
2020-11-18 |
2023-08-13 |
Not clear |
| Weihong Xu, Bin Xu, Yiting Yao, Xiaoling Yu, Hua Cao, Jun Zhang, Jie Liu, Huiming Shen. Overexpression and biological function of IQGAP3 in human pancreatic cancer. American journal of translational research. vol 8. issue 12. 2020-10-01. PMID:28078013. |
gene set enrichment analysis (gsea) on the cancer genome atlas (tcga) dataset showed that cell apoptosis, metastasis and cdc42 pathways were strongly associated with iqgap3 expression in pancreatic cancer patients. |
2020-10-01 |
2023-08-13 |
human |