| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Chen, Lu Zhan. MiR-29a inhibits cell proliferation and migration by targeting the CDC42/PAK1 signaling pathway in cervical cancer. Anti-cancer drugs. vol 30. issue 6. 2020-09-22. PMID:30724771. |
mir-29a inhibited cell proliferation, migration, and invasion, as well as promoted cell apoptosis through repressing the pak1/limk signaling pathway by targeting cdc42 in cervical cancer. |
2020-09-22 |
2023-08-13 |
Not clear |
| John Huang, Allen Huang, Amelia Poplawski, Frank DiPino, Jolinda A Traugh, Jun Lin. PAK2 activated by Cdc42 and caspase 3 mediates different cellular responses to oxidative stress-induced apoptosis. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 4. 2020-06-30. PMID:31926209. |
pak2 activated by cdc42 and caspase 3 mediates different cellular responses to oxidative stress-induced apoptosis. |
2020-06-30 |
2023-08-13 |
Not clear |
| John Huang, Allen Huang, Amelia Poplawski, Frank DiPino, Jolinda A Traugh, Jun Lin. PAK2 activated by Cdc42 and caspase 3 mediates different cellular responses to oxidative stress-induced apoptosis. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 4. 2020-06-30. PMID:31926209. |
however, when pak2 was pre-activated by cdc42 or by mild stress such as serum deprivation, it was no longer able to be cleaved by caspase 3 upon hydrogen peroxide treatment, and the subsequent apoptosis was also largely inhibited. |
2020-06-30 |
2023-08-13 |
Not clear |
| J Zheng, X Nie, L He, A J Yoon, L Wu, X Zhang, M Vats, M D Schiff, L Xiang, Z Tian, J Ling, J J Ma. Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis. Journal of dental research. vol 97. issue 12. 2019-09-09. PMID:29874522. |
apoptosis occurred in the cdc42 mutant enamel organ prior to and synchronously with cystogenesis. |
2019-09-09 |
2023-08-13 |
mouse |
| Meiping Lu, Chengyun Xu, Qin Zhang, Xiling Wu, Lanfang Tang, Xiangzhi Wang, Junsong Wu, Ximei W. Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells. Biochemical pharmacology. vol 154. 2019-04-03. PMID:29906467. |
mechanistically, pak1 is not involved in the maturation, apoptosis, antigen uptake, and t cell activation of cultured dcs, but pak1 dose lie on the downstream of rac and cdc42 to regulate the dc migration toward the chemokine c-c motif chemokine ligand 19. |
2019-04-03 |
2023-08-13 |
mouse |
| Jing-Rong Kong, Xue-Li Qiao, Ping Yang, Ting Peng, Yuan Liu, Wei-Na Wan. LvCdc42 is a potential negative regulator of Lvp53 in Litopenaeus vannamei exposed to Vibrio alginolyticus stress. Developmental and comparative immunology. vol 82. 2018-11-05. PMID:29407479. |
as a crucial molecular switch, cdc42 is a signal regulation hub which is involved in a wide range of cellular processes, including cytokinesis, gene expression, cell cycle progression and apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wan. Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251334. |
in this study, we found that niclosamide could not only inhibit proliferation and promote apoptosis of oral cancer cells, but also inhibited vm formation in vitro and in vivo through downregulation of the expression of vm-related genes vegfa, mmp2, rock1 and cdc42. |
2018-08-23 |
2023-08-13 |
human |
| X Xu, L Kong, X Song, Z Hao, F Yua. Effect of Cdc42 on myocardial ischemia-reperfusion of rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 63. issue 7. 2018-04-30. PMID:28838336. |
in comparison with control group, cdc42, the cardiacmyocyte apoptosis rate and phosphorylation of jnk were increased and the ratio of bcl-2/bax was reduced in the i/r group; cdc42, the cardiacmyocyte apoptosis rate and phosphorylation of jnk in as group was lower than the i/r group, oli group and the ms group, and the ratio of bcl-2/bax was the highest in the four groups; cdc42, cardiacmyocyte apoptosis rate, phosphorylation of jnk and the ratio of bcl-2/bax showed no differences in the i/r group, oli group and the ms group. |
2018-04-30 |
2023-08-13 |
rat |
| X Xu, L Kong, X Song, Z Hao, F Yua. Effect of Cdc42 on myocardial ischemia-reperfusion of rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 63. issue 7. 2018-04-30. PMID:28838336. |
cdc42 in myocardial i/r can promote cardiacmyocyte apoptosis rate. |
2018-04-30 |
2023-08-13 |
rat |
| X Xu, L Kong, X Song, Z Hao, F Yua. Effect of Cdc42 on myocardial ischemia-reperfusion of rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 63. issue 7. 2018-04-30. PMID:28838336. |
as-odn of cdc42 can decrease the cardiacmyocyte apoptosis rate in i/r. |
2018-04-30 |
2023-08-13 |
rat |
| Wenping Lin, Siyuan Wang, Zhen Yang, Jianhua Lin, Qingfeng Ke, Wenbin Lan, Jinxing Shi, Shiqiang Wu, Bin Ca. Heme Oxygenase-1 Inhibits Neuronal Apoptosis in Spinal Cord Injury through Down-Regulation of Cdc42-MLK3-MKK7-JNK3 Axis. Journal of neurotrauma. vol 34. issue 3. 2018-01-12. PMID:27526795. |
in vitro experiments indicated that cdc42 was essential for neuronal apoptosis, while transduction of neurons with ho-1-expressing adeno-associated virus significantly reduced neuronal apoptosis to enhance neuronal survival. |
2018-01-12 |
2023-08-13 |
Not clear |
| Bin Jiang, Jia Zhang, Jinmei Xia, Wentao Zhao, Yanan Wu, Minggang Shi, Lianzhong Luo, Huamin Zhou, Ai Chen, Huanhuan Ma, Qingwen Zhao, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Ying He, Xiaotong Li, Li-Man Hung, Tak Wah Mak, Qinxi L. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell reports. vol 19. issue 2. 2017-05-01. PMID:28402860. |
2-hg binds to cdc42 and abolishes its association with mlk3, inactivating mlk3 and apoptosis. |
2017-05-01 |
2023-08-13 |
mouse |
| Yongru Xu, Yingzi Qi, Jing Luo, Jing Yang, Qi Xie, Chen Deng, Na Su, Wei Wei, Deshun Shi, Feng Xu, Xiangping Li, Ping X. Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42. International journal of molecular sciences. vol 18. issue 3. 2017-04-28. PMID:28282856. |
hepatitis b virus x protein stimulates proliferation, wound closure and inhibits apoptosis of huh-7 cells via cdc42. |
2017-04-28 |
2023-08-13 |
Not clear |
| Z Huang, L Zhang, Y Chen, H Zhang, Q Zhang, R Li, J Ma, Z Li, C Yu, Y Lai, T Lin, X Zhao, B Zhang, Z Ye, S Liu, W Wang, X Liang, R Liao, W Sh. Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. Cell death & disease. vol 7. 2016-11-14. PMID:26986510. |
cdc42 deficiency induces podocyte apoptosis by inhibiting the nwasp/stress fibers/yap pathway. |
2016-11-14 |
2023-08-13 |
Not clear |
| Z Huang, L Zhang, Y Chen, H Zhang, Q Zhang, R Li, J Ma, Z Li, C Yu, Y Lai, T Lin, X Zhao, B Zhang, Z Ye, S Liu, W Wang, X Liang, R Liao, W Sh. Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. Cell death & disease. vol 7. 2016-11-14. PMID:26986510. |
here, we assessed the cellular mechanisms by which cdc42 regulates podocyte apoptosis. |
2016-11-14 |
2023-08-13 |
Not clear |
| Z Huang, L Zhang, Y Chen, H Zhang, Q Zhang, R Li, J Ma, Z Li, C Yu, Y Lai, T Lin, X Zhao, B Zhang, Z Ye, S Liu, W Wang, X Liang, R Liao, W Sh. Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. Cell death & disease. vol 7. 2016-11-14. PMID:26986510. |
reduced cdc42 expression in vitro and in vivo by small interfering rna and selective cdc42 inhibitor ml-141, respectively, caused podocyte apoptosis and proteinuria. |
2016-11-14 |
2023-08-13 |
Not clear |
| Junnan Wang, Rihao Xu, Junduo Wu, Zhibo L. MicroRNA-137 Negatively Regulates H₂O₂-Induced Cardiomyocyte Apoptosis Through CDC42. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-09-30. PMID:26566162. |
microrna-137 negatively regulates h₂o₂-induced cardiomyocyte apoptosis through cdc42. |
2016-09-30 |
2023-08-13 |
Not clear |
| Ramesh Choudhari, Valerio Giacomo Minero, Matteo Menotti, Roberta Pulito, Cord Brakebusch, Mara Compagno, Claudia Voena, Chiara Ambrogio, Roberto Chiarl. Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice. Blood. vol 127. issue 10. 2016-08-01. PMID:26747246. |
apoptosis of lymphoma cells was equally induced following cdc42 or rac1 deletion, was associated with upregulation of the proapoptotic molecule bid, and was blocked by bcl2 overexpression. |
2016-08-01 |
2023-08-13 |
mouse |
| Ting Peng, Wei-Na Wang, Mei-Mei Gu, Chen-Ying Xie, Yu-Chao Xiao, Yuan Liu, Lei Wan. Essential roles of Cdc42 and MAPK in cadmium-induced apoptosis in Litopenaeus vannamei. Aquatic toxicology (Amsterdam, Netherlands). vol 163. 2016-01-11. PMID:25863597. |
essential roles of cdc42 and mapk in cadmium-induced apoptosis in litopenaeus vannamei. |
2016-01-11 |
2023-08-13 |
Not clear |
| Ting Peng, Wei-Na Wang, Mei-Mei Gu, Chen-Ying Xie, Yu-Chao Xiao, Yuan Liu, Lei Wan. Essential roles of Cdc42 and MAPK in cadmium-induced apoptosis in Litopenaeus vannamei. Aquatic toxicology (Amsterdam, Netherlands). vol 163. 2016-01-11. PMID:25863597. |
the mitogen-activated protein kinase (mapk) signaling pathway plays a vital role in animals' stress responses, including mediation of apoptosis induced by the rho gtpase cdc42. |
2016-01-11 |
2023-08-13 |
Not clear |