| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarzyna Sołkiewicz, Izabela Kokot, Monika Kacperczyk, Violetta Dymicka-Piekarska, Justyna Dorf, Ewa Maria Krat. Serum Clusterin Concentration and Its Glycosylation Changes as Potential New Diagnostic Markers of SARS-CoV-2 Infection and Recovery Process. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673784. |
glycoprotein clusterin (clu) has many functions such as phagocyte recruitment, complement system inhibition, apoptosis inhibition, hormone and lipid transport, as well as in the immune response. |
2024-04-27 |
2024-04-29 |
human |
| Jeong Man Cho, Sojung Sun, Eunji Im, Hyunwon Yang, Tag Keun Yo. Triple Silencing of HSP27, cFLIP, and CLU Genes Promotes the Sensitivity of Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells. Medicines (Basel, Switzerland). vol 11. issue 3. 2024-03-27. PMID:38535120. |
triple silencing of hsp27, cflip, and clu genes promotes the sensitivity of doxazosin-induced apoptosis in pc-3 prostate cancer cells. |
2024-03-27 |
2024-03-29 |
Not clear |
| Prakash P Praharaj, Srimanta Patra, Amruta Singh, Debasna P Panigrahi, Hwa Y Lee, Mohammad F Kabir, Muhammad K Hossain, Samir K Patra, Birija S Patro, Shankargouda Patil, Daniel J Klionsky, Han J Chae, Sujit K Bhuti. CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival. Autophagy. 2024-03-06. PMID:38447939. |
interestingly, clu triggers class iii phosphatidylinositol 3-kinase (ptdins3k) activity around damaged mitochondria, and inhibition of mitophagic flux causes the accumulation of excessive mitophagosomes resulting in reactive oxygen species (ros)-dependent apoptosis during cisplatin treatment in oral cancer cells. |
2024-03-06 |
2024-03-09 |
Not clear |
| Qinyi Zhang, Jun Yao Teow, Jesinda Pauline Kerishnan, Adyani Azizah Abd Halim, Yeng Che. Clusterin and Its Isoforms in Oral Squamous Cell Carcinoma and Their Potential as Biomarkers: A Comprehensive Review. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37239129. |
clu has been implicated as playing a vital role in many biological processes such as apoptosis, cell cycle, etc. |
2023-05-27 |
2023-08-14 |
human |
| Kohei Amada, Naoki Hijiya, Sawa Ikarimoto, Kazuyoshi Yanagihara, Toshikatsu Hanada, Shinya Hidano, Shusaku Kurogi, Yoshiyuki Tsukamoto, Chisato Nakada, Keisuke Kinoshita, Yuka Hirashita, Tomohisa Uchida, Toshitaka Shin, Kazuhiro Yada, Teijiro Hirashita, Takashi Kobayashi, Kazunari Murakami, Masafumi Inomata, Kuniaki Shirao, Masahiro Aoki, Mutsuhiro Takekawa, Masatsugu Moriyam. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer science. 2023-01-25. PMID:36694355. |
clu was shown to be induced immediately after treatment with pd0325901 or expressed primarily in more than half of pdac cell lines, enhancing cell viability by escaping from apoptosis. |
2023-01-25 |
2023-08-14 |
human |
| Yun-Mi Kim, SuJi Park, Su Yeon Choi, Shin Bi Oh, MinKyo Jung, Chan-Gi Pack, Jung Jin Hwang, Eunyoung Tak, Joo-Yong Le. Clusterin Binding Modulates the Aggregation and Neurotoxicity of Amyloid-β(1-42). Molecular neurobiology. 2022-07-29. PMID:35904715. |
clu either alleviated or augmented aβ42-induced cytotoxicity and apoptosis in the neuroblastoma-derived sh-sy5y and n2a cells, depending on the incubation period and the molar ratio of clu:aβ42 involved in the reaction before addition to the cells. |
2022-07-29 |
2023-08-14 |
mouse |
| Xiaodong Weng, Jing Li, Qiunong Guan, Haimei Zhao, Zihuan Wang, Martin E Gleave, Christopher Yc Nguan, Caigan D. The functions of clusterin in renal mesenchymal stromal cells: Promotion of cell growth and regulation of macrophage activation. Experimental cell research. 2022-02-26. PMID:35218723. |
cell surface markers, apoptosis and phagocytosis were determined by flow cytometry, and clu protein by western blot. |
2022-02-26 |
2023-08-13 |
Not clear |
| Xiaodong Weng, Jing Li, Qiunong Guan, Haimei Zhao, Zihuan Wang, Martin E Gleave, Christopher Yc Nguan, Caigan D. The functions of clusterin in renal mesenchymal stromal cells: Promotion of cell growth and regulation of macrophage activation. Experimental cell research. 2022-02-26. PMID:35218723. |
clu did not prevent hypoxia-induced cell apoptosis but promoted cell growth in kmsc cultures. |
2022-02-26 |
2023-08-13 |
Not clear |
| Ursule Kalvaityte, Csaba Matta, Eiva Bernotiene, Peter Natesan Pushparaj, Ata M Kiapour, Ali Mobasher. Exploring the translational potential of clusterin as a biomarker of early osteoarthritis. Journal of orthopaedic translation. vol 32. 2022-01-03. PMID:34976733. |
the intracellular form of clu may suppress stress-induced apoptosis by forming complexes with misfolded proteins and facilitates their degradation. |
2022-01-03 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Mst Marium Begum, Md Siddiqul Islam, Tapan Behl, Ghulam Md Ashra. Exploring the Role of CLU in the Pathogenesis of Alzheimer's Disease. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:32820456. |
growing evidence indicates that clu plays roles in ad pathogenesis via various processes, including aggregation and clearance of aβ, neuroinflammation, lipid metabolism, wnt signaling, copper homeostasis, and regulation of neuronal cell cycle and apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Shanshui Zeng, Yue Pan, Fei Liu, Jiaye Yin, Min Jiang, Yan Long, Xueqin Zhao, Gendie E Lash, Hongling Yan. Role of clusterin in the regulation of trophoblast development and preeclampsia. Biochemical and biophysical research communications. vol 583. 2021-11-15. PMID:34735874. |
then, rna sequencing, cell counting kit-8, matrigel invasion, cell apoptosis, and angiogenesis assay were performed to evaluate the role of clu on primary isolation trophoblast cells. |
2021-11-15 |
2023-08-13 |
Not clear |
| Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Soh. Clusterin Deficiency Exacerbates Hyperoxia-Induced Acute Lung Injury. Cells. vol 10. issue 4. 2021-10-20. PMID:33921872. |
however, treatment with recombinant clu attenuated hyperoxia-induced apoptosis. |
2021-10-20 |
2023-08-13 |
mouse |
| Yuan Tian, Yue-Hai Xiao, Tian Geng, Chao Sun, Jiang Gu, Kai-Fa Tang, Bei Liu, Yi-Meng Liu, Fa Su. Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis. Biology of the cell. vol 113. issue 1. 2021-08-30. PMID:32942336. |
clu was overexpressed in gc-1 spg cells, followed by detection of serum testosterone, cell proliferation, cell apoptosis and autophagy. |
2021-08-30 |
2023-08-13 |
mouse |
| Katie A McNaught, Joanna S Morris, Mark McLaughli. Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma. Veterinary and comparative oncology. vol 18. issue 3. 2021-07-13. PMID:31654603. |
clusterin (clu), also known as apolipoprotein j, is a widely expressed, heterodimeric, glycoprotein, important in tumourigenesis, apoptosis and immunoregulation. |
2021-07-13 |
2023-08-13 |
dog |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we previously proved that clusterin (clu) can inhibit the apoptosis of l02 hepatocytes induced by cr(vi) through mitochondrial pathway, but the associated molecular mechanism has not been further studied. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we demonstrated in the present study that cr(vi) triggered mitochondrial biogenesis dysfunction-associated apoptosis, and clu delayed cr(vi)-induced apoptosis by enhancing mitochondrial biogenesis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
signal transducer and activator of transcription 3 (stat3) was down-regulated in cr(vi)-induced apoptosis, and clu may regulate stat3 via protein kinase b (pkb/akt) in cr(vi)-exposed hepatocytes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we used the stat3 inhibitor c188-9 and the akt inhibitor uprosertib to eliminate the anti-apoptotic effect of clu, and found that clu inhibited cr(vi)-induced apoptosis by up-regulating akt/stat3 signal. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
based on the fact that both akt and stat3 are closely related to mitochondrial biogenesis and mitochondrial pathway-associated apoptosis, this study is the first time to link clu, stat3, akt and mitochondrial biogenesis function after cr(vi) exposure, to further enrich the experimental basis of cr(vi)-induced hepatotoxicity, clarify the molecular mechanism of clu helping cells to escape apoptosis, and also suggest that new ways can be sought to prevent and treat cr(vi)-induced hepatotoxicity by regulating mitochondrial biosynthesis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Z-D Wei, Y-Z Sun, C-X Tu, R-Q Qi, W Huo, H-D Chen, X-H Ga. DNAJA4 deficiency augments hyperthermia-induced Clusterin and ERK activation: two critical protective factors of human keratinocytes from hyperthermia-induced injury. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 34. issue 10. 2021-05-14. PMID:32277496. |
clusterin (clu) and phosphorylated erk (p-erk) play a role in regulating cell proliferation and apoptosis, under environmental stress. |
2021-05-14 |
2023-08-13 |
human |