| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Liao, Shiqin Peng, Lei He, Yu Wang, Yang Li, Danwei Ma, Yanan Wang, Liang Sun, Hong Zheng, Wenke Yang, Fengyan Dai, Jiayuan Zha. Methylmercury cytotoxicity and possible mechanisms in human trophoblastic HTR-8/SVneo cells. Ecotoxicology and environmental safety. vol 207. 2020-12-18. PMID:33254395. |
genes related to oxidative stress (hspa6, hspa1a, nrf2, sod1, ho-1, nqo1, osgin1, and gpx1), cell cycle (p21 and cdc25a), apoptosis (cycs and aifm2), and migration and invasion (cxcl8, cxcl3, clu, il24, col3a1, mapt, and itga7) were differentially expressed in the mehg-treated group, indicating mehg toxicity and mechanism of action. |
2020-12-18 |
2023-08-13 |
human |
| Natalie Schwarz, Srinu Tumpara, Sabine Wrenger, Evrim Ercetin, Jürg Hamacher, Tobias Welte, Sabina Janciauskien. Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32533048. |
comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of aat revealed that in the presence of aat cells acquire better proliferative properties, resistance to staurosporine (sts)-induced apoptosis, and show higher expression of clu, a pro-tumorigenic gene coding clusterin protein. |
2020-12-08 |
2023-08-13 |
Not clear |
| Sixuan Tang, Shuzi Ye, Yu Ma, Yuehui Liang, NingJuan Liang, Fang Xia. Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca Ecotoxicology and environmental safety. vol 205. 2020-10-21. PMID:32961495. |
in this study, we aimed to explore the effect of clu on cr(vi)-induced mitochondrial fission and apoptosis. |
2020-10-21 |
2023-08-13 |
Not clear |
| Sixuan Tang, Shuzi Ye, Yu Ma, Yuehui Liang, NingJuan Liang, Fang Xia. Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca Ecotoxicology and environmental safety. vol 205. 2020-10-21. PMID:32961495. |
clu over-expression could protect the hepatocytes from cr(vi)-induced mitochondrial apoptosis. |
2020-10-21 |
2023-08-13 |
Not clear |
| Muhammad Assad Riaz, Angelika Stammler, Mareike Borgers, Lutz Konra. Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386352. |
clusterin (clu) is a ubiquitously expressed heterodimeric glycoprotein that is involved in a variety of functions like cell-cell interactions, apoptosis, epithelial-mesenchymal transition, carcinogenesis, and chaperone function. |
2020-09-30 |
2023-08-13 |
rat |
| Muhammad Assad Riaz, Angelika Stammler, Mareike Borgers, Lutz Konra. Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386352. |
in cultured seminiferous tubules, we found that secretion of clu protein is upregulated by transforming growth factor-betas (tgf-β1-3) and observed inhibition of staurosporine-induced apoptosis by recombinant clu. |
2020-09-30 |
2023-08-13 |
rat |
| Annie Turkieh, Sina Porouchani, Olivia Beseme, Maggy Chwastyniak, Philippe Amouyel, Nicolas Lamblin, Jean-Luc Balligand, Christophe Bauters, Florence Pine. Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity. Cell death & disease. vol 10. issue 8. 2020-07-30. PMID:31406108. |
in another hand, clu silencing in ncm has no effect either on macroautophagy or apoptosis induced by mg132. |
2020-07-30 |
2023-08-13 |
human |
| Annie Turkieh, Sina Porouchani, Olivia Beseme, Maggy Chwastyniak, Philippe Amouyel, Nicolas Lamblin, Jean-Luc Balligand, Christophe Bauters, Florence Pine. Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity. Cell death & disease. vol 10. issue 8. 2020-07-30. PMID:31406108. |
however, the overexpression of clu secreted isoform in h9c2 cells, but not in ncm decreased apoptosis after mg132 treatment. |
2020-07-30 |
2023-08-13 |
human |
| Annie Turkieh, Sina Porouchani, Olivia Beseme, Maggy Chwastyniak, Philippe Amouyel, Nicolas Lamblin, Jean-Luc Balligand, Christophe Bauters, Florence Pine. Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity. Cell death & disease. vol 10. issue 8. 2020-07-30. PMID:31406108. |
all these data suggest that increased clu expression and secretion after mi is, in part, due to a defect of ups and macroautophagy activities in the heart and may have a protective effect by decreasing apoptosis induced by proteasome inhibition. |
2020-07-30 |
2023-08-13 |
human |
| Jixian Xiong, Shaoxiang Wang, Tie Chen, Xingsheng Shu, Xianming Mo, Gang Chang, Jia-Jie Chen, Chenyang Li, Hui Luo, Jiing-Dwan Le. Verteporfin blocks Clusterin which is required for survival of gastric cancer stem cell by modulating HSP90 function. International journal of biological sciences. vol 15. issue 2. 2020-01-13. PMID:30745823. |
depletion of clusterin (clu, the full-length intracellular clusterin) led to the declustering of gcsc tumorspheres and apoptosis of gcsc. |
2020-01-13 |
2023-08-13 |
human |
| Sushmita Mustafi, David W Sant, Zhao-Jun Liu, Gaofeng Wan. Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28623268. |
rna-seq analysis revealed that expression of the clusterin (clu) gene, which is related to apoptosis, was downregulated by ascorbate. |
2019-06-11 |
2023-08-13 |
Not clear |
| Xiaokun Ma, Liyuan Zou, Xing Li, Zhanhong Chen, Qu Lin, Xiangyuan W. MicroRNA-195 regulates docetaxel resistance by targeting clusterin in prostate cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-09-17. PMID:29665645. |
knockdown of clu diminished the ic50 of doc and enhanced the apoptosis of du145/doc cells, which was consistent with the influence of mir-195 on doc-induced cell apoptosis. |
2018-09-17 |
2023-08-13 |
Not clear |
| Jingtao Zhong, Xiaoming Yu, Xiaofeng Dong, Hong Lu, Wuyuan Zhou, Lei Li, Zhongchao Li, Pengfei Sun, Xuetao Sh. Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436591. |
the downregulation of sclu by clu shrna synergistically increased sor sensitivity in the bel‑7402 and smmc‑7721 cells, and potentiated sor‑induced cell apoptosis. |
2018-08-27 |
2023-08-13 |
Not clear |
| Elena Terenina, Stephane Fabre, Agnès Bonnet, Danielle Monniaux, Christèle Robert-Granié, Magali SanCristobal, Julien Sarry, Florence Vignoles, Florence Gondret, Philippe Monget, Gwenola Tosser-Klop. Differentially expressed genes and gene networks involved in pig ovarian follicular atresia. Physiological genomics. vol 49. issue 2. 2018-02-09. PMID:27940565. |
among these genes known to be inhibitors of apoptosis, stimulators of apoptosis, or tumor suppressors inhbb, hnf4, clu, different interleukins (il5, il24), tnf-associated receptor (tnfr1), and cytochrome-c oxidase (cox) were suggested as playing an important role in porcine atresia. |
2018-02-09 |
2023-08-13 |
Not clear |
| R Buquicchio, C Foti, F Loconsole, L Polimeno, M T Ventur. Clusterin serum level: how does it affect psoriatic patients? Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28958138. |
clusterin (clu), also known as apolipoprotein j (apoj), is a highly conserved disulfide-linked heterodimeric glycoprotein implicated in a great variety of physiological and pathophysiological processes including lipid transportation, tissue remodeling, senescence, cell interaction, stress response, inflammation, apoptosis, diabetes mellitus and metabolic syndrome. |
2017-12-14 |
2023-08-13 |
human |
| Marilina García-Aranda, Teresa Téllez, Miguel Muñoz, Maximino Redond. Clusterin inhibition mediates sensitivity to chemotherapy and radiotherapy in human cancer. Anti-cancer drugs. vol 28. issue 7. 2017-12-04. PMID:28471806. |
during the last few years, several studies have shown the cytoprotective role of secretory clu in tumor cells, inhibiting their apoptosis and enhancing their resistance to conventional treatments including hormone depletion, chemotherapy, and radiotherapy. |
2017-12-04 |
2023-08-13 |
human |
| S Kumar, R Deb, U Singh, I Ganguly, D K Mandal, S Tyagi, M Kumar, G Sengar, S Sharma, R Singh, R Sing. Bovine Circadian Locomotor Output Cycles Kaput (CLOCK) and Clusterin (CLU) mRNA Quantitation in Ejaculated Crossbred Bull Spermatozoa. Reproduction in domestic animals = Zuchthygiene. vol 50. issue 3. 2016-01-25. PMID:25845404. |
clusterins (clu) are series of genes associated with a variety of physiological activities including spermatogenesis, apoptosis and degenerative disease conditions. |
2016-01-25 |
2023-08-13 |
human |
| Miao Xu, Xiumei Chen, Yanling Han, Chunqing Ma, Lin Ma, Shirong L. Clusterin silencing sensitizes pancreatic cancer MIA-PaCa-2 cells to gmcitabine via regulation of NF-kB/Bcl-2 signaling. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550158. |
clusterin (clu) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. |
2015-11-09 |
2023-08-13 |
Not clear |
| Fan Zhang, Masafumi Kumano, Eliana Beraldi, Ladan Fazli, Caigan Du, Susan Moore, Poul Sorensen, Amina Zoubeidi, Martin E Gleav. Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival. Nature communications. vol 5. 2015-11-03. PMID:25503391. |
combining clu inhibition with anticancer treatments attenuates autophagy activation, increases apoptosis and reduces prostate cancer growth. |
2015-11-03 |
2023-08-13 |
mouse |
| Xiaoqing Ren, Xue Bai, Xuefei Zhang, Zheyi Li, Lingfang Tang, Xuyang Zhao, Zeyang Li, Yanfei Ren, Shicheng Wei, Qingsong Wang, Cong Liu, Jianguo J. Quantitative nuclear proteomics identifies that miR-137-mediated EZH2 reduction regulates resveratrol-induced apoptosis of neuroblastoma cells. Molecular & cellular proteomics : MCP. vol 14. issue 2. 2015-10-08. PMID:25505154. |
inhibition of mir-137 expression rescued the cellular apoptosis phenotypes, ezh2 reduction, and clu and ngfr reactivation, associated with rsv treatment. |
2015-10-08 |
2023-08-13 |
Not clear |