| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adel Zalata, Ayman Z El-Samanoudy, Dalia Shaalan, Youssef El-Baiomy, Mai Taymour, Taymour Mostaf. Seminal clusterin gene expression associated with seminal variables in fertile and infertile men. The Journal of urology. vol 188. issue 4. 2012-11-19. PMID:22902018. |
clu is a disulfide linked, heterodimeric protein associated with the clearance of cellular debris and apoptosis. |
2012-11-19 |
2023-08-12 |
Not clear |
| Nayoung Kim, Jae Cheal Yoo, Jae Yoon Han, Eun Mi Hwang, Yoon Sook Kim, Eun Young Jeong, Choong-Hyun Sun, Gwan-Su Yi, Gu Seob Roh, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Jae-Yong Park, Wan Sung Cho. Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567405. |
clusterin (clu), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types. |
2012-04-25 |
2023-08-12 |
human |
| Francois Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Eliana Beraldi, Ladan Fazli, Amina Zoubeidi, Martin E Gleav. Clusterin inhibition using OGX-011 synergistically enhances Hsp90 inhibitor activity by suppressing the heat shock response in castrate-resistant prostate cancer. Cancer research. vol 71. issue 17. 2011-10-25. PMID:21737488. |
treatment-induced increases in clu were blocked by ogx-011, which synergistically enhanced the activity of hsp90 inhibition on crpc cell growth and apoptosis. |
2011-10-25 |
2023-08-12 |
human |
| Dong-Hwa Lee, Ji-Hyang Ha, Yul Kim, Kwang-Hee Bae, Jae-Yong Park, Wan Sung Choi, Ho Sup Yoon, Sung Goo Park, Byoung Chul Park, Gwan-Su Yi, Seung-Wook Ch. Interaction of a putative BH3 domain of clusterin with anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy. Biochemical and biophysical research communications. vol 408. issue 4. 2011-08-02. PMID:21527247. |
although clu is known to be involved in the regulation of apoptosis and cell survival, the precise molecular mechanism underlying the pro-apoptotic function of nuclear clu (nclu) remains unclear. |
2011-08-02 |
2023-08-12 |
Not clear |
| Abdellatif Essabbani, Florence Margottin-Goguet, Gilles Chiocchi. Identification of clusterin domain involved in NF-kappaB pathway regulation. The Journal of biological chemistry. vol 285. issue 7. 2010-05-11. PMID:20028970. |
clusterin (clu) is a ubiquitous protein that has been implicated in tumorigenesis, apoptosis, inflammation, and cell proliferation. |
2010-05-11 |
2023-08-12 |
Not clear |
| Arturo Sala, Saverio Bettuzzi, Sabina Pucci, Olesya Chayka, Michael Dews, Andrei Thomas-Tikhonenk. Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis. Advances in cancer research. vol 105. 2010-01-07. PMID:19879426. |
however, owing to the recent efforts of several laboratories, the role of clu in important cellular processes like proliferation, apoptosis, differentiation, and transformation is beginning to emerge. |
2010-01-07 |
2023-08-12 |
human |
| Soultana Markopoulou, Evangelos Kontargiris, Christina Batsi, Theodore Tzavaras, Ioannis Trougakos, David A Boothman, Efstathios S Gonos, Evangelos Koletta. Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. The FEBS journal. vol 276. issue 14. 2009-10-13. PMID:19531052. |
induction of apoptosis correlated with upregulation of the c-fos oncoprotein, changes in the expression of clusterin (clu), an altered ratio of antiapoptotic to proapoptotic bcl-2 protein family members, and poly(adp-ribose) polymerase-1 cleavage. |
2009-10-13 |
2023-08-12 |
human |
| Soultana Markopoulou, Evangelos Kontargiris, Christina Batsi, Theodore Tzavaras, Ioannis Trougakos, David A Boothman, Efstathios S Gonos, Evangelos Koletta. Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. The FEBS journal. vol 276. issue 14. 2009-10-13. PMID:19531052. |
forced overexpression of c-fos induced apoptosis in hacat cells that correlated with secretory clu downregulation and upregulation of nuclear clu (nclu), a pro-death protein. |
2009-10-13 |
2023-08-12 |
human |
| Soultana Markopoulou, Evangelos Kontargiris, Christina Batsi, Theodore Tzavaras, Ioannis Trougakos, David A Boothman, Efstathios S Gonos, Evangelos Koletta. Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. The FEBS journal. vol 276. issue 14. 2009-10-13. PMID:19531052. |
overexpression of bcl-2 protected hacat cells from vanadium-induced apoptosis, whereas secretory clu overexpression offered no cytoprotection. |
2009-10-13 |
2023-08-12 |
human |
| Soultana Markopoulou, Evangelos Kontargiris, Christina Batsi, Theodore Tzavaras, Ioannis Trougakos, David A Boothman, Efstathios S Gonos, Evangelos Koletta. Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. The FEBS journal. vol 276. issue 14. 2009-10-13. PMID:19531052. |
our data suggest that vanadium-mediated apoptosis was promoted by c-fos, leading to alterations in clu isoform processing and induction of the pro-death nclu protein. |
2009-10-13 |
2023-08-12 |
human |
| F Rizzi, S Bettuzz. Targeting Clusterin in prostate cancer. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 59 Suppl 9. 2009-04-10. PMID:19261985. |
clu plays important roles nearly in all most important biological phenomena including cell proliferation and apoptosis, as well as in many diseases including cancer. |
2009-04-10 |
2023-08-12 |
Not clear |
| Federica Rizzi, Alessandro Emanuele Caccamo, Lucia Belloni, Saverio Bettuzz. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. Journal of cellular physiology. vol 219. issue 2. 2009-03-16. PMID:19137541. |
both the extra- and intracellular clu forms regulate cell proliferation and apoptosis. |
2009-03-16 |
2023-08-12 |
Not clear |
| Federica Rizzi, Alessandro Emanuele Caccamo, Lucia Belloni, Saverio Bettuzz. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. Journal of cellular physiology. vol 219. issue 2. 2009-03-16. PMID:19137541. |
we found that clu over-expression inhibited cell proliferation and induced apoptosis in prostate cancer cells. |
2009-03-16 |
2023-08-12 |
Not clear |
| Zhiliang Wu, Isao Nagano, Yuzo Takahash. Candidate genes responsible for common and different pathology of infected muscle tissues between Trichinella spiralis and T. pseudospiralis infection. Parasitology international. vol 57. issue 3. 2008-09-09. PMID:18501667. |
many of these differentially expressed genes were associated with satellite cell activation and proliferation (paired box gene 7, pax7; pax3; desmin; m-cadherin), myogenesis and muscle development (eyes absent 2 homolog, eya2; myocyte enhancer factor 2c, mef2c; pre b-cell leukemia transcription factor 1, pbx1; chordin-like 2, chrdl2), cell differentiation (galectin 1; insulin like growth factors, igfs; c-ski; msh-like 1, msx1; numb), cell proliferation and cycle regulation (retinoblastoma 1, rb1; granulin; p21, cdk4, cyclin a2), and apoptosis (tumor necrosis factor receptor 1, tnf-r1; programmed cell death protein 11, pdcd11; pdcd1; nuclear protein 1, nuprl; clusterin, clu). |
2008-09-09 |
2023-08-12 |
Not clear |
| Kwan-Bok Lee, Jun-Ho Jeon, Inpyo Choi, O-Yu Kwon, Kweon Yu, Kwan-Hee Yo. Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability. Biochemical and biophysical research communications. vol 366. issue 4. 2008-02-05. PMID:18082619. |
clusterin (clu) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
| Ivan Martinez, Jun Wang, Kenosha F Hobson, Robert L Ferris, Saleem A Kha. Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. European journal of cancer (Oxford, England : 1990). vol 43. issue 2. 2007-04-09. PMID:17079134. |
the upregulated genes included those involved in cell proliferation (akr1c3) and transcription regulation (snapc1), while downregulated genes included those involved in apoptosis (clu) and rna processing (rbm3). |
2007-04-09 |
2023-08-12 |
human |
| Andrea Caporali, Pierpaola Davalli, Serenella Astancolle, Domenico D'Arca, Maurizio Brausi, Saverio Bettuzzi, Arnaldo Cort. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Carcinogenesis. vol 25. issue 11. 2007-03-12. PMID:15358631. |
clusterin (clu) protein is widely distributed in animal tissues and is involved in many different processes, including apoptosis and neoplastic transformation. |
2007-03-12 |
2023-08-12 |
mouse |
| Magda Lourda, Ioannis P Trougakos, Efstathios S Gono. Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. International journal of cancer. vol 120. issue 3. 2007-02-05. PMID:17096323. |
moreover, sirna-mediated clu knock down in the absence of dxr induced high levels of endogenous spontaneous apoptosis in both the parental and r2 os cell lines. |
2007-02-05 |
2023-08-12 |
human |
| Valérie Devauchelle, Abdellatif Essabbani, Gonzague De Pinieux, Stéphane Germain, Léa Tourneur, Sylvie Mistou, Florence Margottin-Goguet, Philippe Anract, Henri Migaud, Dominique Le Nen, Thierry Lequerré, Alain Saraux, Maxime Dougados, Maxime Breban, Catherine Fournier, Gilles Chiocchi. Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 9. 2006-12-13. PMID:17056579. |
transgenic overexpression of clu in ra fls promoted apoptosis within 24 h. we observed that clu knockdown with small interfering rna promoted il-6 and il-8 production. |
2006-12-13 |
2023-08-12 |
Not clear |
| Alessandro E Caccamo, Silvia Desenzani, Lucia Belloni, Angelo F Borghetti, Saverio Bettuzz. Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells. Journal of cellular physiology. vol 207. issue 1. 2006-06-05. PMID:16331665. |
clusterin (clu), whose role is still debated, is differentially regulated in several patho-physiological processes and invariably induced during apoptosis. |
2006-06-05 |
2023-08-12 |
human |