| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ioannis P Trougakos, Magda Lourda, Georgia Agiostratidou, Dimitris Kletsas, Efstathios S Gono. Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free radical biology & medicine. vol 38. issue 4. 2006-05-16. PMID:15649646. |
we found that induction of high intracellular clu amounts increases spontaneous apoptosis in kh os cells and reduces dna synthesis in all three cell lines assayed. |
2006-05-16 |
2023-08-12 |
human |
| B Shannan, M Seifert, K Leskov, J Willis, D Boothman, W Tilgen, J Reichrat. Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell death and differentiation. vol 13. issue 1. 2006-03-20. PMID:16179938. |
furthermore, clu expression is modulated by many factors that are believed to regulate tumour growth and/or apoptosis, including 1,25-dihydroxyvitamin d3, transforming growth factor beta-1, ultraviolet radiation, and ir. |
2006-03-20 |
2023-08-12 |
human |
| Ioannis P Trougakos, Efstathios S Gono. Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Annals of the New York Academy of Sciences. vol 1019. 2004-08-20. PMID:15247015. |
in all three cell lines, clu knockdown resulted in increased sensitization to dxr-induced apoptosis. |
2004-08-20 |
2023-08-12 |
human |
| Ioannis P Trougakos, Efstathios S Gono. Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Annals of the New York Academy of Sciences. vol 1019. 2004-08-20. PMID:15247015. |
supportively, moderate levels of forced transgene-mediated clu stable overexpression in kh os cells could rescue them from dxr-mediated apoptosis. |
2004-08-20 |
2023-08-12 |
human |
| Ioannis P Trougakos, Efstathios S Gono. Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Annals of the New York Academy of Sciences. vol 1019. 2004-08-20. PMID:15247015. |
in contrast, stable overexpression of high clu levels in sa os and u-2 os cells augmented apoptosis induced by cell exposure to severe dxr-mediated genotoxic stress. |
2004-08-20 |
2023-08-12 |
human |
| Ioannis P Trougakos, Alan So, Burkhard Jansen, Martin E Gleave, Efstathios S Gono. Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer research. vol 64. issue 5. 2004-03-31. PMID:14996747. |
our data demonstrate that clu knockdown in human cancer cells induces significant reduction of cellular growth and higher rates of spontaneous endogenous apoptosis. |
2004-03-31 |
2023-08-12 |
human |