| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qi. Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway. International journal of molecular medicine. vol 35. issue 3. 2015-10-05. PMID:25605314. |
furthermore, the inhibition of cell apoptosis induced by exposure to aae was abrogated after silencing the expression of the clu gene. |
2015-10-05 |
2023-08-13 |
rat |
| Wenjie Zheng, Wenli Sai, Min Yao, Hongbin Gu, Yao Yao, Qi Qian, Dengfu Ya. Silencing clusterin gene transcription on effects of multidrug resistance reversing of human hepatoma HepG2/ADM cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 5. 2015-08-05. PMID:25600802. |
after the hepg2/adm cells transfected with shrna-1, the inhibition of clu expression was 73.68 % at messenger rna (mrna) level by real-time quantitative rt-pcr with obvious enhancement in cell chemosensitivity, increasing apoptosis induced by doxorubicin using fluorescence kit, and rh-123 retention qualified with flow cytometry. |
2015-08-05 |
2023-08-13 |
human |
| Chao Wang, Zhenyu Zeng, Qiong Liu, Renli Zhang, Jiazuan N. Se-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411798. |
over-expression of clusterin (clu) can antagonize apoptosis in various cells. |
2015-07-14 |
2023-08-13 |
mouse |
| Chao Wang, Zhenyu Zeng, Qiong Liu, Renli Zhang, Jiazuan N. Se-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411798. |
to explore the function of clu and the impact of se in the process of apoptosis, several short-hairpin rnas (shrna) were designed for the construction of two sets of recombinant plasmids: one set for plasmid-transfection of mouse neuroblastoma n2a cells (n2a cells); and the other set for lentiviral infection of human neuroblastoma sh-sy5y cells (sh-sy5y cells). |
2015-07-14 |
2023-08-13 |
mouse |
| S Park, K W Mathis, I K Le. The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases. Reviews in endocrine & metabolic disorders. vol 15. issue 1. 2014-10-28. PMID:24097125. |
nuclear clu, a truncated clu formed by alternative splicing, is responsible for promoting apoptosis via a bax-dependent pathway. |
2014-10-28 |
2023-08-12 |
Not clear |
| Hans Prochnow, Rene Gollan, Philipp Rohne, Matthias Hassemer, Claudia Koch-Brandt, Markus Baiersdörfe. Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway. PloS one. vol 8. issue 9. 2014-05-27. PMID:24073260. |
by investigating human clu mrnas we here unravel mechanisms leading to the synthesis of distinct clu protein isoforms and analyze their subcellular localization and their impact on apoptosis and on nf-κb-activity. |
2014-05-27 |
2023-08-12 |
human |
| Hans Prochnow, Rene Gollan, Philipp Rohne, Matthias Hassemer, Claudia Koch-Brandt, Markus Baiersdörfe. Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway. PloS one. vol 8. issue 9. 2014-05-27. PMID:24073260. |
functional analysis revealed that none of these cytosolic clu forms modulate caspase-mediated intrinsic apoptosis or significantly affects tnf-α-induced nf-κb-activity. |
2014-05-27 |
2023-08-12 |
human |
| Hua Shi, Jun-Hong Deng, Zhu Wang, Kai-Yuan Cao, Liang Zhou, Hua Wa. Knockdown of clusterin inhibits the growth and migration of renal carcinoma cells and leads to differential gene expression. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23670677. |
we observed that clu knockdown induced apoptosis and inhibited the proliferation and migration of 786-o cells. |
2014-01-07 |
2023-08-12 |
human |
| Hua Shi, Jun-Hong Deng, Zhu Wang, Kai-Yuan Cao, Liang Zhou, Hua Wa. Knockdown of clusterin inhibits the growth and migration of renal carcinoma cells and leads to differential gene expression. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23670677. |
in this study, we demonstrated that clu acts as an oncogene in rcc by promoting cell proliferation and migration and inhibiting apoptosis. |
2014-01-07 |
2023-08-12 |
human |
| Yanxia Fu, Yingrong Lai, Qiongjuan Wang, Xingyang Liu, Weipeng He, Haihong Zhang, Chunyang Fan, Guofen Yan. Overexpression of clusterin promotes angiogenesis via the vascular endothelial growth factor in primary ovarian cancer. Molecular medicine reports. vol 7. issue 6. 2013-11-07. PMID:23616046. |
clu has been shown to play significant roles in many of the biological behaviours of human tumors, such as cell proliferation, apoptosis, chemoresistance and angiogenesis. |
2013-11-07 |
2023-08-12 |
human |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
therefore, in order to explore the molecular mechanisms by which clu inhibited er stress-induced apoptosis, hcc cell lines were treated with tunicamycin (tn), an er stress inducer. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
knockdown of clu expression in smmc7721 and hcclm3 cells inhibited grp78 expression after tn treatment and enhanced er stress-induced apoptosis, whereas over-expression of clu in hepg2 cells increased grp78 expression after tn induction and abolished the effect of tn on cell apoptosis. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
the effect of clu knockdown on grp78 expression and cell apoptosis in hcc tumors were further determined in orthotopic xenograft tumor model. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
taken together, these findings reveal that clu protects hcc cells from er stress induced apoptosis at least partially through interacting with grp78. |
2013-08-26 |
2023-08-12 |
Not clear |
| S Tripathi, J Batra, W Cao, K Sharma, J R Patel, P Ranjan, A Kumar, J M Katz, N J Cox, R B Lal, S Sambhara, S K La. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Cell death & disease. vol 4. 2013-08-23. PMID:23538443. |
we screened host cellular factors for those that may be targeted by np for inducing apoptosis and identified human antiapoptotic protein clusterin (clu) as a novel interacting partner. |
2013-08-23 |
2023-08-12 |
human |
| S Tripathi, J Batra, W Cao, K Sharma, J R Patel, P Ranjan, A Kumar, J M Katz, N J Cox, R B Lal, S Sambhara, S K La. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Cell death & disease. vol 4. 2013-08-23. PMID:23538443. |
also clu was found to interact specifically with iav np and not with any other known apoptosis modulatory protein of iav. |
2013-08-23 |
2023-08-12 |
human |
| S Tripathi, J Batra, W Cao, K Sharma, J R Patel, P Ranjan, A Kumar, J M Katz, N J Cox, R B Lal, S Sambhara, S K La. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Cell death & disease. vol 4. 2013-08-23. PMID:23538443. |
clu prevents induction of the intrinsic apoptosis pathway by binding to bax and inhibiting its movement into the mitochondria. |
2013-08-23 |
2023-08-12 |
human |
| N Li, A Zoubeidi, E Beraldi, M E Gleav. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. vol 32. issue 15. 2013-06-19. PMID:22689054. |
expression of clusterin (clu) closely correlates with the regulation of apoptosis in cancer. |
2013-06-19 |
2023-08-12 |
human |
| N Li, A Zoubeidi, E Beraldi, M E Gleav. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. vol 32. issue 15. 2013-06-19. PMID:22689054. |
moreover, subcellular fractionation and confocal microscopy with clugfp indicated that grp78 increased stress-induced clu retrotranslocation from the er with co-localized redistribution to the mitochondria, thereby reducing stress-induced apoptosis by cooperatively stabilizing mitochondrial membrane integrity. |
2013-06-19 |
2023-08-12 |
human |
| N Li, A Zoubeidi, E Beraldi, M E Gleav. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. vol 32. issue 15. 2013-06-19. PMID:22689054. |
grp78 silencing reduced clu protein, but not mrna levels, and enhanced paclitaxel-induced cell apoptosis. |
2013-06-19 |
2023-08-12 |
human |