| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Amour, M Bird, L Chaudry, J Deadman, D Hayes, C Ka. General considerations for proteolytic cascades. Biochemical Society transactions. vol 32. issue Pt 1. 2004-09-24. PMID:14748703. |
four major proteolytic cascades with disease relevance are candidates for therapeutic intervention, namely caspase-mediated apoptosis, blood coagulation, the matrix metalloproteinase cascade and the complement cascade. |
2004-09-24 |
2023-08-12 |
Not clear |
| Jens M Kelm, Elisabeth Ehler, Lars K Nielsen, Stefan Schlatter, Jean-Claude Perriard, Martin Fussenegge. Design of artificial myocardial microtissues. Tissue engineering. vol 10. issue 1-2. 2004-09-24. PMID:15009946. |
embedded in a three-dimensional environment, cells are expected to develop tissue-like higher order intercellular structures (cell-cell contacts, extracellular matrix) that orchestrate cellular functions including proliferation, differentiation, apoptosis, and angiogenesis with unmatched quality. |
2004-09-24 |
2023-08-12 |
mouse |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
the purpose of this study was to investigate whether this matrix protects beta-cells against apoptosis and to elucidate signaling pathways involved. |
2004-09-17 |
2023-08-12 |
rat |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
matrix protected sorted rat beta-cells against apoptosis under standard conditions (11.2 mmol/l glucose, 10% serum), after serum deprivation (1% serum), and in response to interleukin-1beta (il-1beta; 2 ng/ml), compared with control (poly-l-lysine [pll]). |
2004-09-17 |
2023-08-12 |
rat |
| Warren B Nothnick, Xuan Zhang, Han-E Zho. Steroidal regulation of uterine edema and tissue inhibitors of metalloproteinase (TIMP)-3 messenger RNA expression is altered in TIMP-1-deficient mice. Biology of reproduction. vol 70. issue 2. 2004-09-16. PMID:14568914. |
tissue inhibitors of metalloproteinases (timps) are expressed within the uteri of virtually all species where they are postulated to control extracellular matrix turnover, cellular apoptosis, and proliferation. |
2004-09-16 |
2023-08-12 |
mouse |
| Yuying Liu, Lawrence H Cheung, Walter N Hittelman, Michael G Rosenblu. Targeted delivery of human pro-apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents. Molecular cancer therapeutics. vol 2. issue 12. 2004-09-16. PMID:14707275. |
the serine protease granzyme b (grb, 25 kda) can initiate apoptosis by multiple mechanisms including directly activating caspases, inducing dna fragmentation, activating the mitochondrial death pathway, and directly cleaving the nuclear matrix. |
2004-09-16 |
2023-08-12 |
human |
| Orla M Casey, Richard Fitzpatrick, James O McInerney, Dermot G Morris, Richard Powell, Joseph M Sreena. Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs. Biochimica et biophysica acta. vol 1679. issue 1. 2004-09-16. PMID:15245912. |
several previously unidentified bovine genes encoding proteins associated with key aspects of cl function including extracellular matrix remodelling, lipid metabolism/steroid biosynthesis and apoptosis, were identified. |
2004-09-16 |
2023-08-12 |
human |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
recently it has been shown that matrix metalloproteinase-9 (mmp-9)/gelatinase b is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
tartrate-resistant acid phosphatase (trap) activity, in situ hybridization for matrix metalloproteinase-9 (mmp-9), immunostaining for cd31, and in situ detection of apoptosis (tunel) were studied. |
2004-09-16 |
2023-08-12 |
Not clear |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
these results suggest that chondrocytes separated from the cartilage matrix may undergo apoptosis. |
2004-09-16 |
2023-08-12 |
Not clear |
| Agnieszka Chrobak, Grzegorz B Gmyrek, Rafał Sozański, Urszula Sieradzka, Maria Paprocka, Marian Gabryś, Małgorzata Jerza. The influence of extracellular matrix proteins on T-cell proliferation and apoptosis in women with endometriosis or uterine leiomyoma. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748838. |
the influence of extracellular matrix proteins on t-cell proliferation and apoptosis in women with endometriosis or uterine leiomyoma. |
2004-09-15 |
2023-08-12 |
Not clear |
| Małgorzata Jerzak, Monika Kasprzycka, Włodzimierz Baranowski, Andrzej Górsk. Extracellular Matrix Protein-dependent Apoptosis of T Cells in Women with a History of Recurrent Spontaneous Abortion. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748839. |
extracellular matrix protein-dependent apoptosis of t cells in women with a history of recurrent spontaneous abortion. |
2004-09-15 |
2023-08-12 |
Not clear |
| Małgorzata Jerzak, Monika Kasprzycka, Włodzimierz Baranowski, Andrzej Górsk. Extracellular Matrix Protein-dependent Apoptosis of T Cells in Women with a History of Recurrent Spontaneous Abortion. American journal of reproductive immunology (New York, N.Y. : 1989). vol 51. issue 2. 2004-09-15. PMID:14748839. |
the purpose of the study was to determine the role of t-cell apoptosis in extracellular matrix (ecm) environment in pregnancy maintenance in women with a history of recurrent spontaneous abortion (rsa). |
2004-09-15 |
2023-08-12 |
Not clear |
| Xifeng Wu, Hua Zhao, Rebecca Suk, David C Christian. Genetic susceptibility to tobacco-related cancer. Oncogene. vol 23. issue 38. 2004-09-15. PMID:15322521. |
these pathways include regulation of xenobiotic metabolism; control of genomic stability, including dna repair mechanisms, cell-cycle checkpoints, apoptosis and telomere length; and control of microenvironmental factors, such as matrix metalloproteinases, inflammation and growth factors. |
2004-09-15 |
2023-08-12 |
Not clear |
| Anthony J Valentijn, Andrew P Gilmor. Translocation of full-length Bid to mitochondria during anoikis. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15148322. |
epithelial cells require adhesion to the extracellular matrix for survival, and in the absence of adhesion they undergo apoptosis (anoikis). |
2004-09-10 |
2023-08-12 |
Not clear |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
the beta(1) integrin, functioning as a mechanoreceptor, senses a mechanical stimulus generated during collagen matrix contraction and down-regulates the phosphatidylinositol 3-kinase (pi3k)/akt survival signal triggering apoptosis. |
2004-09-10 |
2023-08-12 |
Not clear |
| Tamara Vanhaecke, Tom Henkens, George E N Kass, Vera Rogier. Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. Biochemical pharmacology. vol 68. issue 4. 2004-09-08. PMID:15276083. |
in contrast, in hepatocyte culture models in which spontaneous apoptosis is already minimised through the addition of either extracellular matrix components (sandwich cultures) or non-parenchymal liver cells (co-cultures), tsa did not have any additional anti-apoptotic effect. |
2004-09-08 |
2023-08-12 |
rat |
| Doan H Nguyen, Hiroshi Toshida, Jill Schurr, Roger W Beuerma. Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiological genomics. vol 18. issue 1. 2004-08-30. PMID:15084711. |
conversely, transcripts for cytoskeleton and extracellular matrix components, inflammation, and apoptosis were upregulated. |
2004-08-30 |
2023-08-12 |
rat |
| Nestor F Gonzalez-Cadavid, Jacob Rajfe. Therapy of erectile dysfunction: potential future treatments. Endocrine. vol 23. issue 2-3. 2004-08-30. PMID:15146097. |
in the second approach, the first type of correction comprises regulators of endogenous cell number and integrity and extracellular matrix turnover (inhibitors of apoptosis and fibrosis, neurotrophic and angiogenic factors), testosterone, and tissue and cell explants (nerve and smooth muscle grafting, adult pluripotent cells), whereas the second includes in vivo gene therapy with different genes and vectors, and ex vivo gene therapy, combining gene transfer with stem cell implants. |
2004-08-30 |
2023-08-12 |
Not clear |