| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mani Alikhani, Zoubin Alikhani, Markos Raptis, Dana T Grave. TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes. Journal of cellular physiology. vol 201. issue 3. 2004-12-14. PMID:15389560. |
apoptosis of matrix producing cells is common among many inflammatory diseases. |
2004-12-14 |
2023-08-12 |
mouse |
| Diane R Bielenberg, Yasuhiro Hida, Akio Shimizu, Arja Kaipainen, Michael Kreuter, Caroline Choi Kim, Michael Klagsbru. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. The Journal of clinical investigation. vol 114. issue 9. 2004-12-13. PMID:15520858. |
rather, the primary tumors resembled benign nevi characterized by large areas of apoptosis, diminished vascularity, inhibition of hyperplasia in overlying epidermal cells, and encapsulated tumor borders delineated by thick layers of fibroblasts and collagen matrix. |
2004-12-13 |
2023-08-12 |
mouse |
| Elizabeth W Newcom. Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. Anti-cancer drugs. vol 15. issue 5. 2004-12-07. PMID:15166614. |
flavopiridol possesses several important anti-angiogenic activities including induction of apoptosis of endothelial cells; inhibition of the hypoxic induction of vascular endothelial growth factor and/or its production under hypoxic conditions through inhibition of hif-1alpha transcription; and decreased secretion of matrix metalloproteinases that is linked with significant inhibition of invasive potential in matrigel assays. |
2004-12-07 |
2023-08-12 |
human |
| Rowan J Milner, James Farese, Carolyn J Henry, Kim Selting, Timothy M Fan, Louis-Philippe de Lorimie. Bisphosphonates and cancer. Journal of veterinary internal medicine. vol 18. issue 5. 2004-12-07. PMID:15515572. |
bisphosphonates also inhibit cancer cell proliferation, induce apoptosis in in vitro cultures, inhibit angiogenesis, inhibit matrix metalloproteinase, have effects on cytokine and growth factors, and are immunomodulatory. |
2004-12-07 |
2023-08-12 |
Not clear |
| Jack Lawler, Michael Detma. Tumor progression: the effects of thrombospondin-1 and -2. The international journal of biochemistry & cell biology. vol 36. issue 6. 2004-12-02. PMID:15094119. |
the normal suppression of angiogenesis by tsp-1 and -2 involves multiple mechanisms including direct interaction with vascular endothelial cell growth factor (vegf), inhibition of matrix metalloproteinase 9 (mmp9) activation, inhibition of endothelial cell migration and induction of endothelial cell apoptosis. |
2004-12-02 |
2023-08-12 |
Not clear |
| Silvia Selleri, Francesca Arnaboldi, Laura Vizzotto, Andrea Balsari, Cristiano Rumi. Epithelium-mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 11. 2004-12-02. PMID:15378070. |
as a first sign of damage, significant apoptosis was detected in the proximal perifollicular connective tissue sheath and sporadically in the matrix, near the interface between matrix and follicular papilla. |
2004-12-02 |
2023-08-12 |
rat |
| Erika Suzuki, Kazuko Handa, Marcos S Toledo, Senitiroh Hakomor. Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 41. 2004-12-02. PMID:15466700. |
in addition, sph induces apoptosis through a separate process: the blocking of "survival signal" through the akt kinase pathway induced by alpha3beta1-mediated cell adhesion to laminin 10/11 in extracellular matrix. |
2004-12-02 |
2023-08-12 |
Not clear |
| Charles J Malemu. Protein kinases in chondrocyte signaling and osteoarthritis. Clinical orthopaedics and related research. issue 427 Suppl. 2004-12-02. PMID:15480058. |
protein kinases, particularly mitogen-activated protein kinases and receptor-tyrosine kinases play crucial roles in mammalian cellular metabolism by regulating intracellular signaling pathways that control proliferation, differentiation, cytokine gene induction and cytokine responsiveness, matrix metalloproteinase gene expression, mechanical transduction, as well as programmed cell death (apoptosis). |
2004-12-02 |
2023-08-12 |
Not clear |
| R Lane Smith, Dennis R Carter, David J Schurma. Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Clinical orthopaedics and related research. issue 427 Suppl. 2004-12-02. PMID:15480081. |
application of shear stress to osteoarthritic chondrocytes increased the release of the proinflammatory mediator, nitric oxide, decreased aggrecan and type ii collagen expression, and induced molecular changes associated with apoptosis whereas hydrostatic pressure increased matrix macromolecule expression. |
2004-12-02 |
2023-08-12 |
human |
| Zhao-cai Zhang, Shuang-jie Li, Ying-zhen Yang, Rui-zhen Chen, Jun-bo Ge, Hao-zhu Che. Microarray analysis of extracellular matrix genes expression in myocardium of mouse with Coxsackie virus B3 myocarditis. Chinese medical journal. vol 117. issue 8. 2004-11-30. PMID:15361300. |
extracellular matrix (ecm) orchestrates cell behaviour including growth, death, apoptosis, adhesion, migration, and invasion by activating several signalling pathways. |
2004-11-30 |
2023-08-12 |
mouse |
| Stéphane Fouquet, Verónica-Haydée Lugo-Martínez, Anne-Marie Faussat, Flore Renaud, Philippe Cardot, Jean Chambaz, Martine Pinçon-Raymond, Sophie Thene. Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes. The Journal of biological chemistry. vol 279. issue 41. 2004-11-24. PMID:15292248. |
apoptosis induced by detachment from the extracellular matrix, is thought to be involved in the shedding of enterocytes at the tip of intestinal villi. |
2004-11-24 |
2023-08-12 |
Not clear |
| R S Fife, B Stott, R E Car. Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726667. |
we now report on the effects of a selective cox-2 inhibitor, celecoxib, on cell proliferation, matrix metalloproteinase (mmp) concentration, angiogenesis using an in vitro assay, and apoptosis in several human cancer cell lines. |
2004-11-19 |
2023-08-12 |
human |
| M Mandel, M Gurevich, R Pauzner, N Kaminski, A Achiro. Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus. Clinical and experimental immunology. vol 138. issue 1. 2004-11-19. PMID:15373920. |
the autoimmune signature included genes that encode proteins involved in apoptosis, cell cycle, inflammation and regulation of matrix metalloproteinase pathways. |
2004-11-19 |
2023-08-12 |
human |
| b' Nevena Grdovi\\xc4\\x87, Goran Poznanovi\\xc4\\x8. Characterization of an Mg2+-dependent endonucleolytic activity of the rat hepatocyte nuclear matrix. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 136. issue 3. 2004-11-16. PMID:14602157.' |
in view of its properties and preferential localization on the nuclear matrix, the endonuclease described herein could be a possible candidate that brings about initial dna cleavage during apoptosis. |
2004-11-16 |
2023-08-12 |
rat |
| Laura Hertel, Edward S Mocarsk. Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. Journal of virology. vol 78. issue 21. 2004-11-16. PMID:15479839. |
cmv infection resulted in lower levels of transcripts encoding cytoskeletal, extracellular matrix, and adhesion proteins, together with small gtpases and apoptosis regulators, and in higher levels of transcripts encoding cell cycle, dna replication, energy production, and inflammation-related gene products. |
2004-11-16 |
2023-08-12 |
human |
| B Wappenschmidt, E Wardelmann, A Gehrig, T Schöndorf, N Maass, G Bonatz, A-M Gassel, T Pietsch, P Mallmann, B H F Weber, R K Schmutzle. PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas. Human pathology. vol 35. issue 10. 2004-11-10. PMID:15492994. |
pten encodes a dual-specificity phosphatase with lipid phosphatase and protein tyrosine phosphatase activities that regulate both apoptosis and interactions with the extracellular matrix. |
2004-11-10 |
2023-08-12 |
Not clear |
| D Kumar, D W Lundgren, R M Moore, R J Silver, J J Moor. Hydrogen peroxide induced apoptosis in amnion-derived WISH cells is not inhibited by vitamin C. Placenta. vol 25. issue 4. 2004-11-06. PMID:15028418. |
hp induced apoptosis in wish cells; as assessed by cytochrome-c release from mitochondria, poly-(adp-ribose)-polymerase (parp) cleavage, nuclear matrix protein (nmp) release and dna fragmentation analysis. |
2004-11-06 |
2023-08-12 |
Not clear |
| Yingpei Zhang, Catherine Haskins, Marisa Lopez-Cruzan, Jianhua Zhang, Victoria E Centonze, Brian Herma. Detection of mitochondrial caspase activity in real time in situ in live cells. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. vol 10. issue 4. 2004-11-01. PMID:15327705. |
using a mitochondrially targeted cfp-caspase 3 substrate-yfp construct (mc3y), we demonstrate for the first time that there is caspase-3-like activity in the mitochondrial matrix of some cells at very late stage of apoptosis. |
2004-11-01 |
2023-08-12 |
Not clear |
| Paul S Brookes, Yisang Yoon, James L Robotham, M W Anders, Shey-Shing She. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. American journal of physiology. Cell physiology. vol 287. issue 4. 2004-10-28. PMID:15355853. |
for example, mitochondrial matrix ca(2+) overload can lead to enhanced generation of reactive oxygen species, triggering of the permeability transition pore, and cytochrome c release, leading to apoptosis. |
2004-10-28 |
2023-08-12 |
Not clear |
| Soo-Mi Kweon, Zee-Won Lee, Sun-Ju Yi, Young-Myeong Kim, Jeong-A Han, Sang-Gi Paik, Skwon-Soo H. Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells. Journal of biochemistry and molecular biology. vol 37. issue 2. 2004-10-28. PMID:15469694. |
tissue transglutaminase (ttgase) regulates various biological processes, including extracellular matrix organization, cellular differentiation, and apoptosis. |
2004-10-28 |
2023-08-12 |
human |