| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshiya Tanaka, Shingo Nakayamada, Hiroko Fujimoto, Yosuke Okada, Hisanori Umehara, Tohru Kataoka, Yasuhiro Minam. H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts. The Journal of biological chemistry. vol 277. issue 24. 2002-07-25. PMID:11934900. |
thus, we propose that h-ras signals followed by raf-1/mapk pathway but not pi3k not only reduces beta(1)-mediated adhesion of osteoblasts to matrix proteins but induces apoptosis presumably via the fas up-regulation and bcl-2 down-regulation. |
2002-07-25 |
2023-08-12 |
human |
| H Wang, A Davis, S Yu, K Ahme. Response of cancer cells to molecular interruption of the CK2 signal. Molecular and cellular biochemistry. vol 227. issue 1-2. 2002-07-24. PMID:11827168. |
significantly, the effects of the antisense odn on the ck2 activity in the nuclear matrix were relatively small compared to the much stronger induction of apoptosis in cells. |
2002-07-24 |
2023-08-12 |
Not clear |
| Amanda D Miller, Suresh C Tyag. Mutation in collagen gene induces cardiomyopathy in transgenic mice. Journal of cellular biochemistry. vol 85. issue 2. 2002-07-22. PMID:11948682. |
however, complete loss of integrin signaling due to disconnection from extracellular matrix (ecm) leads to apoptosis and dilatation. |
2002-07-22 |
2023-08-12 |
mouse |
| William J Murdoch, Anna C McDonne. Roles of the ovarian surface epithelium in ovulation and carcinogenesis. Reproduction (Cambridge, England). vol 123. issue 6. 2002-07-19. PMID:12052228. |
tumour necrosis factor alpha progressively induces matrix metalloproteinase gene expression, apoptosis and inflammatory necrosis. |
2002-07-19 |
2023-08-12 |
human |
| Yun Zhao, Dawn A Gever. Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Biochemical and biophysical research communications. vol 294. issue 2. 2002-07-16. PMID:12051713. |
transforming growth factor-beta (tgf-beta) is a multifunctional cytokine involved in controlling critical cellular activities including proliferation, differentiation, extracellular matrix production, and apoptosis. |
2002-07-16 |
2023-08-12 |
Not clear |
| Harry C Blair, Mone Zaidi, Paul H Schlesinge. Mechanisms balancing skeletal matrix synthesis and degradation. The Biochemical journal. vol 364. issue Pt 2. 2002-07-15. PMID:12023876. |
bone is regulated by evolutionarily conserved signals that balance continuous differentiation of bone matrix-producing cells against apoptosis and matrix removal. |
2002-07-15 |
2023-08-12 |
Not clear |
| Harry C Blair, Mone Zaidi, Paul H Schlesinge. Mechanisms balancing skeletal matrix synthesis and degradation. The Biochemical journal. vol 364. issue Pt 2. 2002-07-15. PMID:12023876. |
removal of mineralized matrix involves apoptosis of matrix cells and differentiation of acid-secreting cells (osteoclasts) from macrophage precursors. |
2002-07-15 |
2023-08-12 |
Not clear |
| M P McNamara, K A Bjornstad, P Y Chang, W Chou, S J Lockett, E A Blakel. Modulation of lens cell adhesion molecules by particle beams. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). vol 17 Suppl 1. 2002-07-12. PMID:11776988. |
cell adhesion molecules (cams) are proteins which anchor cells to each other and to the extracellular matrix (ecm), but whose functions also include signal transduction, differentiation, and apoptosis. |
2002-07-12 |
2023-08-12 |
human |
| Ian A Darby, Teresa Bisucci, Brigitte Pittet, Stefania Garbin, Giulio Gabbiani, Alexis Desmoulièr. Skin flap-induced regression of granulation tissue correlates with reduced growth factor and increased metalloproteinase expression. The Journal of pathology. vol 197. issue 1. 2002-07-12. PMID:12081196. |
the additive effect of reduced growth factor expression, increased extracellular matrix turnover, and nitric oxide generation may result in the fibroblast and vascular cell apoptosis seen during the rapid remodelling of this tissue. |
2002-07-12 |
2023-08-12 |
rat |
| D R Pfeiffer, T E Gunter, R Eliseev, K M Broekemeier, K K Gunte. Release of Ca2+ from mitochondria via the saturable mechanisms and the permeability transition. IUBMB life. vol 52. issue 3-5. 2002-07-09. PMID:11798034. |
in addition, the permeability transition or pt, which may also remove ca2+ from the mitochondrial matrix, is intimately involved in other important functions such as apoptosis. |
2002-07-09 |
2023-08-12 |
Not clear |
| Kevin M McGowan, Xuemei Tong, Emma Colucci-Guyon, Francina Langa, Charles Babinet, Pierre A Coulomb. Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes & development. vol 16. issue 11. 2002-07-05. PMID:12050118. |
we report that k17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. |
2002-07-05 |
2023-08-12 |
mouse |
| Emmanouil Chavakis, Stefanie Dimmele. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arteriosclerosis, thrombosis, and vascular biology. vol 22. issue 6. 2002-07-03. PMID:12067894. |
in this review, we focus on the regulation of ec survival and apoptosis during angiogenesis and especially on the effects and intracellular signaling promoted by angiogenic growth factors, endogenous angiogenic inhibitors (such as angiostatin, endostatin, and thrombospondin-1), and the adhesion to the extracellular matrix. |
2002-07-03 |
2023-08-12 |
Not clear |
| Jianguo Gu, Akemi Fujibayashi, Kenneth M Yamada, Kiyotoshi Sekiguch. Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11891225. |
cell adhesion to the extracellular matrix inhibits apoptosis, but the molecular mechanisms underlying the signals transduced by different matrix components are not well understood. |
2002-07-02 |
2023-08-12 |
Not clear |
| Umesh M Hanumegowda, Barbara M Judy, Wade V Welshons, Chada S Redd. Selective inhibition of murine palatal mesenchymal cell proliferation in vitro by secalonic acid D. Toxicological sciences : an official journal of the Society of Toxicology. vol 66. issue 1. 2002-06-25. PMID:11861983. |
since reduced proliferation, increased apoptosis, and/or decreased extracellular matrix (ecm) synthesis of palatal mesenchymal cells (pmc) can all contribute to smaller shelf size, the hypothesis that teratogenically relevant concentrations (0 to 120 microg/ml) of sad will have adverse effects on one or more of these cellular processes was tested, using primary murine pmc cultures. |
2002-06-25 |
2023-08-12 |
mouse |
| Lillian Shum, Glen Nuckoll. The life cycle of chondrocytes in the developing skeleton. Arthritis research. vol 4. issue 2. 2002-06-20. PMID:11879545. |
extracellular growth and differentiation factors including bone morphogenetic proteins, fibroblast growth factors, parathyroid hormone-related peptide, extracellular matrix components, and members of the hedgehog and wnt families provide important signals for the regulation of cell proliferation, differentiation and apoptosis. |
2002-06-20 |
2023-08-12 |
Not clear |
| Marc Desforges, Geneviève Despars, Stéphane Bérard, Myriam Gosselin, Margie O McKenzie, Douglas S Lyles, Pierre J Talbot, Laurent Poliqui. Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus. Virology. vol 295. issue 1. 2002-06-20. PMID:12033766. |
matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus. |
2002-06-20 |
2023-08-12 |
human |
| Satohiko Araki, Shinako Masuda, Hiroki Maeda, Miao Jun Ying, Hiroshi Hayash. Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein 1. Toxicon : official journal of the International Society on Toxinology. vol 40. issue 5. 2002-06-18. PMID:11821125. |
since other various metalloproteases and disintegrins in snake venoms are known to influence extracellular matrix and cell adhesion, we investigated here the involvement of these adhesion molecules in vap1-induced apoptosis. |
2002-06-18 |
2023-08-12 |
Not clear |
| Satohiko Araki, Shinako Masuda, Hiroki Maeda, Miao Jun Ying, Hiroshi Hayash. Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein 1. Toxicon : official journal of the International Society on Toxinology. vol 40. issue 5. 2002-06-18. PMID:11821125. |
consequently, vap1 induced apoptosis without degrading extracellular matrix or inhibiting adhesion of vec. |
2002-06-18 |
2023-08-12 |
Not clear |
| Satohiko Araki, Shinako Masuda, Hiroki Maeda, Miao Jun Ying, Hiroshi Hayash. Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein 1. Toxicon : official journal of the International Society on Toxinology. vol 40. issue 5. 2002-06-18. PMID:11821125. |
these results suggest that integrins are involved in vap1-induced apoptosis by some specific role rather than that of adhesion to extracellular matrix. |
2002-06-18 |
2023-08-12 |
Not clear |
| Robert L Perlot, Irving M Shapiro, Kyle Mansfield, Christopher S Adam. Matrix regulation of skeletal cell apoptosis II: role of Arg-Gly-Asp-containing peptides. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 1. 2002-06-17. PMID:11771671. |
matrix regulation of skeletal cell apoptosis ii: role of arg-gly-asp-containing peptides. |
2002-06-17 |
2023-08-12 |
mouse |