| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Tucci, Daniela Grinello, Paola Cafforio, Franco Silvestris, Franco Dammacc. Anemia in multiple myeloma: role of deregulated plasma cell apoptosis. Leukemia & lymphoma. vol 43. issue 8. 2003-03-12. PMID:12400594. |
besides the altered cytokine network, chronic erythropoietin deficiency, blood loss and hemolysis, we have shown that deregulated myeloma cell apoptosis may contribute to progressive destruction of the erythroid matrix by inducing erythroblast cytotoxicity. |
2003-03-12 |
2023-08-12 |
Not clear |
| Wataru Yoshida, Miwa Uzuki, Akira Kurose, Masaaki Yoshida, Jun Nishida, Tadashi Shimamura, Takashi Sawa. Cell characterization of mononuclear and giant cells constituting pigmented villonodular synovitis. Human pathology. vol 34. issue 1. 2003-03-11. PMID:12605368. |
five methods were used for cell analysis: (1) enzyme-histochemistry for tartrate-resistant acid phosphatase (trap); (2) immunohistochemistry using antibodies for cd68, macrophage colony-stimulating factor (m-csf), mib-1, p53, p21, p16, and cathepsin-l (cath l); (3) tdt-mediated deoxyuridine triphosphate-biotin terminal end labeling (tunel) as a measure of apoptosis; (4) fluorescence-based polymerase chain reaction single-strand conformation polymorphism analyses (fpcr-sscp) to detect p53 gene mutations; and (5) in situ hybridization using gene-specific oligoprobes for matrix metalloproteinase (mmp)-2, mmp-9, receptor activator of nuclear factor kappab ligand (rankl), and calcitonin receptor (ctr). |
2003-03-11 |
2023-08-12 |
Not clear |
| Robert M Moore, David W Lundgren, Rebecca J Silver, John J Moor. Lactosylceramide-induced apoptosis in primary amnion cells and amnion-derived WISH cells. Journal of the Society for Gynecologic Investigation. vol 9. issue 5. 2003-03-07. PMID:12383912. |
apoptosis was confirmed by agarose gel electrophoretic dna fragmentation analysis, nuclear matrix protein (nmp), and nucleosome enzyme-linked immunosorbent assay. |
2003-03-07 |
2023-08-12 |
Not clear |
| Mingyu Liang, Baozhi Yuan, Elizabeth Rute, Andrew S Greene, Michael Olivier, Allen W Cowle. Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. Physiological genomics. vol 12. issue 3. 2003-02-28. PMID:12488510. |
thirty of these genes could be linked to the regulation of arterial blood pressure or renal injury based on their known involvement in functional pathways such as renal tubular transport, metabolism of vasoactive substances, extracellular matrix formation, and apoptosis. |
2003-02-28 |
2023-08-12 |
rat |
| Sergei Kochlatyi, Nora Gibbons, Joseph Mattan. Extracellular matrix oxidation modulates survival, NF-kappaB translocation, and MAPK activity in mesangial cells. Experimental and molecular pathology. vol 73. issue 3. 2003-02-27. PMID:12565794. |
in this study we evaluated how extracellular matrix oxidation could modulate the development of apoptosis as well as the activity of the transcription factor nf-kappab and that of the mapk family members erk-1,2 and jnk. |
2003-02-27 |
2023-08-12 |
Not clear |
| Takeshi Shimamura, Michiie Sakamoto, Yoshinori Ino, Kazuaki Shimada, Tomoo Kosuge, Yasuto Sato, Katsuaki Tanaka, Hisahiko Sekihara, Setsuo Hirohash. Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 8. 2003-02-26. PMID:12171885. |
galectin-3, a member of the beta-galactoside-binding lectin family, has multiple biological functions including cell-cell interactions and cell-extracellular matrix adhesion, cellular proliferation, cellular differentiation, and apoptosis. |
2003-02-26 |
2023-08-12 |
Not clear |
| Paul Sweeney, Takashi Karashima, Sun-Jin Kim, Daniel Kedar, Badar Mian, Samuel Huang, Cheryl Baker, Zhen Fan, Daniel J Hicklin, Curtis A Pettaway, Colin P N Dinne. Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 8. 2003-02-26. PMID:12171905. |
anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. |
2003-02-26 |
2023-08-12 |
Not clear |
| Hironobu Ih. Pathogenesis of fibrosis: role of TGF-beta and CTGF. Current opinion in rheumatology. vol 14. issue 6. 2003-02-26. PMID:12410091. |
transforming growth factor (tgf)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ecm) synthesis. |
2003-02-26 |
2023-08-12 |
Not clear |
| Koji Ishida, Hikaru Nagahara, Tomomi Kogiso, Tomoko Aso, Naoaki Hayashi, Toshihiro Akaik. Cell adhesion aside from integrin system can abrogate anoikis in rat liver cells by down-regulation of FasL expression, not by activation of PI-3K/Akt and ERK signaling pathway. Biochemical and biophysical research communications. vol 300. issue 1. 2003-02-13. PMID:12480544. |
epithelial cells require contact with extracellular matrix (ecm) to inhibit detachment-induced apoptosis (anoikis). |
2003-02-13 |
2023-08-12 |
rat |
| Razao Issa, Xiaoying Zhou, Nathan Trim, Harry Millward-Sadler, Stephen Krane, Christopher Benyon, John Iredal. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 1. 2003-02-10. PMID:12475903. |
recovery from liver fibrosis is accompanied by hepatocyte regeneration, matrix degradation, and hsc apoptosis. |
2003-02-10 |
2023-08-12 |
mouse |
| D Mangoldt, B Sinn, M Lein, H W Krell, D Schnorr, S A Loening, K Jun. The novel synthetic inhibitor of matrix metalloproteinases Ro 28-2653 induces apoptosis in Dunning tumor cells. Apoptosis : an international journal on programmed cell death. vol 7. issue 3. 2003-02-07. PMID:11997665. |
the novel synthetic inhibitor of matrix metalloproteinases ro 28-2653 induces apoptosis in dunning tumor cells. |
2003-02-07 |
2023-08-12 |
rat |
| Jonathan R Green, Philippe Clézardi. Mechanisms of bisphosphonate effects on osteoclasts, tumor cell growth, and metastasis. American journal of clinical oncology. vol 25. issue 6 Suppl 1. 2003-02-04. PMID:12562045. |
as a result of these biochemical effects on the mevalonate pathway, bisphosphonates appear to modulate the expression of bcl-2 leading to caspase-dependent apoptosis, inhibit matrix metalloproteinases, downregulate alphavbeta3 and alphavbeta5 integrins, and increase expression of osteoprotegerin, thereby antagonizing osteoclastogenesis. |
2003-02-04 |
2023-08-12 |
Not clear |
| Changhai Din. Do NSAIDs affect the progression of osteoarthritis? Inflammation. vol 26. issue 3. 2003-01-30. PMID:12083420. |
in vitro studies showed several types of nsaids (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of nsaids (e.g., aceclofenac, meloxicam, nimesulide) increased the matrix component synthesis and protected the chondrocytes against apoptosis, while others (e.g., piroxicam) had no effects. |
2003-01-30 |
2023-08-12 |
Not clear |
| Sabrina Di Bartolomeo, Angelo Spined. Ordering ceramide-induced cell detachment and apoptosis in human neuroepithelioma. Neuroscience letters. vol 334. issue 3. 2003-01-28. PMID:12453617. |
we studied whether cell detachment from the matrix, observed during ceramide-induced apoptosis, is secondary to completion of the apoptotic program. |
2003-01-28 |
2023-08-12 |
human |
| Hiromichi Iwasaki, Hitoshi Inoue, Yasuhiko Mitsuke, Adel Badran, Satoshi Ikegaya, Takanori Ued. Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells. The Journal of laboratory and clinical medicine. vol 140. issue 6. 2003-01-23. PMID:12486404. |
doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human t-lymphoblastic leukemia ccrf-cem cells. |
2003-01-23 |
2023-08-12 |
human |
| Dagmara Piestrzeniewicz-Ulanska, Magdalena Brys, Andrzej Semczuk, Jerzy A Jakowicki, Wanda M Krajewsk. Expression of TGF-beta type I and II receptors in normal and cancerous human endometrium. Cancer letters. vol 186. issue 2. 2003-01-10. PMID:12213293. |
transforming growth factor-beta (tgf-beta) belongs to a superfamily of structurally related polypeptides involved in various biological processes, including cell growth, proliferation and differentiation, angiogenesis, apoptosis, and extracellular matrix remodeling. |
2003-01-10 |
2023-08-12 |
human |
| Rosa Maria Borzi, Ilaria Mazzetti, Giorgia Magagnoli, Samantha Paoletti, Mariagrazia Uguccioni, Rita Gatti, Guido Orlandini, Luca Cattini, Andrea Facchin. Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes. Arthritis and rheumatism. vol 46. issue 12. 2003-01-10. PMID:12483724. |
chondrocyte apoptosis is considered to be a major determinant of cartilage damage in oa, a disease resulting from the aberrant production of inflammatory mediators (cytokines and chemokines) and effectors (matrix metalloproteinases and reactive oxygen and nitrogen species) by chondrocytes. |
2003-01-10 |
2023-08-12 |
Not clear |
| Kirill Rosen, Wen Shi, Bruno Calabretta, Jorge Filmu. Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells. The Journal of biological chemistry. vol 277. issue 48. 2003-01-08. PMID:12356751. |
many cell types undergo apoptosis when they are detached from the extracellular matrix (ecm). |
2003-01-08 |
2023-08-12 |
Not clear |
| A Mobasher. Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis. Medical hypotheses. vol 58. issue 3. 2003-01-07. PMID:12018969. |
although nitric oxide and fas ligand have been shown to be inducers of chondrocyte apoptosis in vitro and in vivo, the contribution of other triggers such as hypoxia, matrix acidosis, abnormal shear stress and catabolic cytokines like interleukin-1beta and tumour necrosis factor alpha has not been examined. |
2003-01-07 |
2023-08-12 |
human |
| Morten A Karsdal, Lykke Larsen, Michael T Engsig, Henriette Lou, Mercedes Ferreras, Andre Lochter, Jean-Marie Delaissé, Niels T Foge. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12226090. |
matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. |
2003-01-02 |
2023-08-12 |
mouse |