| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Young, W D Hirst, E Solito, G P Wilki. De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia. vol 26. issue 4. 1999-09-09. PMID:10383052. |
lc-1 was detected in microglial but not astrocytic, conditioned media, confirming the in vivo observations that activated microglia may secrete lc-1. |
1999-09-09 |
2023-08-12 |
rat |
| P J Kingham, M L Cuzner, J M Pococ. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428049. |
conditioned medium from activated microglia kills cerebellar granule cells by inducing caspase-3-dependent neuronal apoptosis. |
1999-08-13 |
2023-08-12 |
rat |
| M P Flavin, L T H. Propentofylline protects neurons in culture from death triggered by macrophage or microglial secretory products. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213475. |
we recently demonstrated that conditioned medium (cm) from peritoneal macrophages or activated microglia triggers a predominantly apoptotic death in hippocampal neurons in culture. |
1999-06-07 |
2023-08-12 |
Not clear |
| R Zietlow, S B Dunnett, J W Fawcet. The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215919. |
conditioned medium from 7-day-old microglia was found to decrease the number of dopamine neurons surviving in primary culture, but activation of the microglia with n-formyl-methionyl-leucyl-phenylalanine (fmlp) or zymosan a did not increase the toxicity of the conditioned medium. |
1999-05-26 |
2023-08-12 |
rat |
| R Zietlow, S B Dunnett, J W Fawcet. The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215919. |
the change in microglial effect from toxic to protective was caused by soluble molecules secreted by cells in the neuronal cultures, as conditioned medium derived from microglia-neuronal cocultures also had a dopaminergic neuron survival effect, indicating that microglia in cocultures behave differently from microglia removed from neuronal and glial influence. |
1999-05-26 |
2023-08-12 |
rat |
| S Kyrkanides, J A Olschowka, J P Williams, J T Hansen, M K O'Banio. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. Journal of neuroimmunology. vol 95. issue 1-2. 1999-05-17. PMID:10229119. |
however, exposure of astrocytes to conditioned medium collected from irradiated microglia resulted in icam-1 induction, which was abrogated when the conditioned medium was pre-incubated with neutralizing antibodies raised against murine tnf alpha and il-1beta. |
1999-05-17 |
2023-08-12 |
mouse |
| C K Combs, D E Johnson, S B Cannady, T M Lehman, G E Landret. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 3. 1999-02-25. PMID:9920656. |
we have demonstrated in a tissue culture model that conditioned media from beta-amyloid- and prion-stimulated microglia or from thp-1 monocytes are neurotoxic to mouse cortical neurons. |
1999-02-25 |
2023-08-12 |
mouse |
| S Sudo, J Tanaka, K Toku, J Desaki, S Matsuda, T Arai, M Sakanaka, N Maed. Neurons induce the activation of microglial cells in vitro. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878185. |
medium conditioned by neurons significantly enhanced o2- generation by microglia, but microglial cells in contact with or in close apposition to cocultured neurons were much more intensely activated than those remote from the neurons. |
1999-02-04 |
2023-08-12 |
rat |
| L Yang, J Tanaka, B Zhang, M Sakanaka, N Maed. Astrocytes modulate nitric oxide production by microglial cells through secretion of serine and glycine. Biochemical and biophysical research communications. vol 251. issue 1. 1998-11-23. PMID:9790946. |
conditioned media obtained from microglia culture and neuron-microglia coculture contained less than 10 microm of ser and gly, while media from astrocyte culture and astrocyte-microglia coculture contained 33-41 microm ser and 20-26 microm gly. |
1998-11-23 |
2023-08-12 |
rat |
| D R Brown, B Schmidt, H A Kretzschma. A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia. Neurobiology of disease. vol 4. issue 6. 1998-09-21. PMID:9666480. |
using conditioned medium from microglia we have shown that prpc-expressing astrocytes proliferate in response to factors released by microglia stimulated by granulocyte/macrophage colony-stimulating factor. |
1998-09-21 |
2023-08-12 |
Not clear |
| G W Perry, R W Kean. Modulation of microglial form and immune function by factors released from goldfish optic nerves. The International journal of neuroscience. vol 91. issue 1-2. 1997-12-29. PMID:9394221. |
to begin to investigate their role, microglia purified from mouse brain were grown in media conditioned (cm) by goldfish optic nerve (gfon), optic tectum (gfot), vagal lobe, telencephalon and cerebellum, and medium conditioned by rat optic nerves (ron). |
1997-12-29 |
2023-08-12 |
mouse |
| G W Perry, R W Kean. Modulation of microglial form and immune function by factors released from goldfish optic nerves. The International journal of neuroscience. vol 91. issue 1-2. 1997-12-29. PMID:9394221. |
microglia maintained in gfon- or gfot-cm assumed an ameboid morphology, whereas microglia grown in media conditioned by the other neural tissues produced long, crenellated processes that resembled the ramified microglial form. |
1997-12-29 |
2023-08-12 |
mouse |
| Y Sugita, S P Becerra, G J Chader, J P Schwart. Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. Journal of neuroscience research. vol 49. issue 6. 1997-11-05. PMID:9335258. |
proliferation of isolated astrocytes was also blocked by conditioned medium from microglia treated with pedf (pmcm). |
1997-11-05 |
2023-08-12 |
human |
| M P Flavin, K Coughlin, L T H. Soluble macrophage factors trigger apoptosis in cultured hippocampal neurons. Neuroscience. vol 80. issue 2. 1997-10-17. PMID:9284347. |
conditioned medium from stimulated microglia showed a similar pattern of injury. |
1997-10-17 |
2023-08-12 |
Not clear |
| J Frackowiak, B Mazur-Kolecka, R T Carroll, A Chauhan, H M Wisniewsk. Factors secreted by activated microglia and monocytes reduce amyloidogenesis in vascular smooth muscle cells. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243622. |
we now show that accumulation of "a beta" deposits in this model can be significantly reduced by culture in conditioned media from microglia and monocytes. |
1997-10-07 |
2023-08-12 |
Not clear |
| H Wilms, D Hartmann, J Siever. Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media. Cell and tissue research. vol 287. issue 3. 1997-04-10. PMID:9023076. |
ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media. |
1997-04-10 |
2023-08-12 |
Not clear |
| G M Jonakait, M B Luskin, R Wei, X F Tian, L N. Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. Developmental biology. vol 177. issue 1. 1996-08-27. PMID:8660879. |
conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. |
1996-08-27 |
2023-08-12 |
Not clear |
| G M Jonakait, M B Luskin, R Wei, X F Tian, L N. Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. Developmental biology. vol 177. issue 1. 1996-08-27. PMID:8660879. |
consistent with this hypothesis, conditioned media from cultures of enriched, activated microglia also increased chat activity in a dose-dependent fashion. |
1996-08-27 |
2023-08-12 |
Not clear |
| G M Jonakait, M B Luskin, R Wei, X F Tian, L N. Conditioned medium from activated microglia promotes cholinergic differentiation in the basal forebrain in vitro. Developmental biology. vol 177. issue 1. 1996-08-27. PMID:8660879. |
in addition, conditioned media from both activated microglia and raw 264.7 cells increased the proportion of chat-positive cells in retrovirally labeled clones to the same extent as ifn itself, suggesting the possibility that they contain the molecule(s) that mediates the action of ifn. |
1996-08-27 |
2023-08-12 |
Not clear |
| P E Gottschall, X Yu, B Bin. Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture. Journal of neuroscience research. vol 42. issue 3. 1996-03-20. PMID:8583501. |
conditioned media samples obtained from cultured microglia that were stimulated with various activating agents were subjected to gelatin-substrate zymography. |
1996-03-20 |
2023-08-12 |
rat |