| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Phillips, E Szabadi, C M Bradsha. The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1A receptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667616. |
we investigated the effects of two 5-ht1a receptor agonists, buspirone and lesopitron, upon pupil size in human volunteers at an ambient luminance level of 32 cd m(-2) and in darkness. |
2000-02-18 |
2023-08-12 |
human |
| M S Herness, Y Che. Serotonergic agonists inhibit calcium-activated potassium and voltage-dependent sodium currents in rat taste receptor cells. The Journal of membrane biology. vol 173. issue 2. 2000-02-17. PMID:10630928. |
the agonists 1-(1-naphthyl)piperazine and buspirone (both serotonin receptor 1a agonists) were similarly effective in reducing k(ca). |
2000-02-17 |
2023-08-12 |
rat |
| A Brambilla, A Baschirotto, N Grippa, F Borsin. Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647099. |
the selective serotonergic uptake blocker, fluoxetine, and two serotonin1a (5-ht1a) agonists, 8-hydroxy-2-(di-n-propylamino)tetraline (8-oh-dpat) and buspirone, were used as reference compounds. |
2000-02-02 |
2023-08-12 |
rat |
| O Stork, H Welzl, C T Wotjak, D Hoyer, M Delling, H Cremer, M Schachne. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. Journal of neurobiology. vol 40. issue 3. 1999-12-20. PMID:10440734. |
anxiety-like behavior was reduced in both ncam+/+ and ncam-/- mice by systemic administration of the benzodiazepine agonist diazepam and the 5-ht1a receptor agonists buspirone and 8-oh-dpat. |
1999-12-20 |
2023-08-12 |
mouse |
| B Olivier, A Herremans, J Mos, M van Drimmelen, M Tulp, R van Oorschot, T Hijze. Discriminative stimulus properties of eltoprazine in the pigeon. Pharmacology, biochemistry, and behavior. vol 64. issue 2. 1999-12-20. PMID:10515324. |
tests for generalization and antagonism showed that 5-ht1a receptor agonists, such as 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin) (66.7%), flesinoxan (72.7%), buspirone (58.3%), and ipsapirone (36.4%) only partially substituted for the eltoprazine cue. |
1999-12-20 |
2023-08-12 |
pigeon |
| N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 5. 1999-11-22. PMID:10523050. |
did not increase the firing activity of dorsal hippocampus ca3 pyramidal neurons, thus failing to reveal an enhanced tonic activation of postsynaptic 5-ht1a receptors as for other antidepressant drugs, including the 5-ht1a receptor agonist gepirone. |
1999-11-22 |
2023-08-12 |
rat |
| D S Dupuis, S Tardif, T Wurch, F C Colpaert, P J Pauwel. Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428422. |
for comparison, maximal responses of 8-oh-dpat and buspirone were enhanced versus 5-ht upon co-expression of the 5-ht1a receptor with the respective galpha(o) proteins, probably due to an altered receptor: galpha(o) protein density ratio. |
1999-09-03 |
2023-08-12 |
rat |
| N K Jain, S K Kulkarn. L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception. Methods and findings in experimental and clinical pharmacology. vol 21. issue 3. 1999-08-31. PMID:10389117. |
systemic administration of sumatriptan and buspirone (20 mg/kg: 5-ht1a agonists) produced antinociception against acetic acid-induced writhing. |
1999-08-31 |
2023-08-12 |
Not clear |
| J J Sramek, W W Hong, S Hamid, B Nape, N R Cutle. Meta-analysis of the safety and tolerability of two dose regimens of buspirone in patients with persistent anxiety. Depression and anxiety. vol 9. issue 3. 1999-08-27. PMID:10356651. |
buspirone is an azapirone with 5-ht1a partial agonist activity which has demonstrated efficacy in the treatment of generalized anxiety disorder, commonly referred to as persistent anxiety. |
1999-08-27 |
2023-08-12 |
Not clear |
| L Hedlund, G Wahlströ. Acute and long term effects of buspirone treatments on voluntary ethanol intake in a rat model of alcoholism. Alcoholism, clinical and experimental research. vol 23. issue 5. 1999-08-17. PMID:10371401. |
buspirone, a 5-ht1a agonist, has been shown to decrease the intake of ethanol when given as a single dose to rats with a psychological dependence induced according to our rat model of alcoholism. |
1999-08-17 |
2023-08-12 |
rat |
| C Boast, A C Bartolomeo, H Morris, J A Moye. 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. Neurobiology of learning and memory. vol 71. issue 3. 1999-08-05. PMID:10196105. |
specifically, way-100635, a selective 5-ht1a receptor antagonist, buspirone, a 5-ht1a partial agonist, ritanserin, a 5-ht2 antagonist, and ondansetron, a 5-ht3 antagonist, were assessed. |
1999-08-05 |
2023-08-12 |
rat |
| M F O'Neill, G J Sange. GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. European journal of pharmacology. vol 370. issue 2. 1999-07-16. PMID:10323255. |
the full agonist at 5-ht1a receptors, 8-oh-dpat (r(+)-8-hydroxy-dipropylaminotetralin hbr) dose-dependently increased locomotor activity in guinea pigs (0.3-1.25 mg kg(-1) s.c.), as to a lesser extent, did the partial agonist, buspirone (8-[4-[4-(2-pyramidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5 ]decane-7,9-dione hcl) (5.0-20.0 mg kg(-1) s.c.). |
1999-07-16 |
2023-08-12 |
rat |
| C López-Rubalcava, S L Cruz, A Fernández-Guast. Blockade of the anxiolytic-like action of ipsapirone and buspirone, but not that of 8-OH-DPAT, by adrenalectomy in male rats. Psychoneuroendocrinology. vol 24. issue 4. 1999-07-15. PMID:10341368. |
the effect of the 5-ht1a agonists ipsapirone (5 mg/kg), buspirone (5 mg/kg) and 8-oh-dpat (0.5 mg/kg) on experimental anxiety was examined in sham-operated, adrenalectomized and adrenally demedullated male rats. |
1999-07-15 |
2023-08-12 |
human |
| N K Jain, S K Kulkarn. Antinociceptive effect of sumatriptan in mice. Indian journal of experimental biology. vol 36. issue 10. 1999-07-07. PMID:10356959. |
the antinociceptive effect of sumatriptan was compared with an another 5-ht agonist (5-ht1a) buspirone which also produced antinociception. |
1999-07-07 |
2023-08-12 |
mouse |
| C Becker, M Hamon, J J Benolie. Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221756. |
as expected of the involvement of 5-ht1a receptors, tertatolol (10 mg/kg i.p) markedly reduced the inhibitory effect of buspirone on restraint stress-evoked ccklm overflow. |
1999-07-02 |
2023-08-12 |
rat |
| J Sandell, C Halldin, H Hall, S O Thorberg, T Werner, D Sohn, G Sedvall, L Fard. Radiosynthesis and autoradiographic evaluation of [11C]NAD-299, a radioligand for visualization of the 5-HT1A receptor. Nuclear medicine and biology. vol 26. issue 2. 1999-07-01. PMID:10100214. |
[11c]nad-299 binding was inhibited by addition of the 5-ht1a receptor ligands way-100635, pindolol, (+/-)-8-oh-dpat, 5-ht, and buspirone, leaving a low background of nonspecific binding. |
1999-07-01 |
2023-08-12 |
human |
| H K Strüder, W Hollmann, H Weicker, T Schiffer, K Webe. Blood oxygen partial pressure affects plasma prolactin concentration in humans. Acta physiologica Scandinavica. vol 165. issue 3. 1999-06-21. PMID:10192175. |
during pre- and post-examination a baseline blood sample was drawn, followed by a neuroendocrine test of serotonergic function using a partial 5-ht1a receptor agonist (60 mg of buspirone hydrochloride). |
1999-06-21 |
2023-08-12 |
human |
| I Artaiz, A Zazpe, J Del Rí. Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice. Behavioural pharmacology. vol 9. issue 2. 1999-06-09. PMID:10065930. |
the suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-ht1a receptors, and also by the "silent" 5-ht1a receptor antagonist way 100635, but not by the full agonist 8-oh-dpat. |
1999-06-09 |
2023-08-12 |
mouse |
| D R Cherek, F G Moeller, F Khan-Dawood, A Swann, S D Lan. Prolactin response to buspirone was reduced in violent compared to nonviolent parolees. Psychopharmacology. vol 142. issue 2. 1999-05-27. PMID:10102766. |
buspirone (0.4 mg/kg), a 5-ht1a agonist, was used as the challenge agent and plasma prolactin levels were determined. |
1999-05-27 |
2023-08-12 |
Not clear |
| L E Rueter, P Blie. Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188973. |
the responsiveness of postsynaptic 5-ht1a receptors located on ca3 hippocampus pyramidal neurons and mpfc neurons, examined using microiontophoretically-applied 5-ht and gepirone, was unchanged following a 7-day flibanserin treatment. |
1999-05-27 |
2023-08-12 |
rat |