| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Passchier, A van Waard. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system. European journal of nuclear medicine. vol 28. issue 1. 2001-03-22. PMID:11202445. |
the 5-ht1a subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. |
2001-03-22 |
2023-08-12 |
human |
| V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martre. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947809. |
specific labelling with radioligands and antibodies, and competitive rt-pcr, showed that 5-ht1a receptor protein and mrna levels were significantly decreased in the dorsal raphe nucleus (drn), increased in the hippocampus and unchanged in other forebrain areas of 5-htt-/- vs. 5-htt+/+ mice. |
2000-09-19 |
2023-08-12 |
mouse |
| E Le Poul, C Boni, N Hanoun, A M Laporte, N Laaris, J Chauveau, M Hamon, L Lanfume. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology. vol 39. issue 1. 2000-02-18. PMID:10665824. |
however, a significant decrease (-38%) in 5-ht1a mrna levels in the anterior raphe area (but not forebrain regions) and increases in 5-ht1b mrna levels in the striatum (+127%) and the cerebral cortex (+34%) were noted in fluoxetine-treated rats. |
2000-02-18 |
2023-08-12 |
rat |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
thus, we have recently shown that the selective 5-ht1a receptor antagonist, way 100635, blocks the inhibitory effect of an ssri on 5-ht cell firing, and enhances its ability to elevate extracellular 5-ht in the forebrain. |
1999-09-01 |
2023-08-12 |
Not clear |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
our data suggest that (-)-tertatolol enhances the effect of paroxetine on forebrain 5-ht via blockade of 5-ht1a autoreceptors which mediate paroxetine-induced inhibition of 5-ht cell firing. |
1999-09-01 |
2023-08-12 |
Not clear |
| J M Casanovas, M T Vilaró, G Mengod, F Artiga. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886078. |
single treatment with the serotonin (5-hydroxytryptamine) 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and alnespirone (s-20499) reduces the extracellular 5-ht concentration (5-htext) in the rat midbrain and forebrain. |
1999-01-21 |
2023-08-12 |
rat |
| I Hervás, N Bel, A G Fernández, J M Palacios, F Artiga. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774218. |
this effect is due to the activation of somatodendritic 5-ht1a receptors and it displays a regional pattern comparable to that of selective 5-ht1a agonists, i.e., preferentially in forebrain areas innervated by the dorsal raphe nucleus (drn). |
1998-12-22 |
2023-08-12 |
rat |
| I Hervás, N Bel, A G Fernández, J M Palacios, F Artiga. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774218. |
thus, the present data suggest that the comparable effects of ssris in drn- and mrn-innervated forebrain regions are not explained by a preferential attenuation of 5-ht release by terminal 5-ht1b autoreceptors in hippocampus, an area with a low inhibitory influence of somatodendritic 5-ht1a receptors. |
1998-12-22 |
2023-08-12 |
rat |
| N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822768. |
long-term antidepressant treatments result in a tonic activation of forebrain 5-ht1a receptors. |
1998-12-18 |
2023-08-12 |
rat |
| N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822768. |
these data indicate that such antidepressant treatments, acting on entirely different primary targets, might alleviate depression by enhancing the tonic activation of forebrain postsynaptic 5-ht1a receptors. |
1998-12-18 |
2023-08-12 |
rat |
| K A Miczek, S Hussain, S Faccidom. Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Psychopharmacology. vol 139. issue 1-2. 1998-12-09. PMID:9768554. |
one of the critical mechanisms by which alcohol heightens aggression involves forebrain serotonin (5-ht) systems, possibly via actions on 5-ht1a receptors. |
1998-12-09 |
2023-08-12 |
mouse |
| I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience. vol 10. issue 4. 1998-10-22. PMID:9749777. |
these results suggest that galanin can modulate postsynaptic 5-ht1a receptor transmission in vivo in discrete cell populations in forebrain regions such as the dorsal and ventral hippocampus and parts of the amygdala. |
1998-10-22 |
2023-08-12 |
rat |
| H J Bengtsson, A Kullberg, M J Millan, S Hjort. The role of 5-HT1A autoreceptors and alpha1-adrenoceptors in the modulation of 5-HT release--III. Clozapine and the novel putative antipsychotic S 16924. Neuropharmacology. vol 37. issue 3. 1998-10-02. PMID:9681933. |
with regard to the interplay between alpha1-adrenoceptor and 5-ht1a (auto)receptor mechanisms in the control of 5-ht release in the rat forebrain, the present data suggest that an excitation mediated by the former is outweighed by the simultaneous activation of the latter-inhibitory-receptors. |
1998-10-02 |
2023-08-12 |
rat |
| A Szabó, B L Butz, R H Alpe. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain research bulletin. vol 45. issue 6. 1998-06-08. PMID:9566502. |
it has been shown recently that activation of forebrain serotonin1a (5-ht1a) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. |
1998-06-08 |
2023-08-12 |
rat |
| J M Casanovas, M Lésourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology. vol 122. issue 4. 1998-01-02. PMID:9375971. |
we have examined the effects of the systemic administration of the selective 5-ht1a agonist alnespirone (s-20499) on in vivo 5-hydroxytryptamine (5-ht) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). |
1998-01-02 |
2023-08-12 |
rat |
| N S Kula, R J Baldessarini, J W Kebabian, V Bakthavachalam, L X. RBI-257: a highly potent dopamine D4 receptor-selective ligand. European journal of pharmacology. vol 331. issue 2-3. 1997-10-27. PMID:9274997. |
rbi-257 had much lower affinity at d1 and d5 dopamine receptors in transfected cells, as well as dopamine d1-like receptors, alpha1, alpha2 or beta(1,2) adrenoceptors, sigma(1,2) receptors and 5-ht1a or 5-ht2a receptors, and transporters for dopamine, norepinephrine or serotonin in rat forebrain tissue. |
1997-10-27 |
2023-08-12 |
rat |
| C Nyakas, B J Oosterink, J Keijser, K Felszeghy, G I de Jong, J Korf, P G Luite. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of chemical neuroanatomy. vol 13. issue 1. 1997-09-29. PMID:9271195. |
the effect of aging on 5-ht1a receptor binding in several forebrain areas associated with the basal forebrain cholinergic system was investigated in rats of 3-, 24- and 30-months-old by receptor autoradiography and biochemical binding assay using [3h]8-oh-dpat as a ligand. |
1997-09-29 |
2023-08-12 |
rat |
| C Nyakas, B J Oosterink, J Keijser, K Felszeghy, G I de Jong, J Korf, P G Luite. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of chemical neuroanatomy. vol 13. issue 1. 1997-09-29. PMID:9271195. |
the results clearly show that with increasing age the decrement of 5-ht1a receptor binding in the rat forebrain is remarkably region-selective and particularly affects the cholinergic cell groups that innervate cortex and hippocampus. |
1997-09-29 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
selective 5-hydroxytryptamine (5-ht; serotonin) reuptake inhibitors (ssris) cause a greater increase in extracellular 5-ht in the forebrain when the somatodendritic 5-ht1a autoreceptor is blocked. |
1997-09-15 |
2023-08-12 |
rat |
| S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225270. |
the data confirm previous findings that 5-ht1a autoreceptor blockade enhances the citalopram-induced increase of extracellular 5-ht in the forebrain. |
1997-09-15 |
2023-08-12 |
rat |