| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Prehn, M Welsch, C Backhauss, J Nuglisch, F Ausmeier, C Karkoutly, J Krieglstei. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain research. vol 630. issue 1-2. 1994-04-05. PMID:8118677. |
in order to examine the effects of 5-ht1a receptor activation in a different context, 10 min of forebrain ischemia was induced in male wistar rats by a bilateral occlusion of the common carotid arteries combined with systemic hypotension. |
1994-04-05 |
2023-08-12 |
mouse |
| P J Fletcher, D V Coscin. Injecting 5-HT into the PVN does not prevent feeding induced by injecting 8-OH-DPAT into the raphe. Pharmacology, biochemistry, and behavior. vol 46. issue 2. 1994-01-27. PMID:8265706. |
the selective 5-hydroxytryptamine1a (5-ht1a) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) activates raphe somatodendritic autoreceptors, leading to an inhibition of 5-ht neuronal activity and reduced synthesis and release of 5-ht in forebrain terminal areas. |
1994-01-27 |
2023-08-12 |
rat |
| S Ahlenius, V Hillegaart, P Salmi, A Wijkströ. Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. Pharmacology & toxicology. vol 72. issue 6. 1993-09-30. PMID:8361951. |
effects of 5-ht1a receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. |
1993-09-30 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
5-ht1a, 5-ht1b, 5ht1nonab and 5-ht2 sites were labeled with [3h]8-oh-dpat, [125i]cyanopindolol, [3h]5-ht and [125i]doi, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. |
1993-06-14 |
2023-08-12 |
rat |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
to clarify which 5-ht1a receptors, autoreceptors located in the raphe nuclei or post-synaptic receptors in the forebrain areas receiving a 5-ht input, mediate the anticonflict action of tandospirone (a 5-ht1a receptor-related anxiolytics), the behavioral effects of tandospirone were studied in 5,7-dihydroxytryptamine (5,7-dht) treated rats. |
1992-09-22 |
2023-08-11 |
rat |
| b' F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1548468.' |
numerous data suggested that the pharmacological and biochemical properties of 5-hydroxytryptamine1a (5-ht1a) receptors exhibit some regional differences in the cns, notably within the raphe nuclei compared with various forebrain areas (such as the hippocampus). |
1992-04-17 |
2023-08-11 |
rat |
| G A Higgins, P J Elliot. Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists. European journal of pharmacology. vol 193. issue 3. 1991-07-31. PMID:1675996. |
the contrasting behavioural profiles of the 5-ht1a agents observed after drn or mrn microinfusions are probably related to the differential innervation of forebrain structures by each raphe nucleus. |
1991-07-31 |
2023-08-11 |
rat |
| J G Cannon, S T Moe, J P Lon. Enantiomers of 11-hydroxy-10-methylaporphine having opposing pharmacological effects at 5-HT1A receptors. Chirality. vol 3. issue 1. 1991-07-08. PMID:2039679. |
both bind strongly to 5-ht1a receptors from rat forebrain membrane tissue. |
1991-07-08 |
2023-08-11 |
rat |
| P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702486. |
it is concluded that the sustained administration of a 5-ht1a agonist results in an enhanced tonic activation of postsynaptic 5-ht1a receptors in the forebrain. |
1991-02-11 |
2023-08-11 |
rat |
| S Ahlenius, V Hillegaart, A Wijkströ. Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat. The Journal of pharmacy and pharmacology. vol 42. issue 4. 1990-09-12. PMID:1974300. |
both the 5-ht1a agonist flesinoxan (0.06-17.8 mumos kg-1 s.c. -50 min) and the mixed 5-ht1 and 5-ht2 agonist 5-meodmt (1.6-26.0 mumols kg-1 s.c.-50 min) produced a decrease in forebrain 5-htp accumulation (striatum and neocortex), following decarboxylase inhibition by means of nsd-1015 in reserpine treated rats, indicating stimulation of central 5-ht receptors by these two compounds. |
1990-09-12 |
2023-08-11 |
rat |