| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
the maximal elevations of extracellular concentration of 5-ht (5-ht(ext)) induced by the 5-ht uptake inhibitor paroxetine in forebrain were potentiated by the 5-ht1a antagonist way-100635 (1 mg/kg s.c.) in a regionally dependent manner (striatum > frontal cortex > dorsal hippocampus). |
1997-06-17 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
therefore, potentiation by 5-ht1a antagonists occurs preferentially in forebrain areas innervated by serotonergic neurons of the dorsal raphe nucleus. |
1997-06-17 |
2023-08-12 |
Not clear |
| A Szabó, M Bowman, C J Braun, R H Alpe. Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats. European journal of pharmacology. vol 315. issue 2. 1997-04-03. PMID:8960883. |
experiments were designed to test the hypothesis that activation of forebrain 5-ht1a receptors elicits cardiovascular responses. |
1997-04-03 |
2023-08-12 |
rat |
| A Szabó, M Bowman, C J Braun, R H Alpe. Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats. European journal of pharmacology. vol 315. issue 2. 1997-04-03. PMID:8960883. |
these results suggest that activation of 5-ht1a receptors in the preoptic area or an adjacent region of the forebrain produces: (1) an increase in heart rate consistent with sympathoadrenal activation; and (2) an increase in blood pressure which might be the result of sympathoexcitation or secondary to behavioral arousal. |
1997-04-03 |
2023-08-12 |
rat |
| S Hjorth, H J Bengtsson, S Milan. Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. European journal of pharmacology. vol 316. issue 1. 1997-03-21. PMID:8982649. |
in vivo microdialysis in rat ventral hippocampus was used (i) to verify the importance of 5-ht1a autoreceptors in the raphe as targets for drugs that enhance the citalopram-induced elevation of forebrain 5-hydroxytryptamine (5-ht), and (ii) to further examine the specificity of (-)-penbutolol in this regard. |
1997-03-21 |
2023-08-12 |
rat |
| S Hjorth, H J Bengtsson, S Milan. Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. European journal of pharmacology. vol 316. issue 1. 1997-03-21. PMID:8982649. |
these data provide direct evidence that increased stimulation of 5-ht1a autoreceptors in the midbrain raphe impedes the effect of citalopram on forebrain extracellular 5-ht, whereas neither postsynaptic 5-ht1a receptors nor beta-adrenoceptors appear to be involved. |
1997-03-21 |
2023-08-12 |
rat |
| L Romero, I Hervás, F Artiga. The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neuroscience letters. vol 219. issue 2. 1997-03-20. PMID:8971795. |
the increases in extracellular serotonin (5-hydroxytryptamine; 5-ht) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-ht1a autoreceptors by the excess 5-ht induced by these agents in the midbrain raphe. |
1997-03-20 |
2023-08-12 |
rat |
| L Romero, N Bel, J M Casanovas, F Artiga. Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. International clinical psychopharmacology. vol 11 Suppl 4. 1997-03-19. PMID:8923121. |
this effect is maximal in forebrain areas innervated by the dorsal raphe nucleus and can be prevented by the administration of non-selective [(-)pindolol, (-)tertatolol] and selective (way-100635) 5-ht1a antagonists. |
1997-03-19 |
2023-08-12 |
Not clear |
| S B Auerbach, S Hjort. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 6. 1997-03-07. PMID:9053730. |
under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-ht, an effect that can be inhibited by pretreatment with antagonists of 5-ht1a receptors. |
1997-03-07 |
2023-08-12 |
rat |
| S M Korte, O C Meijer, E R de Kloet, B Buwalda, J Keijser, F Sluyter, G van Oortmerssen, B Bohu. Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. Brain research. vol 736. issue 1-2. 1997-02-26. PMID:8930340. |
enhanced 5-ht1a receptor expression in forebrain regions of aggressive house mice. |
1997-02-26 |
2023-08-12 |
mouse |
| F Artigas, L Romero, C de Montigny, P Blie. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in neurosciences. vol 19. issue 9. 1997-01-15. PMID:8873352. |
overriding this feedback by using antagonists of 5-ht1a autoreceptors permits ssris to produce a marked increase of extracellular 5-ht in the forebrain. |
1997-01-15 |
2023-08-12 |
Not clear |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
the present observations indicate that clonazepam produces a reduction of serotonin turnover rate in the hippocampus of the rat concomitant with a down-regulation of 5-ht1a binding sites, probably by an effect at the forebrain projections. |
1996-03-04 |
2023-08-12 |
rat |
| S Numan, K H Lundgren, D E Wright, J P Herman, K B Seroog. Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway. Brain research. Molecular brain research. vol 29. issue 2. 1995-08-15. PMID:7609629. |
in situ hybridization for 5ht1a, 5ht1c, and 5ht2 receptor subtype mrnas was performed in rat striatum following unilateral injection of 6-ohda into the medial forebrain bundle or directly into the ventral midbrain. |
1995-08-15 |
2023-08-12 |
rat |
| S D Mendelson, B S McEwe. Quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-HT1A receptors in rat forebrain. Neuroendocrinology. vol 56. issue 6. 1995-07-20. PMID:1369598. |
quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-ht1a receptors in rat forebrain. |
1995-07-20 |
2023-08-11 |
rat |
| T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853210. |
these data indicated that postsynaptic 5-ht1a receptors were not responsible for the inhibitory effects of 8-oh-dpat and ipsapirone injected in forebrain areas on the electrical activity of serotonergic neurons and the usv response in rats. |
1995-03-15 |
2023-08-12 |
rat |
| T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853210. |
as shown by the autoradiographic labeling by [3h]8-oh-dpat at distance from its injection site in the dorsal hippocampus, the diffusion of 5-ht1a receptor agonists (from injected areas in the forebrain to the drn where they directly inhibit the electrical activity of serotonergic neurons) more likely accounted for their anxiolytic-like effects. |
1995-03-15 |
2023-08-12 |
rat |
| A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.). vol 18. issue 3. 1995-03-14. PMID:7855734. |
in this study, we investigated the effects of +/-8-hydroxy-2(di-n-propylamino)tetralin [+/-8-oh-dpat], a serotonergic 5-ht1a agonist, on basal and stress-induced changes in dopamine utilization and release in selected forebrain dopamine terminal fields in the rat. |
1995-03-14 |
2023-08-12 |
human |
| H Gozlan, A M Laporte, S Thibault, L E Schechter, F Bolaños, M Hamo. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984280. |
analyses of the time-course recovery of respective binding sites after eedq administration showed that the turnover rate of 5-ht1a sites did not significantly differ in the dorsal raphe nucleus and in various forebrain areas (hippocampus, septum, cerebral cortex; half-life: approximately 4 days), but was lower than that of cortical 5-ht2a sites (half-life: 2.9 days). |
1994-12-30 |
2023-08-12 |
rat |
| K Kasamo, K Tada, N Ueda, T Kojima, M Kogure, K Ishikaw. Effects of several 5-HT1A agonists on hippocampal rhythmical slow activity in unanesthetized rats. Neuropharmacology. vol 33. issue 7. 1994-12-28. PMID:7969811. |
these results indicate that 5-ht1a agonists reduce both power and median frequency values of wr-rsa through activation of post-synaptic 5-ht1a receptors in the forebrain in unanesthetized rats, in vivo. |
1994-12-28 |
2023-08-12 |
rat |
| b' M C Miquel, H K Kia, C Boni, E Doucet, G Daval, L Matthiessen, M Hamon, D Verg\\xc3\\xa. Postnatal development and localization of 5-HT1A receptor mRNA in rat forebrain and cerebellum. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7955340.' |
postnatal development and localization of 5-ht1a receptor mrna in rat forebrain and cerebellum. |
1994-12-20 |
2023-08-12 |
rat |