| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ken-Ichi Kasahara, Shinji Hashimoto, Tsuyoshi Hattori, Koh Kawasaki, Ryuichi Tsujita, Osamu Nakazono, Katsuyuki Takao, Hiromu Kawakubo, Tadashi Nagatan. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. Journal of pharmacological sciences. vol 127. issue 1. 2016-04-25. PMID:25704026. |
tandospirone, which can stimulate the presynaptic 5-ht1a receptors in the raphe, tended to decrease extracellular 5-ht concentration in the medial prefrontal cortex (mpfc) in rats. |
2016-04-25 |
2023-08-13 |
human |
| Per-Ove Thörnqvist, Erik Höglund, Svante Winber. Natural selection constrains personality and brain gene expression differences in Atlantic salmon (Salmo salar). The Journal of experimental biology. vol 218. issue Pt 7. 2016-04-20. PMID:25722007. |
similarly, in late emerging fish, stress resulted in elevated expression of mrna coding for serotonin 1a receptors (5-ht1a), gaba-a receptor-associated protein and ependymin, effects not observed in fish from the early emerging fraction. |
2016-04-20 |
2023-08-13 |
Not clear |
| Jan Brosda, Nadine Müller, Bettina Bert, Heidrun Fin. Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25781502. |
the ingestive effects of 5-ht are mediated by various receptor subtypes, among others the 5-ht1a receptor. |
2016-04-19 |
2023-08-13 |
mouse |
| Yoshiteru Takekita, Chiara Fabbri, Masaki Kato, Shinpei Nonen, Shiho Sakai, Naotaka Sunada, Yosuke Koshikawa, Masataka Wakeno, Gaku Okugawa, Toshihiko Kinoshita, Alessandro Serrett. HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia. Journal of clinical psychopharmacology. vol 35. issue 3. 2016-04-19. PMID:25822479. |
individual differences in serotonin 1a (5-ht1a) receptor may result in variable response to antipsychotics with 5-ht1a receptor partial agonism. |
2016-04-19 |
2023-08-13 |
Not clear |
| Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Charles K Perry, Rajender Vemula, Raymond G Boot. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:26011730. |
an orally active phenylaminotetralin-chemotype serotonin 5-ht7 and 5-ht1a receptor partial agonist that corrects motor stereotypy in mouse models. |
2016-04-19 |
2023-08-13 |
mouse |
| Carl Gommoll, Suresh Durgam, Maju Mathews, Giovanna Forero, Rene Nunez, Xiongwen Tang, Michael E Thas. A double-blind, randomized, placebo-controlled, fixed-dose phase III study of vilazodone in patients with generalized anxiety disorder. Depression and anxiety. vol 32. issue 6. 2016-04-18. PMID:25891440. |
vilazodone, a selective serotonin reuptake inhibitor and 5-ht1a receptor partial agonist, is approved for treating major depressive disorder in adults. |
2016-04-18 |
2023-08-13 |
Not clear |
| Anna Gomółka, Agnieszka Ciesielska, Martyna Z Wróbel, Andrzej Chodkowski, Jerzy Kleps, Maciej Dawidowski, Agata Siwek, Małgorzata Wolak, Katarzyna Stachowicz, Anna Sławińska, Gabriel Nowak, Grzegorz Satała, Andrzej J Bojarski, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Paweł Skowronek, Jadwiga Turło, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5. European journal of medicinal chemistry. vol 98. 2016-04-12. PMID:26043160. |
affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-ht1a, 5-ht2a receptors and serotonin transporter (sert) was evaluated in an in vitro radioligand binding assay. |
2016-04-12 |
2023-08-13 |
mouse |
| Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohame. Biphasic Effects of α-Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement of the Noradrenergic and Serotonergic Systems in Its Antidepressant-Like Activity. Frontiers in pharmacology. vol 7. 2016-04-12. PMID:27065863. |
moreover, pretreatment of mice with noradrenergic neuromodulators such as ampt (100 mg/kg, i.p., a catecholamine synthesis inhibitor), prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist) and with serotonergic neuromodulators such as pcpa (100 mg/kg, i.p., once daily for four consecutive days, a serotonin synthesis inhibitor,) and way100635 (0.1 mg/kg, s.c., a selective 5-ht1a receptor antagonist) significantly reversed the anti-immobility effect of α-asarone (20 mg/kg, i.p.). |
2016-04-12 |
2023-08-13 |
mouse |
| N K Popova, E G Ponimaskin, V S Naumenk. [CROSS-TALK BETWEEN 5-HT1A AND 5-HT7 RECEPTORS: ROLE IN THE AUTOREGULATION OF THE BRAIN SEROTONIN SYSTEM AND IN MECHANISM OF ANTIDEPRESSANTS ACTION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 11. 2016-04-08. PMID:26995955. |
the results described in the present review indicate that: i) dimerization and formation of mobile receptor complexes is a common feature for the members of g-protein coupled receptor superfamily; ii) 5-ht7 receptor appears to be a modulator for 5-ht1a receptor - the key autoregulator of the brain serotonin system; iii) 5-ht1a/5-ht7 receptor complexes formation is one of the mechanisms for inactivation and desensitization of the 5-htia receptors in the brain; iv) differences in the 5-ht7 receptor and 5-htia/5-ht7 heterodimers density define different sensitivity of pre- and postsynaptic 5-htla receptors to chronic treatment with selective serotonin reuptake inhibitors. |
2016-04-08 |
2023-08-13 |
Not clear |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
the serotonin transporter (sert), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1a (5-ht1a) and -1b (5-ht1b) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
this finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the sert and 5-ht1b receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-ht1a receptors. |
2016-04-07 |
2023-08-13 |
human |
| Ramesh Boinpally, Dahlia Henry, Samir Gupta, John Edwards, James Longstreth, Antonia Periclo. Pharmacokinetics and Safety of Vilazodone in Hepatic Impairment. American journal of therapeutics. vol 22. issue 4. 2016-04-05. PMID:25474324. |
vilazodone, a selective serotonin reuptake inhibitor and 5-ht1a partial agonist approved for the treatment of major depressive disorder, is extensively hepatically metabolized. |
2016-04-05 |
2023-08-13 |
human |
| Durairaj Ragu Varman, Koilmani Emmanuvel Raja. Environmental Enrichment Reduces Anxiety by Differentially Activating Serotonergic and Neuropeptide Y (NPY)-Ergic System in Indian Field Mouse (Mus booduga): An Animal Model of Post-Traumatic Stress Disorder. PloS one. vol 10. issue 5. 2016-04-05. PMID:26016844. |
subsequently, the serotonin transporter (sert) and 5-ht1a receptor were up-regulated significantly, but the same did not occur in the 5-ht2c receptor, which is associated with the activation of calmodulin-dependent protein kinase-ii (camkii) and a transcription factor camp response element binding protein (creb). |
2016-04-05 |
2023-08-13 |
mouse |
| H Bonilla-Jaime, G Guadarrama-Cruz, F J Alarcon-Aguilar, O Limón-Morales, G Vazquez-Palacio. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. Journal of natural medicines. vol 69. issue 4. 2016-04-01. PMID:26062718. |
the animals were pretreated with a 5-ht1a receptor antagonist (way-100635, 0.5 mg/kg), a 5-ht2a receptor antagonist (ketanserin, 5 mg/kg), a β-noradrenergic receptor antagonist (propranolol, 200 mg/kg), and with a α2-noradrenergic receptor antagonist (yohimbine, 1 mg/kg) alone or combined with the extract and pretreated with a serotonin synthesis inhibitor (pcpa) before treatment with 8-oh-dpat + the extract of t. lucida. |
2016-04-01 |
2023-08-13 |
rat |
| Renyu Zhang, Xiang Li, Yanan Shi, Yufeng Shao, Kaoxiang Sun, Aiping Wang, Fengying Sun, Wanhui Liu, Di Wang, Jingji Jin, Youxin L. The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamine and norepinephrine levels in rats. PloS one. vol 9. issue 3. 2016-03-31. PMID:24614602. |
these data suggest that lpm570065 may have greater efficacy and/or a more rapid onset of antidepressant action than desvenlafaxine and also counterbalance the harmful effects of desvenlafaxine on 5-ht neurotransmission related to 5-ht1a autoreceptors. |
2016-03-31 |
2023-08-12 |
rat |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
extracellular electrophysiological recordings of 5-ht neurons revealed that, while α1-adrenoceptor-mediated excitation was unchanged, excitatory responses to ampa were enhanced and the 5-ht1a autoreceptor-mediated inhibitory response to 5-ht was attenuated in gria1(5-ht-/-) mice. |
2016-03-29 |
2023-08-13 |
mouse |
| Gordon F Buchanan, Haleigh R Smith, Amanda MacAskill, George B Richerso. 5-HT2A receptor activation is necessary for CO2-induced arousal. Journal of neurophysiology. vol 114. issue 1. 2016-03-28. PMID:25925320. |
the 5-ht(2c) receptor antagonist, rs-102221, and the 5-ht1a receptor agonist, 8-oh-dpat, attenuated but did not completely block co2-induced arousal. |
2016-03-28 |
2023-08-13 |
mouse |
| Urszula Stępińska, Takashi Kuwana, Bożenna Olszańsk. Serotonin receptors are selectively expressed in the avian germ cells and early embryos. Zygote (Cambridge, England). vol 23. issue 3. 2016-03-15. PMID:24521994. |
we show the presence/absence of nine serotonin transcripts known in birds for receptors 5-ht1a, 5-ht1f, 5-ht2b, 5-ht2c, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7a in avian germ cells and early embryos. |
2016-03-15 |
2023-08-12 |
Not clear |
| Takeshi Kanno, Akito Tanaka, Tomoyuki Nishizak. Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β. Molecular neurobiology. vol 51. issue 2. 2016-03-14. PMID:24788685. |
linoleic acid derivative dcp-la ameliorates stress-induced depression-related behavior by promoting cell surface 5-ht1a receptor translocation, stimulating serotonin release, and inactivating gsk-3β. |
2016-03-14 |
2023-08-13 |
mouse |
| Takeshi Kanno, Akito Tanaka, Tomoyuki Nishizak. Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β. Molecular neurobiology. vol 51. issue 2. 2016-03-14. PMID:24788685. |
taken together, the results of the present study indicate that dcp-la could ameliorate depression-like behavior by promoting translocation of 5-ht1a receptor to the plasma membrane on postsynaptic cells, stimulating serotonin release, and inactivating gsk-3β. |
2016-03-14 |
2023-08-13 |
mouse |