| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun-Sok Kim, Hyun-Jong Jang, Kwang-Hyun Cho, Sang June Hahn, Myung-Jun Kim, Shin Hee Yoon, Yang-Hyeok Jo, Myung-Suk Kim, Duck-Joo Rhi. Serotonin inhibits the induction of NMDA receptor-dependent long-term potentiation in the rat primary visual cortex. Brain research. vol 1103. issue 1. 2006-09-28. PMID:16784733. |
based on these findings, we conclude that nmdar-dependent ltp is specifically inhibited by coactivation of 5-ht1a and 5-ht2 receptors with the increase in 5-ht levels in the rat visual cortex at the end of the critical period. |
2006-09-28 |
2023-08-12 |
rat |
| Baptiste Lacoste, Mustapha Riad, Laurent Descarrie. Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus. The European journal of neuroscience. vol 23. issue 11. 2006-09-28. PMID:16819984. |
in rodents, treatment with nk1r antagonists has been shown to increase the firing of dorsal raphe nucleus (drn) serotonin (5-hydroxytryptamine, 5-ht) neurons and to induce a desensitization of their 5-ht1a autoreceptors, suggesting local interactions between the sp and 5-ht systems. |
2006-09-28 |
2023-08-12 |
mouse |
| M A Tikhonova, V V Lebedeva, A V Kulikov, D V Bazovkina, N K Popov. Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy. Bulletin of experimental biology and medicine. vol 141. issue 1. 2006-09-28. PMID:16929962. |
effect of imipramine on the behavior and cerebral 5-ht1a serotonin receptors in mice genetically predisposed to catalepsy. |
2006-09-28 |
2023-08-12 |
mouse |
| M A Tikhonova, V V Lebedeva, A V Kulikov, D V Bazovkina, N K Popov. Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy. Bulletin of experimental biology and medicine. vol 141. issue 1. 2006-09-28. PMID:16929962. |
chronic treatment with imipramine reduced the severity of catalepsy and functional activity of 5-ht1a serotonin receptors, but did not modify their expression in the hippocampus. |
2006-09-28 |
2023-08-12 |
mouse |
| Sven Ove Ogren, Eugenia Kuteeva, Tomas Hökfelt, Jan Keh. Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863269. |
moreover, intracerebroventricular galanin alters the gene expression of serotonin 5-ht1a autoreceptors in the dorsal raphe and also changes their functional activity. |
2006-09-19 |
2023-08-12 |
mouse |
| Sven Ove Ogren, Eugenia Kuteeva, Tomas Hökfelt, Jan Keh. Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863269. |
these results indicate an important (mainly inhibitory) role of galanin as a regulator of brain serotonin and 5-ht1a receptor-mediated transmission, which may be of potential importance for understanding mood disorders and for the development of antidepressant drugs. |
2006-09-19 |
2023-08-12 |
mouse |
| Joanna Dabrowska, Michal Brylinsk. Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: biochemical and molecular modeling study. Biochemical pharmacology. vol 72. issue 4. 2006-09-11. PMID:16796994. |
stereoselectivity of 8-oh-dpat toward the serotonin 5-ht1a receptor: biochemical and molecular modeling study. |
2006-09-11 |
2023-08-12 |
rat |
| Jolanta Obniska, Marcin Kołaczkowski, Sijka Charakchieva-Minol, Krystyna Nedza, Małgorzata Dybała, Andrzej J Bojarsk. Synthesis, anticonvulsant properties and 5-HT1A/5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane and [4.5]decane-1,3-dione derivatives. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985716. |
in addition, since the investigated compounds belong to a class of long-chain arylpiperazines, their serotonin 5-ht1a and 5-ht2a receptor affinity was determined. |
2006-09-07 |
2023-08-12 |
Not clear |
| Reuven Sandy. Serotonergic mechanisms in amyotrophic lateral sclerosis. The International journal of neuroscience. vol 116. issue 7. 2006-09-05. PMID:16861147. |
thus, progressive degeneration of 5-ht neurons affecting motoneuron activity constitutes the prime mover of the disease and its progression and treatment of als needs to be focused primarily on boosting 5-ht functions (e.g., pharmacologically via its precursors, reuptake inhibitors, selective 5-ht1a receptor agonists/5-ht2 receptor antagonists, and electrically through transcranial administration of ac pulsed picotesla electromagnetic fields) to prevent excessive glutamate activity in the motoneurons. |
2006-09-05 |
2023-08-12 |
mouse |
| Reuven Sandy. Serotonergic mechanisms in amyotrophic lateral sclerosis. The International journal of neuroscience. vol 116. issue 7. 2006-09-05. PMID:16861147. |
in fact, 5ht1a and 5ht2 receptor agonists have been shown to prevent glutamate-induced neurotoxicity in primary cortical cell cultures and the 5-ht precursor 5-hydroxytryptophan (5-htp) improved locomotor function and survival of transgenic sod1 g93a mice, an animal model of als. |
2006-09-05 |
2023-08-12 |
mouse |
| Ramin V Parsey, Doreen M Olvet, Maria A Oquendo, Yung-yu Huang, R Todd Ogden, J John Man. Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 8. 2006-08-31. PMID:16395308. |
serotonin 1a (5-ht1a) binding potential (bp) as assessed by positron emission tomography (pet) is higher in major depressive disorder (mdd) in association with the higher expressing gg genotype of the 5-ht1a c-1019g polymorphism. |
2006-08-31 |
2023-08-12 |
human |
| Nicole T Hatzenbuhler, Deborah A Evrard, Boyd L Harrison, Donna Huryn, Jennifer Inghrim, Christina Kraml, James F Mattes, Richard E Mewshaw, Dahui Zhou, Geoffrey Hornby, Qian Lin, Deborah L Smith, Kelly M Sullivan, Lee E Schechter, Chad E Beyer, Terrance H Andre. Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854086. |
synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-ht1a receptor and serotonin transporter affinity. |
2006-08-31 |
2023-08-12 |
rat |
| Nicole T Hatzenbuhler, Deborah A Evrard, Boyd L Harrison, Donna Huryn, Jennifer Inghrim, Christina Kraml, James F Mattes, Richard E Mewshaw, Dahui Zhou, Geoffrey Hornby, Qian Lin, Deborah L Smith, Kelly M Sullivan, Lee E Schechter, Chad E Beyer, Terrance H Andre. Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854086. |
compounds containing a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2h-1-benzopyran and a 3-alkylindole moiety linked through a common basic nitrogen were prepared and evaluated for 5-ht1a affinity, serotonin rat transporter affinity, and functional antagonist activity in vitro. |
2006-08-31 |
2023-08-12 |
rat |
| I P Voronova, A V Kulikov, N K Popova, T V Kozyrev. [Effect of long-term cold adaptation on the mRNA expression of serotonin 5-HT1A and 5-HT2A receptors]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 92. issue 5. 2006-08-18. PMID:16869289. |
[effect of long-term cold adaptation on the mrna expression of serotonin 5-ht1a and 5-ht2a receptors]. |
2006-08-18 |
2023-08-12 |
rat |
| I P Voronova, A V Kulikov, N K Popova, T V Kozyrev. [Effect of long-term cold adaptation on the mRNA expression of serotonin 5-HT1A and 5-HT2A receptors]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 92. issue 5. 2006-08-18. PMID:16869289. |
the mrna expression of serotonin receptors 5-ht1a and 5-ht2a was investigated by the quantitative method rt-pcr in rats adapted to cold (5 weeks at +4 -(+6) degrees c) and in control (5 weeks at +20-22 degrees c). |
2006-08-18 |
2023-08-12 |
rat |
| Changfeng Tai, Cynthia L Miscik, Timothy D Ungerer, James R Roppolo, William C de Groa. Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors. Experimental neurology. vol 199. issue 2. 2006-08-11. PMID:16488413. |
suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-ht1a receptors. |
2006-08-11 |
2023-08-12 |
Not clear |
| Christopher Bishop, Jennifer L Taylor, Donald M Kuhn, Karen L Eskow, John Y Park, Paul D Walke. MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. The European journal of neuroscience. vol 23. issue 10. 2006-08-04. PMID:16817869. |
while the mechanism by which these effects occur is not clear, recent research suggests that serotonin 5-ht1a receptors may play a pivotal role. |
2006-08-04 |
2023-08-12 |
rat |
| Hui-Yi Chang, Chen-Li Cheng, Jia-Jin J Chen, William C de Groa. Roles of glutamatergic and serotonergic mechanisms in reflex control of the external urethral sphincter in urethane-anesthetized female rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16469836. |
the serotonin (5-ht1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (1 mg/kg iv) enhanced spontaneous eus activity and the pelvic-eus reflex. |
2006-07-26 |
2023-08-12 |
rat |
| Cynthia A Crawford, Michael T Williams, Jodie L Kohutek, Fiona Y Choi, Shelly T Yoshida, Sanders A McDougall, Charles V Vorhee. Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPgammaS binding in adult rats. Brain research. vol 1077. issue 1. 2006-07-26. PMID:16483555. |
results indicated that early mdma exposure caused a decrease in pka activity and 5-ht content in the prefrontal cortex and hippocampus while increasing the efficacy of 5-ht1a receptors as measured by agonist-stimulated [35s]gtpgammas binding. |
2006-07-26 |
2023-08-12 |
rat |
| Cynthia A Crawford, Michael T Williams, Jodie L Kohutek, Fiona Y Choi, Shelly T Yoshida, Sanders A McDougall, Charles V Vorhee. Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPgammaS binding in adult rats. Brain research. vol 1077. issue 1. 2006-07-26. PMID:16483555. |
these data indicate that early mdma exposure has long-term effects on the 5-ht and da neurotransmitter systems that may be mediated, at least partially, by changes in 5-ht1a receptor sensitivity. |
2006-07-26 |
2023-08-12 |
rat |