| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter F Buckle. Aripiprazole: efficacy and tolerability profile of a novel-acting atypical antipsychotic. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 2. 2003-09-04. PMID:12698209. |
aripiprazole, the latest atypical antipsychotic to come to clinical practice, has a proposed mechanism of action different to other agents, most notably in its partial agonist action at dopamine (d2) receptors and at serotonin (5ht1a) receptors. |
2003-09-04 |
2023-08-12 |
Not clear |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
to avoid the interaction with raphe 5-ht1a autoreceptors, 1 micro m paroxetine was perfused locally through the dialysis probe implanted in the ventral hippocampus; similar increases in hippocampal [5-ht]ext were found in acutely or chronically treated wild-type mice. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
systemic administration of the mixed 5-ht1b/1d receptor antagonist gr 127935 (4 mg/kg) in chronically treated wild-type mice potentiated the effect of a paroxetine challenge dose on [5-ht]ext in the ventral hippocampus, whereas systemic administration of the selective 5-ht1a receptor antagonist way 100635 did not. |
2003-08-26 |
2023-08-12 |
mouse |
| Yoko Hagino, Masayuki Watanab. Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT1A receptors. Canadian journal of physiology and pharmacology. vol 80. issue 12. 2003-08-13. PMID:12564641. |
effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-ht1a receptors. |
2003-08-13 |
2023-08-12 |
rat |
| Yoko Hagino, Masayuki Watanab. Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT1A receptors. Canadian journal of physiology and pharmacology. vol 80. issue 12. 2003-08-13. PMID:12564641. |
this result suggests that the ability of clozapine to enhance the extracellular concentrations of 5-ht in the dorsal raphe attenuates this drug's effect in the frontal cortex, probably through the stimulation of 5-ht1a somatodendritic autoreceptors in the dorsal raphe. |
2003-08-13 |
2023-08-12 |
rat |
| H Jørgensen, A Kjaer, U Knigge, M Møller, J Warber. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716407. |
intracerebroventricular infusion of 5-ht agonists selective for the 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptor increased oxytocin mrna in the son and pvn. |
2003-08-13 |
2023-08-12 |
rat |
| H Jørgensen, A Kjaer, U Knigge, M Møller, J Warber. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716407. |
we conclude that stimulation with 5-hydroxytryptophan or 5-ht agonists increases mrna expression of oxytocin in the pvn and the son via stimulation of at least 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors. |
2003-08-13 |
2023-08-12 |
rat |
| Mihály Hajós, Sarah E Gartside, Viktor Varga, Trevor Shar. In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors. Neuropharmacology. vol 45. issue 1. 2003-08-11. PMID:12814660. |
these data suggest that drn and mrn 5-ht neurones inhibit neurones in the ventral mpfc via activation of 5-ht1a receptors. |
2003-08-11 |
2023-08-12 |
rat |
| S Todorov, C Pozzoli, R Zamfirova, E Pol. Prejunctional modulation of non-adrenergic non-cholinergic (NANC) inhibitory responses in the isolated guinea-pig gastric fundus. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 15. issue 3. 2003-08-05. PMID:12787339. |
these latter responses were also refractory to a variety of receptor agonists and antagonists, acting at gamma aminobutyric acid (gaba), serotonin 5ht1a, opioid micro , delta and kappa, muscarinic m1 and m2, histamine h2 and h3 and cannabinoid receptors. |
2003-08-05 |
2023-08-12 |
Not clear |
| Michelle Landry, Thérèse Di Paol. Effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-HT1A receptor. Brain research. Molecular brain research. vol 112. issue 1-2. 2003-07-31. PMID:12670705. |
effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-ht1a receptor. |
2003-07-31 |
2023-08-12 |
rat |
| Joachim Klisch, K M Bode-Greuel, E Horvath, C Klisch, Th El. Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil. Neuroscience letters. vol 342. issue 1-2. 2003-07-31. PMID:12727309. |
modulation of the serotonin (5ht) system via 5ht1a or 5ht2a receptors exerts a neuroprotective effect on delayed neuronal death after transient forebrain ischemia. |
2003-07-31 |
2023-08-12 |
Not clear |
| Michael B Gatc. Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life sciences. vol 73. issue 11. 2003-07-31. PMID:12850497. |
the roles of serotonin reuptake and 5-ht1a receptors have been well characterized, but the contribution of other serotonin receptor subtypes is not as clear. |
2003-07-31 |
2023-08-12 |
Not clear |
| Jesse A May, Marsha A McLaughlin, Najam A Sharif, Mark R Hellberg, Thomas R Dea. Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12676887. |
evaluation of the ocular hypotensive response of serotonin 5-ht1a and 5-ht2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys. |
2003-07-24 |
2023-08-12 |
human |
| J G Hensler, E E Ladenheim, W E Lyon. Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753073. |
as disturbances of serotonin neurotransmission are implicated in alcohol abuse and aggression, we have examined in bdnf (+/-) mice alcohol drinking behavior, as well as central 5-hydroxytryptamine (5-ht)1a receptor function at the level of 5-ht1a receptor-g protein interaction. |
2003-07-24 |
2023-08-12 |
mouse |
| Mitchell K P Lai, Shirley W Y Tsang, Paul T Francis, Margaret M Esiri, Janet Keene, Tony Hope, Christopher P L-H Che. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742626. |
reduced serotonin 5-ht1a receptor binding in the temporal cortex correlates with aggressive behavior in alzheimer disease. |
2003-07-22 |
2023-08-12 |
human |
| Eitan Gur, Michael E Newman, Yosefa Avraham, Eliyahu Dremencov, Elliot M Berr. The differential effects of food restriction on 5-HT1A and 5-HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats. Nutritional neuroscience. vol 6. issue 3. 2003-07-18. PMID:12793521. |
we recorded basal 5-ht release in the hypothalamus and hippocampus, and the sensitivity of the somatodendritic 5-ht1a autoreceptors in the raphe nuclei, and the nerve terminal 5-ht1b autoreceptors which together regulate the synthesis and release of 5-ht in these regions. |
2003-07-18 |
2023-08-12 |
rat |
| Eitan Gur, Michael E Newman, Yosefa Avraham, Eliyahu Dremencov, Elliot M Berr. The differential effects of food restriction on 5-HT1A and 5-HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats. Nutritional neuroscience. vol 6. issue 3. 2003-07-18. PMID:12793521. |
sensitivity of the somatodendritic 5-ht1a autoreceptors was assessed by measuring the reduction in extracellular 5-ht induced by systemic administration of the 5-ht1a receptor agonist 8-hydroxy-2-di-n-(propylamino)-tetralin (8-oh-dpat), while sensitivity of nerve terminal 5-ht1b autoreceptors was measured by observing the increase in 5-ht release after systemic injection of the 5-ht1b receptor antagonist gr 127935. |
2003-07-18 |
2023-08-12 |
rat |
| Elena Castro, Rosa M Tordera, Zoe A Hughes, Qi Pei, Trevor Shar. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787067. |
here, arc expression was used to test whether, in rats, co-administration of a 5-ht re-uptake inhibitor (paroxetine) and a 5-ht1a receptor antagonist (way 100635) increases postsynaptic 5-ht function. |
2003-07-10 |
2023-08-12 |
rat |
| Elena Castro, Rosa M Tordera, Zoe A Hughes, Qi Pei, Trevor Shar. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787067. |
these data provide molecular evidence that co-administration of a 5-ht re-uptake inhibitor and 5-ht1a receptor antagonist increases 5-ht function at the postsynaptic level. |
2003-07-10 |
2023-08-12 |
rat |
| James L Osterhout, Abdul A Waheed, Abel Hiol, Richard J Ward, Penelope C Davey, Lylia Nini, Jiun Wang, Graeme Milligan, Teresa L Z Jones, Kirk M Drue. Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. The Journal of biological chemistry. vol 278. issue 21. 2003-07-07. PMID:12642592. |
278, 19301-19308), we determined that mutation of nh2-terminal cysteine residues in rgs16 (cys-2 and cys-12) reduced gtpase accelerating (gap) activity toward a 5-hydroxytryptamine (5-ht1a)/g alpha o1 receptor fusion protein in cell membranes. |
2003-07-07 |
2023-08-12 |
Not clear |