| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
the distribution of 5-ht1b and 5-ht1d receptors in all species examined so far, is very similar: high concentrations of sites are found in the nigro-striatal pathway, caudate-putamen, globus pallidus and especially substantia nigra. |
1991-01-14 |
2023-08-11 |
mouse |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
thus, 5-ht1d receptors are negatively coupled to adenylate cyclase in guinea-pig and calf substantia nigra, and 5-ht1b receptors are negatively coupled to adenylate cyclase in rat substantia nigra. |
1991-01-14 |
2023-08-11 |
mouse |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
further, it is established that terminal 5-ht autoreceptors are of the 5-ht1b type in rat cortex, and of the 5-ht1d type in guinea-pig, pig, human and possibly rabbit cortex. |
1991-01-14 |
2023-08-11 |
mouse |
| R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry. vol 33. issue 10. 1990-11-20. PMID:2213830. |
whereas tryptamine derivatives generally display little selectivity for the various populations of 5-ht receptors, n1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (ki = 12 nm) and selectivity at 5-ht2 receptors relative to 5-ht1a (ki = 7100 nm), 5-ht1b (ki = 5000 nm), 5-ht1c (ki = 120 nm), and 5-ht1d (ki greater than 10,000 nm) receptors. |
1990-11-20 |
2023-08-11 |
Not clear |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. 5-HT1D receptors in guinea-pig and pigeon brain. Radioligand binding and biochemical studies. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 5. 1990-03-01. PMID:2533324. |
the rank order of affinities of agonists and antagonists (5-ct (5-carboxamidotryptamine) greater than 5-ht greater than ru 24969 (5-methoxy-3-(1,2,3,6-tetrahydro-4- pyridinyl)-1h indole succinate) greater than yohimbine greater than or equal to rauwolscine greater than dp-5-ct (n,n dipropyl-5-carboxamidotryptamine) greater than or equal to mianserin greater than 8-oh-dpat greater than mesulergine greater than sdz 21-009 ((+/-)-4(3-tert-butyl-amino-2-hydroxypropoxy)-indol-2 carbonic acid isopropyl ester) greater than (-)propranolol), as well as their individual pkd values, were very similar to those at porcine caudate 5-ht1d sites and clearly different from those at rat cortex 5-ht1b sites. |
1990-03-01 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 3. 1989-12-12. PMID:2572975. |
5-hydroxytryptamine 5-ht1b and 5-ht1d receptors mediating inhibition of adenylate cyclase activity. |
1989-12-12 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 3. 1989-12-12. PMID:2572975. |
5-hydroxytryptamine1b (5-ht1b) receptor mediated-inhibition of forskolin-stimulated adenylate cyclase activity in rat substantia nigra was characterized pharmacologically and compared to 5-ht1d receptor mediated-inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra. |
1989-12-12 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 3. 1989-12-12. PMID:2572975. |
special attention was paid to the effects of drugs known to bind with high affinity to 5-ht1b (pindolol, propranolol, cyanopindolol, sdz 21-009, isamoltane) or 5-ht1d recognition sites (yohimbine, rauwolscine). |
1989-12-12 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 3. 1989-12-12. PMID:2572975. |
the results strengthen the identity between 5-ht receptors mediating inhibition of adenylate cyclase activity in rat and calf substantia nigra and 5-ht1b and 5-ht1d binding sites, respectively. |
1989-12-12 |
2023-08-11 |
rat |
| W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences. vol 45. issue 16. 1989-12-05. PMID:2811600. |
characterization of a [3h]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-ht1a, 5-ht1b, 5-ht1c and 5-ht1d subtypes. |
1989-12-05 |
2023-08-11 |
rabbit |
| W C Xiong, D L Nelso. Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Life sciences. vol 45. issue 16. 1989-12-05. PMID:2811600. |
the present findings demonstrate the presence of a high-affinity [3h]5-ht binding site in rabbit cn, designated 5-ht1r, that is different from previously defined 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 sites. |
1989-12-05 |
2023-08-11 |
rabbit |
| D J McKenna, S J Peroutk. Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 10. 1989-11-14. PMID:2795135. |
no significant correlations were found between drug affinities for 125i-r-(-)doi-labeled sites in rat cortex and 5-ht1a, 5-ht1b, 5-ht1d, or 5-ht3 sites, as determined by previous investigators. |
1989-11-14 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2552330. |
the effects of the compound were investigated in radioligand binding studies and in functional models for 5-ht1a, 5-ht1b, and 5-ht1d receptors (inhibition of forskolin-stimulated adenylate cyclase activity in calf hippocampus, rat and calf substantia nigra, respectively) and 5-ht1c receptors (stimulation of inositol phosphate production in pig choroid plexus). |
1989-11-08 |
2023-08-11 |
human |
| P Schoeffter, D Hoye. How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2552330. |
gr 43175 displayed the following order of affinity for 5-ht recognition sites (pkd values, -log mol/l, in parentheses): 5-ht1d (7.54) greater than 5-ht1b (6.35) greater than 5-ht1a (6.13) much greater than 5-ht1c (4.13) greater than 5-ht2 (3.67). |
1989-11-08 |
2023-08-11 |
human |
| E Schlicker, K Fink, M Göthert, D Hoyer, G Molderings, I Roschke, P Schoeffte. The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype. Naunyn-Schmiedeberg's archives of pharmacology. vol 340. issue 1. 1989-11-08. PMID:2797214. |
the potencies of the serotonin receptor agonists and antagonists were compared with their affinities for 5-ht1a, 5-ht1b, 5-ht1c, and 5-ht1d binding sites in pig or rat tissue membranes; in addition, the potencies of the agonists were compared to their potencies in inhibiting adenylate cyclase activity in membranes of calf substantia nigra. |
1989-11-08 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 6. 1989-10-12. PMID:2770889. |
the effects of several putative 5-ht1 receptor-subtype selective ligands were investigated in biochemical models for 5-ht1a, 5-ht1b, and 5-ht1d receptors (inhibition of forskolin-stimulated adenylate cyclase activity in calf hippocampus, rat and calf substantia nigra, respectively) and 5-ht1c receptors (stimulation of inositol phosphates production in pig choroid plexus). |
1989-10-12 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 6. 1989-10-12. PMID:2770889. |
among reported 5-ht1b receptor selective drugs, tfmpp had similar potency at 5-ht1a, 5-ht1b and 5-ht1c receptors, mcpp did not separate between 5-ht1b and 5-ht1c receptors, cgs 12066 was equipotent at 5-ht1b and 5-ht1d receptors, and isamoltane was only slightly 5-ht1b versus 5-ht1a selective. |
1989-10-12 |
2023-08-11 |
rat |
| S Leonhardt, K Herrick-Davis, M Titele. Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of neurochemistry. vol 53. issue 2. 1989-08-25. PMID:2664084. |
to investigate the non-5-ht1d component of the binding, 100 nm 5-ct (to block 5-ht1a, 5-ht1b, and 5-ht1d receptors) was coincubated with [3h]5-ht, membranes, and mesulergine. |
1989-08-25 |
2023-08-11 |
human |
| S J Peroutka, B G McCarth. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2545459. |
sumatriptan (gr 43175) interacts selectively with 5-ht1b and 5-ht1d binding sites. |
1989-08-21 |
2023-08-11 |
Not clear |
| S J Peroutka, B G McCarth. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. European journal of pharmacology. vol 163. issue 1. 1989-08-21. PMID:2545459. |
sumatriptan displayed the highest affinity for 5-ht1d (ki = 17 nm) and 5-ht1b (ki = 27 nm) binding sites and was slightly less potent at 5-ht1a binding sites (ki = 100 nm). |
1989-08-21 |
2023-08-11 |
Not clear |