| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Rinaldi-Carmona, C Congy, V Santucci, J Simiand, B Gautret, G Neliat, B Labeeuw, G Le Fur, P Soubrie, J C Brelier. Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1501121. |
furthermore, sr 46349b displayed moderate affinity for the 5-ht1c receptor and had no affinity for the other 5-ht1 subclass (5-ht1a, 5-ht1b or 5-ht1d), dopamine (d1 or d2), "alpha" adrenergic (alpha-1 or alpha-2), sodium and calcium channel and histamine (h1) receptors. |
1992-09-11 |
2023-08-11 |
mouse |
| A Dumuis, H Gozlan, M Sebben, H Ansanay, C A Rizzi, M Turconi, E Monferini, E Giraldo, P Schiantarelli, H Ladinsk. Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 3. 1992-08-05. PMID:1320204. |
no significant binding (ki greater than 10 mumol/l) of dau 6285 to serotonergic 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht2 receptors as well as to adrenergic alpha 1, alpha 2, dopaminergic d1, d2 or muscarinic m1-m3 receptor subtypes was found. |
1992-08-05 |
2023-08-11 |
mouse |
| M R Pranzatelli, J Ballett. Serotonin receptors in human neuroblastoma: a possible biologic tumor marker. Experimental neurology. vol 115. issue 3. 1992-04-02. PMID:1537397. |
no 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, or 5-ht uptake sites were found in any of the tumors, although all were detected in human or rat brain. |
1992-04-02 |
2023-08-11 |
human |
| N Adham, P Romanienko, P Hartig, R L Weinshank, T Branche. The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor. Molecular pharmacology. vol 41. issue 1. 1992-02-26. PMID:1732716. |
the relationship between the serotonin 5-hydroxytryptamine1b (5-ht1b) and 5-ht1d receptors has been the topic of much investigation and speculation since their complementary species distribution was first appreciated. |
1992-02-26 |
2023-08-11 |
human |
| H Sijbesma, J Schipper, J C Cornelissen, E R de Kloe. Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig. Brain research. vol 555. issue 2. 1991-12-23. PMID:1834309. |
good correlations were found between species in the regional distribution of 5-ht1 sites labelled with [3h]5-ht (r = 0.73), 5-ht1a sites labelled with [3h]8-oh-dpat (r = 0.87), and 5-ht1b versus 5-ht1d sites labelled with [3h]5-ht in the presence of ipsapirone and doi (r = 0.76). |
1991-12-23 |
2023-08-11 |
rat |
| H Sijbesma, J Schipper, J C Cornelissen, E R de Kloe. Species differences in the distribution of central 5-HT1 binding sites: a comparative autoradiographic study between rat and guinea pig. Brain research. vol 555. issue 2. 1991-12-23. PMID:1834309. |
areas almost exclusively containing 5-ht1b or 5-ht1d sites, such as the ventral pallidum, globus pallidus and substantia nigra, expressed markedly more [3h]5-ht binding in rat as compared to guinea pig, while the opposite occurred in claustrum, dorsal endopiriform nucleus, lateral geniculate nucleus, and superficial grey layer of the superior colliculus. |
1991-12-23 |
2023-08-11 |
rat |
| F P Zemlan, E F Schwa. Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein. Journal of neurochemistry. vol 57. issue 6. 1991-12-18. PMID:1834802. |
[3h]5-ht competition studies performed in the presence of 100 nm 8-oh-dpat and 10 nm ru 24969 (to block 5-ht1a and 5-ht1b receptors, respectively) indicated that the remaining 49% of [3h]5-ht binding did not possess the pharmacologic profile previous reported for 5-ht1c, 5-ht1d, 5-ht1e, 5-ht2, or 5-ht3 receptors. |
1991-12-18 |
2023-08-11 |
rat |
| L Segu, J Chauveau, P Boulenguez, A Morel, J Lanoir, M Delaag. [Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 312. issue 13. 1991-10-28. PMID:1913239. |
[synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-ht1b and 5-ht1d binding sites of the central nervous system]. |
1991-10-28 |
2023-08-11 |
rat |
| L Segu, J Chauveau, P Boulenguez, A Morel, J Lanoir, M Delaag. [Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 312. issue 13. 1991-10-28. PMID:1913239. |
quantitative autoradiographic studies on rat and guinea pig brain sections incubated with 2 nm [3h]5-ht showed a preferential affinity of s-cm-gtnh2 for 5-ht1b and 5-ht1d sites. |
1991-10-28 |
2023-08-11 |
rat |
| P Schoeffter, D Hoye. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. European journal of pharmacology. vol 196. issue 2. 1991-09-20. PMID:1678720. |
interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-ht1a, 5-ht1b, 5-ht1c and 5-ht1d receptors. |
1991-09-20 |
2023-08-11 |
Not clear |
| P Schoeffter, D Hoye. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. European journal of pharmacology. vol 196. issue 2. 1991-09-20. PMID:1678720. |
oxymetazoline was recognized with nanomolar affinity by 5-ht1a, 5-ht1b and 5-ht1d binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. |
1991-09-20 |
2023-08-11 |
Not clear |
| N Limberger, R Deicher, K Stark. Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 4. 1991-08-16. PMID:1852219. |
species differences in presynaptic serotonin autoreceptors: mainly 5-ht1b but possibly in addition 5-ht1d in the rat, 5-ht1d in the rabbit and guinea-pig brain cortex. |
1991-08-16 |
2023-08-11 |
rat |
| N Limberger, R Deicher, K Stark. Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 343. issue 4. 1991-08-16. PMID:1852219. |
the serotonin axons of rat brain cortex may possess 5-ht1d in addition to 5-ht1b autoreceptors. |
1991-08-16 |
2023-08-11 |
rat |
| E Hamel, D Bouchar. Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites. British journal of pharmacology. vol 102. issue 1. 1991-07-16. PMID:2043924. |
a correlation analysis performed between the agonists vascular potency (pd2 values) and their affinities (pkd values) published at various subtypes of 5-ht binding sites showed a positive significant correlation with rat cortical 5-ht1b (r = 0.86; p less than 0.01) and human caudate 5-ht1d (r = 0.98; p less than 0.005) subtypes. |
1991-07-16 |
2023-08-11 |
human |
| M Hamon, L Lanfumey, S el Mestikawy, C Boni, M C Miquel, F Bolaños, L Schechter, H Gozla. The main features of central 5-HT1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078271. |
the 5-ht1 receptor family comprises five different pharmacologic subtypes, designated 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, and 5-ht1e, whose common property is to bind 5-ht with nanomolar affinity. |
1991-04-29 |
2023-08-11 |
human |
| M Göthert, G J Molderings, K Fink, E Schlicke. Heterogeneity of presynaptic serotonin receptors on sympathetic neurones in blood vessels. Blood vessels. vol 28. issue 1-3. 1991-04-12. PMID:2001464. |
in the rat vena cava, they are of the 5-ht1b subtype, in the pig coronary artery they belong to a novel, so far unknown class of 5-ht receptors, and in the human saphenous vein they could be classified as 5-ht1d. |
1991-04-12 |
2023-08-11 |
human |
| M Göthert, E Schlicke. Identification and classification of 5-HT1 receptor subtypes. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702482. |
in addition, the drugs with antagonistic properties at the 5-ht1a, 5-ht1b, 5-ht1c, and 5-ht1d receptors block other 5-ht receptors or even entirely different receptors (e.g., beta-adrenoceptors); as a rule, they do not discriminate between the four 5-ht receptor subtypes. |
1991-02-11 |
2023-08-11 |
Not clear |
| D Laude, V Baudrie, G R Martin, F Chaoulof. Effects of the 5-HT1 receptor agonists DP-5-CT, CGS 12066B, and RU 24969 on plasma adrenaline and glucose levels in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 4. 1991-01-22. PMID:2255331. |
the data suggest that central 5-ht1a receptors, but neither 5-ht1b nor 5-ht1d receptors, regulate plasma adrenaline and glucose levels. |
1991-01-22 |
2023-08-11 |
rat |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
5-ht1 receptor subtypes are labeled with [3h]5-ht and present a large heterogeneity: no less than 4 subtypes have been characterized: 5-ht1b and 5-ht1d are labeled respectively with [125i]cyanopindolol, and [3h]5-ht under appropriate conditions. |
1991-01-14 |
2023-08-11 |
mouse |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
5-ht1d receptors show high to intermediate affinities to compounds such as papp, dp-5-ct, 8-oh-dpat, yohimbine and rauwolscine, whereas 5-ht1b receptors have very low affinities for these compounds. |
1991-01-14 |
2023-08-11 |
mouse |