| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A T Bruinvels, B Landwehrmeyer, E L Gustafson, M M Durkin, G Mengod, T A Branchek, D Hoyer, J M Palacio. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984275. |
in general, the distribution of 5-ht1b mrna was characterized by high densities, whereas 5-ht1d alpha mrna was expressed at very low levels. |
1994-12-30 |
2023-08-12 |
mouse |
| M N Schwarzber. Application of metoclopramide specificity in migraine attacks therapy. Headache. vol 34. issue 7. 1994-11-04. PMID:7928330. |
the clinical effective dose of ergotamine, beginning from the minimal dose of 1 mg, correlates well with its affinity for 5-ht1b and 5-ht1d receptors, and the rank order of clinical potency of ergotamine is superior to sumatriptan. |
1994-11-04 |
2023-08-12 |
Not clear |
| P J Pauwels, C Palmie. Inhibition by 5-HT of forskolin-induced cAMP formation in the renal opossum epithelial cell line OK: mediation by a 5-HT1B like receptor and antagonism by methiothepin. Neuropharmacology. vol 33. issue 1. 1994-06-16. PMID:7910388. |
the functional activity of various 5-ht receptor agonists, including 5-ct, sumatriptan, cp 93, 129 and 1-naphtylpiperazine, and of drugs known to bind with high affinity to 5-ht1b (pindolol, propranolol, cyanopindolol, sdz 21,009 and isamoltane) or 5-ht1d binding sites (yohimbine and rauwolscine) was measured at 5-ht receptors that are negatively coupled to adenylate cyclase in cultures of the renal epithelial cell line ok. 5-ht receptor-mediated inhibition of adenylate cyclase was studied by measuring inhibition of camp formation, induced by 100 microm forskolin. |
1994-06-16 |
2023-08-12 |
Not clear |
| G W Rebeck, K I Maynard, B T Hyman, M A Moskowit. Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 9. 1994-06-01. PMID:8170966. |
we sought molecular evidence for the expression of an mrna species encoding the 5-ht1d receptor subtype in guinea pig and human trigeminal ganglia, using the polymerase chain reaction with oligonucleotides uniquely homologous to the coding sequences of the 5-ht1b/d family (human 5-ht1d alpha and 5-ht1d beta; rat 5-ht1b). |
1994-06-01 |
2023-08-12 |
human |
| T J Lee, M Ueno, N Sunagane, M H Su. Serotonin relaxes porcine pial veins. The American journal of physiology. vol 266. issue 3 Pt 2. 1994-05-19. PMID:8160803. |
the 5-ht inhibition of src and sat is predominant and is mediated by 5-ht1-like receptors, which, however, do not seem to correspond to 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht1e, or 5-ht1f receptor subtypes. |
1994-05-19 |
2023-08-12 |
Not clear |
| F Hery, M Hamo. [Neuroleptics and serotonin]. L'Encephale. vol 19. issue 5. 1994-03-14. PMID:7905821. |
these studies not only demonstrate the existence of several classes of serotonin receptors called 5-ht1a, 5-ht1b, 5-ht1c, 5-ht1d, 5-ht2, 5-ht3 and 5-ht4, but led also to the development of novel agonists and antagonists for the stimulation or blockade of each of them. |
1994-03-14 |
2023-08-12 |
Not clear |
| M S Beer, J A Stanton, Y Bevan, A Heald, A J Reeve, L J Street, V G Matassa, R J Hargreaves, D N Middlemis. L-694,247: a potent 5-HT1D receptor agonist. British journal of pharmacology. vol 110. issue 3. 1994-03-04. PMID:8298808. |
l-694,247 had an affinity (pic50) of 10.03 at the 5-ht1d binding site and 9.08 at the 5-ht1b binding site (sumatriptan: pic50 values 8.22 and 5.94 respectively). |
1994-03-04 |
2023-08-12 |
Not clear |
| M Briley, C More. Neurobiological mechanisms involved in antidepressant therapies. Clinical neuropharmacology. vol 16. issue 5. 1993-12-22. PMID:8221701. |
the firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5-hydroxytryptamine 1a (5-ht1a) autoreceptors, the release of serotonin from nerve terminals is under the control of 5-ht autoreceptors (5-ht1b subtype in rodents, 5-ht1d in other species), whereas the control of the activity of tryptophan hydroxylase, the rate-limiting enzyme of serotonin synthesis, is complex, involving 5-ht1a but possibly other 5-ht receptors including the 5-ht1b/d subtype. |
1993-12-22 |
2023-08-12 |
Not clear |
| A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 6. 1993-09-28. PMID:8361548. |
the pharmacology of the [125i]gti binding sites was analysed using compounds known to display high affinity for and/or distinguish between 5-ht1b and 5-ht1d sites: 5-carboxamidotryptamine (5-ct), sumatriptan, cp 93129 (5-hydroxy-3(4-1,2,5,6-tetrahydropyridyl)-4-azaindole), (-)pindolol, papp (4[2-[4-[3-(trifluoromethyl)phenyl]-1- piperazinyl]ethyl]benzeneamine), rauwolscine, and 8-oh-dpat. |
1993-09-28 |
2023-08-12 |
rat |
| A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 6. 1993-09-28. PMID:8361548. |
by contrast, the selective 5-ht1b compound cp 93129 and (-)pindolol produced biphasic curves showing a majority of high affinity sites in the globus pallidus and the substantia nigra, whereas papp and sumatriptan (which are somewhat 5-ht1d selective) produced biphasic curves indicating a minority of high affinity sites in these areas. |
1993-09-28 |
2023-08-12 |
rat |
| A T Bruinvels, J M Palacios, D Hoye. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 6. 1993-09-28. PMID:8361548. |
low densities of the 5-ht1d recognition sites were found to be present in globus pallidus, ventral pallidum, caudate-putamen, subthalamic nucleus, entopeduncular nucleus, substantia nigra (reticular part), nuclei of the (normal and accessory) optic tract, different nuclei of the geniculate body and frontoparietal cortex, although higher densities of 5-ht1b sites were always observed in the same structures. |
1993-09-28 |
2023-08-12 |
rat |
| M S Beer, J A Stanton, L M Hawkins, D N Middlemis. 5-Carboxamidotryptamine-insensitive 5-HT1-like receptors are concentrated in guinea pig but not rat, claustrum. European journal of pharmacology. vol 236. issue 1. 1993-07-30. PMID:8319743. |
5-ct (5-carboxamidotryptamine)-insensitive (5-ht1e/5-ht1f) 5-ht1-like recognition sites have been mapped autoradiographically in rat and guinea pig brain using [3h]5-ht in the presence of 5-ct and mesulergine to mask 5-ht1a, 5-ht1b, 5-ht1d and 5-ht2c binding sites. |
1993-07-30 |
2023-08-12 |
rat |
| L O Wilkinson, L M Hawkins, M S Beer, M F Hibert, D N Middlemis. Stereoselective actions of the isomers of metitepine at 5-HT1D receptors in the guinea pig brain. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474615. |
these findings support the identification of the guinea pig 5-ht terminal autoreceptor as a 5-ht1d receptor and reinforce the species homology between the 5-ht1b and 5-ht1d receptors. |
1993-05-17 |
2023-08-12 |
cattle |
| P Schoeffter, J R Fozard, A Stoll, H Siegl, M P Seiler, D Hoye. SDZ 216-525, a selective and potent 5-HT1A receptor antagonist. European journal of pharmacology. vol 244. issue 3. 1993-04-23. PMID:8384569. |
the effects of sdz 216-525, mdl 73005 and nan 190 on 5-ht1 receptor-linked second messengers were characterised in the following tests: inhibition of forskolin-stimulated adenylate cyclase activity in calf hippocampus (5-ht1a), rat substantia nigra (5-ht1b) and calf substantia nigra (5-ht1d) and stimulation of inositol phosphate production in pig choroid plexus (5-ht1c). |
1993-04-23 |
2023-08-12 |
rat |
| F J Monsma, Y Shen, R P Ward, M W Hamblin, D R Sible. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology. vol 43. issue 3. 1993-04-13. PMID:7680751. |
within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-ht)] receptors: 5-ht2 > 5-ht1d > 5-ht1c > 5-ht1b > 5-ht1a > 5-ht1e. |
1993-04-13 |
2023-08-12 |
rat |
| M A Metcalf, R W McGuffin, M W Hambli. Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis. Biochemical pharmacology. vol 44. issue 10. 1992-12-24. PMID:1449511. |
we now report that thr355asn mutagenesis of the human 5-ht1d beta receptor alters the binding characteristics of the recombinant receptor in [3h]5-ht binding assays to a profile very similar to that of the rat 5-ht1b binding site. |
1992-12-24 |
2023-08-11 |
human |
| A T Bruinvels, H Lery, J Nozulak, J M Palacios, D Hoye. 5-HT1D binding sites in various species: similar pharmacological profile in dog, monkey, calf, guinea-pig and human brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 3. 1992-11-19. PMID:1407009. |
radioligand binding studies were performed in membranes of calf caudate, guinea-pig cortex, dog caudate and whole brain, monkey caudate and whole brain, and human caudate using the novel iodinated radioligand, serotonin-5-o-carboxymethyl-glycyl[125i] tyrosinamide (abbreviated [125i]gti for the sake of simplicity), a ligand known to label 5-ht1b and 5-ht1d sites. |
1992-11-19 |
2023-08-11 |
human |
| D Hoyer, H Lery, C Waeber, A T Bruinvels, J Nozulak, J M Palacio. "5-HT1R" or 5-HT1D sites? Evidence for 5-HT1D binding sites in rabbit brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 3. 1992-11-19. PMID:1407010. |
radioligand binding studies were performed in membranes of rabbit whole brain and striatum using the novel iodinated radioligand for 5-hydroxytryptamine 5-ht1b and 5-ht1d sites, serotonin-5-o-carboxymethyl-glycyl[125i]tyrosinamide ([125i]gti). |
1992-11-19 |
2023-08-11 |
human |
| M O Den Boer, C M Villalón, P R Saxen. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 5. 1992-10-22. PMID:1326717. |
the effect of metergoline (1 mg.kg-1), a substance with a very high affinity for the 5-ht1d receptor as well as for the 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 receptors, was studied on the responses to 5-ht and sumatriptan. |
1992-10-22 |
2023-08-11 |
Not clear |
| K M Dhasmana, C M Villalón, Y N Zhu, S Tadipatri, P R Saxen. Role of 5-HT1-like receptors in the increase in intragastric pressure induced by 5-hydroxytryptamine in the rat. European journal of pharmacology. vol 213. issue 2. 1992-10-13. PMID:1521563. |
these data suggest that the 5-ht-induced increase in intragastric pressure in the spinal and bilaterally vagotomized rat is mediated by an atypical 5-ht1-like receptor, which, based on the low agonist potency of 5-carboxamidotryptamine and ru 24969 and the resistance to blockade by metergoline, does not seem to correspond to either the 5-ht1a, 5-ht1b, 5-ht1c or the 5-ht1d receptor subtypes. |
1992-10-13 |
2023-08-11 |
rat |