| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Lars Edvinsson, Erik Uddman, Angelica Wackenfors, Anthony Davenport, Jenny Longmore, Malin Malmsj\\xc3\\xb. Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect. Clinical science (London, England : 1979). vol 109. issue 3. 2005-12-13. PMID:15853772.' |
triptans are agonists at 5-ht1b and 5-ht1d (where 5-ht is 5-hydroxytryptamine; serotonin) receptors and cause vasoconstriction of isolated blood vessels. |
2005-12-13 |
2023-08-12 |
human |
| b' Angelica Wackenfors, Malin Jarvius, Richard Ingemansson, Lars Edvinsson, Malin Malmsj\\xc3\\xb. Triptans induce vasoconstriction of human arteries and veins from the thoracic wall. Journal of cardiovascular pharmacology. vol 45. issue 5. 2005-08-16. PMID:15821444.' |
5-carboxamidotryptamine (5-ct) and sumatriptan elicited a vasoconstriction that was antagonized by the 5-ht1b receptor antagonist sb224289, whereas the 5-ht1d receptor antagonist brl115572 had no effect. |
2005-08-16 |
2023-08-12 |
human |
| Luis F Valdivia, David Centurión, Udayasankar Arulmani, Pramod R Saxena, Carlos M Villaló. 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs. Naunyn-Schmiedeberg's archives of pharmacology. vol 370. issue 1. 2005-06-10. PMID:15224175. |
bolus injection of, either physiological saline (0.3 ml/kg; control), or the antagonists sb224289 (300 microg/kg; 5-ht1b), brl15572 (300 microg/kg; 5-ht1d), rauwolscine (300 microg/kg; alpha2), sb224289 + brl15572 (300 microg/kg each), sb224289 + rauwolscine (300 microg/kg each), brl15572 + rauwolscine (300 microg/kg each), rauwolscine (300 microg/kg) + prazosin (100 microg/kg; alpha1), sb224289 (300 microg/kg) + prazosin (100 microg/kg), sb224289 (300 microg/kg) + rauwolscine (300 microg/kg) + prazosin (100 microg/kg), sb224289 (300 microg/kg) + prazosin (100 microg/kg) + brl44408 (1,000 microg/kg; alpha2a), sb224289 (300 microg/kg) + prazosin (100 microg/kg)+ imiloxan (1,000 microg/kg; alpha2b), or sb224289 (300 microg/kg) + prazosin (100 microg/kg) + mk912 (300 microg/kg; alpha2c). |
2005-06-10 |
2023-08-12 |
Not clear |
| M W Nash, K Sugden, P Huezo-Diaz, R Williamson, A Sterne, S Purcell, P C Sham, I W Crai. Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 135B. issue 1. 2005-05-31. PMID:15729745. |
in a pathway based candidate gene study, we examined five microsatellite markers located within or nearby to five serotonin system genes (5ht2c, 5ht1d, 5ht1b, tph1, and maob). |
2005-05-31 |
2023-08-12 |
Not clear |
| Ricardo Mostany, Angel Pazos, M Elena Castr. Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain. Neuropharmacology. vol 48. issue 1. 2005-04-28. PMID:15617724. |
the selective 5-ht1b antagonist sb-224289 inhibited gti- and cp 93129-stimulated [35s]gtpgammas binding in basal ganglia and substantia nigra, while coincubation with brl 15572 (selective 5-ht1d antagonist) did not result in any significant change. |
2005-04-28 |
2023-08-12 |
human |
| J Veselá, P Rehák, J Mihalik, S Czikková, J Pokorný, J Koppe. Expression of serotonin receptors in mouse oocytes and preimplantation embryos. Physiological research. vol 52. issue 2. 2004-01-05. PMID:12678665. |
we analyzed the expression of three types of serotonin receptors: 5-ht1b, 5-ht2c and 5-ht1d by reverse transcription-polymerase chain reaction in mouse unfertilized oocytes and preimplantation embryos from zygotes to the blastocyst stage in vivo. |
2004-01-05 |
2023-08-12 |
mouse |
| Stephen D Silberstein, Douglas C McCror. Ergotamine and dihydroergotamine: history, pharmacology, and efficacy. Headache. vol 43. issue 2. 2003-09-03. PMID:12558771. |
ergotamine and dihydroergotamine are highly potent at the 5-ht1b and 5-ht1d antimigraine receptors and, as a consequence, the plasma concentrations that are necessary to produce the appropriate therapeutic and physiologic effects are very low. |
2003-09-03 |
2023-08-12 |
Not clear |
| Fabrizio De Ponti, Francesca Crema, Elisabetta Moro, Giuseppe Nardelli, Gianmario Frigo, Antonio Crem. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 1. 2003-07-24. PMID:12646419. |
thus, in four conscious dogs, we compared the effects of sumatriptan alone or combined with n-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1-biphenyl]-4-carboxamide hydrocloride (gr-127935), n-[3-[3 (dimethylamino)-ethoxy]-4-methoxyphenyl]-2'-[methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)]-[1,1-biphenyl]-4-carboxamide hydrocloride (sb-216641 hydrochloride), or 3-[4-(4-chloro-phenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride (brl-15572 hydrochloride) (respectively, nonselective 5-ht1b/d, selective 5-ht1b, and selective 5-ht1d receptor antagonists) on gastric accommodation to isobaric distensions performed with a barostat. |
2003-07-24 |
2023-08-12 |
Not clear |
| Paul J L M Strijbos, Andrew A Parsons, Anders Fugell. Eletriptan Pfizer. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 9. 2003-05-27. PMID:12498013. |
eletriptan has 6-fold greater affinity for the 5-ht1d receptor than sumatriptan, and a 3-fold greater affinity for the 5-ht1b receptor [249570]. |
2003-05-27 |
2023-08-12 |
Not clear |
| R Nicholson, J Small, A K Dixon, D Spanswick, K Le. Serotonin receptor mRNA expression in rat dorsal root ganglion neurons. Neuroscience letters. vol 337. issue 3. 2003-03-28. PMID:12536038. |
within drg neurons, mrnas for 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht3b and 5-ht4 receptors were readily detected in small (<25 microm), medium (25-45 microm) and large (>45 microm) diameter neurons. |
2003-03-28 |
2023-08-12 |
rat |
| Demet Akin, Hakan Gurda. Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. British journal of pharmacology. vol 136. issue 2. 2002-10-29. PMID:12010765. |
involvement of 5-ht1b and 5-ht1d receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. |
2002-10-29 |
2023-08-12 |
rabbit |
| Cathy Donaldson, Peter Michael Boers, Karen Lisa Hoskin, Alessandro Stefano Zagami, Geoffrey Andrew Lamber. The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons. Neuropharmacology. vol 42. issue 3. 2002-06-27. PMID:11897116. |
the role of 5-ht1b and 5-ht1d receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons. |
2002-06-27 |
2023-08-12 |
Not clear |
| Maxime Richer, René Hen, Pierre Blie. Modification of serotonin neuron properties in mice lacking 5-HT1A receptors. European journal of pharmacology. vol 435. issue 2-3. 2002-03-27. PMID:11821026. |
in addition, it was not associated with changes in the function of 5-ht1d and 5-ht1b autoreceptors and of alpha2-adrenergic heteroreceptors on 5-ht neurons, nor of that of alpha2-adrenoceptors on norepinephrine terminals. |
2002-03-27 |
2023-08-12 |
mouse |
| S E Easthope, K L Go. Frovatriptan. CNS drugs. vol 15. issue 12. 2002-01-15. PMID:11735616. |
black triangle frovatriptan, a new serotonin receptor agonist developed for the acute treatment of migraine, has high affinity for serotonin 5-ht1b and 5-ht1d receptor subtypes and is a potent stimulator of contraction in human basilar arteries. |
2002-01-15 |
2023-08-12 |
human |
| Q P M. Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats. Neuroreport. vol 12. issue 8. 2001-12-04. PMID:11409721. |
the majority of 5-ht1b, 5-ht1d or 5-ht1f receptor positive neurons were also glutamate positive, but both 5-ht1b, 5-ht1d or 5-ht1f receptor single-labeled and glutamate single-labeled neurons were observed. |
2001-12-04 |
2023-08-12 |
rat |
| G Cipolla, S Sacco, F Crema, E Moro, F De Ponti, G Frig. Gastric motor effects of triptans: open questions and future perspectives. Pharmacological research. vol 43. issue 3. 2001-07-12. PMID:11401410. |
taken together, the available evidence warrants further studies to clarify the following issues: first, the mechanism responsible for the gastric motor effect of sumatriptan [receptor subtype(s) involved; central vs peripheral mechanism]; secondly, the effects on gastric motility/visceral sensitivity of second-generation triptans (which are 5-ht1b/d receptor agonists) and more recent selective 5-ht1d receptor agonists (proposed as investigational antimigraine agents with less potential to induce coronary vasoconstriction through 5-ht1b receptors); finally, the possible use of drugs improving gastric accommodation to a meal in the management of those dyspeptic patients with impaired fundic relaxation/altered visceral sensitivity. |
2001-07-12 |
2023-08-12 |
Not clear |
| C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
5-ht1a, 5-ht1b and 5-ht1d receptors are known to function as 5-ht autoreceptors in the rat dorsal raphe nucleus (drn), modulating local 5-ht efflux. |
2001-05-10 |
2023-08-12 |
rat |
| C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
we investigated the effect of 5-ht1b and 5-ht1d receptor antagonists on 5-ht efflux in rat drn, alone and in the presence of 5-ht1a receptor antagonists, using the technique of fast cyclic voltammetry. |
2001-05-10 |
2023-08-12 |
rat |
| C Roberts, G W Pric. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neuroscience letters. vol 300. issue 1. 2001-05-10. PMID:11172936. |
these data confirm that 5-ht efflux within the drn is under the control of 5-ht1a, 5-ht1b and 5-ht1d autoreceptors and elevation of 5-ht efflux was greatest following antagonism of 5-ht1a and 5-ht1b receptors. |
2001-05-10 |
2023-08-12 |
rat |
| P Tfelt-Hansen, P De Vries, P R Saxen. Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy. Drugs. vol 60. issue 6. 2001-04-12. PMID:11152011. |
the first of the class, sumatriptan, and the newer triptans (zolmitriptan, naratriptan, rizatriptan, eletriptan, almotriptan and frovatriptan) display high agonist activity at mainly the serotonin 5-ht1b and 5-ht1d receptor subtypes. |
2001-04-12 |
2023-08-12 |
Not clear |