| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Rousselle, M Plantefol, M P Fillion, O Massot, P J Pauwels, G Fillio. Specific interaction of 5-HT-moduline with human 5-HT1b as well as 5-HT1d receptors expressed in transfected cultured cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774213. |
the observed effect corresponds to a marked decrease of the maximal binding for [3h]5-ht on 5-ht1b (-51.2 +/- 1%) as well as 5-ht1d binding (-47.2 +/- 7.7% of the control binding) whereas the affinity of 5-ht is increased by a factor close to 3. |
1998-12-22 |
2023-08-12 |
human |
| J C Rousselle, M Plantefol, M P Fillion, O Massot, P J Pauwels, G Fillio. Specific interaction of 5-HT-moduline with human 5-HT1b as well as 5-HT1d receptors expressed in transfected cultured cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774213. |
5-ht-moduline yields an antagonistic effect on the 5-ht induced coupling with a corresponding ic50 = 1.2 +/- 0.7x10(-12) m for 5-ht1b and 9.8 +/- 4.0x10(-12) m for 5-ht1d receptors, respectively. |
1998-12-22 |
2023-08-12 |
human |
| R Verheggen, A G Hundeshagen, A M Brown, M Schindler, A J Kauman. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. British journal of pharmacology. vol 124. issue 7. 1998-11-13. PMID:9723944. |
in the human temporal artery both 5-ht1-like and 5-ht2a receptors mediate the contractile effects of 5-hydroxytryptamine (5-ht) and we have suggested that the 5-ht1-like receptors resemble more closely recombinant 5-ht1b than 5-ht1d receptors. |
1998-11-13 |
2023-08-12 |
human |
| R Verheggen, A G Hundeshagen, A M Brown, M Schindler, A J Kauman. 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. British journal of pharmacology. vol 124. issue 7. 1998-11-13. PMID:9723944. |
we also used rt-pcr to search for the mrna of 5-ht1b, 5-ht1d and other 5-ht receptors. |
1998-11-13 |
2023-08-12 |
human |
| A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology. vol 122. issue 5. 1998-09-24. PMID:9384503. |
these data suggest a possible involvement of 5-ht2a and 5-ht1b or 5-ht1d receptors in the response to 5-ht. |
1998-09-24 |
2023-08-12 |
rabbit |
| A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology. vol 122. issue 5. 1998-09-24. PMID:9384503. |
this reinforces the evidence that 5-ht1b and/or 5-ht1d receptors contribute to the effects of 5-ht in the tissue. |
1998-09-24 |
2023-08-12 |
rabbit |
| A J Ellwood, M J Curti. Involvement of 5-HT(1B/1D) and 5-HT2A receptors in 5-HT-induced contraction of endothelium-denuded rabbit epicardial coronary arteries. British journal of pharmacology. vol 122. issue 5. 1998-09-24. PMID:9384503. |
in conclusion, in endothelium denuded rabbit epicardial coronary arteries, 5-ht activates 5-ht2a and 5-ht1d and/or 5-ht1b receptors to cause contraction. |
1998-09-24 |
2023-08-12 |
rabbit |
| P Bonaventure, A Schotte, P Cras, J E Leyse. Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand. Receptors & channels. vol 5. issue 3-4. 1998-08-11. PMID:9606727. |
[3h]alniditan, a new potent non-indole serotonin 5-ht1b/1d agonist, was used as a radioligand to characterize 5-ht1b and 5-ht1d receptor (previously termed 5-ht1d beta and 5-ht1d alpha) in various regions of the human brain. |
1998-08-11 |
2023-08-12 |
human |
| A S Lesage, R Wouters, P Van Gompel, L Heylen, P Vanhoenacker, G Haegeman, W H Luyten, J E Leyse. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605573. |
agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-ht1b and 5-ht1d receptors expressed in various mammalian cell lines. |
1998-07-07 |
2023-08-12 |
human |
| A S Lesage, R Wouters, P Van Gompel, L Heylen, P Vanhoenacker, G Haegeman, W H Luyten, J E Leyse. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. British journal of pharmacology. vol 123. issue 8. 1998-07-07. PMID:9605573. |
we compared the agonistic properties of alniditan, sumatriptan and dihydroergotamine on the cloned human 5-ht1b receptor expressed at 200 fmol mg(-1) protein (bmax) in non-induced l929sa cells, at 740 fmol mg(-1) protein in hek 293 and at 2300 fmol mg(-1) protein in mifnbeta-induced l929sa cells, and on the human cloned 5-ht1d receptor expressed in c6 glioma cells (bmax 780 fmol mg(-1) protein). |
1998-07-07 |
2023-08-12 |
human |
| P Bonaventure, P Voorn, W H Luyten, J E Leyse. 5HT1B and 5HT1D receptor mRNA differential co-localization with peptide mRNA in the guinea pig trigeminal ganglion. Neuroreport. vol 9. issue 4. 1998-06-02. PMID:9559931. |
to investigate the possible role of 5ht1b and/or 5ht1d receptors in controlling neurogenic inflammation, we performed a co-localization study of the mrna for 5ht1b and 5ht1d receptors and of substance p or calcitonin gene-related peptide (cgrp) mrna in the guinea pig trigeminal ganglion using double labelling in situ hybridization techniques. |
1998-06-02 |
2023-08-12 |
Not clear |
| L M Gaster, F E Blaney, S Davies, D M Duckworth, P Ham, S Jenkins, A J Jennings, G F Joiner, F D King, K R Mulholland, P A Wyman, J J Hagan, J Hatcher, B J Jones, D N Middlemiss, G W Price, G Riley, C Roberts, C Routledge, J Selkirk, P D Slad. The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. Journal of medicinal chemistry. vol 41. issue 8. 1998-05-01. PMID:9548813. |
pharmacologically, these two receptors have been differentiated using nonselective chemical tools such as ketanserin and ritanserin, but the absence of truly selective agents has meant that the precise function of the 5-ht1b and 5-ht1d receptors has not been defined. |
1998-05-01 |
2023-08-12 |
human |
| G Maura, M Marcoli, M Tortarolo, G C Andrioli, M Raiter. Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors. British journal of pharmacology. vol 123. issue 1. 1998-03-30. PMID:9484853. |
the effect of sumatriptan was prevented by ketanserin, a drug known to display much higher affinity for recombinant h 5-ht1d than for h 5-ht1b receptors. |
1998-03-30 |
2023-08-12 |
human |
| P Bonaventure, P Voorn, W H Luyten, M Jurzak, A Schotte, J E Leyse. Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience. vol 82. issue 2. 1998-03-11. PMID:9466454. |
detailed mapping of serotonin 5-ht1b and 5-ht1d receptor messenger rna and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. |
1998-03-11 |
2023-08-12 |
Not clear |
| P Bonaventure, P Voorn, W H Luyten, M Jurzak, A Schotte, J E Leyse. Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience. vol 82. issue 2. 1998-03-11. PMID:9466454. |
while 5-ht1b receptor messenger rna was abundant throughout the brain (with highest levels in the striatum, nucleus accumbens, olfactory tubercle, cortex, hypothalamus, hippocampal formation, amygdala, thalamus, dorsal raphe and cerebellum), 5-ht1d receptor messenger rna exhibited a more restricted pattern; it was found mainly in the olfactory tubercle, entorhinal cortex, dorsal raphe, cerebellum, mesencephalic trigeminal nucleus and in the trigeminal ganglion. |
1998-03-11 |
2023-08-12 |
Not clear |
| A M Ismaiel, M Dukat, H Law, R Kamboj, E Fan, D K Lee, L Mazzocco, D Buekschkens, M Teitler, M E Pierson, R A Glenno. 2-(1-Naphthyloxy)ethylamines with enhanced affinity for human 5-HT1D beta (h5-HT1B) serotonin receptors. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435911. |
although the beta-adrenergic antagonist propranolol (1) binds at rodent 5-ht1b serotonin receptors, it displays low affinity (ki > 10,000 nm) for its species homologue 5-ht1d beta (i.e., h5-ht1b) receptors. |
1998-02-13 |
2023-08-12 |
human |
| L Monari, M Mochi, M L Valentino, C Arnaldi, P Cortelli, A De Monte, G Pierangeli, G Prologo, C Scapoli, S Soriani, P Montagn. Searching for migraine genes: exclusion of 290 cM out of the whole human genome. Italian journal of neurological sciences. vol 18. issue 5. 1998-01-30. PMID:9412851. |
we analyzed five chromosomal regions surrounding the candidate genes 5ht1d (1p36.3-34.3), 5ht1b (6q13), 5ht2a (13q14-21), 5ht transporter (17q11.2-12), cacnlb1 (17q11.2-22) and fhm (19p13), using 29 dna polymorphic markers. |
1998-01-30 |
2023-08-12 |
human |
| J Pascual, M E Castro, A Pazo. Central sites of actions of zolmitriptan and sumatriptan: 5HT1B, 5HT1D and 5HT1F receptor distribution. Cephalalgia : an international journal of headache. vol 17. issue 6. 1997-12-09. PMID:9350394. |
central sites of actions of zolmitriptan and sumatriptan: 5ht1b, 5ht1d and 5ht1f receptor distribution. |
1997-12-09 |
2023-08-12 |
Not clear |
| H M Clawges, K M Depree, E M Parker, S G Grabe. Human 5-HT1 receptor subtypes exhibit distinct G protein coupling behaviors in membranes from Sf9 cells. Biochemistry. vol 36. issue 42. 1997-11-20. PMID:9335552. |
the g protein coupling behavior of four human 5-hydroxytryptamine receptor subtypes (5-ht1a, 5-ht1b, 5-ht1d, and 5-ht1e) has been studied in membranes from sf9 cells expressing the individual receptors. |
1997-11-20 |
2023-08-12 |
human |
| A C Trillat, I Malagié, K Scearce, D Pons, M C Anmella, C Jacquot, R Hen, A M Gardie. Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. Journal of neurochemistry. vol 69. issue 5. 1997-11-20. PMID:9349547. |
these data provide in vivo evidence that, in mice, 5-ht1b, but not 5-ht1d, autoreceptors inhibit 5-ht release at nerve terminals located in the frontal cortex and ventral hippocampus. |
1997-11-20 |
2023-08-12 |
mouse |