| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Millson, S J Tepper, A M Rapopor. Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert opinion on pharmacotherapy. vol 1. issue 3. 2001-04-05. PMID:11249525. |
central penetration and increased receptor affinity and selectivity for the neuronal (5-ht1d) receptor also combine to allow for lower total oral dosing (i.e., unit doses of 15 mg or less compared with 50-300 mg doses of sumatriptan) and reduced peripheral exposure to the coronary vasoconstrictor (5-ht1b) receptor. |
2001-04-05 |
2023-08-12 |
Not clear |
| C M Villalón, D Centurión, A Sánchez-López, P De Vries, P Saxen. 5-HT receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 20. issue 12. 2001-03-01. PMID:11216445. |
it was proposed that these receptors could belong to the 5-ht1b, rather than the 5-ht1d, subtype on the basis of their resistance to blockade by a high dose of ritanserin (a potential 5-ht1d receptor antagonist) and the presence of mrna for 5-ht1b(5-ht1d beta) receptors, but not for 5-ht1d(5-ht1d alpha) receptors, in vascular smooth muscle. |
2001-03-01 |
2023-08-12 |
human |
| C M Villalón, D Centurión, A Sánchez-López, P De Vries, P Saxen. 5-HT receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 20. issue 12. 2001-03-01. PMID:11216445. |
with the advent of subtype-selective antagonists it was subsequently shown that external carotid vasoconstriction to 5-ht and sumatriptan is dose-dependently antagonized by the selective 5-ht1b receptor antagonist sb224289 (2,3,6,7-tetrahydro-1'-methyl-5-[2'-methyl-4' (5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-carbonyl] furo [2,3-f] indole-3-spiro-4'-piperidine hydrochloride), whereas the selective 5-ht1d receptor antagonist brl15572 (1-(3-chlorophenyl)-4-[3,3-diphenyl (2-(s,r) hydroxypropanyl) piperazine] hydrochloride) was ineffective. |
2001-03-01 |
2023-08-12 |
human |
| C M Villalón, D Centurión, A Sánchez-López, P De Vries, P Saxen. 5-HT receptors mediating external carotid vasoconstriction in vagosympathectomized dogs. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 20. issue 12. 2001-03-01. PMID:11216445. |
these findings represent the first in vivo evidence showing that vascular constriction induced by 5-ht and sumatriptan is mediated primarily via 5-ht1b, but not 5-ht1d receptors. |
2001-03-01 |
2023-08-12 |
human |
| M Hamon, S Bourgoi. [Role of serotonin and other neuroactive molecules in the physiopathogenesis of migraine. Current hypotheses]. Pathologie-biologie. vol 48. issue 7. 2000-12-04. PMID:11072640. |
in this context, two discoveries have been especially important: 1) these anti-migraine drugs are specifically recognized by three main types of serotonin receptors (5-ht1b, 5-ht1d, and 5-ht1f); and 2) these receptors are present in the meninges, where they are expressed by both smooth muscle cells and/or endothelial cells of the vascular wall and/or the perivascular trigeminal to be deleted axon terminals. |
2000-12-04 |
2023-08-12 |
Not clear |
| D Deleu, Y Hanssen. Current and emerging second-generation triptans in acute migraine therapy: a comparative review. Journal of clinical pharmacology. vol 40. issue 7. 2000-10-19. PMID:10883409. |
the action of 5-hydroxytryptamine (5-ht1b/1d) agonists--so-called triptans--on receptors located in meningeal arteries (5-ht1b) and trigeminovascular fiber endings (5-ht1d) has an inhibitory effect on this neurogenic inflammation. |
2000-10-19 |
2023-08-12 |
Not clear |
| C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international. vol 36. issue 2. 2000-02-25. PMID:10676872. |
effect of chronic paroxetine treatment on 5-ht1b and 5-ht1d autoreceptors in rat dorsal raphe nucleus. |
2000-02-25 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international. vol 36. issue 2. 2000-02-25. PMID:10676872. |
this study reports the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on 5-ht1b and 5-ht1d autoreceptors controlling stimulated 5-ht efflux in slices of rat dorsal raphe nucleus. |
2000-02-25 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international. vol 36. issue 2. 2000-02-25. PMID:10676872. |
5-ht efflux was inhibited by cp 93129 (10 nm-10 microm) and by sumatriptan (1 nm-1 microm) agonists at 5-ht1b and 5-ht1d receptors, respectively. |
2000-02-25 |
2023-08-12 |
rat |
| R J Hargreaves, S L Shephear. Pathophysiology of migraine--new insights. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 26 Suppl 3. 1999-12-07. PMID:10563228. |
sumatriptan, rizatriptan, zolmitriptan naratriptan) are serotonergic agonists that have been shown to act selectively by causing vasoconstriction through 5-ht1b receptors that are expressed in human intracranial arteries and by inhibiting nociceptive transmission through an action at 5-ht1d receptors on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. |
1999-12-07 |
2023-08-12 |
human |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
enhancement of 5-ht1b and 5-ht1d receptor antagonist effects on extracellular 5-ht levels in the guinea-pig brain following concurrent 5-ht1a or 5-ht re-uptake site blockade. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
the aim of the study was to further investigate the autoreceptor roles of the 5-ht1a, 5-ht1b and 5-ht1d receptors in the median vs dorsal raphe nuclei. |
1999-10-25 |
2023-08-12 |
Not clear |
| C Roberts, D F Boyd, D N Middlemiss, C Routledg. Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade. Neuropharmacology. vol 38. issue 9. 1999-10-25. PMID:10471095. |
these data demonstrate that to simultaneously increase extracellular 5-ht in both frontal cortex and dorsal hippocampus of the guinea-pig brain concurrent 5-hta1a, 5-ht1b and 5-ht1d receptor blockade is required. |
1999-10-25 |
2023-08-12 |
Not clear |
| P De Vries, E W Willems, J P Heiligers, C M Villalón, P R Saxen. Investigation of the role of 5-HT1B and 5-HT1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses. British journal of pharmacology. vol 127. issue 2. 1999-10-15. PMID:10385240. |
the results indicate that sumatriptan constricts porcine carotid arteriovenous anastomoses primarily via 5-ht1b, but not via 5-ht1d receptors. |
1999-10-15 |
2023-08-12 |
Not clear |
| R Whale, Z Bhagwagar, P J Cowe. Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors? Psychopharmacology. vol 145. issue 2. 1999-10-14. PMID:10463324. |
effective neuroendocrine probes of 5-ht1b and 5-ht1d receptor function may facilitate investigation of the role of these receptor subtypes in the pathophysiology of depression and the mode of action of antidepressant medication. |
1999-10-14 |
2023-08-12 |
Not clear |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
consequently, the present study using in vivo microdialysis was undertaken to (i) characterize the effects of alpha2d, 5-ht1b and 5-ht1d receptor stimulation or blockade on 5-ht efflux in the fc given the purported regulatory role of these sites on 5-ht release, and (ii) to investigate the ability of risperidone to interfere with these receptors in order to examine their putative role in the facilitatory action or risperidone on cortical 5-ht output. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
the present in vivo biochemical data indicate that the output of 5-ht in the fc is negatively regulated via alpha2d, 5-ht1b and tentatively also via 5-ht1d receptors located in the nerve terminal area. |
1999-10-12 |
2023-08-12 |
rat |
| D N Middlemiss, M Göthert, E Schlicker, C M Scott, J V Selkirk, J Watson, L M Gaster, P Wyman, G Riley, G W Pric. SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor. European journal of pharmacology. vol 375. issue 1-3. 1999-10-08. PMID:10443589. |
a novel compound, sb-236057 (1'-ethyl-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl- 4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperid ine]) has been shown to have high affinity for human 5-hydroxytryptamine1b (5-ht1b) receptors (pki = 8.2) and displays over 75 or more-fold selectivity for the human 5-ht1b receptor over other 5-ht receptors, including the human 5-ht1d receptor, and a range of other receptors, ion channels and enzymes. |
1999-10-08 |
2023-08-12 |
human |
| A Newman-Tancredi, D Cussac, V Audinot, M J Milla. Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 6. 1999-10-04. PMID:10431754. |
actions of roxindole at recombinant human dopamine d2, d3 and d4 and serotonin 5-ht1a, 5-ht1b and 5-ht1d receptors. |
1999-10-04 |
2023-08-12 |
human |
| Z Xie, S P Lee, B F O'Dowd, S R Georg. Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed. FEBS letters. vol 456. issue 1. 1999-09-09. PMID:10452531. |
serotonin 5-ht1b and 5-ht1d receptors form homodimers when expressed alone and heterodimers when co-expressed. |
1999-09-09 |
2023-08-12 |
Not clear |