| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akio Kodama, Takeo Itoh, Kimihiro Komor. Possible roles of 5-HT in vein graft failure due to intimal hyperplasia 5-HT, nitric oxide and vein graft. Surgery today. vol 44. issue 2. 2014-09-29. PMID:23532320. |
recent studies have demonstrated that 5-ht induces vasoconstriction through the activation of 5-ht2a receptors in smooth muscle cells or vasodilatation through the activation of endothelial 5-ht1b receptors in arteries from various animals. |
2014-09-29 |
2023-08-12 |
rat |
| C Cervantes-Durán, H I Rocha-González, V Granados-Sot. Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats. Neuroscience. vol 252. 2014-06-11. PMID:23994595. |
the peripheral pronociceptive effect of fluoxetine was prevented by the 5-ht2a (ketanserin, 3-10 pmol/paw), 5-ht2b (3-(2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1h,3h)-quinazolinedione(+) tartrate, rs-127445, 3-10 pmol/paw), 5-ht2c (8-[5-(2,4-dimethoxy-5-(4-trifluoromethylphenylsulphonamido) phenyl-5-oxopentyl]1,3,8-triazaspiro[4.5] decane-2,4-dione hydrochloride, rs-102221, 3-10 pmol/paw), 5-ht3 (ondansetron, 3-10 nmol/paw), 5-ht4 ([1-[2-methylsulphonylamino ethyl]-4-piperidinyl]methyl 1-methyl-1h-indole-3-carboxylate, gr-113808, 3-100 fmol/paw), 5-ht6 (4-iodo-n-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzene-sulfonamide hydrochloride, sb-258585, 3-10 pmol/paw) and 5-ht7 ((r)-3-(2-(2-(4-methylpiperidin-1-yl) ethyl) pyrrolidine-1-sulfonyl) phenol hydrochloride, sb-269970, 0.3-1 nmol/paw), but not by the 5-ht1a (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate, way-100635, 0.3-1 nmol/paw), 5-ht1b/1d (n-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride hydrate, gr-127935, 0.3-1 nmol/paw), 5-ht1b (1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride, sb-224289, 0.3-1 nmol/paw), 5-ht1d (4-(3-chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride, brl-15572, 0.3-1nmol/paw) nor 5-ht5a ((n-[2-(dimethylamino)ethyl]-n-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride, sb-699551, 1-3 nmol/paw), receptor antagonists. |
2014-06-11 |
2023-08-12 |
rat |
| C Cervantes-Durán, H I Rocha-González, V Granados-Sot. Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats. Neuroscience. vol 252. 2014-06-11. PMID:23994595. |
in marked contrast, the spinal antinociceptive effect of fluoxetine was prevented by the 5-ht1a (way-100635, 0.3-1 nmol/rat), 5-ht1b/1d (gr-127935, 0.3-1 nmol/rat), 5-ht1b (sb-224289, 0.3-1 nmol/rat), 5-ht1d (brl-15572, 0.3-1 nmol/rat) and 5-ht5a (sb-699551, 1-3 nmol/rat), but not by the 5-ht2a (ketanserin, 3-10 pmol/rat), 5-ht2b (rs-127445, 3-10 pmol/rat), 5-ht2c (rs-102221, 3-10 pmol/rat), 5-ht3 (ondansetron, 3-10 nmol/rat), 5-ht4 (gr-113808, 3-100 fmol/rat), 5-ht6 (sb-258585, 3-10 pmol/rat) nor 5-ht7 (sb-269970, 0.3-1 nmol/rat), receptor antagonists. |
2014-06-11 |
2023-08-12 |
rat |
| Shuji Gamoh, Hiroaki Hisa, Ryuichi Yamamot. 5-hydroxytryptamine receptors as targets for drug therapies of vascular-related diseases. Biological & pharmaceutical bulletin. vol 36. issue 9. 2014-04-01. PMID:23995651. |
the vasoconstrictive effects of 5-ht are mediated by 5-ht1b and 5-ht2a receptors located on the membrane of smooth muscle cells, except in the intracranial arteries which constrict only through 5-ht1b receptors. |
2014-04-01 |
2023-08-12 |
Not clear |
| Maiko Kawamura, Masanori Ishiguro, Takashi Nagamine, Kiyohiro Houki. Sarpogrelate dilates cerebral arteries in the absence of exogenous serotonin. Neurologia medico-chirurgica. vol 53. issue 5. 2014-03-28. PMID:23708219. |
vasoconstriction of arteries induced by serotonin (5-hydroxytryptamine: 5-ht) is mediated by 5-ht2a and 5-ht1b receptors localized on smooth muscle. |
2014-03-28 |
2023-08-12 |
rabbit |
| Kürşat Altınbaş, Sinan Guloksuz, Esat Timuçin Ora. Clinical potential of cariprazine in the treatment of acute mania. Psychiatria Danubina. vol 25. issue 3. 2014-02-06. PMID:24048386. |
cariprazine has also moderate affinity for serotonin 5-hydroxytryptophan (5-ht) 1a receptors, high affinity for 5-ht1b receptors with pure antagonism and low affinity for 5-ht2a receptors. |
2014-02-06 |
2023-08-12 |
Not clear |
| Jean-François Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen, Anders Victor Peterse. Modulation of the intrinsic properties of motoneurons by serotonin. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360270. |
the somato-dendritic compartments of motoneurons are densely innervated by serotonergic synaptic boutons and several receptors are expressed in the membrane of motoneurons including 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht2c and 5-ht5a. |
2014-01-27 |
2023-08-12 |
Not clear |
| Pau Celada, M Victoria Puig, Francesc Artiga. Serotonin modulation of cortical neurons and networks. Frontiers in integrative neuroscience. vol 7. 2013-04-30. PMID:23626526. |
5-ht and selective receptor agonists modulate the excitability of cortical neurons and their discharge rate through the activation of several receptor subtypes, of which the 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht3 subtypes play a major role. |
2013-04-30 |
2023-08-12 |
Not clear |
| Gyorgy Bagdy, Gabriella Juhasz, Xenia Gond. A new clinical evidence-based gene-environment interaction model of depression. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 14. issue 4. 2013-04-12. PMID:23269207. |
in the newmood cohort polymorphisms of the genes of the serotonin transporter, 5-ht1a, 5-ht1b and 5-ht2a and endocannabinoid cb1 receptors, tryptophan hydroxylase, creb1, bdnf and girk provide evidence for the involvement of these genes in the development of depression. |
2013-04-12 |
2023-08-12 |
human |
| Toru Takahata, Rammohan Shukla, Tetsuo Yamamori, Jon H Kaa. Differential expression patterns of striate cortex-enriched genes among Old World, New World, and prosimian primates. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 10. 2013-01-31. PMID:22065864. |
a group of 5 genes, occ1, testican-1, testican-2, 5-ht1b, and 5-ht2a, are selectively expressed in layer 4 (4c of brodmann) of striate cortex (visual area v1) of both old world macaques and new world marmoset monkeys. |
2013-01-31 |
2023-08-12 |
monkey |
| Toru Takahata, Rammohan Shukla, Tetsuo Yamamori, Jon H Kaa. Differential expression patterns of striate cortex-enriched genes among Old World, New World, and prosimian primates. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 10. 2013-01-31. PMID:22065864. |
in owl monkeys, the expression of 5-ht2a was significantly reduced by monocular tetrodotoxin injection, while those of occ1 and 5-ht1b were not. |
2013-01-31 |
2023-08-12 |
monkey |
| Elias B Nascimento, João Gabriel T Seniuk, Adriana M Godin, Wallace C Ferreira, Marcela B Dutra, Antônio Carlos P Oliveira, Leandro F S Bastos, Bernd L Fiebich, Márcio M Coelh. Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21699915. |
peripheral 5-ht1b and 5-ht2a receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. |
2011-12-09 |
2023-08-12 |
mouse |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
chronic buspirone treatment decreases 5-ht1b receptor densities and the serotonin transporter but increases the density of 5-ht2a receptors in the bulbectomized rat model of depression: an autoradiographic study. |
2010-10-21 |
2023-08-12 |
rat |
| I Okun, S E Tkachenko, A Khvat, O Mitkin, V Kazey, A V Ivachtchenk. From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. Current Alzheimer research. vol 7. issue 2. 2010-06-21. PMID:19939222. |
within serotonergic receptor subtypes, dimebon shows highest affinity for 5-ht7 (ki=8 nm) and 5-ht6 (ki=34 nm) receptors, with the relative affinity rank-order of 5-ht7 > 5-ht6 > or = 5-ht2a = 5-ht2c > 5-ht1a = 5-ht1b > 5-ht2b=5-ht3. |
2010-06-21 |
2023-08-12 |
Not clear |
| Baseer Yasseen, James L Kennedy, Laurie A Zawertailo, Usoa E Bust. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. Psychiatry research. vol 176. issue 1. 2010-04-12. PMID:20071033. |
rflp analysis of single nucleotide polymorphisms were performed in dopamine (drd1, drd2 and drd3) and serotonin receptor and transporter genes (5httlpr, 5ht1b, 5ht2a, 5ht2c). |
2010-04-12 |
2023-08-12 |
Not clear |
| Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L Alberto Pini, Pasquale Montagna, Pietro Cortell. Lack of association between five serotonin metabolism-related genes and medication overuse headache. The journal of headache and pain. vol 11. issue 1. 2010-03-25. PMID:19936617. |
we performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5htt), serotonin receptor 1a(5-ht1a), serotonin receptor 1b (5-ht1b), serotonin receptor 2a (5-ht2a) and serotonin receptor 6 (5ht6)genes. |
2010-03-25 |
2023-08-12 |
Not clear |
| Elvan Ozal. [The genetics of suicidal behavior]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 20. issue 1. 2009-10-06. PMID:19306130. |
the most important candidate genes include the serotonin transporters (serts), tryptophan hydroxylase (tph), some serotonin receptors (5ht1a, 5ht1b, and 5ht2a), catechol-o-methyltransferase (comt), monoamine oxidase-a (mao-a), and tyrosine hydroxylase (th). |
2009-10-06 |
2023-08-12 |
Not clear |
| Akiya Watakabe, Yusuke Komatsu, Osamu Sadakane, Satoshi Shimegi, Toru Takahata, Noriyuki Higo, Shiro Tochitani, Tsutomu Hashikawa, Tomoyuki Naito, Hironobu Osaki, Hiroshi Sakamoto, Masahiro Okamoto, Ayako Ishikawa, Shin-ichiro Hara, Takafumi Akasaki, Hiromichi Sato, Tetsuo Yamamor. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 8. 2009-09-16. PMID:19056862. |
consistent with the high expression level in v1, clear modulatory effects of 5-ht1b and 5-ht2a receptor agonists on the responses of v1 neurons were observed in in vivo electrophysiological experiments. |
2009-09-16 |
2023-08-12 |
monkey |
| T G Noskova, A V Kazantseva, A E Gareeva, D A Gaĭsina, S U Tuktarova, E K Khusnutdinov. [Association of several polymorphic loci of serotoninergic genes with unipolar depression]. Genetika. vol 45. issue 6. 2009-08-28. PMID:19639876. |
using pcr-rflp analysis, we have conducted a study of polymorphic loci of several genes of this system: c1019g of serotonin receptor 1a gene, (htr1a); a438g of serotonin receptor 2a gene, (htr2a); g861c of serotonin receptor 1b gene, (htr1b); stin2vntr and 5-httlpr of serotonin transporter gene (slc6a4) in patients with unipolar depression among ethnic tatars and russians. |
2009-08-28 |
2023-08-12 |
Not clear |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
in comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pki) for serotonin receptors (5-ht1a [8.6], 5-ht1b [8.4], 5-ht2a [10.2], 5-ht2b [9.8], 5-ht2c [10.5], 5-ht5 [8.8], 5-ht6 [9.6] and 5-ht7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2a [8.9], alpha2b [9.5] and alpha2c [8.9]), dopamine receptors (d1 [8.9], d2 [8.9], d3 [9.4] and d4 [9.0]) and histamine receptors (h1 [9.0] and h2 [8.2]). |
2009-04-03 |
2023-08-12 |
human |