| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joëlle Adrie. [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146953. |
homologous recombination knocking-out genes encoding various proteins involved in 5-ht neurotransmission in the mouse has recently allowed further assesment of the role of the serotonin transporter (5-htt), the monoamine oxidase a (mao-a), and the 5-ht1a, 5-ht1b and 5-ht2a receptors in the regulation of sleep. |
2004-07-19 |
2023-08-12 |
mouse |
| Antonio L López-Figueroa, Camille S Norton, Manuel O López-Figueroa, Denise Armellini-Dodel, Sharon Burke, Huda Akil, Juan F López, Stanley J Watso. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological psychiatry. vol 55. issue 3. 2004-04-01. PMID:14744462. |
serotonin 5-ht1a, 5-ht1b, and 5-ht2a receptor mrna expression in subjects with major depression, bipolar disorder, and schizophrenia. |
2004-04-01 |
2023-08-12 |
human |
| Mark J Millan, Sylvie Veiga, Sylvie Girardon, Mauricette Brocc. Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes. Psychopharmacology. vol 168. issue 4. 2003-12-24. PMID:12721776. |
blockade of serotonin 5-ht1b and 5-ht2a receptors suppresses the induction of locomotor activity by 5-ht reuptake inhibitors, citalopram and fluvoxamine, in nmri mice exposed to a novel environment: a comparison to other 5-ht receptor subtypes. |
2003-12-24 |
2023-08-12 |
mouse |
| H Jørgensen, A Kjaer, U Knigge, M Møller, J Warber. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716407. |
intracerebroventricular infusion of 5-ht agonists selective for the 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptor increased oxytocin mrna in the son and pvn. |
2003-08-13 |
2023-08-12 |
rat |
| H Jørgensen, A Kjaer, U Knigge, M Møller, J Warber. Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides. Journal of neuroendocrinology. vol 15. issue 6. 2003-08-13. PMID:12716407. |
we conclude that stimulation with 5-hydroxytryptophan or 5-ht agonists increases mrna expression of oxytocin in the pvn and the son via stimulation of at least 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors. |
2003-08-13 |
2023-08-12 |
rat |
| H Jørgensen, U Knigge, A Kjaer, M Møller, J Warber. Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Journal of neuroendocrinology. vol 14. issue 10. 2003-06-03. PMID:12372003. |
central administration of 5-ht agonists specific to 5-ht1a, 5-ht1b, 5-ht2a or 5-ht2c receptors increased crh mrna in the pvn by 15-50%, pomc mrna in the anterior pituitary by 15-27% and acth secretion three- to five-fold, whereas a specific 5-ht3 agonist had no effect. |
2003-06-03 |
2023-08-12 |
rat |
| H Jørgensen, U Knigge, A Kjaer, M Møller, J Warber. Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Journal of neuroendocrinology. vol 14. issue 10. 2003-06-03. PMID:12372003. |
it is concluded that 5-ht via activation of 5-ht1a, 5-ht2a, 5-ht2c and possibly also 5-ht1b receptors increases the synthesis of crh in the pvn and pomc in the anterior pituitary lobe, which results in increased acth secretion. |
2003-06-03 |
2023-08-12 |
rat |
| R Nicholson, J Small, A K Dixon, D Spanswick, K Le. Serotonin receptor mRNA expression in rat dorsal root ganglion neurons. Neuroscience letters. vol 337. issue 3. 2003-03-28. PMID:12536038. |
within drg neurons, mrnas for 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht3b and 5-ht4 receptors were readily detected in small (<25 microm), medium (25-45 microm) and large (>45 microm) diameter neurons. |
2003-03-28 |
2023-08-12 |
rat |
| A Menese. Could the 5-HT1B receptor inverse agonism affect learning consolidation? Neuroscience and biobehavioral reviews. vol 25. issue 2. 2001-07-05. PMID:11323083. |
evidence indicates that sb-224289 (a 5-ht1b receptor inverse agonist) post-training injection facilitated learning consolidation in an associative autoshaping learning task, this effect was partially reversed by gr 127935 (a 5-ht1b/1d receptor antagonist), but unaffected by mdl 100907 (a 5-ht2a receptor antagonist) or ketanserin (a 5-ht1d/2a/7 receptor antagonist) at low doses. |
2001-07-05 |
2023-08-12 |
Not clear |
| M C Buhot, S Martin, L Seg. Role of serotonin in memory impairment. Annals of medicine. vol 32. issue 3. 2000-08-15. PMID:10821328. |
a better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands, such as 5-ht1a, 5-ht1b, 5-ht2a receptor antagonists, and new molecular tools, such as gene knock-out mice, especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically. |
2000-08-15 |
2023-08-12 |
mouse |
| K Miyata, H Shimokawa, T Higo, T Yamawaki, N Katsumata, T Kandabashi, E Tanaka, Y Takamura, K Yogo, K Egashira, A Takeshit. Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model. Journal of cardiovascular pharmacology. vol 35. issue 2. 2000-03-13. PMID:10672864. |
two weeks after the procedure, angiographic study was performed, followed by binding assay for 5-ht1b and 5-ht2a serotonergic receptors and reverse transcription-polymerase chain reaction (rt-pcr) analysis for mrna of those receptors. |
2000-03-13 |
2023-08-12 |
Not clear |
| I Morecroft, R P Heeley, H M Prentice, A Kirk, M R MacLea. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. British journal of pharmacology. vol 128. issue 3. 1999-12-22. PMID:10516655. |
these findings suggest that a heterogeneous population of 5-ht2a and 5-ht1b receptors co-exist in human small muscular pulmonary arteries but that the 5-ht1b receptor mediates 5-ht-induced vasoconstriction at physiological and pathophysiological concentrations of 5-ht. |
1999-12-22 |
2023-08-12 |
human |
| S Kato, H Kumamoto, M Hirano, H Akiyama, N Kanek. Expression of 5-HT2A and 5-HT1B receptor mRNA in blood vessels. Molecular and cellular biochemistry. vol 199. issue 1-2. 1999-11-30. PMID:10544952. |
expression of two subtypes of 5-hydroxytryptamine (5-ht) receptors, 5-ht1b and 5-ht2a, was investigated in normal rat arteries (abdominal aorta) and veins (inferior vena cava) by the quantitative reverse transcription-polymerase chain reaction (rt-pcr). |
1999-11-30 |
2023-08-12 |
rat |
| A Sparatore, M Goegan, A Cagnotto, F Sparator. 2-[4-[3-(4-aryl/heteroaryl-1-piperazinyl)propoxy]phenyl]-2H- benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors. Farmaco (Societa chimica italiana : 1989). vol 54. issue 6. 1999-11-10. PMID:10443019. |
the synthesized compounds were able to bind on some serotonin (5-ht1a, 5-ht2a) and dopamine (d2, d3) receptors, while displaying poor or no affinity for 5-ht1b, 5-ht2c, 5-ht3, and 5-ht4 subtypes. |
1999-11-10 |
2023-08-12 |
mouse |
| F Lovren, X F Li, J Lytton, C Triggl. Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455272. |
the results suggest that the hua has a functional population of 5-ht1b and 5-ht2a receptor subtypes which are involved in the contractile response to 5-ht. |
1999-10-05 |
2023-08-12 |
human |
| J A Terrón, A Falcón-Ner. Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401550. |
blockade of 5-ht1b 1d and 5-ht2a receptors with gr127935 (1 microm) and ketanserin (0.1 microm), respectively, antagonized the vasoconstrictor component of the response and unmasked a concentration-dependent relaxation to 5-ht, 5-ct and 5-methoxytryptamine; sumatriptan and alpha-methyl-5-ht remained inactive as relaxant agonists. |
1999-09-01 |
2023-08-12 |
dog |
| K E Heslop, G Curzo. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology. vol 38. issue 6. 1999-08-25. PMID:10465692. |
effect of reserpine on behavioural responses to agonists at 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht2c receptor subtypes. |
1999-08-25 |
2023-08-12 |
rat |
| K E Heslop, G Curzo. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology. vol 38. issue 6. 1999-08-25. PMID:10465692. |
head shakes on activating 5-ht2a receptors by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and two effects of activating 5-ht2c receptors by 1-(3-chlorophenyl) piperazine (mcpp) were significantly increased (hypophagia, anxiety) and a third effect, hypolocomotion tended to increase but hypophagia on activating postsynaptic 5-ht1b receptors by cp-94, 253 was significantly attenuated. |
1999-08-25 |
2023-08-12 |
rat |
| H H Pertz, A M Brown, T L Gager, A J Kauman. Simple O-acylated derivatives of lysergol and dihydrolysergol-I: synthesis and interaction with 5-HT2A, 5-HT2C and 5-HT1B receptors, and alpha1 adrenergic receptors. The Journal of pharmacy and pharmacology. vol 51. issue 3. 1999-07-28. PMID:10344634. |
a series of simple o-acylated derivatives of the naturally occurring clavine alkaloids lysergol and dihydrolysergol-i were synthesized and tested in-vitro for their ability to interact with 5-ht2a receptors in rat tail artery, 5-ht2c receptors in piglet choroid plexus, 5-ht1b receptors in guinea-pig iliac artery and alpha1-adrenergic receptors in rat aorta. |
1999-07-28 |
2023-08-12 |
rat |
| S Maurel, J De Vry, R Schreibe. 5-HT receptor ligands differentially affect operant oral self-administration of ethanol in the rat. European journal of pharmacology. vol 370. issue 3. 1999-07-16. PMID:10334495. |
the present study evaluated the effects of the selective serotonin (5-hydroxyhyptamine; 5-ht) reuptake inhibitor, fluoxetine, the 5-ht1b receptor agonist, tetrahydro-4-pyridyl[3,2-b]pyridine, cp-94,253 the preferential 5-ht2a receptor agonist, 1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane, doi and the mixed 5-ht2c/1b receptor agonist, 1-(3-chlorophenyl)piperazine, mcpp, on oral ethanol (10% v/v) self-administration in a two-lever, fixed-ratio:1, water vs. ethanol choice procedure in the rat. |
1999-07-16 |
2023-08-12 |
rat |