| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
asenapine behaved as a potent antagonist (pkb) at 5-ht1a (7.4), 5-ht1b (8.1), 5-ht2a (9.0), 5-ht2b (9.3), 5-ht2c (9.0), 5-ht6 (8.0), 5-ht7 (8.5), d2 (9.1), d3 (9.1), alpha2a (7.3), alpha2b (8.3), alpha2c (6.8) and h1 (8.4) receptors. |
2009-04-03 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Naoko Tanaka, Eisaku Nakamura, Masamichi Ohkura, Masachika Kuwabara, Atsushi Yamashita, Toshio Onitsuka, Yujiro Asada, Hiroaki Hisa, Ryuichi Yamamot. Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery. Clinical and experimental pharmacology & physiology. vol 35. issue 7. 2008-10-20. PMID:18430065. |
both 5-hydroxytryptamine 5-ht2a and 5-ht1b receptors are involved in the vasoconstrictor response to 5-ht in the human isolated internal thoracic artery. |
2008-10-20 |
2023-08-12 |
human |
| Henrik Stig Jørgense. Studies on the neuroendocrine role of serotonin. Danish medical bulletin. vol 54. issue 4. 2008-02-14. PMID:18208678. |
the acth response to 5-ht is mediated via 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors and an involvement of the 5-ht4, 5-ht5 and 5-ht7 receptors is proposed. |
2008-02-14 |
2023-08-12 |
rat |
| P Heiser, A Dempfle, S Friedel, K Konrad, A Hinney, H Kiefl, S Walitza, T Bettecken, K Saar, M Linder, A Warnke, B Herpertz-Dahlmann, H Schäfer, H Remschmidt, J Hebebran. Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 4. 2007-10-04. PMID:17093889. |
the aim of this study was to investigate seven genetic variants in three genes (serotonin transporter (5-htt), serotonin receptor 1b (5-htr1b) and serotonin receptor 2a (5-htr2a)), which have previously been shown to be associated with adhd. |
2007-10-04 |
2023-08-12 |
Not clear |
| Valérie Kayser, Iskander Elfihri Elfassi, Bertrand Aubel, Maxette Melfort, David Julius, Jay A Gingrich, Michel Hamon, Sylvie Bourgoi. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain. vol 130. issue 3. 2007-08-09. PMID:17250964. |
pain behaviors of mutants which do not express 5-ht1a, 5-ht1b, 5-ht2a or 5-ht3a receptors, or lacking the 5-ht transporter, compared to paired wild-type mice of the same genetic background, were examined using validated tests based on different sensory modalities. |
2007-08-09 |
2023-08-12 |
mouse |
| Damiaan Denys, Filip Van Nieuwerburgh, Dieter Deforce, Herman G M Westenber. Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial. The Journal of clinical psychiatry. vol 68. issue 5. 2007-05-21. PMID:17503984. |
the purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-htt), 5-ht1b, and 5-ht2a receptor genes affect the efficacy of sri treatment in ocd. |
2007-05-21 |
2023-08-12 |
Not clear |
| K D Alex, E A Pehe. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacology & therapeutics. vol 113. issue 2. 2007-04-19. PMID:17049611. |
several subtypes, including the 5-ht1a, 5-ht1b, 5-ht2a, 5-ht3 and 5-ht4 receptors, act to facilitate da release, while the 5-ht2c receptor mediates an inhibitory effect of 5-ht on da release. |
2007-04-19 |
2023-08-12 |
Not clear |
| Agnieszka Słopién, Monika Dmitrzak-Weglarz, Filip Rybakowski, Andrzej Rajewski, Joanna Hause. [Genetic background of ADHD: population studies, genes of the catecholamine system]. Psychiatria polska. vol 40. issue 1. 2007-03-20. PMID:16756025. |
in other articles authors describe abnormalities of the serotonergic system, such as the polymorphism of the serotonin transporter gene (5htt/sert), serotonin receptors genes 5ht2a and 5ht1b in the development ofadhd. |
2007-03-20 |
2023-08-12 |
Not clear |
| Alberto J Kaumann, Finn Olav Lev. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacology & therapeutics. vol 111. issue 3. 2006-12-04. PMID:16960982. |
acute vascular constriction by 5-ht is usually shared by 5-ht1b and 5-ht2a receptors, except in intracranial arteries which constrict only through 5-ht1b receptors. |
2006-12-04 |
2023-08-12 |
human |
| Alberto J Kaumann, Finn Olav Lev. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacology & therapeutics. vol 111. issue 3. 2006-12-04. PMID:16960982. |
both 5-ht1b and 5-ht2a receptors can mediate coronary artery spasm but only 5-ht1b receptors appear involved in coronary spasm of patients treated with triptans or with prinzmetal angina. |
2006-12-04 |
2023-08-12 |
human |
| Anna M S Kindlundh-Högberg, Per Svenningsson, Helgi B Schiöt. Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain. Neuropharmacology. vol 51. issue 4. 2006-11-06. PMID:16820177. |
we used real-time rt-pcr to determine the gene expression of serotonin 5ht1a, 5ht1b, 5ht2a, 5ht2c, 5ht3, 5ht6 receptors and dopamine d1, d2, d3 receptors in seven brain nuclei. |
2006-11-06 |
2023-08-12 |
rat |
| Damiaan Denys, Filip Van Nieuwerburgh, Dieter Deforce, Herman G M Westenber. Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. Journal of affective disorders. vol 91. issue 1. 2006-10-04. PMID:16443280. |
the purpose of the present study was to investigate the role of the serotonin transporter (5-htt) and serotonin 5-ht1b and 5-ht2a receptor genes in ocd. |
2006-10-04 |
2023-08-12 |
Not clear |
| Tamiko Tachibana, Makoto Endoh, Naoki Fujiwara, Tokio Naw. Receptors and transporter for serotonin in Merkel cell-nerve endings in the rat sinus hair follicle. An immunohistochemical study. Archives of histology and cytology. vol 68. issue 1. 2005-07-22. PMID:15827375. |
for this purpose, we used antibodies for the 5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c and 5-ht3 receptors, and for the 5-ht transporter, as well as antibodies for cytokeratin 20 (as a marker of merkel cells) and neurofilament h (a marker of type i sensory nerve terminals). |
2005-07-22 |
2023-08-12 |
rat |
| Kuo-Pyng Shen, Chaw-Chi Chiu, Sheue-Jiun Chen, Ing-Jun Chen, Bin-Nan W. Hypotensive effects of eugenosedin-A with serotonin, alpha- and beta-adrenoceptor antagonistic activities in spontaneously hypertensive and normotensive rats. Pharmacology. vol 71. issue 2. 2005-05-19. PMID:15118348. |
finally, we suggest that the hypotensive effects of eugenosedin-a can be attributed to its multiple actions on the blockade of 5-ht1b, 5-ht2a, alpha and beta1 receptors in both wky and shr strains. |
2005-05-19 |
2023-08-12 |
rat |
| Aaron J Bobb, Anjene M Addington, Ellen Sidransky, Michele C Gornick, Jason P Lerch, Deanna K Greenstein, Liv S Clasen, Wendy S Sharp, Gale Inoff-Germain, Fabienne Wavrant-De Vrièze, Mauricio Arcos-Burgos, Richard E Straub, John A Hardy, F Xavier Castellanos, Judith L Rapopor. Support for association between ADHD and two candidate genes: NET1 and DRD1. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 134B. issue 1. 2005-05-09. PMID:15717291. |
dna from 163 adhd probands, 192 parents, and 129 healthy controls was used to investigate possible associations between adhd and polymorphisms in 12 previously studied candidate genes (5-ht1b, 5-ht2a, 5-ht2c, adra2a, chrna4, comt, dat1, drd1, drd4, drd5, net1, and snap-25). |
2005-05-09 |
2023-08-12 |
mouse |
| Masashi Fujita, Tetsuo Minamino, Shoji Sanada, Hiroshi Asanuma, Akio Hirata, Hisakazu Ogita, Ken-ichiro Okada, Osamu Tsukamoto, Seiji Takashima, Hitonobu Tomoike, Koichi Node, Masatsugu Hori, Masafumi Kitakaz. Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts. Journal of molecular and cellular cardiology. vol 37. issue 6. 2005-04-19. PMID:15572052. |
selective blockade of serotonin 5-ht2a receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-ht1b receptor in hypoperfused canine hearts. |
2005-04-19 |
2023-08-12 |
Not clear |
| Masashi Fujita, Tetsuo Minamino, Shoji Sanada, Hiroshi Asanuma, Akio Hirata, Hisakazu Ogita, Ken-ichiro Okada, Osamu Tsukamoto, Seiji Takashima, Hitonobu Tomoike, Koichi Node, Masatsugu Hori, Masafumi Kitakaz. Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts. Journal of molecular and cellular cardiology. vol 37. issue 6. 2005-04-19. PMID:15572052. |
serotonin (5-hydroxytryptamine [5-ht]), which induces vasoconstriction via 5-ht2a receptors in smooth muscle cells and vasodilation through activating nitric oxide (no) synthase (nos) via 5-ht1b receptors in endothelial cells, possesses divergent effects on regulating vascular tone. |
2005-04-19 |
2023-08-12 |
Not clear |
| Elisabeth Marcos, Elie Fadel, Olivier Sanchez, Marc Humbert, Philippe Dartevelle, Gerald Simonneau, Michel Hamon, Serge Adnot, Saadia Eddahib. Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circulation research. vol 94. issue 9. 2004-10-07. PMID:15059929. |
we investigated the expression and role of the 5-ht transporter (5-htt) and 5-ht1b, 5-ht2a, and 5-ht2b receptors in lungs and isolated pa-smcs from patients with primary ph (n=14), pulmonary veno-occlusive disease (n=4), or secondary ph (sph, n=8) and nonpulmonary hypertensive control subjects. |
2004-10-07 |
2023-08-12 |
human |
| Guglielmina Froldi, Patrizia Nicoletti, Laura Caparrotta, Eugenio Ragazz. 5-HT receptors mediating contraction in the rat-tail artery. Advances in experimental medicine and biology. vol 527. 2004-09-02. PMID:15206788. |
the data indicate that vasoconstriction induced by 5-ht is mainly dependent on 5-ht2a receptors; however, 5-ht1b receptors are also present in rat-tail artery. |
2004-09-02 |
2023-08-12 |
Not clear |