| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Balasubramanian Lakshmi, Chandrasekaran Sinduja, Govind Archunan, Narayanaswamy Srinivasa. Ramachandran analysis of conserved glycyl residues in homologous proteins of known structure. Protein science : a publication of the Protein Society. vol 23. issue 6. 2015-01-09. PMID:24687432. |
in 189 alignment positions, the conserved glycyl residues adopt (φ, ψ) values which are disallowed for ala. in-silico mutation of these gly residues to ala almost always results in steric hindrance involving c(β) atom of ala as one would expect by comparing ramachandran maps for ala and gly. |
2015-01-09 |
2023-08-12 |
Not clear |
| M M Guzyk, Iu T Sergiichuk, K O Dyakun, L V Yanitska, T M Kuchmerovsk. Effect of nicotinamide on amino acids content in bone collagen depending on biological availability of vitamins in diabetic rats. Ukrainian biochemical journal. vol 86. issue 4. 2015-01-08. PMID:25509193. |
diabetes was found to significantly reduce bone collagen contents of o-pro, gly, ala, o-lys and pro, whereas lys, his, arg, glu, thr, leu, phe contents were elevated (p < 0.05). |
2015-01-08 |
2023-08-13 |
rat |
| Shalon E Babbitt, Brian San Francisco, Deanna L Mendez, Gudrun S Lukat-Rodgers, Kenton R Rodgers, Eric C Bretsnyder, Robert G Kran. Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-His. The Journal of biological chemistry. vol 289. issue 42. 2014-12-22. PMID:25170082. |
substitutions of his-19 in cytochrome c to seven other residues (gly, ala, met, arg, lys, cys, and tyr) were used with various approaches to establish other roles played by his-19. |
2014-12-22 |
2023-08-13 |
human |
| Eline K M Lebbe, Steve Peigneur, Ward Brullot, Thierry Verbiest, Jan Tytga. Ala-7, His-10 and Arg-12 are crucial amino acids for activity of a synthetically engineered μ-conotoxin. Peptides. vol 53. 2014-12-18. PMID:23871692. |
electrophysiological recordings indicated that an ala to gly mutation at position 7 increased ic50-values from the nanomolar range to the micromolar range. |
2014-12-18 |
2023-08-12 |
Not clear |
| Bosko M Stojanovski, Gregory A Hunter, Martina Jahn, Dieter Jahn, Gloria C Ferreir. Unstable reaction intermediates and hysteresis during the catalytic cycle of 5-aminolevulinate synthase: implications from using pseudo and alternate substrates and a promiscuous enzyme variant. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24920668. |
5-aminolevulinate (ala), an essential metabolite in all heme-synthesizing organisms, results from the pyridoxal 5'-phosphate (plp)-dependent enzymatic condensation of glycine with succinyl-coa in non-plant eukaryotes and α-proteobacteria. |
2014-12-16 |
2023-08-13 |
Not clear |
| Bosko M Stojanovski, Gregory A Hunter, Martina Jahn, Dieter Jahn, Gloria C Ferreir. Unstable reaction intermediates and hysteresis during the catalytic cycle of 5-aminolevulinate synthase: implications from using pseudo and alternate substrates and a promiscuous enzyme variant. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24920668. |
the predicted chemical mechanism of this ala synthase (alas)-catalyzed reaction includes a short-lived glycine quinonoid intermediate and an unstable 2-amino-3-ketoadipate intermediate. |
2014-12-16 |
2023-08-13 |
Not clear |
| Wei Pu, Jiuzhou Chen, Cunmin Sun, Ning Chen, Jibin Sun, Ping Zheng, Yanhe M. [Deficiency of succinic dehydrogenase or succinyl-coA synthetase enhances the production of 5-aminolevulinic acid in recombinant Escherichia coli]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 29. issue 10. 2014-11-03. PMID:24432664. |
in the previous investigations on ala production with recombinant escherichia coli expressing heterogenous c4 pathway gene, lb media supplemented with glucose and ala precursors succinate and glycine is widely used, leading to high production cost. |
2014-11-03 |
2023-08-12 |
Not clear |
| Muthuraj Muthaiah, Sridharan Jagadeesan, Nisha Ayalusamy, Manupriya Sreenivasan, Sambamurthy Sangamesvara Prabhu, Usharani Muthuraj, Kamatchiyammal Senthilkumar, Saroja Veerappa. Molecular epidemiological study of pyrazinamide-resistance in clinical isolates of mycobacterium tuberculosis from South India. International journal of molecular sciences. vol 11. issue 7. 2014-10-28. PMID:20717529. |
we found two isolates with hitherto unreported mutation at amino acid 26 (ala-->gly) of pnca. |
2014-10-28 |
2023-08-12 |
Not clear |
| Sang-Mo Kang, Ramalingam Radhakrishnan, Young-Hyun You, Gil-Jae Joo, In-Jung Lee, Ko-Eun Lee, Jin-Ho Ki. Phosphate Solubilizing Bacillus megaterium mj1212 Regulates Endogenous Plant Carbohydrates and Amino Acids Contents to Promote Mustard Plant Growth. Indian journal of microbiology. vol 54. issue 4. 2014-10-16. PMID:25320441. |
in the biochemical analysis revealed that chlorophyll, sucrose, glucose, fructose and amino acids (asp, thr, ser, glu, gly, ala, cys, val, met, ilu, leu, tyr, phe, lys, his, arg and pro) were higher in b. megaterium mj1212 treated plants, when compared to their control. |
2014-10-16 |
2023-08-13 |
Not clear |
| Daniel L Reger, Jacob J Horger, Mark D Smith, Gary J Long, Fernande Grandjea. Homochiral, helical supramolecular metal-organic frameworks organized by strong π · · · π stacking interactions: single-crystal to single-crystal transformations in closely packed solids. Inorganic chemistry. vol 50. issue 2. 2014-10-08. PMID:21141941. |
enantiopure, trifunctional carboxylate ligands synthesized by linking the strong π · · · π stacking 1,8-naphthalimide supramolecular synthon to three naturally occurring amino acids using the azide/alkyne click reaction have been prepared [amino acid = glycine (l(gly)(-)), alanine (l(ala)(-)), and serine (l(ser)(-))]. |
2014-10-08 |
2023-08-12 |
Not clear |
| Xiaoyan Liu, Ling Li, Yuqiu Wang, Hui Yan, Xiaofeng Ma, Peng George Wang, Lianwen Zhan. A peptide panel investigation reveals the acceptor specificity of O-GlcNAc transferase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 8. 2014-10-06. PMID:24760753. |
the preferred amino acids were pro > ala > gly at position -2, ala > thr > val > lys > pro at position -1, and ala > gly > arg > glu at position +2. |
2014-10-06 |
2023-08-13 |
cattle |
| Xiaoyan Liu, Ling Li, Yuqiu Wang, Hui Yan, Xiaofeng Ma, Peng George Wang, Lianwen Zhan. A peptide panel investigation reveals the acceptor specificity of O-GlcNAc transferase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 8. 2014-10-06. PMID:24760753. |
altogether, these findings suggested that a substrate (peptide or protein) with pro, ala at position -2, and/or val, ala, thr, ser at position -1, and/or ala, ser, pro, thr, gly at position +2 would have more chances for o-glcnacylation. |
2014-10-06 |
2023-08-13 |
cattle |
| Heike Thiel, Mark Varrelman. Identification of a new PSII target site psbA mutation leading to D1 amino acid Leu218 Val exchange in the Chenopodium album D1 protein and comparison to cross-resistance profiles of known modifications at positions 251 and 264. Pest management science. vol 70. issue 2. 2014-09-30. PMID:23576399. |
resistance of chenopodium album to triazinones and triazines can be caused by two amino acid exchanges, serine-264-glycine (ser(264) gly) and alanine-251-valine (ala(251) val), in the chloroplast d1 protein. |
2014-09-30 |
2023-08-12 |
Not clear |
| Heike Thiel, Mark Varrelman. Identification of a new PSII target site psbA mutation leading to D1 amino acid Leu218 Val exchange in the Chenopodium album D1 protein and comparison to cross-resistance profiles of known modifications at positions 251 and 264. Pest management science. vol 70. issue 2. 2014-09-30. PMID:23576399. |
a greenhouse experiment has been performed to compare the resistance profile of the newly identified biotype with biotypes that carry the ser(264) gly and ala(251) val mutations. |
2014-09-30 |
2023-08-12 |
Not clear |
| Pratap Parida, R N S Yadav, Kishore Sarma, Lalit Mohan Nainwa. Design, virtual screening and docking study of novel NS3 inhibitors by targeting protein-protein interacting sites of dengue virus - a novel approach. Current pharmaceutical biotechnology. vol 14. issue 11. 2014-09-25. PMID:24372240. |
the protein-protein docking showed that the aminoacid residues of ns3 which were interacting with nrbp were found to be ala 325, asp 324, phe 326, asp 335, glu 336, glu 328, asp 485, gln 478, arg 459, gly 446 and leu 480. |
2014-09-25 |
2023-08-12 |
human |
| Katsutaka Oishi, Saori Yamamoto, Nanako Itoh, Koyomi Miyazaki, Tadashi Nemoto, Yasukazu Nakakita, Hirotaka Kaned. Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24971530. |
nocturnal increases in branched-chain amino acids such as ile, leu, and val were further augmented in csd mice, while daytime increases in gly, ala, ser, thr, lys, arg, his, tyr, met, cys, glu, and asn were significantly attenuated. |
2014-09-21 |
2023-08-13 |
mouse |
| Helen M Parry, Alex S F Doney, Colin N A Palmer, Chim C Lan. State of play of pharmacogenetics and personalized medicine in heart failure. Cardiovascular therapeutics. vol 31. issue 6. 2014-09-19. PMID:23480579. |
single-nucleotide polymorphisms (snps) potentially influencing drug response include the arg 389 gly variant and the ser 49 gly variant in the beta-1 adrenergic receptor, the arg 16 gly, gln 27 glu, and thr 164 ile polymorphisms within the beta-2 adrenergic receptor, an insertion at the 287th base pair in the angiotensin-converting enzyme and the gly 264 ala mutation in the sodium chloride co-transporter. |
2014-09-19 |
2023-08-12 |
Not clear |
| Neta Sal-Man, Doron Gerber, Yechiel Sha. Proline localized to the interaction interface can mediate self-association of transmembrane domains. Biochimica et biophysica acta. vol 1838. issue 9. 2014-09-11. PMID:24841754. |
here, we evaluated statistically the frequency of appearance, and experimentally the contribution of proline, compared to other hydrophobic amino acids (gly, ala, val, leu, ile, and met), with regard to tmd-tmd self-assembly. |
2014-09-11 |
2023-08-13 |
Not clear |
| Ameneh Gholami, Travis D Fridge. The unimolecular chemistry of [Zn(amino acid)2-H]+ in the gas phase: H2 elimination when the amino acid is a secondary amine. Physical chemistry chemical physics : PCCP. vol 16. issue 7. 2014-09-04. PMID:24402409. |
in contrast, [zn(gly-h)(gly)](+) and [zn(ala-h)(ala)](+) were found to lose h2o as their primary fragmentation route with no dehydrogenation observed. |
2014-09-04 |
2023-08-12 |
Not clear |
| Vinod K Kannaujiya, Rajesh P Rastogi, Rajeshwar P Sinh. GC constituents and relative codon expressed amino acid composition in cyanobacterial phycobiliproteins. Gene. vol 546. issue 2. 2014-09-04. PMID:24933001. |
the fluctuation in amino acids such as arg, ala, his, asp, gly, leu and glu in α and β subunits was observed at g1c1 position; however, fluctuation in other amino acids such as ser, thr, cys and trp was observed at g2c2 position. |
2014-09-04 |
2023-08-13 |
Not clear |