| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian San Francisco, Eric C Bretsnyder, Kenton R Rodgers, Robert G Kran. Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF. Biochemistry. vol 50. issue 50. 2012-02-13. PMID:22066495. |
exogeneous imidazole is able to correct cytochrome c maturation for his261 and his491 substitutions with small side chains (ala or gly), suggesting that a "cavity" is formed in these ccmf mutants in which imidazole binds and acts as a functional ligand to the b-heme. |
2012-02-13 |
2023-08-12 |
Not clear |
| P L Nilantha Lakshman, Shinjiro Tachibana, Hirohide Toyama, Toki Taira, Toshihiko Suganuma, Worapot Suntornsuk, Masaaki Yasud. Application of an acid proteinase from Monascus purpureus to reduce antigenicity of bovine milk whey protein. Journal of industrial microbiology & biotechnology. vol 38. issue 9. 2012-02-09. PMID:21298320. |
mpuap hydrolyzed primarily five peptide bonds, gln(4)-his(5), his(10)-leu(11), ala(14)-leu(15), gly(23)-phe(24) and phe(24)-phe(25) in the oxidized insulin b-chain. |
2012-02-09 |
2023-08-12 |
cattle |
| Giuseppe Zagotto, Antonio Ricci, Elena Vasquez, Andrea Sandoli, Silvia Benedetti, Manlio Palumbo, Claudia Siss. Tuning G-quadruplex vs double-stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates. Bioconjugate chemistry. vol 22. issue 10. 2012-02-07. PMID:21905741. |
starting from an anthracenedione system symmetrically functionalized with n-terminal lysyl residues, we incremented the length of side chains by introducing a gly, ala, or phe spacer, characterized by different flexibility, lipophilicity, and bulkiness. |
2012-02-07 |
2023-08-12 |
Not clear |
| Milena Gusella, Laura Bertolaso, Caterina Bolzonella, Felice Pasini, Roberto Padrin. Frequency of uridine monophosphate synthase Gly(213)Ala polymorphism in Caucasian gastrointestinal cancer patients and healthy subjects, investigated by means of new, rapid genotyping assays. Genetic testing and molecular biomarkers. vol 15. issue 10. 2012-02-03. PMID:21631301. |
frequency of uridine monophosphate synthase gly(213)ala polymorphism in caucasian gastrointestinal cancer patients and healthy subjects, investigated by means of new, rapid genotyping assays. |
2012-02-03 |
2023-08-12 |
human |
| Camilla Höglund, Nina Sneitz, Anna Radominska-Pandya, Liisa Laakonen, Moshe Fine. Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens. Steroids. vol 76. issue 13. 2012-02-03. PMID:21846474. |
in order to further understand and extend our earlier findings with phenylalanines 90 and 93 of ugt1a10, we have replaced each of them with gly, ala, val, leu, ile or tyr, and tested the activity of the resulting 12 mutants toward eight different substrates. |
2012-02-03 |
2023-08-12 |
human |
| Changzeng Wu, Jianji Wang, Huiyong Wang, Yuanchao Pei, Zhiyong L. Effect of anionic structure on the phase formation and hydrophobicity of amino acid ionic liquids aqueous two-phase systems. Journal of chromatography. A. vol 1218. issue 48. 2012-01-18. PMID:22024343. |
in this work, amino acid ionic liquids 1-butyl-3-methylimidazolium l-serine ([c(4)mim][ser]), 1-butyl-3-methylimidazolium glycine ([c(4)mim][gly]), 1-butyl-3-methylimidazolium l-alanine ([c(4)mim][ala]) and 1-butyl-3-methylimidazolium l-leucine ([c(4)mim][leu]) have been synthesized. |
2012-01-18 |
2023-08-12 |
Not clear |
| Fred F Damberger, Barbara Christen, Daniel R Pérez, Simone Hornemann, Kurt Wüthric. Cellular prion protein conformation and function. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 42. 2011-12-30. PMID:21987789. |
here, it is shown that this local dynamic conformational polymorphism in mouse prp(c) is eliminated through exchange of tyr169 by ala or gly, but is preserved after exchange of tyr 169 with phe. |
2011-12-30 |
2023-08-12 |
mouse |
| Christian Jansen, Katharina Hofheinz, Robert Vogel, Jana Roffeis, Monika Anton, Pallu Reddanna, Hartmut Kuhn, Matthias Walthe. Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept. The Journal of biological chemistry. vol 286. issue 43. 2011-12-15. PMID:21880725. |
animal lipoxygenases (loxs) are classified according to their specificity of arachidonic acid oxygenation, and previous sequence alignments suggested that s-loxs contain a conserved ala at a critical position at the active site but r-loxs carry a gly instead. |
2011-12-15 |
2023-08-12 |
mouse |
| Svetlana V Antonyuk, Neil Rustage, Christine A Petersen, Jamie L Arnst, Derren J Heyes, Raman Sharma, Neil G Berry, Nigel S Scrutton, Robert R Eady, Colin R Andrew, S Samar Hasnai. Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 38. 2011-12-12. PMID:21900609. |
substitution of leu by ala or gly (structures determined at 1.03 and 1.04 Å resolutions) resulted in a haem site that binds co in the linear mode only and where no significant change in redox potential is observed. |
2011-12-12 |
2023-08-12 |
Not clear |
| S Mehata, G C Dua. Molecular mechanism of multi-drug resistance in Shigella isolates from rural China. Nepal Medical College journal : NMCJ. vol 13. issue 1. 2011-11-15. PMID:21991697. |
nucleotide sequencing showed mutations in three positionsÿcodon 6 ( delation of c), 319 (ala gly) and 374 (addition of c). |
2011-11-15 |
2023-08-12 |
Not clear |
| Joanna Griffin, Paul C Enge. An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. Enzyme research. vol 2011. 2011-11-10. PMID:21876794. |
at position 242, "p6" of the "core fingerprint," where nad(+)- and nadp(+)-dependent enzymes normally have gly or ala, respectively, clostridial gdh already has ala. |
2011-11-10 |
2023-08-12 |
Not clear |
| Jianxi Xiao, Balaraman Madhan, Yingjie Li, Barbara Brodsky, Jean Bau. Osteogenesis imperfecta model peptides: incorporation of residues replacing Gly within a triple helix achieved by renucleation and local flexibility. Biophysical journal. vol 101. issue 2. 2011-11-09. PMID:21767498. |
when gly was replaced by ala, the ala residue was incorporated into a fully folded triple helix, whereas replacement of gly by ser or arg resulted in the presence of some partially folded species, suggesting a folding barrier. |
2011-11-09 |
2023-08-12 |
Not clear |
| Hye-Shin Chung, Ji-Yeon Oh, Seung-Bum Yoo, Sang Mee Lee, Heung-Soo Ch. The N-terminal alanine-extended GLP-1/IgG-Fc fusion protein confers resistance to DPP-IV and reduces serum glucose level in db/db mice. Regulatory peptides. vol 170. issue 1-3. 2011-10-21. PMID:21621561. |
we constructed three fusion proteins comprising glp-1 and the human immunoglobulin gamma heavy chain (igg-fc); wild-type glp-1 and igg-fc (glp-1/igg-fc) and two n-terminal-extended fusion proteins in which an additional ala (a) or gly (g) was located on the n-terminus of glp-1 (a-glp-1/igg-fc or g-glp-1/igg-fc). |
2011-10-21 |
2023-08-12 |
mouse |
| Malena A Norrgård, Bengt Mannervi. Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity. Journal of molecular biology. vol 412. issue 1. 2011-10-13. PMID:21821040. |
in general, increased activities were found when the smaller residues gly, ser, and ala replaced the original thr210. |
2011-10-13 |
2023-08-12 |
human |
| Woo Sang Sung, Juneyoung Lee, Jaeyong Cho, Dong Gun Le. The functional role of the tachykinin consensus region of urechistachykinin peptide family for its antimicrobial activity. Biological & pharmaceutical bulletin. vol 34. issue 6. 2011-10-07. PMID:21628896. |
to find out how the tachykinin consensus sequence of the urechistachykinin peptide family affects its antimicrobial activity, analogues substituting the amino acid residues phenylalanine (phe-6; anal 1), glycine (gly-8; anal 2), and arginine (arg-10; anal 3) of u ii to alanine (ala) were designed. |
2011-10-07 |
2023-08-12 |
Not clear |
| Nicholas J Bennett, Dragana Gagic, Andrew J Sutherland-Smith, Jasna Rakonja. Characterization of a dual-function domain that mediates membrane insertion and excision of Ff filamentous bacteriophage. Journal of molecular biology. vol 411. issue 5. 2011-10-06. PMID:21763316. |
the ics contains a predicted amphipathic α-helix and is rich in small amino acids, gly, ala, and ser, which are arranged as a [small]xxx[small]xx[small]xxx[small]xxx[small] motif. |
2011-10-06 |
2023-08-12 |
Not clear |
| Rungtiwa Piamtongkam, Sophie Duquesne, Florence Bordes, Sophie Barbe, Isabelle André, Alain Marty, Warawut Chulalaksananuku. Enantioselectivity of Candida rugosa lipases (Lip1, Lip3, and Lip4) towards 2-bromo phenylacetic acid octyl esters controlled by a single amino acid. Biotechnology and bioengineering. vol 108. issue 8. 2011-09-26. PMID:21391204. |
this led to the construction by site-directed mutagenesis of lip1 and lip4 variants in which position 296 was, respectively, exchanged by a gly, ala, leu, or phe amino acid. |
2011-09-26 |
2023-08-12 |
Not clear |
| Kyo Kobayashi, Yojiro Maehata, Yosuke Kawamura, Masashi Kusubata, Shunji Hattori, Keisuke Tanaka, Chihiro Miyamoto, Fumihiko Yoshino, Ayaka Yoshida, Satoko Wada-Takahashi, Tomoko Komatsu, Shun-Suke Takahashi, Masaichi-Chang-Il Le. Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21512306. |
in addition, the antioxidant effect on (1)o(2) was observed in the peptide fractions rich in gly, pro, hyp, glu, ala, and arg. |
2011-09-22 |
2023-08-12 |
human |
| Kyo Kobayashi, Yojiro Maehata, Yosuke Kawamura, Masashi Kusubata, Shunji Hattori, Keisuke Tanaka, Chihiro Miyamoto, Fumihiko Yoshino, Ayaka Yoshida, Satoko Wada-Takahashi, Tomoko Komatsu, Shun-Suke Takahashi, Masaichi-Chang-Il Le. Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21512306. |
we found that gly, hyp, glu, and ala directly scavenged (1)o(2). |
2011-09-22 |
2023-08-12 |
human |
| Kyo Kobayashi, Yojiro Maehata, Yosuke Kawamura, Masashi Kusubata, Shunji Hattori, Keisuke Tanaka, Chihiro Miyamoto, Fumihiko Yoshino, Ayaka Yoshida, Satoko Wada-Takahashi, Tomoko Komatsu, Shun-Suke Takahashi, Masaichi-Chang-Il Le. Direct assessments of the antioxidant effects of the novel collagen peptide on reactive oxygen species using electron spin resonance spectroscopy. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21512306. |
these results indicated that a peptide sequence including gly, hyp, glu, and ala could play a key role in the antioxidant effects of p-ncp on (1)o(2). |
2011-09-22 |
2023-08-12 |
human |