| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Sheng, M Prorok, F J Castellin. Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20688135. |
tyr at position 5 broadens the nr2 selectivity, and recovery of nr2b selectivity in tyr5 peptides was achieved by incorporating ala or gly at position 8. |
2011-01-11 |
2023-08-12 |
human |
| Daniel Sanghoon Shin, Sang Hee Min, Laura Russell, Rongbao Zhao, Andras Fiser, I David Goldma. Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood. vol 116. issue 24. 2011-01-06. PMID:20805364. |
substantial function was preserved with glu, gly, and, to a lesser extent, with ser, thr, and ala substitutions. |
2011-01-06 |
2023-08-12 |
Not clear |
| Makoto Fujisawa, Oliver J Fackelmayer, Jun Liu, Terry A Krulwich, David B Hick. The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation. The Journal of biological chemistry. vol 285. issue 42. 2010-12-07. PMID:20716528. |
here, lys-180 was replaced with alanine (ala), glycine (gly), cysteine (cys), arginine (arg), or histidine (his) in the chromosome of alkaliphilic bacillus pseudofirmus of4. |
2010-12-07 |
2023-08-12 |
Not clear |
| Makoto Fujisawa, Oliver J Fackelmayer, Jun Liu, Terry A Krulwich, David B Hick. The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation. The Journal of biological chemistry. vol 285. issue 42. 2010-12-07. PMID:20716528. |
atp synthesis by the ala, gly, and his mutants was also impaired at ph 7.5 in the presence of a protonophoric uncoupler. |
2010-12-07 |
2023-08-12 |
Not clear |
| Kazuo Yamauchi, Shizuo Yamasaki, Rui Takahashi, Tetsuo Asakur. Microscopic structural analysis of fractured silk fibers from Bombyx mori and Samia cynthia ricini using 13C CP/MAS NMR with a 1mm microcoil MAS NMR probehead. Solid state nuclear magnetic resonance. vol 38. issue 1. 2010-12-01. PMID:20579856. |
about 300 samples consisting of only the fractured regions of [1-13c]ala or [1-13c]gly labeled silk fibers were collected and observed by 13c cp/mas nmr spectra. |
2010-12-01 |
2023-08-12 |
Not clear |
| Adrien Lugari, Stephane Betzi, Etienne Decroly, Emmanuel Bonnaud, Aurélie Hermant, Jean-Claude Guillemot, Claire Debarnot, Jean-Paul Borg, Mickaël Bouvet, Bruno Canard, Xavier Morelli, Patrick Lécin. Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20699222. |
alanine-scanning mutagenesis, bioinformatics, and molecular modeling were used to identify several "hot spots," such as val(42), met(44), ala(71), lys(93), gly(94), and tyr(96), forming a continuous protein-protein surface of about 830 Å(2), bearing very conserved amino acids among coronaviruses. |
2010-11-24 |
2023-08-12 |
human |
| Richa Sharma, Rani Gupt. Substrate specificity characterization of a thermostable keratinase from Pseudomonas aeruginosa KS-1. Journal of industrial microbiology & biotechnology. vol 37. issue 8. 2010-11-16. PMID:20414794. |
it also cleaved insulin b chain between val(12)-glu(13), ala(14)-leu(15), gly(20)-glu(21) and arg(22)-gly(23) residues. |
2010-11-16 |
2023-08-12 |
chicken |
| Roman M Balabi. Communications: Is quantum chemical treatment of biopolymers accurate? Intramolecular basis set superposition error (BSSE). The Journal of chemical physics. vol 132. issue 23. 2010-10-04. PMID:20572680. |
the studied molecules include ace(gly)(5)nh(2), ace(gly)(10)nh(2), ace(ala)(5)nh(2), and ace(ala)(10)nh(2). |
2010-10-04 |
2023-08-12 |
Not clear |
| Antonis Voutetakis, Ana P Cotrim, Anne Rowzee, Changyu Zheng, Trushar Rathod, Tulin Yanik, Y Peng Loh, Bruce J Baum, Niamh X Cawle. Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology. vol 151. issue 9. 2010-10-04. PMID:20610567. |
the construct was engineered with the signal sequence of mouse gh to direct the peptide into the secretory pathway, followed by a furin cleavage site and the glp-1(7-37) sequence encoding an ala to gly substitution at position 8 to achieve resistance to degradation. |
2010-10-04 |
2023-08-12 |
mouse |
| Hua Li, Chao Li, Zhi-Ying Yan, Jing Yang, Hao Che. Simultaneous monitoring multiple neurotransmitters and neuromodulators during cerebral ischemia/reperfusion in rats by microdialysis and capillary electrophoresis. Journal of neuroscience methods. vol 189. issue 2. 2010-09-28. PMID:20347872. |
an efficient and sensitive chiral capillary electrophoresis with laser-induced fluorescence detection procedure was developed for the simultaneous determination of multiple amino acids neurotransmitter including arg, lys, trp, gaba, l-ser, ala, tau, gly, glu and asp; catcholamine (dopamine) and neuromodulator (d-ser and o-phosphoethanolamine) in microdialysate. |
2010-09-28 |
2023-08-12 |
rat |
| Sara Birtalan, Robert D Fisher, Sachdev S Sidh. The functional capacity of the natural amino acids for molecular recognition. Molecular bioSystems. vol 6. issue 7. 2010-09-27. PMID:20383388. |
nine other residue types (phe, leu, ile, asn, thr, pro, cys, ala, and gly) were found to be ineffective as replacements for tyr. |
2010-09-27 |
2023-08-12 |
Not clear |
| Sara Birtalan, Robert D Fisher, Sachdev S Sidh. The functional capacity of the natural amino acids for molecular recognition. Molecular bioSystems. vol 6. issue 7. 2010-09-27. PMID:20383388. |
by replacing ser with gly or ala, we found that gly is as effective as ser for providing conformational flexibility that allows bulky tyr residues to achieve optimal binding contacts, while ala is less effective but still functional in this capacity. |
2010-09-27 |
2023-08-12 |
Not clear |
| Florian Albrieux, Florent Calvo, Fabien Chirot, Aleksey Vorobyev, Yury O Tsybin, Valéria Lepère, Rodolphe Antoine, Jérôme Lemoine, Philippe Dugour. Conformation of polyalanine and polyglycine dications in the gas phase: insight from ion mobility spectrometry and replica-exchange molecular dynamics. The journal of physical chemistry. A. vol 114. issue 25. 2010-09-24. PMID:20533847. |
the conformation of model [arg(ala)(4)x(ala)(4)lys+2h](2+) and [arg(gly)(4)x(gly)(4)lys+2h](2+) peptides has been systematically investigated as a function of the central amino acid x through a combined experimental and theoretical approach. |
2010-09-24 |
2023-08-12 |
Not clear |
| Alessandra De Riva, Michael J Deery, Sarah McDonald, Torben Lund, Robert Busc. Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes. Analytical biochemistry. vol 403. issue 1-2. 2010-09-22. PMID:20406617. |
experimental data agreed closely with models obtained by mass isotopomer distribution analysis (mida) and were consistent with contributions from ala, gly, and other amino acids to labeling. |
2010-09-22 |
2023-08-12 |
human |
| Matthew R Stump, Lisa M Glos. Mutational studies uncover non-native structure in the dimeric kinetic intermediate of the H2A-H2B heterodimer. Journal of molecular biology. vol 401. issue 3. 2010-09-22. PMID:20600120. |
the contribution of helix propensity to the stability of the i(2) ensemble was assessed with a set of h2a-h2b mutants containing ala and gly replacements at nine sites, focusing mainly on the long, central alpha2 helix. |
2010-09-22 |
2023-08-12 |
Not clear |
| James M Kovacs, Jonathan P Hannan, Elan Z Eisenmesser, V Michael Holer. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20558730. |
with regard to gp350, the binding region of cr2 is primarily focused on scr1 and the inter-scr linker, specifically residues asn(11), arg(13), ala(22), arg(28), ser(32), arg(36), lys(41), lys(57), tyr(64), lys(67), tyr(68), arg(83), gly(84), and arg(89). |
2010-09-17 |
2023-08-12 |
human |
| Fanggui Ye, Yong Huang, Qing Xu, Ming Shi, Shulin Zha. Quantification of taurine and amino acids in mice single fibrosarcoma cell by microchip electrophoresis coupled with chemiluminescence detection. Electrophoresis. vol 31. issue 10. 2010-08-30. PMID:20401902. |
a method based on mce coupled with chemiluminescence (cl) detection was developed for the determination of taurine (tau) and amino acids including alanine (ala), glycine (gly), tryptophan (trp), glutamic acid (glu) and aspartic acid (asp) present in mice single fibrosarcoma (s180) cells. |
2010-08-30 |
2023-08-12 |
mouse |
| Fanggui Ye, Yong Huang, Qing Xu, Ming Shi, Shulin Zha. Quantification of taurine and amino acids in mice single fibrosarcoma cell by microchip electrophoresis coupled with chemiluminescence detection. Electrophoresis. vol 31. issue 10. 2010-08-30. PMID:20401902. |
the average amounts of tau, trp, gly, ala, glu and asp in per s180 cell from a cell population were 4.73, 1.23, 2.65, 1.94, 1.61 and 1.99 fmol. |
2010-08-30 |
2023-08-12 |
mouse |
| Fanggui Ye, Yong Huang, Qing Xu, Ming Shi, Shulin Zha. Quantification of taurine and amino acids in mice single fibrosarcoma cell by microchip electrophoresis coupled with chemiluminescence detection. Electrophoresis. vol 31. issue 10. 2010-08-30. PMID:20401902. |
ten s180 cells were analyzed, and the contents of tau, trp, gly, ala, glu and asp in mice single s180 cells were found to be in the range of 1.78-8.84, 0.95-2.31, 1.08-6.87, 1.03-4.05, 0.84-2.61 and 0.82-3.68 fmol, respectively. |
2010-08-30 |
2023-08-12 |
mouse |
| Derek P Ng, Charles M Debe. Modulation of the oligomerization of myelin proteolipid protein by transmembrane helix interaction motifs. Biochemistry. vol 49. issue 32. 2010-08-27. PMID:20695528. |
in addition, through targeted studies of the plp tm4 alpha-helix with point mutations that selectively eliminate these small residue motifs via substitution of gly, ala, or ser residues with ile residues, we describe a potential mechanism through which disease-causing point mutations can lead to aberrant plp assembly. |
2010-08-27 |
2023-08-12 |
Not clear |