| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helén Sophie Haugen, Gunnar Fimland, Jon Nissen-Meye. Mutational analysis of residues in the helical region of the class IIa bacteriocin pediocin PA-1. Applied and environmental microbiology. vol 77. issue 6. 2011-06-22. PMID:21257813. |
to characterize the environment surrounding these five residues when pediocin pa-1 interacts with target cells, these residues were replaced (one at a time) with a hydrophobic large (leu) residue, a hydrophilic charged (asp or arg) residue, and a small (ala or gly) residue. |
2011-06-22 |
2023-08-12 |
Not clear |
| Łukajtis Rafał, Łegowska Anna, Wysocka Magdalena, Debowski Dawid, Lesner Adam, Rolka Krzyszto. Analogues of trypsin inhibitor SFTI-1 modified in the conserved P₁' position by synthetic or non-proteinogenic amino acids retain their inhibitory activity. Journal of peptide science : an official publication of the European Peptide Society. vol 17. issue 4. 2011-06-17. PMID:21294226. |
in the substrate specificity p₁ position, phe or n-benzylglycine (nphe) were introduced, whereas the conserved ser6 in bownam-birk (bbi) inhibitors was replaced by hse (l-homoserine), nhse [n-(2-hydroxyethyl)glycine], sar, and ala. |
2011-06-17 |
2023-08-12 |
cattle |
| Vikash Jha, Sherif Louis, Prashen Chelikani, Xavi Carpena, Lynda J Donald, Ignacio Fita, Peter C Loewe. Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli. Biochemistry. vol 50. issue 12. 2011-05-19. PMID:21332158. |
in escherichia coli catalase hpii, the residue is ile274, and replacing it with gly, ala, and val, found at the same location in other catalases, results in a reduction in catalytic efficiency, a reduced intensity of the soret absorbance band, and a mixture of heme orientations and species. |
2011-05-19 |
2023-08-12 |
Not clear |
| Tianbo Li, Youshan Yang, Cecilia M Caness. Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block. The Journal of general physiology. vol 137. issue 3. 2011-05-09. PMID:21357733. |
the data also show residue 432 influencing the duration of openings, but here only gly and ala support long openings, whereas all other residues keep channels closed. |
2011-05-09 |
2023-08-12 |
chicken |
| Hongmei Du, Zhaolong Wang, Wenjuan Yu, Yimin Liu, Bingru Huan. Differential metabolic responses of perennial grass Cynodon transvaalensis×Cynodon dactylon (C₄) and Poa Pratensis (C₃) to heat stress. Physiologia plantarum. vol 141. issue 3. 2011-05-05. PMID:21114672. |
the differentially accumulated metabolites included seven sugars (sucrose, fructose, galactose, floridoside, melibiose, maltose and xylose), a sugar alcohol (inositol), six organic acids (malic acid, citric acid, threonic acid, galacturonic acid, isocitric acid and methyl malonic acid) and nine amino acids (asn, ala, val, thr, γ-aminobutyric acid, iie, gly, lys and met). |
2011-05-05 |
2023-08-12 |
Not clear |
| Tuo Zhang, Hua Zhang, Ke Chen, Jishou Ruan, Shiyi Shen, Lukasz Kurga. Analysis and prediction of RNA-binding residues using sequence, evolutionary conservation, and predicted secondary structure and solvent accessibility. Current protein & peptide science. vol 11. issue 7. 2011-04-22. PMID:20887256. |
we demonstrate that (1) interactions with positively charged amino acids arg and lys are preferred by the egatively charged nucleotides; (2) gly provides flexibility for the rna binding sites; (3) glu with negatively charged side chain and several hydrophobic residues such as leu, val, ala and phe are disfavored in the rna-binding sites; (4) coil residues, especially in long segments, are more flexible (than other secondary structures) and more likely to interact with rna; (5) helical residues are more rigid and consequently they are less likely to bind rna; and (6) residues partially exposed to the solvent are more likely to form rna-binding sites. |
2011-04-22 |
2023-08-12 |
Not clear |
| Andrea Heinz, Samuel Taddese, Wolfgang Sippl, Reinhard H H Neubert, Christian E H Schmelze. Insights into the degradation of human elastin by matrilysin-1. Biochimie. vol 93. issue 2. 2011-04-20. PMID:20884320. |
mmp-7 shows a strong preference for leu in p(1)' and also accepts val, gly, and pro at this position, whereas ala is not preferred at p(1)'. |
2011-04-20 |
2023-08-12 |
human |
| Ignacio J General, Hagai Meirovitc. Relative stability of the open and closed conformations of the active site loop of streptavidin. The Journal of chemical physics. vol 134. issue 2. 2011-04-20. PMID:21241152. |
the eight-residue surface loop, 45-52 (ser, ala, val, gly, asn, ala, glu, ser), of the homotetrameric protein streptavidin has a "closed" conformation in the streptavidin-biotin complex, where the corresponding binding affinity is one of the strongest found in nature (Δg ∼ -18 kcal∕mol). |
2011-04-20 |
2023-08-12 |
Not clear |
| Shuangluo Xia, Mina Wang, Harold R Lee, Arjun Sinha, Gregor Blaha, Thomas Christian, Jimin Wang, William Konigsber. Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. Journal of molecular biology. vol 406. issue 4. 2011-04-04. PMID:21216248. |
we have previously observed that stepwise replacement of amino acid residues in the nascent base-pair binding pocket of rb69 dna polymerase (rb69pol) with ala or gly expanded the space in this pocket, resulting in a progressive increase in misincorporation. |
2011-04-04 |
2023-08-12 |
Not clear |
| Jennifer Tzeng, Brian L Lee, Brian D Sykes, Larry Fliege. Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the Na+/H+ exchanger. The Journal of biological chemistry. vol 285. issue 47. 2011-02-28. PMID:20843797. |
of the remaining residues, proteins with the mutations n227c, i233c, and l243c were strongly inhibited by mtset, whereas amino acids phe(230), gly(231), ala(236), val(237), ala(244), val(245), and glu(248) were partially inhibited by mtset. |
2011-02-28 |
2023-08-12 |
Not clear |
| Anatoly M Ruvinsky, Ilya A Vakse. Sequence composition and environment effects on residue fluctuations in protein structures. The Journal of chemical physics. vol 133. issue 15. 2011-02-17. PMID:20969427. |
comparing fluctuations of binding site residues (interface residues) with other surface residues shows that, on average, the interface is more rigid than the rest of the protein surface and gly, ala, ser, cys, leu, and trp have a propensity to form more stable docking patches on the interface. |
2011-02-17 |
2023-08-12 |
Not clear |
| Colin T Mant, Dziuleta Cepeniene, Robert S Hodge. Reversed-phase HPLC of peptides: Assessing column and solvent selectivity on standard, polar-embedded and polar endcapped columns. Journal of separation science. vol 33. issue 19. 2011-02-10. PMID:21038458. |
thus, we have designed and synthesized two series of synthetic peptide standards with the sequence gly-gly-leu-gly-gly-ala-leu-gly-x-leu-lys-lys-amide, where the n-terminal either contains a free α-amino group (amc series) or is n(α)-acetylated (acc series) and where position x is substituted by gly, ala, val, ile, phe or tyr. |
2011-02-10 |
2023-08-12 |
Not clear |
| Colin T Mant, Dziuleta Cepeniene, Robert S Hodge. Reversed-phase HPLC of peptides: Assessing column and solvent selectivity on standard, polar-embedded and polar endcapped columns. Journal of separation science. vol 33. issue 19. 2011-02-10. PMID:21038458. |
these represent series of peptides with single substitutions of n-alkyl (gly<ala
| 2011-02-10 |
2023-08-12 |
Not clear |
|
| Magnus Johansson, Ka-Weng Ieong, Stefan Trobro, Peter Strazewski, Johan Åqvist, Michael Y Pavlov, Måns Ehrenber. pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 1. 2011-02-10. PMID:21169502. |
we studied the ph-dependence of ribosome catalyzed peptidyl transfer from fmet-trna(fmet) to the aa-trnas phe-trna(phe), ala-trna(ala), gly-trna(gly), pro-trna(pro), asn-trna(asn), and ile-trna(ile), selected to cover a large range of intrinsic pk(a)-values for the α-amino group of their amino acids. |
2011-02-10 |
2023-08-12 |
Not clear |
| Magnus Johansson, Ka-Weng Ieong, Stefan Trobro, Peter Strazewski, Johan Åqvist, Michael Y Pavlov, Måns Ehrenber. pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 1. 2011-02-10. PMID:21169502. |
gly-trna(gly) had the smallest downshift, while ile-trna(ile) and ala-trna(ala) had the largest downshifts. |
2011-02-10 |
2023-08-12 |
Not clear |
| Angelo Zinellu, Salvatore Sotgia, Elisabetta Pisanu, Bastianina Scanu, Manuela Sanna, Maria Franca Usai, Roberto Chessa, Luca Deiana, Ciriaco Carr. Quantification of neurotransmitter amino acids by capillary electrophoresis laser-induced fluorescence detection in biological fluids. Analytical and bioanalytical chemistry. vol 398. issue 5. 2011-02-09. PMID:20803002. |
among the various amino acids that have important roles as neurotransmitters, there are alanine (ala), glutamic acid (glu), aspartic acid (asp), serine (ser), taurine (tau) and glycine (gly). |
2011-02-09 |
2023-08-12 |
human |
| Karina B Balestrasse, María L Tomaro, Alcira Batlle, Guillermo O Norieg. The role of 5-aminolevulinic acid in the response to cold stress in soybean plants. Phytochemistry. vol 71. issue 17-18. 2011-02-04. PMID:21051062. |
in this study, the possibility of enhancing cold stress tolerance of soybean plants (glycine max l.) by exogenous application of 5-aminolevulinic acid (ala) was investigated. |
2011-02-04 |
2023-08-12 |
cat |
| Chih-Jung Kuo, Yan-Ping Shih, Daphne Kan, Po-Huang Lian. Engineering a novel endopeptidase based on SARS 3CL(pro). BioTechniques. vol 47. issue 6. 2011-02-02. PMID:20041855. |
a 3c-like protease (3clpro) from the severe acute respiratory syndrome-coronavirus (sars-cov) is required for viral replication, cleaving the replicase polyproteins at 11 sites with the conserved gln [downward arrow](ser, ala, gly) sequences. |
2011-02-02 |
2023-08-12 |
cat |
| Hiroshi Kawaide, Ken-ichiro Hayashi, Ryo Kawanabe, Yuka Sakigi, Akihiko Matsuo, Masahiro Natsume, Hiroshi Nozak. Identification of the single amino acid involved in quenching the ent-kauranyl cation by a water molecule in ent-kaurene synthase of Physcomitrella patens. The FEBS journal. vol 278. issue 1. 2011-01-14. PMID:21122070. |
in contrast, replacing ala710 with gly, cys or ser did not affect the ppcps/ks product profile as much as replacement of cys of jscps/ks by ala. |
2011-01-14 |
2023-08-12 |
Not clear |
| Hua Li, Zhi-Ying Ya. Analysis of amino acid neurotransmitters in hypothalamus of rats during cerebral ischemia-reperfusion by microdialysis and capillary electrophoresis. Biomedical chromatography : BMC. vol 24. issue 11. 2011-01-13. PMID:20954209. |
our results reveal that mcao and reperfusion elicited significant increases in the extracellular levels of arg, lys, trp, phe, gln, gaba, asn, pro, ser, ala, tau, gly, glu and asp. |
2011-01-13 |
2023-08-12 |
rat |