| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Palcic, N O Seto, O Hindsgau. Natural and recombinant A and B gene encoded glycosyltransferases. Transfusion medicine (Oxford, England). vol 11. issue 4. 2001-12-07. PMID:11532187. |
changing the residues arg176-->gly, gly235-->ser, leu266-->met and gly 268-->ala converts the enzyme specificity from blood group a to blood group b glycosyltransferase. |
2001-12-07 |
2023-08-12 |
human |
| D Avrahami, Z Oren, Y Sha. Effect of multiple aliphatic amino acids substitutions on the structure, function, and mode of action of diastereomeric membrane active peptides. Biochemistry. vol 40. issue 42. 2001-12-05. PMID:11601983. |
to this end, we synthesized a series of model amphipathic all l-amino acid peptides and their diastereomers with the sequence kx(3)kwx(2)kx(2)k, where x = gly, ala, val, ile, or leu. |
2001-12-05 |
2023-08-12 |
Not clear |
| B Parhami-Seren, M Viswanathan, R K Strong, M N Margolie. Structural analysis of mutants of high-affinity and low-affinity p-azophenylarsonate-specific antibodies generated by alanine scanning of heavy chain complementarity-determining region 2. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 9. 2001-12-05. PMID:11673524. |
however, in the context of unmutated l chain, of h:gly(54) to ala resulted in significant loss of binding, while abs containing asn(52) to ala, pro(53) to ala, or ile(58) to ala mutation exhibited 4.3- to 7.1-fold reduced affinities. |
2001-12-05 |
2023-08-12 |
Not clear |
| B Gyurcsik, I Vosekalna, E Larse. CD spectroscopic study on the speciation and solution structure of copper(II) complexes of some tripeptides in combination with potentiometric and spectrophotometric results. Journal of inorganic biochemistry. vol 85. issue 2-3. 2001-12-04. PMID:11410228. |
the cd spectra strongly support the coordination also of the c-terminal part of the peptide in the culh(-1) complex of gga, and even the deprotonation of the ala peptide group instead of that belonging to gly cannot be excluded. |
2001-12-04 |
2023-08-12 |
Not clear |
| O Sidorkina, M Dizdaroglu, J Lava. Effect of single mutations on the specificity of Escherichia coli FPG protein for excision of purine lesions from DNA damaged by free radicals. Free radical biology & medicine. vol 31. issue 6. 2001-12-04. PMID:11557320. |
we generated five mutant forms of this enzyme with mutations involving lys-57-->gly (fpgk57g), lys-57-->arg (fpgk57r), lys-155-->ala (fpgk155a), pro-2-->gly (fpgp2g), and pro-2-->glu (fpgp2e), and purified them to homogeneity. |
2001-12-04 |
2023-08-12 |
Not clear |
| G Bulaj, D P Goldenber. Mutational analysis of hydrogen bonding residues in the BPTI folding pathway. Journal of molecular biology. vol 313. issue 3. 2001-12-04. PMID:11676545. |
replacement of this residue with either gly or ala appeared to stabilize the major transition states for folding and unfolding. |
2001-12-04 |
2023-08-12 |
Not clear |
| M A Vieira, M Gao, L N Nikonova, T Maac. Molecular and cellular physiology of the dissociation of atrial natriuretic peptide from guanylyl cyclase a receptors. The Journal of biological chemistry. vol 276. issue 39. 2001-11-01. PMID:11479286. |
substitution of ser(506) by ala and particularly the double substitution of gly(505) and ser(506) by ala within the kinase-like domain markedly reduced anp-induced increases in cgmp, whereas k(off) decreased modestly (albeit significantly) to 0.36 +/- 0.03 and 0.24 +/- 0.02 min(-1), respectively. |
2001-11-01 |
2023-08-12 |
Not clear |
| S T Thomas, V V Loladze, G I Makhatadz. Hydration of the peptide backbone largely defines the thermodynamic propensity scale of residues at the C' position of the C-capping box of alpha-helices. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 19. 2001-11-01. PMID:11535835. |
we determined the following rank order of amino acid residues at the c' position with respect to their effect on the stability: gly>his>asn>arg>lys>gln>ala>phe>met>ser>asp>glu>trp>thr>pro>ile>val. |
2001-11-01 |
2023-08-12 |
Not clear |
| A de Kreij, B van den Burg, O R Veltman, G Vriend, G Venema, V G Eijsin. The effect of changing the hydrophobic S1' subsite of thermolysin-like proteases on substrate specificity. European journal of biochemistry. vol 268. issue 18. 2001-11-01. PMID:11559368. |
in the present study, we have examined the effects of replacing leu202 by smaller (gly, ala, val) and larger (phe, tyr) hydrophobic residues. |
2001-11-01 |
2023-08-12 |
Not clear |
| R W Noble, H L Hui, L D Kwiatkowski, P Paily, A DeYoung, A Wierzba, J E Colby, S Bruno, A Mozzarell. Mutational effects at the subunit interfaces of human hemoglobin: evidence for a unique sensitivity of the T quaternary state to changes in the hinge region of the alpha 1 beta 2 interface. Biochemistry. vol 40. issue 41. 2001-11-01. PMID:11591155. |
a set of variant human hemoglobins, each with an ala or gly substitution at a single residue, has been prepared, and the kinetics of their reactions with carbon monoxide have been measured. |
2001-11-01 |
2023-08-12 |
human |
| R B Shirley, C M Parson. Effect of ash content on protein quality of meat and bone meal. Poultry science. vol 80. issue 5. 2001-10-25. PMID:11372713. |
increases in ala, pro, gly, and arg as a percentage of cp were observed in all mbm samples as ash percentage increased, with pro and gly accounting for most of the increase. |
2001-10-25 |
2023-08-12 |
chicken |
| R G Tirona, B F Leake, G Merino, R B Ki. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. The Journal of biological chemistry. vol 276. issue 38. 2001-10-25. PMID:11477075. |
specifically, alterations in transport were associated with snps that introduce amino acid changes within the transmembrane-spanning domains (t217c (phe-73 --> leu), t245c (val-82 --> ala), t521c (val-174 --> ala), and t1058c (ile-353 --> thr)) and also with those that modify extracellular loop 5 (a1294g (asn-432 --> asp), a1385g (asp-462 --> gly), and a1463c (gly-488 --> ala)). |
2001-10-25 |
2023-08-12 |
human |
| T A Isenbarger, M P Kreb. Thermodynamic stability of the bacteriorhodopsin lattice as measured by lipid dilution. Biochemistry. vol 40. issue 39. 2001-10-25. PMID:11570893. |
by using this method, a series of mutant proteins was examined in which residues at the br-br interface were replaced with smaller amino acids, either ala or gly. |
2001-10-25 |
2023-08-12 |
Not clear |
| R Azriel, E Gazi. Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation. The Journal of biological chemistry. vol 276. issue 36. 2001-10-11. PMID:11445568. |
turbidity assay experiments demonstrated that the wild-type peptide and the asn(1) --> ala and gly(3) --> ala peptides had the highest rate of aggregate formation, whereas the phe(2) --> ala peptide did not form any detectable aggregates. |
2001-10-11 |
2023-08-12 |
Not clear |
| P M Benton, J Christiansen, D R Dean, L C Seefeld. Stereospecificity of acetylene reduction catalyzed by nitrogenase. Journal of the American Chemical Society. vol 123. issue 9. 2001-10-11. PMID:11456800. |
altered mofe proteins examined included those having the alpha-subunit 96(arg) residue substituted by gln, leu, or ala, the alpha-subunit 69(gly) residue substituted by ser, and the alpha-subunit 195(his) residue substituted by asn. |
2001-10-11 |
2023-08-12 |
Not clear |
| R M Epand, R F Epand, I Martin, J M Ruysschaer. Membrane interactions of mutated forms of the influenza fusion peptide. Biochemistry. vol 40. issue 30. 2001-10-11. PMID:11467940. |
we have studied a group of fusion peptides of influenza hemagglutinin in which the n-terminal amino acid, gly (found in the wild-type peptide), has been systematically substituted with ala, ser, val, or glu. |
2001-10-11 |
2023-08-12 |
Not clear |
| A Chanawong, F H M'Zali, J Heritage, A Lulitanond, P M Hawke. Discrimination of SHV beta-lactamase genes by restriction site insertion-PCR. Antimicrobial agents and chemotherapy. vol 45. issue 7. 2001-10-04. PMID:11408231. |
mismatch primers were designed to detect mutations affecting amino acids at positions 8 (sspi), 179 (hinfi), 205 (psti), 238 (gly-->ala) (bsri), and 240 (nrui) of bla(shv) genes. |
2001-10-04 |
2023-08-12 |
Not clear |
| D A Cochran, S Penel, A J Doi. Effect of the N1 residue on the stability of the alpha-helix for all 20 amino acids. Protein science : a publication of the Protein Society. vol 10. issue 3. 2001-09-27. PMID:11344315. |
the rank order for free energies is asp(-), ala > glu(-) > glu(0) > trp, leu, ser > asp(0), thr, gln, met, ile > val, pro > lys(+), arg, his(0) > cys, gly > phe > asn, tyr, his(+). |
2001-09-27 |
2023-08-12 |
Not clear |
| b' S Tuzi, J Hasegawa, R Kawaminami, A Naito, H Sait\\xc3\\xb. Regio-selective detection of dynamic structure of transmembrane alpha-helices as revealed from (13)C NMR spectra of [3-13C]Ala-labeled bacteriorhodopsin in the presence of Mn2+ ion. Biophysical journal. vol 81. issue 1. 2001-09-13. PMID:11423425.' |
the ala c(beta) (13)c nmr peaks corresponding to ala-51, ala-53, ala-81, ala-84, and ala-215 located around the extracellular half of the proton channel and ala-184 located at the kink in the helix f were successfully identified on the basis of (13)c nmr spectra of br in the presence of mn(2+) ion and site-directed replacement of ala by gly or val. |
2001-09-13 |
2023-08-12 |
Not clear |
| T B Stanton, E G Matson, S B Humphre. Brachyspira (Serpulina) hyodysenteriae gyrB mutants and interstrain transfer of coumermycin A(1) resistance. Applied and environmental microbiology. vol 67. issue 5. 2001-09-06. PMID:11319078. |
four cn(r) strains had single nucleotide changes in their gyrb genes, corresponding to gyrb amino acid changes of gly(78) to ser (two strains), gly(78) to cys, and thr(166) to ala. |
2001-09-06 |
2023-08-12 |
Not clear |