| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Mauro Maccarrone, Sandra Cecconi, Gianna Rossi, Natalia Battista, Riccardo Pauselli, Alessandro Finazzi-Agr\\xc3\\xb. Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. Endocrinology. vol 144. issue 1. 2003-01-17. PMID:12488326.' |
these data demonstrate that sertoli cells partake in the peripheral endocannabinoid system, and that fsh reduces the apoptotic potential of aea by activating faah. |
2003-01-17 |
2023-08-12 |
mouse |
| Michael H Bracey, Michael A Hanson, Kim R Masuda, Raymond C Stevens, Benjamin F Cravat. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (New York, N.Y.). vol 298. issue 5599. 2002-12-24. PMID:12459591. |
here, we report the 2.8 angstrom crystal structure of the integral membrane protein fatty acid amide hydrolase (faah), an enzyme that degrades members of the endocannabinoid class of signaling lipids and terminates their activity. |
2002-12-24 |
2023-08-12 |
Not clear |
| Patricia H Reggi. Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052032. |
a membrane bound amidohydrolase (fatty acid amide hydrolase, faah), located intracellularly, hydrolyzes and inactivates anandamide and other endogenous cannabinoids such as 2-ag. |
2002-12-06 |
2023-08-12 |
Not clear |
| D G Deutsch, N Ueda, S Yamamot. The fatty acid amide hydrolase (FAAH). Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052036. |
the fatty acid amide hydrolase (faah), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. |
2002-12-06 |
2023-08-12 |
mouse |
| D G Deutsch, N Ueda, S Yamamot. The fatty acid amide hydrolase (FAAH). Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052036. |
the distribution of faah in the major organs in the body is described as well as regional distribution in the brain and its correlation with cannabinoid receptors. |
2002-12-06 |
2023-08-12 |
mouse |
| E Frid. Endocannabinoids in the central nervous system--an overview. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052038. |
for therapeutic purposes, inhibitors of faah may provide more specific cannabinoid activities than direct agonists, and several such molecules have already been developed. |
2002-12-06 |
2023-08-12 |
Not clear |
| b' M Maccarrone, K Falciglia, M Di Rienzo, A Finazzi-Agr\\xc3\\xb. Endocannabinoids, hormone-cytokine networks and human fertility. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052045.' |
here, we review the roles of aea, of the aea-binding cannabinoid (cb) receptors, of the selective aea membrane transporter (amt), and of the aea-hydrolyzing enzyme fatty acid amide hydrolase (faah), in human gestation. |
2002-12-06 |
2023-08-12 |
mouse |
| Isabel Matias, Pierre Pochard, Pierangelo Orlando, Michel Salzet, Joel Pestel, Vincenzo Di Marz. Presence and regulation of the endocannabinoid system in human dendritic cells. European journal of biochemistry. vol 269. issue 15. 2002-09-09. PMID:12153574. |
here we have analyzed human dendritic cells for the presence of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-ag), the cannabinoid cb1 and cb2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (faah). |
2002-09-09 |
2023-08-12 |
human |
| Mario van der Stelt, J Albert van Kuik, Monica Bari, Guus van Zadelhoff, Bas R Leeflang, Gerrit A Veldink, Alessandro Finazzi-Agrò, Johannes F G Vliegenthart, Mauro Maccarron. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of medicinal chemistry. vol 45. issue 17. 2002-09-04. PMID:12166944. |
oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. |
2002-09-04 |
2023-08-12 |
Not clear |
| Mario van der Stelt, J Albert van Kuik, Monica Bari, Guus van Zadelhoff, Bas R Leeflang, Gerrit A Veldink, Alessandro Finazzi-Agrò, Johannes F G Vliegenthart, Mauro Maccarron. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of medicinal chemistry. vol 45. issue 17. 2002-09-04. PMID:12166944. |
this study was aimed at finding structural requirements for the interaction of the acyl chain of endocannabinoids with cannabinoid receptors, membrane transporter protein, and fatty acid amide hydrolase (faah). |
2002-09-04 |
2023-08-12 |
Not clear |
| Paolo Gubellini, Barbara Picconi, Monica Bari, Natalia Battista, Paolo Calabresi, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Mauro Maccarron. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 16. 2002-09-04. PMID:12177188. |
moreover, we observed a decreased activity of the anandamide membrane transporter (amt) and of the anandamide hydrolase [fatty acid amide hydrolase (faah)], whereas the binding of anandamide to cannabinoid receptors was unaffected. |
2002-09-04 |
2023-08-12 |
rat |
| b' Mauro Maccarrone, Tiziana Bisogno, Herbert Valensise, Natalia Lazzarin, Filomena Fezza, Claudio Manna, Vincenzo Di Marzo, Alessandro Finazzi-Agr\\xc3\\xb. Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. Molecular human reproduction. vol 8. issue 2. 2002-07-24. PMID:11818522.' |
the blood levels of the other endocannabinoid, 2-arachidonoylglycerol, or of the aea congener, n-palmitoylethanolamine, which are metabolized by enzymes different from faah, was not different between the pregnant and nonpregnant women, nor was there any difference in the activity of the aea membrane transporter or the amounts of cannabinoid receptors in lymphocytes. |
2002-07-24 |
2023-08-12 |
human |
| R A Puffenbarger, O Kapulina, J M Howell, D G Deutsc. Characterization of the 5'-sequence of the mouse fatty acid amide hydrolase. Neuroscience letters. vol 314. issue 1-2. 2002-01-07. PMID:11698137. |
fatty acid amide hydrolase (faah) is critical for degradation of several important fatty acid amides including anandamide, an endocannabinoid, as well as oleamide, a sleep-inducing factor. |
2002-01-07 |
2023-08-12 |
mouse |
| b' M Maccarrone, L De Petrocellis, M Bari, F Fezza, S Salvati, V Di Marzo, A Finazzi-Agr\\xc3\\xb. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Archives of biochemistry and biophysics. vol 393. issue 2. 2001-10-18. PMID:11556820.' |
the effect of this endotoxin on faah was not mediated by aea-induced activation of cannabinoid receptors. |
2001-10-18 |
2023-08-12 |
human |
| B F Cravatt, K Demarest, M P Patricelli, M H Bracey, D K Giang, B R Martin, A H Lichtma. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 16. 2001-08-30. PMID:11470906. |
supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. |
2001-08-30 |
2023-08-12 |
mouse |
| B F Cravatt, K Demarest, M P Patricelli, M H Bracey, D K Giang, B R Martin, A H Lichtma. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 16. 2001-08-30. PMID:11470906. |
collectively, these results indicate that faah is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception. |
2001-08-30 |
2023-08-12 |
mouse |
| b' M Maccarrone, H Valensise, M Bari, N Lazzarin, C Romanini, A Finazzi-Agr\\xc3\\xb. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 12. 2001-08-23. PMID:11390466.' |
at variance with faah, the lymphocyte anandamide transporter and cannabinoid receptors were not affected by treatment with progesterone or cytokines. |
2001-08-23 |
2023-08-12 |
human |
| b' M Maccarrone, H Valensise, M Bari, N Lazzarin, C Romanini, A Finazzi-Agr\\xc3\\xb. Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 12. 2001-08-23. PMID:11390466.' |
a clinical study performed on 100 healthy women showed that a low faah activity in lymphocytes correlates with spontaneous abortion, whereas anandamide transporter and cannabinoid receptors in these cells remain unchanged. |
2001-08-23 |
2023-08-12 |
human |
| M P Patricelli, B F Cravat. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. Biochemistry. vol 40. issue 20. 2001-08-16. PMID:11352748. |
fatty acid amide hydrolase (faah) is a mammalian integral membrane enzyme that catabolizes several neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide. |
2001-08-16 |
2023-08-12 |
Not clear |
| G B Quistad, S E Sparks, J E Casid. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. Toxicology and applied pharmacology. vol 173. issue 1. 2001-06-14. PMID:11350214. |
thus, op pesticides and related inhibitors of faah potentiate the cannabinoid activity of anandamide in mice. |
2001-06-14 |
2023-08-12 |
mouse |