| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R K Razdan, A Mahadeva. Recent advances in the synthesis of endocannabinoid related ligands. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505687. |
the chemical strategies used for the synthesis of various ligands related to the endocannabinoid system namely anandamide (aea), 2-arachidonylglycerol (2-ara-gl), cb1/(vanilloid receptors) vr1, anandamide membrane transporter (amt) and fatty acid amide hydrolase (faah) are described in this review. |
2003-08-22 |
2023-08-12 |
Not clear |
| Benjamin F Cravatt, Aron H Lichtma. The enzymatic inactivation of the fatty acid amide class of signaling lipids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505696. |
collectively, these studies promote faah as a central component of faa signaling pathways, especially those mediated by the endocannabinoid anandamide, and suggest that this enzyme may represent an attractive pharmaceutical target for the treatment of pain and related neurophysiological disorders. |
2003-08-22 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
fatty acid amide hydrolase (faah) catalyses hydrolysis of the endocannabinoid arachidonoylethanolamide ("anandamide") in vitro and regulates anandamide levels in the brain. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
to assess more widely the functions of faah in the brain and the potential impact of faah activity on the spatiotemporal dynamics of endocannabinoid signaling in different regions of the brain, here we have employed immunocytochemistry to compare the distribution of faah and cb(1) throughout the mouse brain, using faah(-/-) mice as negative controls to validate the specificity of faah-immunoreactivity observed in wild type animals. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
in these regions of the brain, faah may regulate postsynaptic formation of anandamide, thereby influencing the spatiotemporal dynamics of retrograde endocannabinoid signaling. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
however, in some regions of the brain such as the globus pallidus and substantia nigra pars reticulata, cb(1) receptors are abundant but with little or no associated faah expression and in these brain regions the spatial impact and/or duration of endocannabinoid signaling may be less restricted than in regions enriched with faah. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
here faah may nevertheless influence endocannabinoid signaling but more remotely. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
finally, there are regions of the brain where faah-immunoreactive neurons and/or oligodendrocytes occur in the absence of cb(1)-immunoreactive fibers and here faah may be involved in regulation of signaling mediated by other endocannabinoid receptors or by receptors for other fatty acid amide signaling molecules. |
2003-07-30 |
2023-08-12 |
mouse |
| M Egertová, B F Cravatt, M R Elphic. Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770562. |
in conclusion, by comparing the distribution of faah and cb(1) in the mouse brain, we have provided a neuroanatomical framework for comparative analysis of the role of faah in regulation of the spatiotemporal dynamics of retrograde endocannabinoid signaling in different regions of the brain. |
2003-07-30 |
2023-08-12 |
mouse |
| Giorgio Tarzia, Andrea Duranti, Andrea Tontini, Giovanni Piersanti, Marco Mor, Silvia Rivara, Pier Vincenzo Plazzi, Chris Park, Satish Kathuria, Daniele Piomell. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry. vol 46. issue 12. 2003-07-11. PMID:12773040. |
fatty acid amide hydrolase (faah), an intracellular serine hydrolase enzyme, participates in the deactivation of fatty acid ethanolamides such as the endogenous cannabinoid anandamide, the intestinal satiety factor oleoylethanolamide, and the peripheral analgesic and anti-inflammatory factor palmitoylethanolamide. |
2003-07-11 |
2023-08-12 |
rat |
| Angela B Clement, E Gregory Hawkins, Aron H Lichtman, Benjamin F Cravat. Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736361. |
mice lacking the enzyme fatty acid amide hydrolase [faah (-/-) mice] are severely impaired in their ability to degrade the endocannabinoid anandamide and therefore represent a unique animal model in which to examine the function of this signaling lipid in vivo. |
2003-06-19 |
2023-08-12 |
mouse |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
here, we show that in a rat model of parkinson's disease induced by unilateral nigral lesion with 6-hydroxydopamine (6-ohda), the striatal levels of the endocannabinoid anandamide (aea) were increased, while the activity of its membrane transporter and hydrolase (fatty-acid amide hydrolase, faah) were decreased. |
2003-06-18 |
2023-08-12 |
rat |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
remarkably, the anomalies in the endocannabinoid system, as well as those in glutamatergic activity, were completely reversed by chronic treatment of parkinsonian rats with levodopa, and the pharmacological inhibition of faah restored a normal glutamatergic activity in 6-ohda-lesioned animals. |
2003-06-18 |
2023-08-12 |
rat |
| Mauro Maccarrone, Paolo Gubellini, Monica Bari, Barbara Picconi, Natalia Battista, Diego Centonze, Giorgio Bernardi, Alessandro Finazzi-Agrò, Paolo Calabres. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716433. |
taken together, these data show that anomalies in the endocannabinoid system induced by experimental parkinsonism are restricted to the striatum and can be reversed by chronic levodopa treatment, and suggest that inhibition of faah might represent a possible target to decrease the abnormal cortical glutamatergic drive in parkinson's disease. |
2003-06-18 |
2023-08-12 |
rat |
| Giorgio Ortar, Alessia Ligresti, Luciano De Petrocellis, Enrico Morera, Vincenzo Di Marz. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochemical pharmacology. vol 65. issue 9. 2003-06-16. PMID:12732359. |
novel aromatic analogues of n-oleoylethanolamine and n-arachidonoylethanolamine (anandamide, aea) were synthesized and, based on the capability of similar compounds to interact with proteins of the endocannabinoid and endovanilloid signaling systems, were tested on: (i) cannabinoid cb(1) and cb(2) receptors; (ii) vanilloid vr1 receptors; (iii) anandamide cellular uptake (acu); and (iv) the fatty acid amide hydrolase (faah). |
2003-06-16 |
2023-08-12 |
human |
| I Matias, M Léonhardt, J Lesage, L De Petrocellis, J P Dupouy, D Vieau, V Di Marz. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cellular and molecular life sciences : CMLS. vol 60. issue 2. 2003-04-30. PMID:12678501. |
here we determined the effect of maternal under-nutrition during gestation, lactation, or both, on body weight, and on the levels of endocannabinoids and expression of cannabinoid cb1 receptors and fatty acid amide hydrolase in the hypothalamus of rat pups at weaning (21 days old) or adult rats (4 months old). |
2003-04-30 |
2023-08-12 |
mouse |
| I Matias, M Léonhardt, J Lesage, L De Petrocellis, J P Dupouy, D Vieau, V Di Marz. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cellular and molecular life sciences : CMLS. vol 60. issue 2. 2003-04-30. PMID:12678501. |
no significant change in the hypothalamic expression of either cannabinoid cb1 receptors or fatty acid amide hydrolase mrna was detected in any of the three groups of weaned pups. |
2003-04-30 |
2023-08-12 |
mouse |
| Luciano De Petrocellis, Tiziana Bisogno, Alessia Ligresti, Maurizio Bifulco, Dominique Melck, Vincenzo Di Marz. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundamental & clinical pharmacology. vol 16. issue 4. 2003-04-10. PMID:12570018. |
indeed, long-term treatment of human breast cancer cells (hbccs) with pea downregulates the expression of the enzyme responsible for aea degradation, the fatty acid amide hydrolase, thereby leading to an enhancement of aea-induced, and cannabinoid cb1 receptor-mediated, cytostatic effect on hbccs. |
2003-04-10 |
2023-08-12 |
human |
| Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo, Daniele Piomell. Modulation of anxiety through blockade of anandamide hydrolysis. Nature medicine. vol 9. issue 1. 2003-03-18. PMID:12461523. |
here we describe a class of potent, selective and systemically active inhibitors of fatty acid amide hydrolase, the enzyme responsible for the degradation of the endogenous cannabinoid anandamide. |
2003-03-18 |
2023-08-12 |
rat |