| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P H Reggio, H Traor. Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106780. |
a membrane bound amidohydrolase (fatty acid amide hydrolase, faah), located intracellulary, hydrolyzes and inactivates anandamide and other endogenous cannabinoids such as 2-arachidonoylglycerol (2-ag). |
2001-01-11 |
2023-08-12 |
Not clear |
| P H Reggio, H Traor. Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106780. |
structure-activity relationships (sars) for endocannabinoid interaction with the cb receptors, the anandamide transporter and faah are currently emerging in the literature. |
2001-01-11 |
2023-08-12 |
Not clear |
| N Ueda, R A Puffenbarger, S Yamamoto, D G Deutsc. The fatty acid amide hydrolase (FAAH). Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106785. |
the distribution of faah in the major organs of the body is described as well as regional distribution in the brain and its correlation with cannabinoid receptors. |
2001-01-11 |
2023-08-12 |
mouse |
| N Ueda, R A Puffenbarger, S Yamamoto, D G Deutsc. The fatty acid amide hydrolase (FAAH). Chemistry and physics of lipids. vol 108. issue 1-2. 2001-01-11. PMID:11106785. |
since faah is recognized as a drug target, a large number of inhibitors have been synthesized and tested since 1994 and these are reviewed in terms of reversibility, potency, and specificity for faah and cannabinoid receptors. |
2001-01-11 |
2023-08-12 |
mouse |
| J L Wiley, M A Dewey, R G Jefferson, R L Winckler, D T Bridgen, K A Willoughby, B R Marti. Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects. Life sciences. vol 67. issue 13. 2000-09-22. PMID:10983852. |
the endogenous cannabinoid anandamide produces cannabimimetic effects similar to those produced by delta9-tetrahydrocannabinol (delta9-thc), but has a much shorter duration of action due to its rapid metabolism to arachidonic acid and polar metabolites via action of fatty acid amide hydrolase (faah). |
2000-09-22 |
2023-08-12 |
mouse |
| B R Martin, I Beletskaya, G Patrick, R Jefferson, R Winckler, D G Deutsch, V Di Marzo, O Dasse, A Mahadevan, R K Razda. Cannabinoid properties of methylfluorophosphonate analogs. The Journal of pharmacology and experimental therapeutics. vol 294. issue 3. 2000-09-12. PMID:10945879. |
methylarachidonylfluorophosphonate (mafp) and related analogs have been shown to inhibit fatty acid amidohydrolase activity (faah), the enzyme responsible for hydrolysis of the endogenous cannabinoid ligand anandamide. |
2000-09-12 |
2023-08-12 |
Not clear |
| M P Patricelli, B F Cravat. Clarifying the catalytic roles of conserved residues in the amidase signature family. The Journal of biological chemistry. vol 275. issue 25. 2000-08-16. PMID:10764768. |
fatty acid amide hydrolase (faah) is a mammalian integral membrane enzyme responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide. |
2000-08-16 |
2023-08-12 |
Not clear |
| D L Boger, H Sato, A E Lerner, M P Hedrick, R A Fecik, H Miyauchi, G D Wilkie, B J Austin, M P Patricelli, B F Cravat. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 10. 2000-06-13. PMID:10805767. |
the development of exceptionally potent inhibitors of fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. |
2000-06-13 |
2023-08-12 |
Not clear |
| S Yazulla, K M Studholme, H H McIntosh, D G Deutsc. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. The Journal of comparative neurology. vol 415. issue 1. 1999-12-02. PMID:10540359. |
immunocytochemical localization of cannabinoid cb1 receptor and fatty acid amide hydrolase in rat retina. |
1999-12-02 |
2023-08-12 |
rat |
| S Yazulla, K M Studholme, H H McIntosh, D G Deutsc. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. The Journal of comparative neurology. vol 415. issue 1. 1999-12-02. PMID:10540359. |
immunocytochemical methods were used to localize cannabinoid cb1 receptor immunoreactivity (cb1r-ir) and an endocannabinoid (anandamide and 2-arachidonylglycerol) degradative enzyme, fatty acid amide hydrolase (faah)-ir, in the rat retina. |
1999-12-02 |
2023-08-12 |
rat |
| K Tsou, M I Nogueron, S Muthian, M C Sañudo-Pena, C J Hillard, D G Deutsch, J M Walke. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neuroscience letters. vol 254. issue 3. 1999-06-22. PMID:10214976. |
the distribution in the rat brain of fatty acid amide hydrolase (faah) an enzyme that catalyzes the hydrolysis of the endogenous cannabinoid anandamide was studied by immunohistochemistry. |
1999-06-22 |
2023-08-12 |
rat |
| K Tsou, M I Nogueron, S Muthian, M C Sañudo-Pena, C J Hillard, D G Deutsch, J M Walke. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neuroscience letters. vol 254. issue 3. 1999-06-22. PMID:10214976. |
these data demonstrate that faah is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid cb1 receptors in rat brain. |
1999-06-22 |
2023-08-12 |
rat |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
a new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the cb1 receptor in rat brain. |
1998-12-22 |
2023-08-12 |
rat |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
here we have analysed the distribution of faah in rat brain and compared its cellular localization with cb1-type cannabinoid receptors using immunocytochemistry. |
1998-12-22 |
2023-08-12 |
rat |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
high concentrations of faah activity were detected in the cerebellum, hippocampus and neocortex, regions of the rat brain which are enriched with cannabinoid receptors. |
1998-12-22 |
2023-08-12 |
rat |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
the close correspondence in the distribution of faah and cb1 in rat brain and the complementary pattern of faah and cb1 expression at the cellular level provides important new evidence that faah may participate in cannabinoid signalling mechanisms of the brain. |
1998-12-22 |
2023-08-12 |
rat |
| J Barnett-Norris, F Guarnieri, D P Hurst, P H Reggi. Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories. Journal of medicinal chemistry. vol 41. issue 24. 1998-12-17. PMID:9822555. |
such rigid analogues may be useful in deducing the bioactive conformation of these endogenous cannabinoids, not only at the cb receptors but also at the faah enzyme active site and possibly at the binding site(s) on the newly proposed anandamide transporter. |
1998-12-17 |
2023-08-12 |
Not clear |
| T Bisogno, N Sepe, L De Petrocellis, R Mechoulam, V Di Marz. The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. Biochemical and biophysical research communications. vol 239. issue 2. 1997-11-17. PMID:9344854. |
the enzyme catalyzing the hydrolysis of the amide bond of oleamide as well as of anandamide, the putative endogenous ligand of cannabinoid receptors, was purified from rat liver, cloned, shown to be expressed also in brain and named fatty acid amide hydrolase (faah). |
1997-11-17 |
2023-08-12 |
mouse |