| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Kleiderman, João V Sá, Ana P Teixeira, Catarina Brito, Simon Gutbier, Lars G Evje, Mussie G Hadera, Enrico Glaab, Margit Henry, Agapios Sachinidis, Paula M Alves, Ursula Sonnewald, Marcel Leis. Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells. Glia. vol 64. issue 5. 2016-12-13. PMID:26689134. |
we found here that the exposure of a defined population of pluripotent stem cell-derived neural stem cells (nsc) to bmp4 results in pure, nonproliferating astrocyte cultures within 24-48 h. these murine astrocytes generated from embryonic stem cells (mages) expressed the positive markers gfap, aquaporin 4 and glt-1, supported neuronal function, and acquired innate immune functions such as the response to tumor necrosis factor and interleukin 1. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ana Paula Ardais, Andréia S Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Cássia Sallaberry, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Rodrigo A Cunha, Lisiane de Oliveira Porciúncul. Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life. Behavioural brain research. vol 303. 2016-12-13. PMID:26774980. |
both caffeine treatment regimens decreased gfap (as an astrocyte marker) and snap-25 (as a nerve terminals marker) in the hippocampus from male rats. |
2016-12-13 |
2023-08-13 |
rat |
| H Ueda, S K Halder, H Matsunaga, K Sasaki, S Maed. Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion. Neuroscience. vol 318. 2016-12-13. PMID:26779836. |
in addition, systemic post-treatment with p6q peptide significantly inhibited retinal ischemia-induced microglia and astrocyte activation in terms of increased ionized calcium-binding adaptor molecule 1 (iba-1) and glial fibrillary acidic protein (gfap) intensity, respectively, as well as their morphological changes, increased number and migration. |
2016-12-13 |
2023-08-13 |
mouse |
| Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W Meyer, Paul T Pfluger, Ana M Fernandez, Serge Luquet, Stephen C Woods, Ignacio Torres-Alemán, C Ronald Kahn, Magdalena Götz, Tamas L Horvath, Matthias H Tschö. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. vol 166. issue 4. 2016-12-13. PMID:27518562. |
postnatal ablation of insulin receptors (irs) in glial fibrillary acidic protein (gfap)-expressing cells affects hypothalamic astrocyte morphology, mitochondrial function, and circuit connectivity. |
2016-12-13 |
2023-08-13 |
mouse |
| Libing Ye, Ying Yang, Xie Zhang, Pingtao Cai, Rui Li, Daqing Chen, Xiaojie Wei, Xuesong Zhang, Huazi Xu, Jian Xiao, Xiaokun Li, Li Lin, Hongyu Zhan. The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals. International journal of molecular sciences. vol 17. issue 1. 2016-10-25. PMID:26729092. |
in this study, we demonstrated that exogenous bfgf attenuated astrocyte activation by reducing the expression of glial fibrillary acidic protein (gfap) and other markers, including neurocan and vimentin, but not nestin and decreased the levels of pro-inflammatory cytokines, such as interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), via the regulation of the upstream toll-like receptor 4/nuclear factor κb (tlr4/nfκb) signaling pathway. |
2016-10-25 |
2023-08-13 |
Not clear |
| Ping-Wu Zhang, Amanda M Haidet-Phillips, Jacqueline T Pham, Youngjin Lee, Yuqing Huo, Pentti J Tienari, Nicholas J Maragakis, Rita Sattler, Jeffrey D Rothstei. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. vol 64. issue 1. 2016-10-20. PMID:26295203. |
generation of gfap::gfp astrocyte reporter lines from human adult fibroblast-derived ips cells using zinc-finger nuclease technology. |
2016-10-20 |
2023-08-13 |
human |
| Ping-Wu Zhang, Amanda M Haidet-Phillips, Jacqueline T Pham, Youngjin Lee, Yuqing Huo, Pentti J Tienari, Nicholas J Maragakis, Rita Sattler, Jeffrey D Rothstei. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. vol 64. issue 1. 2016-10-20. PMID:26295203. |
astrocyte populations were enriched using fluorescence activated cell sorting (facs) and after enrichment more than 99% of ips astrocytes expressed mature astrocyte markers including gfap, s100β, nfia and aldh1l1. |
2016-10-20 |
2023-08-13 |
human |
| Ping-Wu Zhang, Amanda M Haidet-Phillips, Jacqueline T Pham, Youngjin Lee, Yuqing Huo, Pentti J Tienari, Nicholas J Maragakis, Rita Sattler, Jeffrey D Rothstei. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. vol 64. issue 1. 2016-10-20. PMID:26295203. |
in conclusion, the generation of gfap::gfp-ips astrocytes provides a powerful in vitro and in vivo tool for studying astrocyte biology and astrocyte-driven disease pathogenesis and therapy. |
2016-10-20 |
2023-08-13 |
human |
| Diana M Norden, Paige J Trojanowski, Emmanuel Villanueva, Elisa Navarro, Jonathan P Godbou. Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia. vol 64. issue 2. 2016-10-06. PMID:26470014. |
sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or gfap immunoreactivity following systemic immune challenge. |
2016-10-06 |
2023-08-13 |
Not clear |
| Diana M Norden, Paige J Trojanowski, Emmanuel Villanueva, Elisa Navarro, Jonathan P Godbou. Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia. vol 64. issue 2. 2016-10-06. PMID:26470014. |
although proinflammatory cytokine expression in microglia peaked 2-4 h after lps, astrocyte cytokine, and chemokine induction was delayed and peaked at 12 h. morphological alterations in microglia (iba-1(+)) and astrocytes (gfap(+)), however, were undetected during this 2-12 h timeframe. |
2016-10-06 |
2023-08-13 |
Not clear |
| X Li, Y Chen, Q Chi, X Hu, X Xu, Z Zhang, M Qiu, K Zhen. miRNAs are required for the terminal differentiation of white matter astrocytes in the developing CNS. Neuroscience. vol 312. 2016-09-29. PMID:26556063. |
in glial fibrillary acidic protein (gfap)/dicer conditional mutants, the initial generation of astrocyte progenitor cells was normal in the spinal cord. |
2016-09-29 |
2023-08-13 |
mouse |
| Aurélie Doméné, Chelsea Cavanagh, Guylène Page, Sylvie Bodard, Christophe Klein, Cécile Delarasse, Sylvie Chalon, Slavica Kranti. Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study. International journal of Alzheimer's disease. vol 2016. 2016-09-27. PMID:27672476. |
subregional immunohistochemical quantification of phenotypic (gfap) and functional (tspo) markers of astrocyte activation indicated a selective and significant increase in gfap-immunoreactive (ir) cells in the dentate gyrus of appswe/ps1de9 mice. |
2016-09-27 |
2023-08-13 |
mouse |
| Meredith K Loth, Judy Choi, Jennifer L McGlothan, Mikhail V Pletnikov, Martin G Pomper, Tomás R Guilart. TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiology of disease. vol 85. 2016-09-21. PMID:26545928. |
notably, tspo colocalization with the astrocyte marker gfap was greater than with the microglia marker, mac-1. |
2016-09-21 |
2023-08-13 |
mouse |
| Jonathan C Sedeyn, Hao Wu, Reilly D Hobbs, Eli C Levin, Robert G Nagele, Venkat Venkatarama. Histamine Induces Alzheimer's Disease-Like Blood Brain Barrier Breach and Local Cellular Responses in Mouse Brain Organotypic Cultures. BioMed research international. vol 2015. 2016-09-21. PMID:26697497. |
for the first time, we have demonstrated that the mbo cultures exhibit increased blood brain barrier (bbb) permeability as shown by igg leakage into the brain parenchyma, astrocyte activation as evidenced by increased expression of glial fibrillary acidic protein (gfap), and neuronal damage-response as suggested by increased vimentin-positive neurons occur upon histamine treatment. |
2016-09-21 |
2023-08-13 |
mouse |
| Siqin Huang, Chenglin Tang, Shanquan Sun, Wenfu Cao, Wei Qi, Jin Xu, Juan Huang, Weitian Lu, Qian Liu, Biao Gong, Yi Zhang, Jin Jian. Protective Effect of Electroacupuncture on Neural Myelin Sheaths is Mediated via Promotion of Oligodendrocyte Proliferation and Inhibition of Oligodendrocyte Death After Compressed Spinal Cord Injury. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25465241. |
phenotypes of proliferating cells were identified by double immunolabeling of 5-ethynyl-2'-deoxyuridine with antibodies to cell markers: ng2 [oligodendrocyte precursor cell (opc) marker], 2',3'-cyclic-nucleotide 3'-phosphodiesterase (cnpase) (oligodendrocyte marker), and glial fibrillary acidic protein (gfap) (astrocyte marker). |
2016-08-30 |
2023-08-13 |
rat |
| Francisco Javier Rodriguez-Jimenez, Ana Alastrue-Agudo, Miodrag Stojkovic, Slaven Erceg, Victoria Moreno-Manzan. Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation. International journal of molecular sciences. vol 16. issue 11. 2016-08-29. PMID:26561800. |
when epspc or epspci were induced to spontaneously differentiate in vitro we found that cx50 favors glial cell fate, since higher expression levels, endogenous or by over-expression of cx50, augmented the expression of the astrocyte marker gfap and impaired the neuronal marker tuj1. |
2016-08-29 |
2023-08-13 |
Not clear |
| Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
changes in the expression levels of glial fibrillary acid protein (gfap), a marker of astrocyte activation in response to a variety of pathogenic stimuli, were examined in the hippocampus of rats treated with the repeated mk-801 injection (0.5 mg/10 ml/kg body weight for 6 days) and in primary cultured hippocampal astrocytes incubated with mk-801 (5 or 20 μm for 24 h). |
2016-08-17 |
2023-08-13 |
rat |
| Joseph Grodecki, Aaron R Short, Jessica O Winter, Shreyas S Rao, Jessica O Winter, José Javier Otero, John J Lannutti, Atom Sarka. Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers. Biotechnology progress. vol 31. issue 5. 2016-08-16. PMID:26081199. |
co-cultures of human gbm cells and rat astrocytes, as performed on the nfs, showed a significant increase in astrocyte gfap expression, particularly in the presence of extracellular matrix (ecm) deposited by gbm cells. |
2016-08-16 |
2023-08-13 |
human |
| Samuel R Beckerman, Joaquin E Jimenez, Yan Shi, Hassan Al-Ali, John L Bixby, Vance P Lemmo. Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies. Assay and drug development technologies. vol 13. issue 7. 2016-08-12. PMID:26230074. |
to test this hypothesis, we developed cell-based phenotypic bioassays to measure changes in (1) gfap morphology/localization and (2) cspg expression/immunoreactivity from primary astrocyte cultures. |
2016-08-12 |
2023-08-13 |
Not clear |
| Haiqun Jia, Ying Wang, Charles D Morris, Vincent Jacques, Joel M Gottesfeld, James R Rusche, Elizabeth A Thoma. The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. PloS one. vol 11. issue 3. 2016-08-12. PMID:27031333. |
accordingly, rgfp966-treated mice showed decreased glial fibrillary acidic protein (gfap) immunoreactivity, a marker of astrocyte activation, in the striatum of n171-82q transgenic mice compared to vehicle-treated mice. |
2016-08-12 |
2023-08-13 |
mouse |