| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
in this study, by employing a microglial-neuronal co-culture model, we showed that microglial inflammatory response induced by lipopolysaccharide led to tau hyperphosphorylation in neurons via activation of a major tau kinase glycogen synthase kinase 3β, confirming the pathogenic effects of activated microglia on the progression of tau pathology. |
2018-10-10 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
more importantly, by manipulating trem2 levels in microglia with a lentiviral-mediated strategy, we demonstrated that trem2 ameliorated the pathological effects of activated microglia on neuronal tau hyperphosphorylation via suppression of microglial inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Elizabeth E Spangenberg, Kim N Gree. Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:27395435. |
use of these models has identified roles of microglia in several pathological facets of ad, including tau propagation, synaptic stripping, neuronal loss, and cognitive decline. |
2018-08-10 |
2023-08-13 |
Not clear |
| Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avil. Absence of CX3CR1 impairs the internalization of Tau by microglia. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28810892. |
absence of cx3cr1 impairs the internalization of tau by microglia. |
2018-06-12 |
2023-08-13 |
Not clear |
| Christian Humpe. Platelets: Their Potential Contribution to the Generation of Beta-amyloid Plaques in Alzheimer's Disease. Current neurovascular research. vol 14. issue 3. 2018-05-14. PMID:28677497. |
alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, caa), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. |
2018-05-14 |
2023-08-13 |
Not clear |
| Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
activated microglia, astrocytes and elevated levels of proinflammatory molecules are also pathological hallmarks that are found in brain regions affected by tau pathology. |
2018-04-17 |
2023-08-13 |
Not clear |
| Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
we consider a physical role for microglia in the spread of tau pathology as well as the non-cell autonomous effects of secreted proinflammatory cytokines, specifically interleukin 1 beta, interleukin 6, tumor necrosis factor alpha and complement proteins. |
2018-04-17 |
2023-08-13 |
Not clear |
| Viktoria Johansson, Joel Jakobsson, Rebecca G Fortgang, Henrik Zetterberg, Kaj Blennow, Tyrone D Cannon, Christina M Hultman, Lennart Wetterberg, Mikael Landé. Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders. European archives of psychiatry and clinical neuroscience. vol 267. issue 5. 2018-01-30. PMID:28039552. |
markers of microglia activation [monocyte chemoattractant protein-1 (mcp-1), chitinase 3-like protein 1 (ykl-40), and soluble cluster of differentiation 14 (scd14)], markers of β-amyloid metabolism (aβx-38, aβx-40, aβx-42 and aβ1-42), soluble amyloid precursor proteins (sapp-α and sapp-β), total tau (t-tau), phosphorylated tau (p-tau), and csf/serum albumin ratio were measured in csf using immunoassays. |
2018-01-30 |
2023-08-13 |
Not clear |
| Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
only the full-effector antibody enhanced tau uptake in cultured microglia, which promoted release of proinflammatory cytokines. |
2018-01-16 |
2023-08-13 |
mouse |
| Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
in neuron-microglia co-cultures, only effectorless anti-tau protected neurons, suggesting full-effector tau antibodies can induce indirect toxicity via microglia. |
2018-01-16 |
2023-08-13 |
mouse |
| Paul D Wes, Faten A Sayed, Frédérique Bard, Li Ga. Targeting microglia for the treatment of Alzheimer's Disease. Glia. vol 64. issue 10. 2018-01-02. PMID:27100611. |
furthermore, microglia may have a substantial effect on current amyloid β (aβ) and tau immunotherapy approaches, since they are the primary cell type in the brain to mediate fc receptor-facilitated antibody effector function. |
2018-01-02 |
2023-08-13 |
Not clear |
| Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajole. Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method. Cell reports. vol 16. issue 4. 2017-11-20. PMID:27425620. |
we visualized amyloid plaques in 3d together with tau, microglia, and vasculature. |
2017-11-20 |
2023-08-13 |
mouse |
| Douglas G Walker, Lih-Fen Lue, Tiffany M Tang, Charles H Adler, John N Caviness, Marwan N Sabbagh, Geidy E Serrano, Lucia I Sue, Thomas G Beac. Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology. Neurobiology of aging. vol 54. 2017-11-16. PMID:28390825. |
double immunohistochemistry for phosphorylated α-synuclein and markers for microglia showed limited association of microglia with lb pathology, but microglia strongly associated with amyloid plaques or phosphorylated tau. |
2017-11-16 |
2023-08-13 |
Not clear |
| Ana M Catafau, Santiago Bullic. Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation. Current Alzheimer research. vol 14. issue 2. 2017-10-10. PMID:27334945. |
this article will focus on the investigational pet tracers targeting tau and alpha-synuclein as misfolded proteins, and activated microglia and astrocytes as cellular targets for neuroinflammation. |
2017-10-10 |
2023-08-13 |
human |
| Yue Sun, Qian Xiao, Cheng Luo, Yuxing Zhao, Die Pu, Kexiang Zhao, Jinliang Chen, Meili Wang, Zhiyin Lia. High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway. Experimental cell research. vol 359. issue 2. 2017-10-10. PMID:28803064. |
during the tau hyperphosphorylation process, tlr9 in microglia plays bidirectional roles. |
2017-10-10 |
2023-08-13 |
Not clear |
| Darrell Sawmiller, Ahsan Habib, Song Li, Donna Darlington, Huayan Hou, Jun Tian, R Douglas Shytle, Adam Smith, Brian Giunta, Takashi Mori, Jun Ta. Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. Journal of neuroimmunology. vol 299. 2017-08-14. PMID:27725131. |
diosmetin, one major bioactive metabolite of diosmin, increased inhibitory gsk-3β phosphorylation, while selectively reducing γ-secretase activity, aβ generation, tau hyperphosphorylation and pro-inflammatory activation of microglia in vitro, without altering notch processing. |
2017-08-14 |
2023-08-13 |
mouse |
| Zhong-Hao Zhang, Lei Wen, Qiu-Yan Wu, Chen Chen, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Guo-Li Son. Long-Term Dietary Supplementation with Selenium-Enriched Yeast Improves Cognitive Impairment, Reverses Synaptic Deficits, and Mitigates Tau Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease. Journal of agricultural and food chemistry. vol 65. issue 24. 2017-07-03. PMID:28578584. |
as the results revealed that se-yeast significantly improved the spatial learning and memory retention of 3×tg-ad mice, promoted neuronal activity, attenuated the activation of astrocytes and microglia, mitigated synaptic deficits, and reduced the levels of total tau and phosphorylated tau though inhibiting the activity of gsk-3β, dietary supplementation with se-yeast exerted multiple beneficial effects on the prevention or treatment of ad. |
2017-07-03 |
2023-08-13 |
mouse |
| A S M Hung, Y Liang, Tony C H Chow, H C Tang, Sharon L Y Wu, M S M Wai, D T Ye. Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review. Progress in histochemistry and cytochemistry. vol 51. issue 1. 2017-04-21. PMID:26851150. |
this review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in alzheimer disease. |
2017-04-21 |
2023-08-13 |
Not clear |
| Marta Bolós, Juan Ramón Perea, Jesús Avil. Alzheimer's disease as an inflammatory disease. Biomolecular concepts. vol 8. issue 1. 2017-03-20. PMID:28231054. |
alzheimer's disease (ad) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. |
2017-03-20 |
2023-08-13 |
Not clear |
| Yinquan Fang, Lemeng Yao, Chenhui Li, Jing Wang, Jianing Wang, Shujian Chen, Xin-Fu Zhou, Hong Lia. The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26939570. |
the blockage of the nogo/ngr signal pathway in microglia alleviates the formation of aβ plaques and tau phosphorylation in app/ps1 transgenic mice. |
2017-02-14 |
2023-08-13 |
mouse |