| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Alana N Vagnozzi, Phillip F Giannopoulos, Domenico Pratic\\xc3\\xb. Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice. Aging cell. vol 17. issue 1. 2019-07-30. PMID:29106033.' |
over-expression of 5lo resulted in microglia and astrocyte activation and significant synaptic pathology, which was associated with a significant elevation of tau phosphorylation at specific epitopes, tau insoluble fraction, and activation of the cdk5 kinase. |
2019-07-30 |
2023-08-13 |
mouse |
| Melanie Dani, Melanie Wood, Ruth Mizoguchi, Zhen Fan, Zuzana Walker, Richard Morgan, Rainer Hinz, Maya Biju, Tarun Kuruvilla, David J Brooks, Paul Ediso. Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30052812. |
we investigated the relationship between amyloid plaques, tau tangles and activated microglia using pet imaging. |
2019-07-17 |
2023-08-13 |
human |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
cell-based assay to study antibody-mediated tau clearance by microglia. |
2019-05-20 |
2023-08-13 |
mouse |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
one of the proposed mechanisms by which therapeutic antibodies reduce pathology is antibody-mediated uptake and clearance of pathological aggregated forms of tau by microglia. |
2019-05-20 |
2023-08-13 |
mouse |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
here, we describe a quantitative cell-based assay to assess tau uptake by microglia. |
2019-05-20 |
2023-08-13 |
mouse |
| Mengya Cao, Jiakai Fang, Xueqin Wang, Yi Wang, Kaiming Duan, Feng Ye, Wen Ouyang, Jianbin Ton. Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats. Brain research. vol 1684. 2019-04-19. PMID:29408499. |
further mechanism studies showed that corresponding to the impairment of learning and memory after surgery, surgery significantly increased the activation of microglia, decreased the expressions of nr2b and p-nr2b, and increased the expressions of tau and p-tau, which also were obviously restored by inhibiting ampk during operation. |
2019-04-19 |
2023-08-13 |
rat |
| Hong Wang, Yupeng Li, John W Ryder, Justin T Hole, Philip J Ebert, David C Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K Murray, Annalisa Cavallini, Suchira Bose, Brian J Eastwood, David A Collier, Jeffrey L Dage, Bradley B Miller, Kalpana M Merchant, Michael J O'Neill, Ronald B Dematto. Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30558641. |
genome-wide rnaseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rtg4510 tau transgenic animal model. |
2019-04-12 |
2023-08-13 |
human |
| Hong Wang, Yupeng Li, John W Ryder, Justin T Hole, Philip J Ebert, David C Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K Murray, Annalisa Cavallini, Suchira Bose, Brian J Eastwood, David A Collier, Jeffrey L Dage, Bradley B Miller, Kalpana M Merchant, Michael J O'Neill, Ronald B Dematto. Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30558641. |
however, the gene expression changes underlying microglia activation in response to tau pathology remain elusive. |
2019-04-12 |
2023-08-13 |
human |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
dephosphorylated rather than hyperphosphorylated tau triggers a pro-inflammatory profile in microglia through the p38 mapk pathway. |
2019-03-21 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
however, the mechanism through which extracellular tau triggers pro-inflammatory responses in microglia remains unknown. |
2019-03-21 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
primary microglia cultures were treated with extracellular tau in its hyperphosphorylated, dephosphorylated or non-phosphorylated form. |
2019-03-21 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
protein cytokine arrays, real-time pcr, inhibition of the p38 mapk pathway, phosphatase assays, and quantification of proteins through immunoblotting were used to analyze the effect of extracellular tau on the pro-inflammatory response of microglia. |
2019-03-21 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
the main finding of this work is that extracellular non-phosphorylated and dephosphorylated forms of tau, rather than hyperphosphorylated tau, activate the p38 mapk pathway in microglia, thus triggering a pro-inflammatory response in these cells. |
2019-03-21 |
2023-08-13 |
Not clear |
| Rachel E Bennett, Annie Bryant, Miwei Hu, Ashley B Robbins, Sarah C Hopp, Bradley T Hyma. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30413160. |
partial reduction of microglia does not affect tau pathology in aged mice. |
2019-01-29 |
2023-08-13 |
mouse |
| Rachel E Bennett, Annie Bryant, Miwei Hu, Ashley B Robbins, Sarah C Hopp, Bradley T Hyma. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30413160. |
the goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute to tau protein accumulation and pathology-associated changes in immune and non-immune cell processes such as neuronal degeneration, astrocyte physiology, cytokine expression, and blood vessel morphology. |
2019-01-29 |
2023-08-13 |
mouse |
| David V Hansen, Jesse E Hanson, Morgan Shen. Microglia in Alzheimer's disease. The Journal of cell biology. vol 217. issue 2. 2018-12-12. PMID:29196460. |
microglia can mediate synapse loss by engulfment of synapses, likely via a complement-dependent mechanism; they can also exacerbate tau pathology and secrete inflammatory factors that can injure neurons directly or via activation of neurotoxic astrocytes. |
2018-12-12 |
2023-08-13 |
human |
| Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
the role of microglia in processing and spreading of bioactive tau seeds in alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
| Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
however, recent studies as well as the data contained herein suggest that microglia, the resident immune cells of the central nervous system, play a direct role in the spread of tau pathology. |
2018-12-11 |
2023-08-13 |
Not clear |
| Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulia. SPECT and PET imaging in Alzheimer's disease. Annals of nuclear medicine. vol 32. issue 9. 2018-11-02. PMID:30128693. |
beta-amyloid (aβ) deposition and neurofibrillary tangles (nfts) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. |
2018-11-02 |
2023-08-13 |
human |
| Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulia. SPECT and PET imaging in Alzheimer's disease. Annals of nuclear medicine. vol 32. issue 9. 2018-11-02. PMID:30128693. |
intense efforts in radiopharmaceuticals research have led to the development of various probes able to detect aβ deposits, tau protein accumulation, microglia activation and neuroinflammation. |
2018-11-02 |
2023-08-13 |
human |