| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Baian Chen, Jing Lu, Yi Wu, Shubo Wang, Zitong Yao, Liming Zhu, Yanhua Qiao, Quan Sun, Wei Qin, Qiao Zhao, Jianping Jia, Cuibai We. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging cell. vol 18. issue 4. 2020-07-07. PMID:31165579. |
the aβ deposits, which were devoid of aβ dimers, induced glial pathology (microgliosis, abnormal microglia morphology, and astrocytosis), but not the subsequent downstream pathologies of ad, including tau pathology, neurodegeneration, and synapse loss. |
2020-07-07 |
2023-08-13 |
monkey |
| Etay Aloni, Efrat Oni-Biton, Micheal Tsoory, Dalia H Moallem, Menahem Sega. Synaptopodin Deficiency Ameliorates Symptoms in the 3xTg Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 20. 2020-06-15. PMID:30872324. |
in addition, there was a marked reduction in 3xtg-associated phosphorylated tau, amyloid β plaques, and activated microglia in 3xtg/spko male and female mice. |
2020-06-15 |
2023-08-13 |
mouse |
| Melissa L Young, James L Frankli. The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice. Molecular and cellular neurosciences. vol 101. 2020-05-05. PMID:31521745. |
mitoq-treated mice showed improved memory retention compared to untreated 3xtg-ad mice as well as reduced brain oxidative stress, synapse loss, astrogliosis, microglial cell proliferation, aβ accumulation, caspase activation, and tau hyperphosphorylation. |
2020-05-05 |
2023-08-13 |
mouse |
| Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Julien Couturier, Alexandre Vanoosthuyse, Sofie Kessels, Chritica Lodder, Bert Brône, François Huaux, Jean-Noël Octave, Dick Terwel, Ilse Dewachte. Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo. Acta neuropathologica. vol 137. issue 4. 2020-04-21. PMID:30721409. |
we demonstrate that tau seeds activate nlrp3-asc-dependent inflammasome in primary microglia, following microglial uptake and lysosomal sorting of tau seeds. |
2020-04-21 |
2023-08-13 |
mouse |
| Jonas Elias Schweig, Hailan Yao, Kyle Coppola, Chao Jin, Fiona Crawford, Michael Mullan, Daniel Pari. Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation The Journal of biological chemistry. vol 294. issue 36. 2020-03-31. PMID:31324720. |
moreover, syk hyperactivation occurs in a subset of activated microglia, in dystrophic neurites surrounding aβ deposits, and in neurons affected by tau pathology both in individuals with alzheimer's disease (ad) and in ad mouse models. |
2020-03-31 |
2023-08-13 |
mouse |
| Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefe. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia. Neurobiology of disease. vol 130. 2020-03-24. PMID:31229689. |
asparagine endopeptidase cleaves tau at n167 after uptake into microglia. |
2020-03-24 |
2023-08-13 |
Not clear |
| Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefe. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia. Neurobiology of disease. vol 130. 2020-03-24. PMID:31229689. |
accordingly, we observe tau cleavage at n167 and n368 after endocytotic uptake into microglia, but not neurons. |
2020-03-24 |
2023-08-13 |
Not clear |
| Kathleen M McAvoy, Hameetha Rajamohamed Sait, Galina Marsh, Michael Peterson, Taylor L Reynolds, Jake Gagnon, Sarah Geisler, Prescott Leach, Chris Roberts, Ellen Cahir-McFarland, Richard M Ransohoff, Andrea Crott. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PloS one. vol 14. issue 8. 2020-03-03. PMID:31408457. |
taken together, our data suggest that the contribution of genetic variation in bin1 locus to ad risk could result from a cell-autonomous reduction of neuronal excitability due to bin1 decrease, exacerbated by the presence of aggregated tau, coupled with a non-cell autonomous microglia activation. |
2020-03-03 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
living neurons with tau filaments aberrantly expose phosphatidylserine and are phagocytosed by microglia. |
2020-01-27 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
consequently, co-cultured phagocytes (bv2 cells or primary microglia) identify and phagocytose the living neurons, thereby engulfing insoluble tau inclusions. |
2020-01-27 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
to facilitate engulfment, neurons induce contacting microglia to secrete the opsonin milk-fat-globule egf-factor-8 (mfge8) and nitric oxide (no), whereas neurons with tau inclusions are rescued when mfge8 or no production is prevented. |
2020-01-27 |
2023-08-13 |
mouse |
| Cira Dansokho, Michael Thomas Henek. Neuroinflammatory responses in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 5. 2019-11-04. PMID:29273951. |
this review discusses recent knowledge on microglia responses toward amyloid and tau pathology in ad, focusing on the role of toll-like receptors and nod-like receptor protein 3 (nlrp3) inflammasome activation in microglial cells. |
2019-11-04 |
2023-08-13 |
mouse |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, Emily L Munger, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of comparative neurology. vol 526. issue 18. 2019-10-28. PMID:30069930. |
activated microglia density and morphology were not associated with age, sex, pretangle density, nft density, or tau neuritic cluster density. |
2019-10-28 |
2023-08-13 |
human |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, Emily L Munger, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of comparative neurology. vol 526. issue 18. 2019-10-28. PMID:30069930. |
in contrast to human ad brains, activated microglia density was not significantly correlated with tau lesions. |
2019-10-28 |
2023-08-13 |
human |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial priming of antigen presentation and adaptive stimulation in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 76. issue 19. 2019-10-17. PMID:31093687. |
primed microglia process and present self-antigen such as amyloid-β and modified tau to the infiltrated t lymphocytes through mhc i/ii molecules. |
2019-10-17 |
2023-08-13 |
Not clear |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915328. |
similar to what was observed in tau brains, overexpressing mir142 in wildtype cortical neurons augments mrna levels of glial fibrillary acidic protein (gfap) and colony stimulating factor 1 (csf1), accompanied by a significant increase in microglia and reactive astrocyte numbers. |
2019-10-09 |
2023-08-13 |
mouse |
| Shorena Janelidze, Niklas Mattsson, Erik Stomrud, Olof Lindberg, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30054439. |
to measure csf levels of biomarkers reflecting microglia and astrocytes activation, neuroinflammation, and cerebrovascular changes and study their associations with the core biomarkers of alzheimer disease (ad) pathology (β-amyloid [aβ] and tau), structural imaging correlates, and clinical disease progression over time. |
2019-08-19 |
2023-08-13 |
Not clear |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
therefore, we investigated the effects of intracerebroventricular administration of adomet on redox homeostasis, microglia activation, synaptophysin levels, and tau phosphorylation in cerebral cortex and striatum of young rats. |
2019-08-06 |
2023-08-13 |
rat |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
finally, we verified that adomet produced microglia activation by increasing iba1 staining and tau phosphorylation, as well as reduced synaptophysin levels in cerebral cortex. |
2019-08-06 |
2023-08-13 |
rat |
| Sho Takatori, Wenbo Wang, Akihiro Iguchi, Taisuke Tomit. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747419. |
we further describe the involvement of microglia in tau pathology and the activation of other glial cells. |
2019-08-02 |
2023-08-13 |
Not clear |