| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nimansha Jain, Jason D Ulric. TREM2 and microglia exosomes: a potential highway for pathological tau. Molecular neurodegeneration. vol 17. issue 1. 2022-11-18. PMID:36397070. |
the mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for microglia in the spread of tau pathology. |
2022-11-18 |
2023-08-14 |
Not clear |
| Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gess. Microglia and Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361780. |
extracellular amyloid and/or intraneuronal phosphorylated tau in ad can both activate microglia. |
2022-11-11 |
2023-08-14 |
Not clear |
| Maud Gratuze, Johannes C M Schlachetzki, Ricardo D'Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O'Brien, Martina P Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K Glass, Jason D Ulrich, David M Holtzma. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. 2022-11-11. PMID:36368315. |
apoe4 exacerbates tau-linked neurodegeneration and inflammation in p301s tau mice and removal of microglia blocks tau-dependent neurodegeneration. |
2022-11-11 |
2023-08-14 |
mouse |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
dysfunctional microglia and tau pathology in alzheimer's disease. |
2022-10-27 |
2023-08-14 |
human |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
loss of microglial neuroprotective and phagocytic functions, as indicated by the faulty clearance of amyloid plaques, as well as correlations between microglial activation and tau tangle spread, all demonstrate the critical involvement of malfunctioning microglia in driving tau propagation. |
2022-10-27 |
2023-08-14 |
human |
| Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M Reima. AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy. Aging. vol 14. issue undefined. 2022-10-13. PMID:36227739. |
we defined the mechanisms by which the chaperone atpase inhibitor ar12 and the multi-kinase inhibitor neratinib interacted to reduce expression of tau and amyloid-precursor protein (app) in microglia and neuronal cells. |
2022-10-13 |
2023-08-14 |
Not clear |
| Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M Reima. AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy. Aging. vol 14. issue undefined. 2022-10-13. PMID:36227739. |
we conclude that ar12 has the potential to reduce tau and app levels in neurons and microglia via the actions of lap, endoplasmic reticulum stress signaling and macroautophagy. |
2022-10-13 |
2023-08-14 |
Not clear |
| Nimansha Jain, Caroline A Lewis, Jason D Ulrich, David M Holtzma. Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 220. issue 1. 2022-10-11. PMID:36219197. |
thus, microglia and trem2 are at a critical intersection of aβ and tau pathologies in ad. |
2022-10-11 |
2023-08-14 |
mouse |
| Lin Lin, Ronald S Petralia, Lynne Holtzclaw, Ya-Xian Wang, Daniel Abebe, Dax A Hoffma. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice. Neurobiology of disease. 2022-10-09. PMID:36209950. |
the amyloid β and phosphorylated tau pathologies were associated with neuroinflammation characterized by increases in microglia and astrocytes. |
2022-10-09 |
2023-08-14 |
mouse |
| Priya Rangan, Fleur Lobo, Edoardo Parrella, Nicolas Rochette, Marco Morselli, Terri-Leigh Stephen, Anna Laura Cremonini, Luca Tagliafico, Angelica Persia, Irene Caffa, Fiammetta Monacelli, Patrizio Odetti, Tommaso Bonfiglio, Alessio Nencioni, Martina Pigliautile, Virginia Boccardi, Patrizia Mecocci, Christian J Pike, Pinchas Cohen, Mary Jo LaDu, Matteo Pellegrini, Kyle Xia, Katelynn Tran, Brandon Ann, Dolly Chowdhury, Valter D Long. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell reports. vol 40. issue 13. 2022-09-28. PMID:36170815. |
in 3xtg mice, long-term fmd cycles reduce hippocampal aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating nadph oxidase (nox2). |
2022-09-28 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
weekly treatment of 5xfad mice (a model of ad) with ab18 tvd-ig/αtfr showed a considerable reduction of amyloid burden with increased microglia migration to and phagocytosis of amyloid plaques, improved synaptic and neuronal marker intensity, improved cognitive functions, reduced endogenous tau hyperphosphorylation, and decreased phosphorylated neurofilament h immunostaining. |
2022-09-07 |
2023-08-14 |
mouse |
| Boris-Stephan Rauchmann, Matthias Brendel, Nicolai Franzmeier, Lena Trappmann, Mirlind Zaganjori, Ersin Ersoezlue, Estrella Morenas-Rodriguez, Selim Guersel, Lena Burow, Carolin Kurz, Jan Haeckert, Maia Tatò, Julia Utecht, Boris Papazov, Oliver Pogarell, Daniel Janowitz, Katharina Buerger, Michael Ewers, Carla Palleis, Endy Weidinger, Gloria Biechele, Sebastian Schuster, Anika Finze, Florian Eckenweber, Rainer Rupprecht, Axel Rominger, Oliver Goldhardt, Timo Grimmer, Daniel Keeser, Sophia Stoecklein, Olaf Dietrich, Peter Bartenstein, Johannes Levin, Günter Höglinger, Robert Perneczk. Microglial Activation and Connectivity in Alzheimer Disease and Aging. Annals of neurology. 2022-09-02. PMID:36053756. |
alzheimer disease (ad) is characterized by amyloid β (aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven by the activation of microglia. |
2022-09-02 |
2023-08-14 |
Not clear |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. |
2022-09-02 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
microglia and astrocytes have been described as playing important roles in synaptic spreading of toxic tau in several neurodegenerative diseases (nds). |
2022-09-02 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
by immunohistochemistry and co-immunofluorescence assays using toma/ttc-ms and cell-type specific markers for neurons, astrocytes, and microglia, we observed that toma/ttc-ms were immunoreactive to diverse tau species in different cell types. |
2022-09-02 |
2023-08-14 |
mouse |
| Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y Huan. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular neurodegeneration. vol 17. issue 1. 2022-09-02. PMID:36056435. |
trem2 deletion enhances tau dispersion and pathology through microglia exosomes. |
2022-09-02 |
2023-08-14 |
Not clear |
| Qing Wang, Chunming Xi. Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease. Frontiers in neuroscience. vol 16. 2022-08-29. PMID:36033617. |
microglia activation linking amyloid-β drive tau spatial propagation in alzheimer's disease. |
2022-08-29 |
2023-08-14 |
Not clear |
| Emily Sun, Aishat Motolani, Leonardo Campos, Tao L. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012242. |
some of these cell types and molecules include reactive microglia and astrocytes, β-secretase, apoe, glutamate, mirna, and tau protein, among others. |
2022-08-26 |
2023-08-14 |
mouse |
| Erin John Rieger de Almeida, Hélio Jungkenn Ibrahim, Maria Rosa Chitolina Schetinger, Cinthia Melazzo de Andrade, Andréia Machado Cardos. Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases. Neurochemical research. 2022-08-13. PMID:35962936. |
in this context, ad is a neurodegenerative and neuroinflammatory disease characterized by the deposition of beta-amyloid plaques, formation of fibrillar tangles of tau protein, and loss of neurons due to neurotoxic activation of microglia. |
2022-08-13 |
2023-08-14 |
Not clear |
| Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines. vol 10. issue 8. 2022-07-27. PMID:35892700. |
aβ and tau regulate microglia metabolism via exosomes in alzheimer's disease. |
2022-07-27 |
2023-08-14 |
Not clear |