| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, anosmia was significantly associated with higher plasma total tau and nfl concentrations, smaller hippocampal and entorhinal cortex volumes, and greater wmh volume, and marginally with lower ad-signature cortical thickness. |
2022-11-07 |
2023-08-14 |
human |
| Gabriel A Marx, Daniel G Koenigsberg, Andrew T McKenzie, Justin Kauffman, Russell W Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A Iida, Charles L White, Jamie M Walker, Timothy E Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F Crary, Kurt Farrel. Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta neuropathologica communications. vol 10. issue 1. 2022-11-01. PMID:36316708. |
we utilized a cnn trained to segment nfts on hippocampus sections immunohistochemically stained with antisera recognizing abnormal hyperphosphorylated tau (p-tau), which yielded metrics of regional nft counts, nft positive pixel density, as well as a novel graph-theory based metric measuring the spatial distribution of nfts. |
2022-11-01 |
2023-08-14 |
human |
| Carolyn Tallon, Benjamin J Bell, Anjali Sharma, Arindom Pal, Medhinee M Malvankar, Ajit G Thomas, Seung-Wan Yoo, Kristen R Hollinger, Kaleem Coleman, Elizabeth L Wilkinson, Sujatha Kannan, Norman J Haughey, Rangaramanujam M Kannan, Rana Rais, Barbara S Slushe. Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice. Pharmaceutics. vol 14. issue 10. 2022-10-27. PMID:36297501. |
in a mouse tau propagation model, where a mutant htau (p301l/s320f) containing adeno-associated virus was unilaterally seeded into the hippocampus, oral d-dptip (dosed 3× weekly) significantly inhibited brain nsmase2 activity and blocked the spread of ptau to the contralateral hippocampus. |
2022-10-27 |
2023-08-14 |
mouse |
| Pardeep Yadav, Yeon-Hee Lee, Hrithika Panday, Shubham Kant, Neha Bajwa, Ritika Parashar, Saurabh Kumar Jha, Niraj Kumar Jha, Parma Nand, Sang-Soo Lee, Abhimanyu Kumar Jh. Implications of Microorganisms in Alzheimer's Disease. Current issues in molecular biology. vol 44. issue 10. 2022-10-26. PMID:36286029. |
ad is manifested with hyperphosphorylated tau protein levels and amyloid beta (aβ) peptide buildup in the hippocampus and cortex regions of the brain. |
2022-10-26 |
2023-08-14 |
Not clear |
| Julia J Segura-Uribe, Paola Garcia-de la Torre, Tzayaka Castillo-Mendieta, Iván Bribiesca-Cruz, Sandra Orozco-Suárez, Marvin Soriano-Ursúa, Rodolfo Pinto-Almazán, Claudia Fuentes-Venado, Christian Guerra-Araiz. Tibolone Improves Memory and Decreases the Content of Amyloid-β Peptides and Tau Protein in the Hippocampus of a Mice Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-24. PMID:36278346. |
tibolone improves memory and decreases the content of amyloid-β peptides and tau protein in the hippocampus of a mice model of alzheimer's disease. |
2022-10-24 |
2023-08-14 |
mouse |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |
| Ramón Martínez-Mármol, Christopher Small, Anmin Jiang, Tishila Palliyaguru, Tristan P Wallis, Rachel S Gormal, Jean-Baptiste Sibarita, Jürgen Götz, Frédéric A Meunie. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular psychiatry. 2022-10-18. PMID:36258016. |
expression of p301l mutant tau promotes aberrant trapping of fyn in nanoclusters within hippocampal dendrites by an unknown mechanism. |
2022-10-18 |
2023-08-14 |
Not clear |
| Jianping Tang, Yanjun Li, Xu Liu, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Yating Zhang, Wenya Shao, Siying Wu, Huangyuan L. Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction. The Science of the total environment. 2022-10-15. PMID:36243078. |
we first reveal cobalt as an environmental toxicant to severely induce β amyloid (aβ) deposition, tau hyperphosphorylation, and dysregulated autophagy in the hippocampus and cortex of mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
therefore, mhdis listed in this review protect against aβ-induced cognitive decline by inhibiting aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late ad phases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Mychael V Lourenco, Guilherme B de Freitas, Ícaro Raony, Sergio T Ferreira, Fernanda G De Felic. Irisin stimulates protective signaling pathways in rat hippocampal neurons. Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187295. |
finally, analysis of rna sequencing (rnaseq) datasets shows a trend of reduction of hippocampal fndc5 mrna with aging and tau pathology in humans. |
2022-10-03 |
2023-08-14 |
mouse |
| Dongli Meng, Mengzhe Yang, Lilin Hu, Tonglin Liu, Huiliang Zhang, Xuying Sun, Xiaochuan Wang, Yu Chen, Yu Jin, Rong Li. Rifaximin protects against circadian rhythm disruption-induced cognitive impairment through preventing gut barrier damage and neuroinflammation. Journal of neurochemistry. 2022-10-03. PMID:36189686. |
furthermore, the impairment in hippocampal neurogenesis, tau hyperphosphorylation and loss in synaptic proteins in crd mice is also reversed by rifaximin. |
2022-10-03 |
2023-08-14 |
mouse |
| Priya Rangan, Fleur Lobo, Edoardo Parrella, Nicolas Rochette, Marco Morselli, Terri-Leigh Stephen, Anna Laura Cremonini, Luca Tagliafico, Angelica Persia, Irene Caffa, Fiammetta Monacelli, Patrizio Odetti, Tommaso Bonfiglio, Alessio Nencioni, Martina Pigliautile, Virginia Boccardi, Patrizia Mecocci, Christian J Pike, Pinchas Cohen, Mary Jo LaDu, Matteo Pellegrini, Kyle Xia, Katelynn Tran, Brandon Ann, Dolly Chowdhury, Valter D Long. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell reports. vol 40. issue 13. 2022-09-28. PMID:36170815. |
in 3xtg mice, long-term fmd cycles reduce hippocampal aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating nadph oxidase (nox2). |
2022-09-28 |
2023-08-14 |
mouse |
| Xiu Chen, Juan-Ling He, Xue-Ting Liu, Na Zhao, Fan Geng, Meng-Meng Zhu, Gong-Ping Liu, Qing-Guo Re. DI-3-n-butylphthalide mitigates stress-induced cognitive deficits in mice through inhibition of NLRP3-Mediated neuroinflammation. Neurobiology of stress. vol 20. 2022-09-26. PMID:36160816. |
the results showed that both depressive and resilient mice displayed spatial memory deficits and an accumulation of tau in the hippocampus. |
2022-09-26 |
2023-08-14 |
mouse |
| Dhwani S Korde, Christian Humpe. Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures. Biomolecules. vol 12. issue 9. 2022-09-23. PMID:36139003. |
slices with un- and hyperphosphorylated p301s aggregated tau demonstrate significant spreading to the ventral parts of the hippocampal slices compared to empty collagen hydrogels after 8 weeks. |
2022-09-23 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging. vol 2022. 2022-09-23. PMID:36147309. |
investigating the effect of tau deposition and apoe on hippocampal morphometry in alzheimer's disease: a federated chow test model. |
2022-09-23 |
2023-08-14 |
Not clear |
| Churaibhon Wisessaowapak, Luksamee Worasuttayangkurn, Kanjanamas Maliphol, Watanyoo Nakareangrit, Wanida Cholpraipimolrat, Sumontha Nookabkaew, Piyajit Watcharasit, Jutamaad Satayaviva. The 28-day repeated arsenic exposure increases tau phosphorylation in the rat brain. Environmental toxicology and pharmacology. 2022-09-11. PMID:36089238. |
interestingly, we found an increase in tau phosphorylation at the tau 1 region (189-207) and s202 in the hippocampus, s404 in the cerebral cortex, and s396 and s404 in the cerebellum of arsenic-treated rats. |
2022-09-11 |
2023-08-14 |
rat |
| Pengfang Zheng, Xiaojun She, Chunping Wang, Yingwen Zhu, Bo Fu, Kefeng Ma, Honglian Yang, Xiujie Gao, Xiaofang Li, Fangshan Wu, Bo Cu. Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis. Cells. vol 11. issue 17. 2022-09-09. PMID:36078149. |
the levels of phosphorylated tau, amyloid-β (aβ), and neuroinflammation in the cortex and hippocampus were assessed and autophagosome (ap) aggregation was observed by transmission electron microscopy. |
2022-09-09 |
2023-08-14 |
rat |
| Georgiana F Stan, Timothy W Church, Ellie Randall, Jenna R M Harvey, Jon T Brown, Kevin A Wilkinson, Jonathan G Hanley, Neil V Marrio. Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. Scientific reports. vol 12. issue 1. 2022-09-08. PMID:36075936. |
tau isoform-specific enhancement of l-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. |
2022-09-08 |
2023-08-14 |
human |
| Rocío Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice. Brain pathology (Zurich, Switzerland). 2022-09-04. PMID:36058615. |
different modes of synaptic and extrasynaptic nmda receptor alteration in the hippocampus of p301s tau transgenic mice. |
2022-09-04 |
2023-08-14 |
mouse |