| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing-Hua Ma, Liu-Fang Jiang, Jian-Liang Mao, Wen-Xin Xu, Min Huan. Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29257340. |
these results indicate that vildagliptin administration exerts a protective effect against cognitive deficits by reducing tau phosphorylation and increasing the expression of proteins associated with synaptic plasticity in the hippocampus. |
2018-08-15 |
2023-08-13 |
rat |
| Melike Yuksel, Kevser Biberoglu, Seda Onder, K Gonca Akbulut, Ozden Taca. Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease. Biochimie. vol 146. 2018-08-13. PMID:29248542. |
similarly, tbo did not recover hyperphosphorylation of tau at residues thr181 and ser202/thr205 significantly in soluble and insoluble hippocampal fractions of 3xtg-ad mice. |
2018-08-13 |
2023-08-13 |
mouse |
| M Bolós, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J Ávila, M Llorens-Martí. Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons. Translational psychiatry. vol 7. issue 12. 2018-07-30. PMID:29217824. |
soluble tau has devastating effects on the structural plasticity of hippocampal granule neurons. |
2018-07-30 |
2023-08-13 |
mouse |
| M Bolós, N Pallas-Bazarra, J Terreros-Roncal, J R Perea, J Jurado-Arjona, J Ávila, M Llorens-Martí. Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons. Translational psychiatry. vol 7. issue 12. 2018-07-30. PMID:29217824. |
here we evaluated the long-term impact of a single stereotaxic injection of human soluble tau on hippocampal granule neurons in mice. |
2018-07-30 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukaw. The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. Bioscience, biotechnology, and biochemistry. vol 82. issue 5. 2018-07-30. PMID:29424280. |
the peel of citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. |
2018-07-30 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukaw. The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice. Bioscience, biotechnology, and biochemistry. vol 82. issue 5. 2018-07-30. PMID:29424280. |
the c. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus. |
2018-07-30 |
2023-08-13 |
mouse |
| Chunyan Zhu, Bing Xu, Xiaohong Sun, Qiwen Zhu, Yi Su. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878757. |
in the present study, we showed that ccr3, the receptor for ccl11, was expressed by hippocampal neurons and treatment of primary hippocampal neuronal cultures (14 days in vitro) with ccl11 resulted in activation of cyclin-dependent kinase 5 and glycogen synthase kinase-3β, associated with elevated tau phosphorylation at multiple sites. |
2018-07-27 |
2023-08-13 |
mouse |
| Huan Zhou, Ying Guo, Xing Li, Zheng-Yu Liuyang, Yang-Ping Shentu, Xiao-Peng Jing, Jia-Wei Liang, Xin-Wen Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, Ji Zeng, Rong Li. Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 6. 2018-07-26. PMID:29270738. |
however, there was no significant change of tau phosphorylation at thr205 (pt205), thr231 (pt231), ser396 (ps396) and ser404 (ps404) sites in the hippocampus and cerebral cortex. |
2018-07-26 |
2023-08-13 |
human |
| S L Angulo, R Orman, S A Neymotin, L Liu, L Buitrago, E Cepeda-Prado, D Stefanov, W W Lytton, M Stewart, S A Small, K E Duff, H Moren. Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiology of disease. vol 108. 2018-07-23. PMID:28860088. |
tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. |
2018-07-23 |
2023-08-13 |
mouse |
| Miranda Tuwaig, Mélissa Savard, Benoît Jutras, Judes Poirier, D Louis Collins, Pedro Rosa-Neto, David Fontaine, John C S Breitne. Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:28984583. |
adjusting for age, sex, education, pure-tone hearing, and apoeɛ4 status, we observed a persistent relationship between cap scores and csf tau levels, entorhinal and hippocampal cortex volumes, cortical thickness, and deficits in cognition (repeatable battery for assessment of neuropsychological status total score, and several of its index scales). |
2018-07-23 |
2023-08-13 |
Not clear |
| Zhong-Hong Kong, Xin Chen, Hui-Po Hua, Liang Liang, Long-Juan Li. The Oral Pretreatment of Glycyrrhizin Prevents Surgery-Induced Cognitive Impairment in Aged Mice by Reducing Neuroinflammation and Alzheimer's-Related Pathology via HMGB1 Inhibition. Journal of molecular neuroscience : MN. vol 63. issue 3-4. 2018-07-20. PMID:29034441. |
additionally, the pretreatment of glycyrrhizin reduced the postoperative neuroinflammation (production of pro-inflammatory cytokines including il-1β, tnf-α, and il-6 as well as nf-κb nuclear expression) and alzheimer's-related pathology (tau phosphorylation at the site of at-8 and ser396 as well as aβ40 and 42 concentrations) in the hippocampus of the aged mice undergoing splenectomy surgery. |
2018-07-20 |
2023-08-13 |
mouse |
| Diana Klakotskaia, Cansu Agca, Rachel A Richardson, Edward G Stopa, Todd R Schachtman, Yuksel Agc. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PloS one. vol 13. issue 4. 2018-07-16. PMID:29641600. |
immunohistochemistry using an antibody against amyloid-β (aβ) showed extensive and mostly diffuse aβ plaques in the hippocampus and dense plaques that contained tau in the cortex of the brains of the app+ps1 rats. |
2018-07-16 |
2023-08-13 |
human |
| Kristian Steen Frederiksen, Le Gjerum, Gunhild Waldemar, Steen Gregers Hasselbalc. Effects of Physical Exercise on Alzheimer's Disease Biomarkers: A Systematic Review of Intervention Studies. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154278. |
we carried out a systematic review of intervention studies of physical exercise with hippocampal volume (on mri), amyloid-β, total tau, phosphorylated tau in cerebrospinal fluid (csf), 18f-fdg-pet or amyloid pet as outcome measures in healthy subjects, patients with subjective memory complaints, mild cognitive impairment, or ad. |
2018-07-13 |
2023-08-13 |
human |
| Elizabeth M Lane, Timothy J Hohman, Angela L Jefferso. Insulin-like growth factor binding protein-2 interactions with Alzheimer's disease biomarkers. Brain imaging and behavior. vol 11. issue 6. 2018-07-09. PMID:27817134. |
ad neuroimaging initiative data were accessed (n = 354, 75 ± 7 years, 38 % female), including plasma igfbp-2, csf total tau, csf aβ-42, mri-quantified hippocampal volume, and neuropsychological performances. |
2018-07-09 |
2023-08-13 |
Not clear |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
the levels of glucose, insulin, aβ, ages, tau protein and acetylcholinesterase in the blood and/or hippocampus of rats were determined by blood‑glucose meter, radioimmunoassay, chemical chromatometry, enzyme‑linked immunosorbent assay (elisa) and immunohistochemical analysis, respectively. |
2018-07-09 |
2023-08-13 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
the levels of glucose, insulin, aβ, ages and tau protein were significantly increased in the blood and/or hippocampus of t2dm rats, while lse remarkably decreased their levels compared to vehicle treatment (p<0.01). |
2018-07-09 |
2023-08-13 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
the possible mechanisms may be associated with ir improvement and decreased formations of aβ, ages and tau protein in the hippocampus of t2dm rats. |
2018-07-09 |
2023-08-13 |
rat |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
the hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as alzheimer's disease. |
2018-07-02 |
2023-08-13 |
mouse |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
in this study, we used a high-fat diet to induce obesity and insulin resistance in adult swiss mice and checked whether supplementation with myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. |
2018-07-02 |
2023-08-13 |
mouse |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
the treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the morris water maze test. |
2018-07-02 |
2023-08-13 |
mouse |