| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Shin, T Iwaki, T Kitamoto, Y Sato, J Tateish. Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method. The American journal of pathology. vol 140. issue 4. 1992-05-11. PMID:1373272. |
using the hydrated autoclaving method, a new immunohistochemical procedure to enhance tau immunoreactivity in formalin-fixed brain tissue, the authors recently reported that tau protein is detected in neuronal cell bodies and proximal dendrites, gray matter neuropil, axons, and glial cells in normal human hippocampus and neocortex. |
1992-05-11 |
2023-08-11 |
human |
| J J Hauw, M Verny, P Delaère, P Cervera, Y He, C Duyckaert. Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer's disease and aging. Neuroscience letters. vol 119. issue 2. 1991-03-12. PMID:1704110. |
psp is thus another example of abnormal storage of tau developing in the neocortex in the absence of beta-amyloid deposits. |
1991-03-12 |
2023-08-11 |
Not clear |
| S Flament, A Delacourte, P Delaère, C Duyckaerts, J J Hau. Correlation between microscopical changes and Tau 64 and 69 biochemical detection in senile dementia of the Alzheimer type. Tau 64 and 69 are reliable markers of the neurofibrillary degeneration. Acta neuropathologica. vol 80. issue 2. 1990-09-27. PMID:2117842. |
therefore, these pathological forms of tau proteins are reliable markers of the presence of nft and sp in the neocortex and may be used as a diagnostic tool. |
1990-09-27 |
2023-08-11 |
Not clear |
| S Flament, A Delacourte, B Hémon, A Défosse. Characterization of two pathological tau protein, variants in Alzheimer brain cortices. Journal of the neurological sciences. vol 92. issue 2-3. 1989-12-01. PMID:2509637. |
moreover, in association areas of neocortex from alzheimer brains, the antisera detected 2 additional tau variants of 64 and 69 kda. |
1989-12-01 |
2023-08-11 |
Not clear |
| P Delaère, C Duyckaerts, J P Brion, V Poulain, J J Hau. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta neuropathologica. vol 77. issue 6. 1989-08-25. PMID:2501966. |
tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of alzheimer type. |
1989-08-25 |
2023-08-11 |
Not clear |
| P Delaère, C Duyckaerts, J P Brion, V Poulain, J J Hau. Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta neuropathologica. vol 77. issue 6. 1989-08-25. PMID:2501966. |
tau immunoreactivity was studied in temporal neocortex, area 22, in 15 cases with graded intellectual status and compared with the immunoreactivity observed with an antiserum against paired helical filaments (phf) and with the density of amyloid revealed by thioflavin s. samples came from women over 75 years either intellectually normal or affected by senile dementia of the alzheimer type at various degrees of severity. |
1989-08-25 |
2023-08-11 |
Not clear |
| G Mangin, D Couchie, C Charrière-Bertrand, J Nune. Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2498465. |
timing of expression of tau and its encoding mrnas in the developing cerebral neocortex and cerebellum of the mouse. |
1989-07-13 |
2023-08-11 |
mouse |
| G Mangin, D Couchie, C Charrière-Bertrand, J Nune. Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2498465. |
the expression of tau mrna and of the corresponding encoded protein variants was studied during postnatal development in two brain regions differing in their timing of differentiation: the cerebral neocortex and the cerebellum. |
1989-07-13 |
2023-08-11 |
mouse |
| G Mangin, D Couchie, C Charrière-Bertrand, J Nune. Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2498465. |
(b) the expression of total tau proteins was similar to that of their encoding mrnas in the cerebral neocortex, i.e., high concentrations after birth and low contents at later stages. |
1989-07-13 |
2023-08-11 |
mouse |
| G Mangin, D Couchie, C Charrière-Bertrand, J Nune. Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2498465. |
(c) both in the cerebral neocortex and especially in the cerebellum, increasing concentrations of mature tau variants were expressed at late developmental stages, i.e., when total tau protein contents were decreased. |
1989-07-13 |
2023-08-11 |
mouse |
| G Mangin, D Couchie, C Charrière-Bertrand, J Nune. Timing of expression of tau and its encoding mRNAs in the developing cerebral neocortex and cerebellum of the mouse. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2498465. |
the adult tau variants appear in both the neocortex and the cerebellum only at late developmental stages, i.e., when most of the circuitry has been established, although these two regions markedly differ in their timing of differentiation. |
1989-07-13 |
2023-08-11 |
mouse |
| J Q Trojanowski, T Schuck, M L Schmidt, V M Le. Distribution of tau proteins in the normal human central and peripheral nervous system. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 37. issue 2. 1989-02-16. PMID:2492045. |
in neocortex, hippocampus, and cerebellum, immunoreactive tau was widely expressed but segregated into the axon-neuropil domain of neurons. |
1989-02-16 |
2023-08-11 |
human |
| Y Ihar. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain research. vol 459. issue 1. 1988-11-21. PMID:3139259. |
in addition to neurofibrillary tangles and senile plaques, antibodies to human tau revealed extensive tau-immunoreactive meshworks in layers iii and v of the neocortex affected with alzheimer's disease. |
1988-11-21 |
2023-08-11 |
human |